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Diffuse cerebral calcification

MedGen UID:
870671
•Concept ID:
C4025125
•
Finding
HPO: HP:0005849

Definition

Generalized deposition of calcium salts within the cerebrum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse cerebral calcification

Professional guidelines

PubMed

The clinical utility of QSM: disease diagnosis, medical management, and surgical planning.
Eskreis-Winkler S, Zhang Y, Zhang J, Liu Z, Dimov A, Gupta A, Wang Y
NMR Biomed 2017 Apr;30(4) Epub 2016 Dec 1 doi: 10.1002/nbm.3668. PMID: 27906525
Central nervous system paracoccidioidomycosis: diagnosis and treatment.
Elias J Jr, dos Santos AC, Carlotti CG Jr, Colli BO, Canheu A, Matias C, Furlanetti L, Martinez R, Takayanagui OM, Sakamoto AC, Serafini LN, Chimelli L
Surg Neurol 2005;63 Suppl 1:S13-21; discussion S21. doi: 10.1016/j.surneu.2004.09.019. PMID: 15629337
Histological heterogeneity of dysembryoplastic neuroepithelial tumour: identification and differential diagnosis in a series of 74 cases.
Honavar M, Janota I, Polkey CE
Histopathology 1999 Apr;34(4):342-56. doi: 10.1046/j.1365-2559.1999.00576.x. PMID: 10231402

Recent clinical studies

Etiology

Antithrombotic and Statin Prescription After Intracerebral Hemorrhage in the Get With The Guidelines-Stroke Registry.
Murthy SB, Zhang C, Shah S, Schwamm LH, Fonarow GC, Smith EE, Bhatt DL, Ziai WC, Kamel H, Sheth KN
Stroke 2023 Dec;54(12):2972-2980. Epub 2023 Nov 9 doi: 10.1161/STROKEAHA.123.043194. PMID: 37942641Free PMC Article
The correlation between intracranial arterial calcification and the outcome of reperfusion therapy.
Du H, Zheng J, Li X, Bos D, Yang W, Cheng Y, Liu C, Wong LKS, Hu J, Chen X
Ann Clin Transl Neurol 2023 Jun;10(6):974-982. Epub 2023 Apr 23 doi: 10.1002/acn3.51780. PMID: 37088543Free PMC Article
The CLDN5 gene at the blood-brain barrier in health and disease.
Hashimoto Y, Greene C, Munnich A, Campbell M
Fluids Barriers CNS 2023 Mar 28;20(1):22. doi: 10.1186/s12987-023-00424-5. PMID: 36978081Free PMC Article
An update on clinical, pathological, diagnostic, and therapeutic perspectives of childhood leukodystrophies.
Ashrafi MR, Amanat M, Garshasbi M, Kameli R, Nilipour Y, Heidari M, Rezaei Z, Tavasoli AR
Expert Rev Neurother 2020 Jan;20(1):65-84. Epub 2019 Dec 12 doi: 10.1080/14737175.2020.1699060. PMID: 31829048
TORCH syndrome.
Epps RE, Pittelkow MR, Su WP
Semin Dermatol 1995 Jun;14(2):179-86. doi: 10.1016/s1085-5629(05)80016-1. PMID: 7640200

Diagnosis

A new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co-altered: a clinico-radiological and histomolecular characterisation.
Auffret L, Ajlil Y, Tauziède-Espariat A, Kergrohen T, Puiseux C, Riffaud L, Blouin P, Bertozzi AI, Leblond P, Blomgren K, Froelich S, Picca A, Touat M, Sanson M, Beccaria K, Blauwblomme T, Dangouloff-Ros V, Boddaert N, Varlet P, Debily MA, Grill J, Castel D
Acta Neuropathol 2023 Dec 8;147(1):2. doi: 10.1007/s00401-023-02651-4. PMID: 38066305Free PMC Article
Sepsis Unmasking Fahr's Disease.
Mandal AKJ, Patel NB, Missouris CG
Am J Med Sci 2020 Oct;360(4):406-409. Epub 2020 May 21 doi: 10.1016/j.amjms.2020.05.023. PMID: 32593413
Fetal MRI of CNS abnormalities.
Masselli G, Vaccaro Notte MR, Zacharzewska-Gondek A, Laghi F, Manganaro L, Brunelli R
Clin Radiol 2020 Aug;75(8):640.e1-640.e11. Epub 2020 Apr 26 doi: 10.1016/j.crad.2020.03.035. PMID: 32349872
An update on clinical, pathological, diagnostic, and therapeutic perspectives of childhood leukodystrophies.
Ashrafi MR, Amanat M, Garshasbi M, Kameli R, Nilipour Y, Heidari M, Rezaei Z, Tavasoli AR
Expert Rev Neurother 2020 Jan;20(1):65-84. Epub 2019 Dec 12 doi: 10.1080/14737175.2020.1699060. PMID: 31829048
Infection.
Saigal G, Nagornaya N, Post MJD
Handb Clin Neurol 2016;135:365-397. doi: 10.1016/B978-0-444-53485-9.00019-2. PMID: 27432675

Therapy

Antithrombotic and Statin Prescription After Intracerebral Hemorrhage in the Get With The Guidelines-Stroke Registry.
Murthy SB, Zhang C, Shah S, Schwamm LH, Fonarow GC, Smith EE, Bhatt DL, Ziai WC, Kamel H, Sheth KN
Stroke 2023 Dec;54(12):2972-2980. Epub 2023 Nov 9 doi: 10.1161/STROKEAHA.123.043194. PMID: 37942641Free PMC Article
Shorter Door-to-Needle Times Are Associated With Better Outcomes After Intravenous Thrombolytic Therapy and Endovascular Thrombectomy for Acute Ischemic Stroke.
Man S, Solomon N, Mac Grory B, Alhanti B, Uchino K, Saver JL, Smith EE, Xian Y, Bhatt DL, Schwamm LH, Hussain MS, Fonarow GC
Circulation 2023 Jul 4;148(1):20-34. Epub 2023 May 18 doi: 10.1161/CIRCULATIONAHA.123.064053. PMID: 37199147Free PMC Article
The correlation between intracranial arterial calcification and the outcome of reperfusion therapy.
Du H, Zheng J, Li X, Bos D, Yang W, Cheng Y, Liu C, Wong LKS, Hu J, Chen X
Ann Clin Transl Neurol 2023 Jun;10(6):974-982. Epub 2023 Apr 23 doi: 10.1002/acn3.51780. PMID: 37088543Free PMC Article
Sepsis Unmasking Fahr's Disease.
Mandal AKJ, Patel NB, Missouris CG
Am J Med Sci 2020 Oct;360(4):406-409. Epub 2020 May 21 doi: 10.1016/j.amjms.2020.05.023. PMID: 32593413
TORCH syndrome.
Epps RE, Pittelkow MR, Su WP
Semin Dermatol 1995 Jun;14(2):179-86. doi: 10.1016/s1085-5629(05)80016-1. PMID: 7640200

Prognosis

A new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co-altered: a clinico-radiological and histomolecular characterisation.
Auffret L, Ajlil Y, Tauziède-Espariat A, Kergrohen T, Puiseux C, Riffaud L, Blouin P, Bertozzi AI, Leblond P, Blomgren K, Froelich S, Picca A, Touat M, Sanson M, Beccaria K, Blauwblomme T, Dangouloff-Ros V, Boddaert N, Varlet P, Debily MA, Grill J, Castel D
Acta Neuropathol 2023 Dec 8;147(1):2. doi: 10.1007/s00401-023-02651-4. PMID: 38066305Free PMC Article
The correlation between intracranial arterial calcification and the outcome of reperfusion therapy.
Du H, Zheng J, Li X, Bos D, Yang W, Cheng Y, Liu C, Wong LKS, Hu J, Chen X
Ann Clin Transl Neurol 2023 Jun;10(6):974-982. Epub 2023 Apr 23 doi: 10.1002/acn3.51780. PMID: 37088543Free PMC Article
Cerebral Microangiopathy in Leukoencephalopathy With Cerebral Calcifications and Cysts: A Pathological Description.
Helman G, Viaene AN, Takanohashi A, Breur M, Berger R, Woidill S, Cottrell JR, Schiffmann R, Crow YJ, Simons C, Bugiani M, Vanderver A
J Child Neurol 2021 Feb;36(2):133-140. Epub 2020 Sep 28 doi: 10.1177/0883073820958330. PMID: 32988269
The MRI spectrum of congenital cytomegalovirus infection.
Diogo MC, Glatter S, Binder J, Kiss H, Prayer D
Prenat Diagn 2020 Jan;40(1):110-124. Epub 2020 Jan 6 doi: 10.1002/pd.5591. PMID: 31802515Free PMC Article
Cognition and Cerebral Infarction in Older Adults After Surgical Aortic Valve Replacement.
Giovannetti T, Price CC, Fanning M, Messé S, Ratcliffe SJ, Lyon A, Kasner SE, Seidel G, Bavaria JE, Szeto WY, Hargrove WC 3rd, Acker MA, Floyd TF; DENOVO Investigators
Ann Thorac Surg 2019 Mar;107(3):787-794. Epub 2018 Nov 10 doi: 10.1016/j.athoracsur.2018.09.057. PMID: 30423336Free PMC Article

Clinical prediction guides

The correlation between intracranial arterial calcification and the outcome of reperfusion therapy.
Du H, Zheng J, Li X, Bos D, Yang W, Cheng Y, Liu C, Wong LKS, Hu J, Chen X
Ann Clin Transl Neurol 2023 Jun;10(6):974-982. Epub 2023 Apr 23 doi: 10.1002/acn3.51780. PMID: 37088543Free PMC Article
T2-FLAIR mismatch sign in dysembryoplasticneuroepithelial tumor.
Onishi S, Amatya VJ, Kolakshyapati M, Takano M, Yonezawa U, Taguchi A, Kaichi Y, Takeshima Y, Awai K, Sugiyama K, Kurisu K, Yamasaki F
Eur J Radiol 2020 May;126:108924. Epub 2020 Mar 2 doi: 10.1016/j.ejrad.2020.108924. PMID: 32193035
Relevance of calcification and contrast enhancement pattern for molecular diagnosis and survival prediction of gliomas based on the 2016 World Health Organization Classification.
Michiwaki Y, Hata N, Mizoguchi M, Hiwatashi A, Kuga D, Hatae R, Akagi Y, Amemiya T, Fujioka Y, Togao O, Suzuki SO, Yoshimoto K, Iwaki T, Iihara K
Clin Neurol Neurosurg 2019 Dec;187:105556. Epub 2019 Oct 12 doi: 10.1016/j.clineuro.2019.105556. PMID: 31639630
Imaging features of rosette-forming glioneuronal tumours.
Gao L, Han F, Jin Y, Xiong J, Lv Y, Yao Z, Zhang J
Clin Radiol 2018 Mar;73(3):275-282. Epub 2017 Nov 13 doi: 10.1016/j.crad.2017.10.011. PMID: 29146003
Basal ganglia lesions in children and adults.
Bekiesinska-Figatowska M, Mierzewska H, Jurkiewicz E
Eur J Radiol 2013 May;82(5):837-49. Epub 2013 Jan 10 doi: 10.1016/j.ejrad.2012.12.006. PMID: 23313708

Recent systematic reviews

Intrasellar Dermoid Cyst: Case Report of a Rare Lesion and Systematic Literature Review Comparing Intrasellar, Suprasellar, and Parasellar Locations.
Donofrio CA, Bertazzoni G, Riccio L, Pinacoli A, Pianta L, Generali D, Ungari M, Servadei F, Roncaroli F, Fioravanti A
World Neurosurg 2024 Feb;182:83-90. Epub 2023 Nov 22 doi: 10.1016/j.wneu.2023.11.057. PMID: 37995988
Neuroimaging phenotypes of CSF1R-related leukoencephalopathy: Systematic review, meta-analysis, and imaging recommendations.
Mickeviciute GC, Valiuskyte M, Plattén M, Wszolek ZK, Andersen O, Danylaité Karrenbauer V, Ineichen BV, Granberg T
J Intern Med 2022 Mar;291(3):269-282. Epub 2021 Dec 22 doi: 10.1111/joim.13420. PMID: 34875121
The role of imaging for the management of newly diagnosed glioblastoma in adults: a systematic review and evidence-based clinical practice guideline update.
Lundy P, Domino J, Ryken T, Fouke S, McCracken DJ, Ormond DR, Olson JJ
J Neurooncol 2020 Nov;150(2):95-120. Epub 2020 Nov 19 doi: 10.1007/s11060-020-03597-3. PMID: 33215340
Neuroradiologic characteristics of astroblastoma and systematic review of the literature: 2 new cases and 125 cases reported in 59 publications.
Cunningham DA, Lowe LH, Shao L, Acosta NR
Pediatr Radiol 2016 Aug;46(9):1301-8. Epub 2016 Apr 5 doi: 10.1007/s00247-016-3607-x. PMID: 27048363
The role of imaging in the management of adults with diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Fouke SJ, Benzinger T, Gibson D, Ryken TC, Kalkanis SN, Olson JJ
J Neurooncol 2015 Dec;125(3):457-79. Epub 2015 Nov 3 doi: 10.1007/s11060-015-1908-9. PMID: 26530262

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