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T cell chronic lymphocytic lymphoma/leukemia

MedGen UID:
870727
•Concept ID:
C4025181
•
Neoplastic Process
HPO: HP:0005539

Definition

A form of lymphoid leukemia or lymphoma in which too many T-cell lymphoblasts are found in the blood, bone marrow, and tissues. Leukemia or lymphoma classification depends on which feature is more prominent. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVT cell chronic lymphocytic lymphoma/leukemia

Professional guidelines

PubMed

Immunotoxins in the treatment of hematologic malignancies.
Kreitman RJ, Pastan I
Curr Drug Targets 2006 Oct;7(10):1301-11. doi: 10.2174/138945006778559139. PMID: 17073592

Recent clinical studies

Prognosis

Clonal cytopenia of undetermined significance (CCUS)-associated reversion of donor-derived, transient αβ T-cell large granular clonal lymphocytosis, emerging post-transplant in a patient with a history of γδ T-cell large granular lymphocytic leukemia.
El Hussein S, Evans AG, Fitzsimmons JM, Leong N, Buldo M, Segal JP, Jajosky AN, Rothberg PG, Liesveld JL, Oltvai ZN
Cold Spring Harb Mol Case Stud 2023 Apr;9(2) Epub 2023 May 9 doi: 10.1101/mcs.a006241. PMID: 37160316Free PMC Article

Clinical prediction guides

Clonal cytopenia of undetermined significance (CCUS)-associated reversion of donor-derived, transient αβ T-cell large granular clonal lymphocytosis, emerging post-transplant in a patient with a history of γδ T-cell large granular lymphocytic leukemia.
El Hussein S, Evans AG, Fitzsimmons JM, Leong N, Buldo M, Segal JP, Jajosky AN, Rothberg PG, Liesveld JL, Oltvai ZN
Cold Spring Harb Mol Case Stud 2023 Apr;9(2) Epub 2023 May 9 doi: 10.1101/mcs.a006241. PMID: 37160316Free PMC Article

Supplemental Content

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