U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Compensated hemolytic anemia

MedGen UID:
870825
•Concept ID:
C4025283
•
Disease or Syndrome
Synonym: Compensated hemolytic anaemia
 
HPO: HP:0004863

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCompensated hemolytic anemia

Conditions with this feature

Gluthathione peroxidase deficiency
MedGen UID:
473098
•Concept ID:
C0398747
•
Disease or Syndrome
Several documented cases of glutathione peroxidase (GPX1; 138320) deficiency in association with hemolytic anemia have been reported. However, Paglia (1989) stated: 'To date, no defects in glutathione peroxidase have been unequivocally incriminated in the pathogenesis of hemolytic syndromes, although several instances of partial deficiency have been reported in patients with anemias of unknown etiology. This association may be coincidental, since there is a broad range of ethnic variation in the erythrocyte enzyme' (Beutler and Matsumoto, 1975).
See: Condition Record
Hemoglobin--variants for which the chain carrying the mutation is unknown or uncertain
MedGen UID:
333610
•Concept ID:
C1840647
•
Disease or Syndrome
See: Condition Record
Gluthathione peroxidase deficiency
Hemoglobin--variants for which the chain carrying the mutation is unknown or uncertain

Professional guidelines

PubMed

Severe autoimmune hemolytic anemia; epidemiology, clinical management, outcomes and knowledge gaps.
Mulder FVM, Evers D, de Haas M, Cruijsen MJ, Bernelot Moens SJ, Barcellini W, Fattizzo B, Vos JMI
Front Immunol 2023;14:1228142. Epub 2023 Sep 18 doi: 10.3389/fimmu.2023.1228142. PMID: 37795092Free PMC Article
Lovo-cel gene therapy for sickle cell disease: Treatment process evolution and outcomes in the initial groups of the HGB-206 study.
Kanter J, Thompson AA, Pierciey FJ Jr, Hsieh M, Uchida N, Leboulch P, Schmidt M, Bonner M, Guo R, Miller A, Ribeil JA, Davidson D, Asmal M, Walters MC, Tisdale JF
Am J Hematol 2023 Jan;98(1):11-22. Epub 2022 Oct 10 doi: 10.1002/ajh.26741. PMID: 36161320Free PMC Article
Management of pyruvate kinase deficiency in children and adults.
Grace RF, Barcellini W
Blood 2020 Sep 10;136(11):1241-1249. doi: 10.1182/blood.2019000945. PMID: 32702739

Recent clinical studies

Etiology

Retrospective cohort study of 205 cases with congenital dyserythropoietic anemia type II: definition of clinical and molecular spectrum and identification of new diagnostic scores.
Russo R, Gambale A, Langella C, Andolfo I, Unal S, Iolascon A
Am J Hematol 2014 Oct;89(10):E169-75. Epub 2014 Jul 22 doi: 10.1002/ajh.23800. PMID: 25044164
Hereditary red cell membrane disorders and laboratory diagnostic testing.
King MJ, Zanella A
Int J Lab Hematol 2013 Jun;35(3):237-43. Epub 2013 Mar 11 doi: 10.1111/ijlh.12070. PMID: 23480868
Hb Trento: an elongated C-terminal beta chain due to a new frameshift mutation [beta144 (-A)].
Ivaldi G, David O, Baffico M, Leone D, Baldi M, Parodi MI, Scimè-Degani V, Piga A, Scagni P, Rabino-Massa E, Ricco G
Hemoglobin 2003 Feb;27(1):15-25. doi: 10.1081/hem-120018432. PMID: 12603089
Evidence that the red cell skeleton protein 4.2 interacts with the Rh membrane complex member CD47.
Mouro-Chanteloup I, Delaunay J, Gane P, Nicolas V, Johansen M, Brown EJ, Peters LL, Van Kim CL, Cartron JP, Colin Y
Blood 2003 Jan 1;101(1):338-44. Epub 2002 Sep 5 doi: 10.1182/blood-2002-04-1285. PMID: 12393467
Common mutations in the phosphofructokinase-M gene in Ashkenazi Jewish patients with glycogenesis VII--and their population frequency.
Sherman JB, Raben N, Nicastri C, Argov Z, Nakajima H, Adams EM, Eng CM, Cowan TM, Plotz PH
Am J Hum Genet 1994 Aug;55(2):305-13. PMID: 8037209Free PMC Article

Diagnosis

Retrospective cohort study of 205 cases with congenital dyserythropoietic anemia type II: definition of clinical and molecular spectrum and identification of new diagnostic scores.
Russo R, Gambale A, Langella C, Andolfo I, Unal S, Iolascon A
Am J Hematol 2014 Oct;89(10):E169-75. Epub 2014 Jul 22 doi: 10.1002/ajh.23800. PMID: 25044164
Hereditary red cell membrane disorders and laboratory diagnostic testing.
King MJ, Zanella A
Int J Lab Hematol 2013 Jun;35(3):237-43. Epub 2013 Mar 11 doi: 10.1111/ijlh.12070. PMID: 23480868
Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1.
Andolfo I, Alper SL, De Franceschi L, Auriemma C, Russo R, De Falco L, Vallefuoco F, Esposito MR, Vandorpe DH, Shmukler BE, Narayan R, Montanaro D, D'Armiento M, Vetro A, Limongelli I, Zuffardi O, Glader BE, Schrier SL, Brugnara C, Stewart GW, Delaunay J, Iolascon A
Blood 2013 May 9;121(19):3925-35, S1-12. Epub 2013 Mar 11 doi: 10.1182/blood-2013-02-482489. PMID: 23479567
Laboratory investigation of hemoglobinopathies and thalassemias: review and update.
Clarke GM, Higgins TN
Clin Chem 2000 Aug;46(8 Pt 2):1284-90. PMID: 10926923
Case for diagnosis. Chronic compensated hemolytic anemia.
Kark JA, Tarassoff PG, Williams HL, Mehm WJ
Mil Med 1989 Feb;154(2):98-100, 105. PMID: 2494590

Therapy

Fluoropyrimidine therapy: hyperbilirubinemia as a consequence of hemolysis.
Nikolic-Tomasevic Z, Jelic S, Cassidy J, Filipovic-Ljeskovic I, Tomasevic Z
Cancer Chemother Pharmacol 2005 Dec;56(6):594-602. Epub 2005 Jul 26 doi: 10.1007/s00280-005-1011-6. PMID: 16044340

Clinical prediction guides

Retrospective cohort study of 205 cases with congenital dyserythropoietic anemia type II: definition of clinical and molecular spectrum and identification of new diagnostic scores.
Russo R, Gambale A, Langella C, Andolfo I, Unal S, Iolascon A
Am J Hematol 2014 Oct;89(10):E169-75. Epub 2014 Jul 22 doi: 10.1002/ajh.23800. PMID: 25044164
Fluoropyrimidine therapy: hyperbilirubinemia as a consequence of hemolysis.
Nikolic-Tomasevic Z, Jelic S, Cassidy J, Filipovic-Ljeskovic I, Tomasevic Z
Cancer Chemother Pharmacol 2005 Dec;56(6):594-602. Epub 2005 Jul 26 doi: 10.1007/s00280-005-1011-6. PMID: 16044340
Hb Trento: an elongated C-terminal beta chain due to a new frameshift mutation [beta144 (-A)].
Ivaldi G, David O, Baffico M, Leone D, Baldi M, Parodi MI, Scimè-Degani V, Piga A, Scagni P, Rabino-Massa E, Ricco G
Hemoglobin 2003 Feb;27(1):15-25. doi: 10.1081/hem-120018432. PMID: 12603089
5-oxoprolinuria: biochemical observations and case report.
Spielberg SP, Kramer LI, Goodman SI, Butler J, Tietze F, Quinn P, Schulman JD
J Pediatr 1977 Aug;91(2):237-41. doi: 10.1016/s0022-3476(77)80819-6. PMID: 874680

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...