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Abnormality of the metopic suture

MedGen UID:
870726
•Concept ID:
C4025180
•
Anatomical Abnormality
HPO: HP:0005556

Definition

The frontal suture divides the two halves of the frontal bone of the skull in infants and children and generally undergoes fusion by the age of six. A persistent frontal suture is referred to as a "metopic suture". [from HPO]

Professional guidelines

PubMed

Diagnosis and Management of Suture-Related Concerns of the Infant Skull.
Hersh DS, Bookland MJ, Hughes CD
Pediatr Clin North Am 2021 Aug;68(4):727-742. doi: 10.1016/j.pcl.2021.04.002. PMID: 34247705
Craniosynostosis as a clinical and diagnostic problem: molecular pathology and genetic counseling.
Kutkowska-Kaźmierczak A, Gos M, Obersztyn E
J Appl Genet 2018 May;59(2):133-147. Epub 2018 Feb 1 doi: 10.1007/s13353-017-0423-4. PMID: 29392564
The Management of Trigonoscaphocephaly as a Result of Combined Metopic and Sagittal Synostosis.
Dobbs TD, Salahuddin O, Jayamohan J, Richards P, Magdum S, Wall SA, Johnson D
Plast Reconstr Surg 2017 Jun;139(6):1325e-1332e. doi: 10.1097/PRS.0000000000003371. PMID: 28538575

Recent clinical studies

Etiology

Saethre-Chotzen Syndrome: A Report of 7 Patients and Review of the Literature.
Abulezz TA, Allam KA, Wan DC, Lee JC, Kawamoto HK
Ann Plast Surg 2020 Sep;85(3):251-255. doi: 10.1097/SAP.0000000000002391. PMID: 32487807
The Impact of Ethnicity on Craniosynostosis in the United States.
Sacks GN, Skolnick GB, Trachtenberg A, Naidoo SD, Lopez J, Oh AK, Chao JW, Dorafshar A, Vercler CJ, Buchman SR, Patel K
J Craniofac Surg 2019 Nov-Dec;30(8):2526-2529. doi: 10.1097/SCS.0000000000006009. PMID: 31609944
The metopic suture: Natural history.
Vinchon M
Neurochirurgie 2019 Nov;65(5):239-245. Epub 2019 Sep 25 doi: 10.1016/j.neuchi.2019.09.006. PMID: 31562880
Complex craniosynostosis.
Czerwinski M, Kolar JC, Fearon JA
Plast Reconstr Surg 2011 Oct;128(4):955-961. doi: 10.1097/PRS.0b013e3182268ca6. PMID: 21681124
Consensus: trigonocephaly.
Collmann H, Sörensen N, Krauss J
Childs Nerv Syst 1996 Nov;12(11):664-8. doi: 10.1007/BF00366148. PMID: 9118128

Diagnosis

Diagnosis and Management of Suture-Related Concerns of the Infant Skull.
Hersh DS, Bookland MJ, Hughes CD
Pediatr Clin North Am 2021 Aug;68(4):727-742. doi: 10.1016/j.pcl.2021.04.002. PMID: 34247705
Saethre-Chotzen Syndrome: A Report of 7 Patients and Review of the Literature.
Abulezz TA, Allam KA, Wan DC, Lee JC, Kawamoto HK
Ann Plast Surg 2020 Sep;85(3):251-255. doi: 10.1097/SAP.0000000000002391. PMID: 32487807
The metopic suture: Natural history.
Vinchon M
Neurochirurgie 2019 Nov;65(5):239-245. Epub 2019 Sep 25 doi: 10.1016/j.neuchi.2019.09.006. PMID: 31562880
Current Controversies in Metopic Suture Craniosynostosis.
Jaskolka MS
Oral Maxillofac Surg Clin North Am 2017 Nov;29(4):447-463. doi: 10.1016/j.coms.2017.07.003. PMID: 28987228
Complex craniosynostosis.
Czerwinski M, Kolar JC, Fearon JA
Plast Reconstr Surg 2011 Oct;128(4):955-961. doi: 10.1097/PRS.0b013e3182268ca6. PMID: 21681124

Therapy

Recent advances in trigonocephaly.
Mocquard C, Aillet S, Riffaud L
Neurochirurgie 2019 Nov;65(5):246-251. Epub 2019 Sep 27 doi: 10.1016/j.neuchi.2019.09.014. PMID: 31568780
Nonsyndromic Craniosynostosis.
Dempsey RF, Monson LA, Maricevich RS, Truong TA, Olarunnipa S, Lam SK, Dauser RC, Hollier LH Jr, Buchanan EP
Clin Plast Surg 2019 Apr;46(2):123-139. Epub 2019 Jan 30 doi: 10.1016/j.cps.2018.11.001. PMID: 30851746
Short- and Long-Term Outcomes by Procedure Type for Nonsagittal Single-Suture Craniosynostosis.
Bennett KG, Hespe GE, Vercler CJ, Buchman SR
J Craniofac Surg 2019 Mar/Apr;30(2):458-464. doi: 10.1097/SCS.0000000000005129. PMID: 30640851Free PMC Article
The Biomechanical Properties of Human Craniofacial Sutures and Relevant Variables in Sutural Distraction Osteogenesis: A Critical Review.
Savoldi F, Tsoi JKH, Paganelli C, Matinlinna JP
Tissue Eng Part B Rev 2018 Feb;24(1):25-36. Epub 2017 Jul 21 doi: 10.1089/ten.TEB.2017.0116. PMID: 28610544
Trigonocephaly - Our Experience and Treatment in the Republic of Macedonia.
Mircevsk V, Zogovska E, Chaparoski A, Micunovic M, Filipce V, Mirchevski MM, Kostov M, Мicunovic L
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Mar 1;38(1):35-40. doi: 10.1515/prilozi-2017-0004. PMID: 28593893

Prognosis

Targeted Sequencing of Candidate Regions Associated with Sagittal and Metopic Nonsyndromic Craniosynostosis.
Justice CM, Musolf AM, Cuellar A, Lattanzi W, Simeonov E, Kaneva R, Paschall J, Cunningham M, Wilkie AOM, Wilson AF, Romitti PA, Boyadjiev SA
Genes (Basel) 2022 May 3;13(5) doi: 10.3390/genes13050816. PMID: 35627201Free PMC Article
Nonsyndromic Craniosynostosis.
Dempsey RF, Monson LA, Maricevich RS, Truong TA, Olarunnipa S, Lam SK, Dauser RC, Hollier LH Jr, Buchanan EP
Clin Plast Surg 2019 Apr;46(2):123-139. Epub 2019 Jan 30 doi: 10.1016/j.cps.2018.11.001. PMID: 30851746
Metopic synostosis.
van der Meulen J
Childs Nerv Syst 2012 Sep;28(9):1359-67. Epub 2012 Aug 8 doi: 10.1007/s00381-012-1803-z. PMID: 22872249Free PMC Article
Complex craniosynostosis.
Czerwinski M, Kolar JC, Fearon JA
Plast Reconstr Surg 2011 Oct;128(4):955-961. doi: 10.1097/PRS.0b013e3182268ca6. PMID: 21681124
Consensus: trigonocephaly.
Collmann H, Sörensen N, Krauss J
Childs Nerv Syst 1996 Nov;12(11):664-8. doi: 10.1007/BF00366148. PMID: 9118128

Clinical prediction guides

Clinical interest of molecular study in cases of isolated midline craniosynostosis.
Di Rocco F, Rossi M, Verlut I, Szathmari A, Beuriat PA, Chatron N, Chauvel-Picard J, Mottolese C, Monin P, Vinchon M, Guernouche S, Collet C
Eur J Hum Genet 2023 Jun;31(6):621-628. Epub 2023 Feb 3 doi: 10.1038/s41431-023-01295-y. PMID: 36732661Free PMC Article
Recent advances in trigonocephaly.
Mocquard C, Aillet S, Riffaud L
Neurochirurgie 2019 Nov;65(5):246-251. Epub 2019 Sep 27 doi: 10.1016/j.neuchi.2019.09.014. PMID: 31568780
Nonsyndromic Craniosynostosis.
Dempsey RF, Monson LA, Maricevich RS, Truong TA, Olarunnipa S, Lam SK, Dauser RC, Hollier LH Jr, Buchanan EP
Clin Plast Surg 2019 Apr;46(2):123-139. Epub 2019 Jan 30 doi: 10.1016/j.cps.2018.11.001. PMID: 30851746
Genetic basis of single-suture synostoses: genes, chromosomes and clinical implications.
Lattanzi W, Bukvic N, Barba M, Tamburrini G, Bernardini C, Michetti F, Di Rocco C
Childs Nerv Syst 2012 Sep;28(9):1301-10. Epub 2012 Aug 8 doi: 10.1007/s00381-012-1781-1. PMID: 22872241
Consensus: trigonocephaly.
Collmann H, Sörensen N, Krauss J
Childs Nerv Syst 1996 Nov;12(11):664-8. doi: 10.1007/BF00366148. PMID: 9118128

Recent systematic reviews

Craniofacial Distraction in the Management of Anterior Plagiocephaly: A Novel Idea and a Systematic Review of the Literature.
Elbanoby T
Pediatr Neurosurg 2018;53(3):193-199. Epub 2018 Feb 7 doi: 10.1159/000486202. PMID: 29408824

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