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Increased circulating purine concentration

MedGen UID:
870871
Concept ID:
C4025332
Finding
Synonyms: Increased purine level; Increased purine levels
 
HPO: HP:0004368

Definition

Abnormally elevated concentration of a purine compound. Purine compounds are aromatic heterocyclic compounds containing a purine moiety, which is formed a pyrimidine-ring ring fused to an imidazole ring. [from HPO]

Professional guidelines

PubMed

Maldonado V, Loza-Mejía MA, Chávez-Alderete J
Med Hypotheses 2020 Nov;144:109988. Epub 2020 Jun 9 doi: 10.1016/j.mehy.2020.109988. PMID: 32540603Free PMC Article
Pylvänen V, Pakarinen A, Knip M, Isojärvi J
Epilepsy Behav 2006 May;8(3):643-8. Epub 2006 Apr 5 doi: 10.1016/j.yebeh.2006.02.008. PMID: 16600693
Gandhi V, Robertson LE, Keating MJ, Plunkett W
Cancer Chemother Pharmacol 1994;34(1):30-6. doi: 10.1007/BF00686108. PMID: 8174200

Recent clinical studies

Etiology

Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S
J Clin Endocrinol Metab 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. PMID: 36740954
Pencina KM, Lavu S, Dos Santos M, Beleva YM, Cheng M, Livingston D, Bhasin S
J Gerontol A Biol Sci Med Sci 2023 Jan 26;78(1):90-96. doi: 10.1093/gerona/glac049. PMID: 35182418
Bailey CJ
Diabetes Obes Metab 2019 Jun;21(6):1291-1298. Epub 2019 Mar 15 doi: 10.1111/dom.13670. PMID: 30762288
Rutkowski B, Rutkowski P, Słomińska E, Swierczyński J
J Ren Nutr 2010 Sep;20(5 Suppl):S7-10. doi: 10.1053/j.jrn.2010.05.003. PMID: 20797575
Mezey E
Fed Proc 1985 Jan;44(1 Pt 1):134-8. PMID: 3881285

Diagnosis

Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S
J Clin Endocrinol Metab 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. PMID: 36740954
Xun C, Zhao Y, Wang W, Chen C
Ann Clin Lab Sci 2018 Mar;48(2):205-207. PMID: 29678848
Brouns F, van der Vusse GJ
Br J Nutr 1998 Feb;79(2):117-28. doi: 10.1079/bjn19980022. PMID: 9536855
Nehlig A, Daval JL, Debry G
Brain Res Brain Res Rev 1992 May-Aug;17(2):139-70. doi: 10.1016/0165-0173(92)90012-b. PMID: 1356551
Farah AE
Pharmacol Rev 1983 Sep;35(3):181-217. PMID: 6318231

Therapy

Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S
J Clin Endocrinol Metab 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. PMID: 36740954
Pencina KM, Lavu S, Dos Santos M, Beleva YM, Cheng M, Livingston D, Bhasin S
J Gerontol A Biol Sci Med Sci 2023 Jan 26;78(1):90-96. doi: 10.1093/gerona/glac049. PMID: 35182418
Imenshahidi M, Hossenzadeh H
J Endocrinol Invest 2022 May;45(5):927-939. Epub 2022 Jan 11 doi: 10.1007/s40618-021-01720-3. PMID: 35013990
Bailey CJ
Diabetes Obes Metab 2019 Jun;21(6):1291-1298. Epub 2019 Mar 15 doi: 10.1111/dom.13670. PMID: 30762288
Nehlig A, Daval JL, Debry G
Brain Res Brain Res Rev 1992 May-Aug;17(2):139-70. doi: 10.1016/0165-0173(92)90012-b. PMID: 1356551

Prognosis

Savale L, Akagi S, Tu L, Cumont A, Thuillet R, Phan C, Le Vely B, Berrebeh N, Huertas A, Jaïs X, Cottin V, Chaouat A, Tromeur C, Boucly A, Jutant EM, Mercier O, Fadel E, Montani D, Sitbon O, Humbert M, Tamura Y, Guignabert C
Eur Respir J 2021 Aug;58(2) Epub 2021 Aug 5 doi: 10.1183/13993003.00332-2020. PMID: 33446602
Rohraff DM, He Y, Farkash EA, Schonfeld M, Tsou PS, Sawalha AH
Arthritis Rheumatol 2019 Oct;71(10):1681-1690. Epub 2019 Aug 12 doi: 10.1002/art.40931. PMID: 31106974Free PMC Article
Bailey CJ
Diabetes Obes Metab 2019 Jun;21(6):1291-1298. Epub 2019 Mar 15 doi: 10.1111/dom.13670. PMID: 30762288
Williams DM, Hägg S, Pedersen NL
Am J Clin Nutr 2019 Jan 1;109(1):90-98. doi: 10.1093/ajcn/nqy225. PMID: 30596810Free PMC Article
Kuchel O, Cuche JL, Hamet P, Tolis G, Messerli FH, Barbeau A, Boucher R, Genest J
Angiology 1975 Sep;26(8):619-31. doi: 10.1177/000331977502600805. PMID: 233754

Clinical prediction guides

Broekhuizen M, de Vries R, Smits MAW, Dik WA, Schoenmakers S, Koch BCP, Merkus D, Reiss IKM, Danser AHJ, Simons SHP, Hitzerd E
Br J Pharmacol 2022 Nov;179(22):5074-5088. Epub 2022 Aug 5 doi: 10.1111/bph.15931. PMID: 35861684Free PMC Article
Savale L, Akagi S, Tu L, Cumont A, Thuillet R, Phan C, Le Vely B, Berrebeh N, Huertas A, Jaïs X, Cottin V, Chaouat A, Tromeur C, Boucly A, Jutant EM, Mercier O, Fadel E, Montani D, Sitbon O, Humbert M, Tamura Y, Guignabert C
Eur Respir J 2021 Aug;58(2) Epub 2021 Aug 5 doi: 10.1183/13993003.00332-2020. PMID: 33446602
Ramanathan S, Jin F, Sharma S, Kearney BP
Clin Pharmacokinet 2016 Jan;55(1):33-45. doi: 10.1007/s40262-015-0304-0. PMID: 26242379
Cattaneo M, Faioni EM
Thromb Haemost 2012 Dec;108(6):1031-6. Epub 2012 Oct 16 doi: 10.1160/TH12-08-0547. PMID: 23070079
Farah AE
Pharmacol Rev 1983 Sep;35(3):181-217. PMID: 6318231

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