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Imbalanced hemoglobin synthesis

MedGen UID:
870723
Concept ID:
C4025177
Finding
Synonyms: Imbalanced haemoglobin synthesis; Imbalanced Hb synthesis
 
HPO: HP:0005560

Definition

Normal hemoglobin synthesis is characterized by production of equal amounts of alpha and beta globins. This term refers to a deviation from this pattern and is the main characteristic of the various forms of thalassemia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImbalanced hemoglobin synthesis

Conditions with this feature

HEMOGLOBIN NYU
MedGen UID:
855075
Concept ID:
C3889376
Finding

Recent clinical studies

Etiology

Jin X, Dai G, Xuan L, Zhang M, Jiang H, Sui Y
J Immunol Res 2022;2022:6792866. Epub 2022 Apr 6 doi: 10.1155/2022/6792866. PMID: 35434141Free PMC Article
Evans RG, Subasinghe AK, Busingye D, Srikanth VK, Kartik K, Kalyanram K, Suresh O, Arabshahi S, Curkpatrick I, O'Dea K, Walker KZ, Kaye M, Yang J, Thomas N, Arulappan G, Thrift AG
J Hum Hypertens 2021 Dec;35(12):1118-1128. Epub 2021 Jan 18 doi: 10.1038/s41371-020-00473-5. PMID: 33462389
Ueki K, Tanizawa Y, Nakamura J, Yamada Y, Inagaki N, Watada H, Shimomura I, Nishimura R, Miyoshi H, Abiko A, Katagiri H, Hayashi M, Shimada A, Naruse K, Fujimoto S, Fujiwara M, Shikata K, Okada Y, Araki E, Yamazaki T, Kadowaki T; J-BRAND Registry Group
BMJ Open Diabetes Res Care 2021 Jan;9(1) doi: 10.1136/bmjdrc-2020-001787. PMID: 33441417Free PMC Article
Liu G, Li Y, Qin L, Yan Y, Ye Y, Chen Y, Huang C, Zhao S, Yao Y, Su Z, Chen X
BMC Infect Dis 2019 Nov 12;19(1):965. doi: 10.1186/s12879-019-4465-6. PMID: 31718574Free PMC Article
Colah R, Mohanty D
Indian J Pediatr 1998 Nov-Dec;65(6):815-23. doi: 10.1007/BF02831339. PMID: 10773945

Diagnosis

Vasseur C, Domingues-Hamdi E, Ledudal K, Le Corvoisier P, Barau C, Ghaleh B, Rialland A, Pissard S, Galactéros F, Baudin-Creuza V
Br J Haematol 2017 Oct;179(1):142-153. Epub 2017 Jun 23 doi: 10.1111/bjh.14800. PMID: 28643346
Sun YX, Kong HL, Liu CF, Yu S, Tian T, Ma DX, Ji CY
Hum Immunol 2014 Feb;75(2):113-8. Epub 2013 Nov 20 doi: 10.1016/j.humimm.2013.11.014. PMID: 24269703
Tubsuwan A, Munkongdee T, Jearawiriyapaisarn N, Boonchoy C, Winichagoon P, Fucharoen S, Svasti S
Br J Haematol 2011 Sep;154(5):635-43. Epub 2011 Jul 7 doi: 10.1111/j.1365-2141.2011.08770.x. PMID: 21732929
Pautard B, Feo C, Dhermy D, Wajcman H, Baudin-Chich V, Delobel J
Br J Haematol 1988 Oct;70(2):239-45. doi: 10.1111/j.1365-2141.1988.tb02470.x. PMID: 3191034
Rutherford T, Clegg JB, Higgs DR, Jones RW, Thompson J, Weatherall DJ
Proc Natl Acad Sci U S A 1981 Jan;78(1):348-52. doi: 10.1073/pnas.78.1.348. PMID: 6264439Free PMC Article

Therapy

Jin X, Dai G, Xuan L, Zhang M, Jiang H, Sui Y
J Immunol Res 2022;2022:6792866. Epub 2022 Apr 6 doi: 10.1155/2022/6792866. PMID: 35434141Free PMC Article
Porter J, Taher A, Viprakasit V, Kattamis A, Coates TD, Garbowski M, Dürrenberger F, Manolova V, Richard F, Cappellini MD
Expert Rev Hematol 2021 Jul;14(7):633-644. Epub 2021 Jul 29 doi: 10.1080/17474086.2021.1935854. PMID: 34324404
Ueki K, Tanizawa Y, Nakamura J, Yamada Y, Inagaki N, Watada H, Shimomura I, Nishimura R, Miyoshi H, Abiko A, Katagiri H, Hayashi M, Shimada A, Naruse K, Fujimoto S, Fujiwara M, Shikata K, Okada Y, Araki E, Yamazaki T, Kadowaki T; J-BRAND Registry Group
BMJ Open Diabetes Res Care 2021 Jan;9(1) doi: 10.1136/bmjdrc-2020-001787. PMID: 33441417Free PMC Article
Liu G, Li Y, Qin L, Yan Y, Ye Y, Chen Y, Huang C, Zhao S, Yao Y, Su Z, Chen X
BMC Infect Dis 2019 Nov 12;19(1):965. doi: 10.1186/s12879-019-4465-6. PMID: 31718574Free PMC Article
Hagag AA, Hamam MA, Taha OA, Hazaa SM
Infect Disord Drug Targets 2015;15(2):98-105. doi: 10.2174/1871526515666150724111721. PMID: 26205801

Prognosis

Liu G, Li Y, Qin L, Yan Y, Ye Y, Chen Y, Huang C, Zhao S, Yao Y, Su Z, Chen X
BMC Infect Dis 2019 Nov 12;19(1):965. doi: 10.1186/s12879-019-4465-6. PMID: 31718574Free PMC Article
Tubsuwan A, Munkongdee T, Jearawiriyapaisarn N, Boonchoy C, Winichagoon P, Fucharoen S, Svasti S
Br J Haematol 2011 Sep;154(5):635-43. Epub 2011 Jul 7 doi: 10.1111/j.1365-2141.2011.08770.x. PMID: 21732929
Khattab AD, Rawlings B, Ali IS
Br J Nurs 2006 Oct 12-25;15(18):994-8. doi: 10.12968/bjon.2006.15.18.22024. PMID: 17077770
Galanello R, Ruggeri R, Paglietti E, Addis M, Melis MA, Cao A
Blood 1983 Nov;62(5):1035-40. PMID: 6313095
Henni T, Bachir D, Tabone P, Jurdic P, Godet J, Colonna P
Acta Haematol 1981;65(4):240-6. doi: 10.1159/000207187. PMID: 6789587

Clinical prediction guides

Porter J, Taher A, Viprakasit V, Kattamis A, Coates TD, Garbowski M, Dürrenberger F, Manolova V, Richard F, Cappellini MD
Expert Rev Hematol 2021 Jul;14(7):633-644. Epub 2021 Jul 29 doi: 10.1080/17474086.2021.1935854. PMID: 34324404
Ueki K, Tanizawa Y, Nakamura J, Yamada Y, Inagaki N, Watada H, Shimomura I, Nishimura R, Miyoshi H, Abiko A, Katagiri H, Hayashi M, Shimada A, Naruse K, Fujimoto S, Fujiwara M, Shikata K, Okada Y, Araki E, Yamazaki T, Kadowaki T; J-BRAND Registry Group
BMJ Open Diabetes Res Care 2021 Jan;9(1) doi: 10.1136/bmjdrc-2020-001787. PMID: 33441417Free PMC Article
Vasseur C, Domingues-Hamdi E, Ledudal K, Le Corvoisier P, Barau C, Ghaleh B, Rialland A, Pissard S, Galactéros F, Baudin-Creuza V
Br J Haematol 2017 Oct;179(1):142-153. Epub 2017 Jun 23 doi: 10.1111/bjh.14800. PMID: 28643346
Sun YX, Kong HL, Liu CF, Yu S, Tian T, Ma DX, Ji CY
Hum Immunol 2014 Feb;75(2):113-8. Epub 2013 Nov 20 doi: 10.1016/j.humimm.2013.11.014. PMID: 24269703
Varricchio L, Fabucci ME, Alfani E, Godbold J, Migliaccio AR
Transfusion 2010 Mar;50(3):672-84. Epub 2009 Nov 4 doi: 10.1111/j.1537-2995.2009.02483.x. PMID: 19891622

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