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Increased megakaryocyte count

MedGen UID:
870733
Concept ID:
C4025187
Finding
HPO: HP:0005513

Definition

Increased megakaryocyte number, i.e., of platelet precursor cells, present in the bone marrow. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased megakaryocyte count

Conditions with this feature

Acquired polycythemia vera
MedGen UID:
45996
Concept ID:
C0032463
Neoplastic Process
Polycythemia vera (PV), the most common form of primary polycythemia, is caused by somatic mutation in a single hematopoietic stem cell leading to clonal hematopoiesis. PV is a myeloproliferative disorder characterized predominantly by erythroid hyperplasia, but also by myeloid leukocytosis, thrombocytosis, and splenomegaly. Familial cases of PV are very rare and usually manifest in elderly patients (Cario, 2005). PV is distinct from the familial erythrocytoses (see, e.g., ECYT1, 133100), which are caused by inherited mutations resulting in hypersensitivity of erythroid progenitors to hormonal influences or increased levels of circulating hormones, namely erythropoietin (EPO; 133170) (Prchal, 2005).
Thrombocythemia 2
MedGen UID:
477629
Concept ID:
C3275998
Disease or Syndrome
Familial thrombocytosis in which the cause of the disease is a mutation in the MPL gene.

Professional guidelines

PubMed

Marini I, Uzun G, Jamal K, Bakchoul T
Haematologica 2022 Jun 1;107(6):1264-1277. doi: 10.3324/haematol.2021.279484. PMID: 35642486Free PMC Article
Kuter DJ
Haematologica 2022 Jun 1;107(6):1243-1263. doi: 10.3324/haematol.2021.279512. PMID: 35642485Free PMC Article
Althaus K, Faul C, Bakchoul T
Hamostaseologie 2021 Aug;41(4):275-282. Epub 2020 Dec 21 doi: 10.1055/a-1311-8264. PMID: 33348391

Recent clinical studies

Etiology

Marini I, Uzun G, Jamal K, Bakchoul T
Haematologica 2022 Jun 1;107(6):1264-1277. doi: 10.3324/haematol.2021.279484. PMID: 35642486Free PMC Article
Falet H, Rivadeneyra L, Hoffmeister KM
Blood 2022 Jun 2;139(22):3255-3263. doi: 10.1182/blood.2020009303. PMID: 35015813Free PMC Article
Danese E, Montagnana M, Favaloro EJ, Lippi G
Semin Thromb Hemost 2020 Apr;46(3):264-274. Epub 2019 Sep 28 doi: 10.1055/s-0039-1697930. PMID: 31563127
Onisâi M, Vlădăreanu AM, Spînu A, Găman M, Bumbea H
Rom J Intern Med 2019 Dec 1;57(4):273-283. doi: 10.2478/rjim-2019-0014. PMID: 31199777
Tobelem G
Baillieres Clin Haematol 1989 Jul;2(3):719-28. doi: 10.1016/s0950-3536(89)80040-x. PMID: 2505875

Diagnosis

Marini I, Uzun G, Jamal K, Bakchoul T
Haematologica 2022 Jun 1;107(6):1264-1277. doi: 10.3324/haematol.2021.279484. PMID: 35642486Free PMC Article
Kuter DJ
Haematologica 2022 Jun 1;107(6):1243-1263. doi: 10.3324/haematol.2021.279512. PMID: 35642485Free PMC Article
Danese E, Montagnana M, Favaloro EJ, Lippi G
Semin Thromb Hemost 2020 Apr;46(3):264-274. Epub 2019 Sep 28 doi: 10.1055/s-0039-1697930. PMID: 31563127
Onisâi M, Vlădăreanu AM, Spînu A, Găman M, Bumbea H
Rom J Intern Med 2019 Dec 1;57(4):273-283. doi: 10.2478/rjim-2019-0014. PMID: 31199777
Tobelem G
Baillieres Clin Haematol 1989 Jul;2(3):719-28. doi: 10.1016/s0950-3536(89)80040-x. PMID: 2505875

Therapy

Kuter DJ
Haematologica 2022 Jun 1;107(6):1243-1263. doi: 10.3324/haematol.2021.279512. PMID: 35642485Free PMC Article
Bussel JB, Soff G, Balduzzi A, Cooper N, Lawrence T, Semple JW
Drug Des Devel Ther 2021;15:2243-2268. Epub 2021 May 26 doi: 10.2147/DDDT.S299591. PMID: 34079225Free PMC Article
Garnock-Jones KP, Keam SJ
Drugs 2009;69(5):567-76. doi: 10.2165/00003495-200969050-00005. PMID: 19368418
Kuter DJ
Blood 2007 Jun 1;109(11):4607-16. Epub 2007 Feb 8 doi: 10.1182/blood-2006-10-019315. PMID: 17289815Free PMC Article
Scaradavou A
Blood Rev 2002 Mar;16(1):73-6. doi: 10.1054/blre.2001.0188. PMID: 11914001

Prognosis

Allegra A, Cicero N, Mirabile G, Giorgianni CM, Gangemi S
Int J Mol Sci 2023 Feb 23;24(5) doi: 10.3390/ijms24054438. PMID: 36901864Free PMC Article
Kuter DJ
Haematologica 2022 Jun 1;107(6):1243-1263. doi: 10.3324/haematol.2021.279512. PMID: 35642485Free PMC Article
Schrottmaier WC, Schmuckenschlager A, Pirabe A, Assinger A
Front Immunol 2022;13:856713. Epub 2022 Mar 28 doi: 10.3389/fimmu.2022.856713. PMID: 35419008Free PMC Article
Scaradavou A
Blood Rev 2002 Mar;16(1):73-6. doi: 10.1054/blre.2001.0188. PMID: 11914001
Tobelem G
Baillieres Clin Haematol 1989 Jul;2(3):719-28. doi: 10.1016/s0950-3536(89)80040-x. PMID: 2505875

Clinical prediction guides

Kuter DJ
Haematologica 2022 Jun 1;107(6):1243-1263. doi: 10.3324/haematol.2021.279512. PMID: 35642485Free PMC Article
Falet H, Rivadeneyra L, Hoffmeister KM
Blood 2022 Jun 2;139(22):3255-3263. doi: 10.1182/blood.2020009303. PMID: 35015813Free PMC Article
Brissot E, Troadec MB, Loréal O, Brissot P
Am J Hematol 2021 Aug 1;96(8):1008-1016. Epub 2021 May 14 doi: 10.1002/ajh.26189. PMID: 33844865
Garnock-Jones KP, Keam SJ
Drugs 2009;69(5):567-76. doi: 10.2165/00003495-200969050-00005. PMID: 19368418
Tobelem G
Baillieres Clin Haematol 1989 Jul;2(3):719-28. doi: 10.1016/s0950-3536(89)80040-x. PMID: 2505875

Recent systematic reviews

Soff GA, Ray-Coquard I, Rivera LJM, Fryzek J, Mullins M, Bylsma LC, Park JK
PLoS One 2022;17(6):e0257673. Epub 2022 Jun 9 doi: 10.1371/journal.pone.0257673. PMID: 35679540Free PMC Article
Catalá-López F, Corrales I, Martín-Serrano G, Tobías A, Calvo G
Med Clin (Barc) 2012 Oct 20;139(10):421-9. Epub 2012 Jan 23 doi: 10.1016/j.medcli.2011.11.023. PMID: 22266082

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