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Agenesis of maxillary central incisor

MedGen UID:
870617
•Concept ID:
C4025068
•
Finding
Synonyms: Absence of maxillary central incisor; Failure of development of maxillary central incisor; Missing maxillary central incisor; Missing upper central incisor
 
HPO: HP:0006293

Definition

Agenesis of upper secondary incisor or of upper central primary incisor. [from HPO]

Professional guidelines

PubMed

Factors affecting treatment duration of labial inversely impacted maxillary central incisors.
Bhikoo C, Xu J, Sun H, Jin C, Jiang H, Hu R
Am J Orthod Dentofacial Orthop 2018 May;153(5):708-715. doi: 10.1016/j.ajodo.2017.09.017. PMID: 29706219
Nine Novel PAX9 Mutations and a Distinct Tooth Agenesis Genotype-Phenotype.
Wong SW, Han D, Zhang H, Liu Y, Zhang X, Miao MZ, Wang Y, Zhao N, Zeng L, Bai B, Wang YX, Liu H, Frazier-Bowers SA, Feng H
J Dent Res 2018 Feb;97(2):155-162. Epub 2017 Sep 14 doi: 10.1177/0022034517729322. PMID: 28910570Free PMC Article
Congenitally missing maxillary lateral incisors and orthodontic treatment considerations for the single-tooth implant.
Richardson G, Russell KA
J Can Dent Assoc 2001 Jan;67(1):25-8. PMID: 11209502

Recent clinical studies

Etiology

Influence of maxillary lateral incisor width ratio on perception of smile esthetics among orthodontists and laypersons.
Martinez Florez D, Rinchuse D, Zullo T
J Esthet Restor Dent 2021 Apr;33(3):510-515. Epub 2020 Nov 6 doi: 10.1111/jerd.12664. PMID: 33155745
Factors affecting treatment duration of labial inversely impacted maxillary central incisors.
Bhikoo C, Xu J, Sun H, Jin C, Jiang H, Hu R
Am J Orthod Dentofacial Orthop 2018 May;153(5):708-715. doi: 10.1016/j.ajodo.2017.09.017. PMID: 29706219
Prosthetic replacement vs space closure for maxillary lateral incisor agenesis: A systematic review.
Silveira GS, de Almeida NV, Pereira DM, Mattos CT, Mucha JN
Am J Orthod Dentofacial Orthop 2016 Aug;150(2):228-37. doi: 10.1016/j.ajodo.2016.01.018. PMID: 27476355
Esthetic perception of maxillary lateral incisor agenesis treatment by canine mesialization.
Mota A, Pinho T
Int Orthod 2016 Mar;14(1):95-107. Epub 2016 Jan 18 doi: 10.1016/j.ortho.2015.12.005. PMID: 26796152
A study of prevalence and distribution of tooth agenesis.
Bozga A, Stanciu RP, Mănuc D
J Med Life 2014 Oct-Dec;7(4):551-4. PMID: 25713620Free PMC Article

Diagnosis

Sonography of fetal holoprosencephaly: a guide to recognize the lesser varieties.
Montaguti E, Cariello L, Brunelli E, Youssef A, Livi A, Salsi G, Pilu G
J Matern Fetal Neonatal Med 2022 Dec;35(25):9717-9723. Epub 2022 Mar 10 doi: 10.1080/14767058.2022.2050900. PMID: 35272544
Frequency and association of maxillary ectopic canine with incisor root resorption and dental agenesis.
Nagani NI, Ahmed I, Rizwan S, Pervez H, Khan T, Arif T
J Pak Med Assoc 2021 Jan;71(1(B)):277-280. doi: 10.47391/JPMA.782. PMID: 35157664
Molar incisor hypomineralization: Analysis of asymmetry of lesions.
Biondi AM, Córtese SG, Babino L, Toscano MA
Acta Odontol Latinoam 2019 Apr 1;32(1):44-48. PMID: 31206574
The solitary median maxillary central incisor (SMMCI) syndrome: Associations, prenatal diagnosis, and outcomes.
Garcia Rodriguez R, Garcia Cruz L, Novoa Medina Y, Garcia Delgado R, Perez Gonzalez J, Palma Milla C, Lopez Siles J, Medina Castellano M, Garcia Hernandez JA, Santana Rodriguez A
Prenat Diagn 2019 May;39(6):415-419. Epub 2019 Apr 26 doi: 10.1002/pd.5451. PMID: 30900264
Solitary median maxillary central incisor (SMMCI) syndrome.
Hall RK
Orphanet J Rare Dis 2006 Apr 9;1:12. doi: 10.1186/1750-1172-1-12. PMID: 16722608Free PMC Article

Therapy

Prevalence and Etiological Factors of Dental Trauma among 12- and 15-Year-Old Schoolchildren of Lebanon: A National Study.
Abdel Malak C, Chakar C, Romanos A, Rachidi S
ScientificWorldJournal 2021;2021:5587431. Epub 2021 Mar 5 doi: 10.1155/2021/5587431. PMID: 33746633Free PMC Article
Impact of oral-health-related quality of life and self-esteem on patients with missing maxillary lateral incisor after orthodontic space closure: a single-blinded, randomized, controlled trial.
Pithon MM, Vargas EOA, da Silva Coqueiro R, Lacerda-Santos R, Tanaka OM, Maia LC
Eur J Orthod 2021 Apr 3;43(2):208-214. doi: 10.1093/ejo/cjaa075. PMID: 33367539
Cephalometric Findings in Nine Individuals With Richieri-Costa-Pereira Syndrome.
Pinto RO, Peixoto AP, Pinto ADS, Richieri-Costa A, Zechi-Ceide RM, Ozawa TO, Dalben GDS
J Craniofac Surg 2018 Sep;29(6):1596-1600. doi: 10.1097/SCS.0000000000004588. PMID: 29863549
Prosthetic replacement vs space closure for maxillary lateral incisor agenesis: A systematic review.
Silveira GS, de Almeida NV, Pereira DM, Mattos CT, Mucha JN
Am J Orthod Dentofacial Orthop 2016 Aug;150(2):228-37. doi: 10.1016/j.ajodo.2016.01.018. PMID: 27476355
Effectiveness of TAD-anchored maxillary protraction in late mixed dentition.
Feng X, Li J, Li Y, Zhao Z, Zhao S, Wang J
Angle Orthod 2012 Nov;82(6):1107-14. Epub 2012 Mar 29 doi: 10.2319/111411-705.1. PMID: 22458766Free PMC Article

Prognosis

The solitary median maxillary central incisor (SMMCI) syndrome: Associations, prenatal diagnosis, and outcomes.
Garcia Rodriguez R, Garcia Cruz L, Novoa Medina Y, Garcia Delgado R, Perez Gonzalez J, Palma Milla C, Lopez Siles J, Medina Castellano M, Garcia Hernandez JA, Santana Rodriguez A
Prenat Diagn 2019 May;39(6):415-419. Epub 2019 Apr 26 doi: 10.1002/pd.5451. PMID: 30900264
Factors affecting treatment duration of labial inversely impacted maxillary central incisors.
Bhikoo C, Xu J, Sun H, Jin C, Jiang H, Hu R
Am J Orthod Dentofacial Orthop 2018 May;153(5):708-715. doi: 10.1016/j.ajodo.2017.09.017. PMID: 29706219
Impacted and transmigrant mandibular canines incidence, aetiology, and treatment: a systematic review.
Dalessandri D, Parrini S, Rubiano R, Gallone D, Migliorati M
Eur J Orthod 2017 Apr 1;39(2):161-169. doi: 10.1093/ejo/cjw027. PMID: 27036134
Solitary median maxillary central incisor (SMMCI) syndrome.
Hall RK
Orphanet J Rare Dis 2006 Apr 9;1:12. doi: 10.1186/1750-1172-1-12. PMID: 16722608Free PMC Article
Solitary median maxillary central incisor, short stature, choanal atresia/midnasal stenosis (SMMCI) syndrome.
Hall RK, Bankier A, Aldred MJ, Kan K, Lucas JO, Perks AG
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997 Dec;84(6):651-62. doi: 10.1016/s1079-2104(97)90368-1. PMID: 9431535

Clinical prediction guides

Molar incisor hypomineralization: Analysis of asymmetry of lesions.
Biondi AM, Córtese SG, Babino L, Toscano MA
Acta Odontol Latinoam 2019 Apr 1;32(1):44-48. PMID: 31206574
Prosthetic replacement vs space closure for maxillary lateral incisor agenesis: A systematic review.
Silveira GS, de Almeida NV, Pereira DM, Mattos CT, Mucha JN
Am J Orthod Dentofacial Orthop 2016 Aug;150(2):228-37. doi: 10.1016/j.ajodo.2016.01.018. PMID: 27476355
A study of prevalence and distribution of tooth agenesis.
Bozga A, Stanciu RP, Mănuc D
J Med Life 2014 Oct-Dec;7(4):551-4. PMID: 25713620Free PMC Article
Solitary median maxillary central incisor (SMMCI) syndrome.
Hall RK
Orphanet J Rare Dis 2006 Apr 9;1:12. doi: 10.1186/1750-1172-1-12. PMID: 16722608Free PMC Article
Solitary median maxillary central incisor, short stature, choanal atresia/midnasal stenosis (SMMCI) syndrome.
Hall RK, Bankier A, Aldred MJ, Kan K, Lucas JO, Perks AG
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997 Dec;84(6):651-62. doi: 10.1016/s1079-2104(97)90368-1. PMID: 9431535

Recent systematic reviews

A boy with partial dup(18q)/del(18p) due to a maternal pericentric inversion: Genotype-phenotype correlation and risk of recombinant chromosomes based on systematic review of the literature.
Lustosa-Mendes E, Dos Santos AP, Viguetti-Campos NL, Vieira TP, Gil-da-Silva-Lopes VL
Am J Med Genet A 2017 Jan;173(1):143-150. Epub 2016 Sep 15 doi: 10.1002/ajmg.a.37976. PMID: 27633903
Impacted and transmigrant mandibular canines incidence, aetiology, and treatment: a systematic review.
Dalessandri D, Parrini S, Rubiano R, Gallone D, Migliorati M
Eur J Orthod 2017 Apr 1;39(2):161-169. doi: 10.1093/ejo/cjw027. PMID: 27036134
Management of non-syndromic dens evaginatus affecting permanent maxillary central incisors: a systematic review.
Smail-Faugeron V, Picou Rollin J, Muller Bolla M, Courson F
BMJ Case Rep 2016 Oct 5;2016 doi: 10.1136/bcr-2016-216672. PMID: 27707761Free PMC Article
Prosthetic replacement vs space closure for maxillary lateral incisor agenesis: A systematic review.
Silveira GS, de Almeida NV, Pereira DM, Mattos CT, Mucha JN
Am J Orthod Dentofacial Orthop 2016 Aug;150(2):228-37. doi: 10.1016/j.ajodo.2016.01.018. PMID: 27476355
Management of non-syndromic double tooth affecting permanent maxillary central incisors: a systematic review.
Smail-Faugeron V, Terradot J, Muller Bolla M, Courson F
BMJ Case Rep 2016 Jun 15;2016 doi: 10.1136/bcr-2016-215482. PMID: 27307427Free PMC Article

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