U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

T-cell lymphoma/leukemia

MedGen UID:
870732
•Concept ID:
C4025186
•
Neoplastic Process
HPO: HP:0005517

Definition

A type of T-cell lymphoma in which cancerous T-cells may present in the blood (leukemia), lymph nodes (lymphoma), skin or in multiple areas. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVT-cell lymphoma/leukemia

Professional guidelines

PubMed

Identifying highly active anti-CCR4 CAR T cells for the treatment of T-cell lymphoma.
Watanabe K, Gomez AM, Kuramitsu S, Siurala M, Da T, Agarwal S, Song D, Scholler J, Rotolo A, Posey AD, Rook AH, Haun PL, Ruella M, Young RM, June CH
Blood Adv 2023 Jul 25;7(14):3416-3430. doi: 10.1182/bloodadvances.2022008327. PMID: 37058474Free PMC Article
HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management.
Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article

Recent clinical studies

Etiology

HTLV-1, ATLL, severe hypercalcaemia and HIV-1 co-infection: an overview.
Laher AE, Ebrahim O
Pan Afr Med J 2018;30:61. Epub 2018 May 28 doi: 10.11604/pamj.2018.30.61.13238. PMID: 30344845Free PMC Article
Primary cutaneous T-cell lymphoma: experience from the Peruvian National Cancer Institute.
Ruiz R, Morante Z, Mantilla R, Mas L, Casanova L, Gomez HL
An Bras Dermatol 2017 Sep-Oct;92(5):649-654. doi: 10.1590/abd1806-4841.20176825. PMID: 29166501Free PMC Article
Adult T-Cell Leukemia/Lymphoma.
Mehta-Shah N, Ratner L, Horwitz SM
J Oncol Pract 2017 Aug;13(8):487-492. doi: 10.1200/JOP.2017.021907. PMID: 28796966Free PMC Article
Models for mature T-cell lymphomas--a critical appraisal of experimental systems and their contribution to current T-cell tumorigenic concepts.
Warner K, Crispatzu G, Al-Ghaili N, Weit N, Florou V, You MJ, Newrzela S, Herling M
Crit Rev Oncol Hematol 2013 Dec;88(3):680-95. Epub 2013 Aug 21 doi: 10.1016/j.critrevonc.2013.07.014. PMID: 23972664
T-cell lymphoma in HIV-infected patients.
Arzoo KK, Bu X, Espina BM, Seneviratne L, Nathwani B, Levine AM
J Acquir Immune Defic Syndr 2004 Aug 15;36(5):1020-7. doi: 10.1097/00126334-200408150-00004. PMID: 15247554

Diagnosis

Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia.
Gao X, Qin S, Wu Y, Chu C, Jiang B, Johnson RH, Kuang D, Zhang J, Wang X, Mehta A, Tew KD, Leone GW, Yu XZ, Wang H
J Clin Invest 2021 Aug 16;131(16) doi: 10.1172/JCI143119. PMID: 34255748Free PMC Article
Primary cutaneous T-cell lymphoma: experience from the Peruvian National Cancer Institute.
Ruiz R, Morante Z, Mantilla R, Mas L, Casanova L, Gomez HL
An Bras Dermatol 2017 Sep-Oct;92(5):649-654. doi: 10.1590/abd1806-4841.20176825. PMID: 29166501Free PMC Article
Comorbidity between HTLV-1-associated adult T-cell lymphoma/leukemia and verrucous carcinoma: a case report.
Valencia M, Moreno L
Colomb Med (Cali) 2017 Mar 30;48(1):35-38. PMID: 28559645Free PMC Article
T-cell lymphoma in HIV-infected patients.
Arzoo KK, Bu X, Espina BM, Seneviratne L, Nathwani B, Levine AM
J Acquir Immune Defic Syndr 2004 Aug 15;36(5):1020-7. doi: 10.1097/00126334-200408150-00004. PMID: 15247554
Cutaneous T-cell lymphoma/leukemia.
Siegel RS, Kuzel TM
Curr Treat Options Oncol 2000 Apr;1(1):43-50. doi: 10.1007/s11864-000-0014-0. PMID: 12057060

Therapy

Treatment of aggressive T-cell lymphoma/leukemia with anti-CD4 CAR T cells.
Feng J, Xu H, Cinquina A, Wu Z, Zhang W, Sun L, Chen Q, Tian L, Song L, Pinz KG, Wada M, Jiang X, Hanes WM, Ma Y, Zhang H
Front Immunol 2022;13:997482. Epub 2022 Sep 12 doi: 10.3389/fimmu.2022.997482. PMID: 36172388Free PMC Article
Clinical Characteristics and Outcomes of Caribbean Patients With Adult T-Cell Lymphoma/Leukemia at Two Affiliated New York City Hospitals.
Chiu E, Samra B, Tam E, Baseri B, Lin B, Luhrs C, Gonsky J, Sawas A, Taiwo E, Sidhu G
JCO Glob Oncol 2020 Apr;6:548-556. doi: 10.1200/JGO.19.00208. PMID: 32243210Free PMC Article
Adult T-Cell Leukemia/Lymphoma.
Mehta-Shah N, Ratner L, Horwitz SM
J Oncol Pract 2017 Aug;13(8):487-492. doi: 10.1200/JOP.2017.021907. PMID: 28796966Free PMC Article
Comorbidity between HTLV-1-associated adult T-cell lymphoma/leukemia and verrucous carcinoma: a case report.
Valencia M, Moreno L
Colomb Med (Cali) 2017 Mar 30;48(1):35-38. PMID: 28559645Free PMC Article
Cutaneous T-cell lymphoma/leukemia.
Siegel RS, Kuzel TM
Curr Treat Options Oncol 2000 Apr;1(1):43-50. doi: 10.1007/s11864-000-0014-0. PMID: 12057060

Prognosis

Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia.
Gao X, Qin S, Wu Y, Chu C, Jiang B, Johnson RH, Kuang D, Zhang J, Wang X, Mehta A, Tew KD, Leone GW, Yu XZ, Wang H
J Clin Invest 2021 Aug 16;131(16) doi: 10.1172/JCI143119. PMID: 34255748Free PMC Article
Primary cutaneous T-cell lymphoma: experience from the Peruvian National Cancer Institute.
Ruiz R, Morante Z, Mantilla R, Mas L, Casanova L, Gomez HL
An Bras Dermatol 2017 Sep-Oct;92(5):649-654. doi: 10.1590/abd1806-4841.20176825. PMID: 29166501Free PMC Article
Adult T-Cell Leukemia/Lymphoma.
Mehta-Shah N, Ratner L, Horwitz SM
J Oncol Pract 2017 Aug;13(8):487-492. doi: 10.1200/JOP.2017.021907. PMID: 28796966Free PMC Article
Cutaneous T-cell lymphoma/leukemia.
Siegel RS, Kuzel TM
Curr Treat Options Oncol 2000 Apr;1(1):43-50. doi: 10.1007/s11864-000-0014-0. PMID: 12057060
Caribbean T-cell lymphoma/leukemia.
Swerdlow SH, Habeshaw JA, Rohatiner AZ, Lister TA, Stansfeld AG
Cancer 1984 Aug 15;54(4):687-96. doi: 10.1002/1097-0142(1984)54:4<687::aid-cncr2820540416>3.0.co;2-g. PMID: 6234983

Clinical prediction guides

Primary cutaneous T-cell lymphoma: experience from the Peruvian National Cancer Institute.
Ruiz R, Morante Z, Mantilla R, Mas L, Casanova L, Gomez HL
An Bras Dermatol 2017 Sep-Oct;92(5):649-654. doi: 10.1590/abd1806-4841.20176825. PMID: 29166501Free PMC Article
Comorbidity between HTLV-1-associated adult T-cell lymphoma/leukemia and verrucous carcinoma: a case report.
Valencia M, Moreno L
Colomb Med (Cali) 2017 Mar 30;48(1):35-38. PMID: 28559645Free PMC Article
Models for mature T-cell lymphomas--a critical appraisal of experimental systems and their contribution to current T-cell tumorigenic concepts.
Warner K, Crispatzu G, Al-Ghaili N, Weit N, Florou V, You MJ, Newrzela S, Herling M
Crit Rev Oncol Hematol 2013 Dec;88(3):680-95. Epub 2013 Aug 21 doi: 10.1016/j.critrevonc.2013.07.014. PMID: 23972664
18F-fluorodeoxyglucose positron emission tomography in the staging and prognosis of T cell lymphoma.
Casulo C, Schöder H, Feeney J, Lim R, Maragulia J, Zelenetz AD, Horwitz S
Leuk Lymphoma 2013 Oct;54(10):2163-7. Epub 2013 Mar 4 doi: 10.3109/10428194.2013.767901. PMID: 23369041Free PMC Article
T-cell lymphoma in HIV-infected patients.
Arzoo KK, Bu X, Espina BM, Seneviratne L, Nathwani B, Levine AM
J Acquir Immune Defic Syndr 2004 Aug 15;36(5):1020-7. doi: 10.1097/00126334-200408150-00004. PMID: 15247554

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...