U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Increased circulating purine concentration

MedGen UID:
870871
•Concept ID:
C4025332
•
Finding
Synonyms: Increased purine level; Increased purine levels
 
HPO: HP:0004368

Definition

Abnormally elevated concentration of a purine compound. Purine compounds are aromatic heterocyclic compounds containing a purine moiety, which is formed a pyrimidine-ring ring fused to an imidazole ring. [from HPO]

Professional guidelines

PubMed

Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I.
Thum T, Fleissner F, Klink I, Tsikas D, Jakob M, Bauersachs J, Stichtenoth DO
J Clin Endocrinol Metab 2007 Nov;92(11):4172-9. Epub 2007 Aug 28 doi: 10.1210/jc.2007-0922. PMID: 17726074
Insulin-related metabolic changes during treatment with valproate in patients with epilepsy.
Pylvänen V, Pakarinen A, Knip M, Isojärvi J
Epilepsy Behav 2006 May;8(3):643-8. Epub 2006 Apr 5 doi: 10.1016/j.yebeh.2006.02.008. PMID: 16600693
Combination of fludarabine and arabinosylcytosine for treatment of chronic lymphocytic leukemia: clinical efficacy and modulation of arabinosylcytosine pharmacology.
Gandhi V, Robertson LE, Keating MJ, Plunkett W
Cancer Chemother Pharmacol 1994;34(1):30-6. doi: 10.1007/BF00686108. PMID: 8174200

Recent clinical studies

Etiology

Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S
J Clin Endocrinol Metab 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. PMID: 36740954
MIB-626, an Oral Formulation of a Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and its Metabolome in Middle-Aged and Older Adults.
Pencina KM, Lavu S, Dos Santos M, Beleva YM, Cheng M, Livingston D, Bhasin S
J Gerontol A Biol Sci Med Sci 2023 Jan 26;78(1):90-96. doi: 10.1093/gerona/glac049. PMID: 35182418
Uric acid and the cardio-renal effects of SGLT2 inhibitors.
Bailey CJ
Diabetes Obes Metab 2019 Jun;21(6):1291-1298. Epub 2019 Mar 15 doi: 10.1111/dom.13670. PMID: 30762288
Distribution of purine nucleotides in uremic fluids and tissues.
Rutkowski B, Rutkowski P, Słomińska E, Swierczyński J
J Ren Nutr 2010 Sep;20(5 Suppl):S7-10. doi: 10.1053/j.jrn.2010.05.003. PMID: 20797575
Metabolic effects of alcohol.
Mezey E
Fed Proc 1985 Jan;44(1 Pt 1):134-8. PMID: 3881285

Diagnosis

Relationship between uric acid to high-density cholesterol ratio (UHR) and circulating α-klotho: evidence from NHANES 2007-2016.
Huang X, Hu L, Tao S, Xue T, Hou C, Li J
Lipids Health Dis 2024 Aug 9;23(1):244. doi: 10.1186/s12944-024-02234-6. PMID: 39123222Free PMC Article
Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S
J Clin Endocrinol Metab 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. PMID: 36740954
Circulating RBP4 Increase and Its Diagnosis of Chronic Kidney Disease.
Xun C, Zhao Y, Wang W, Chen C
Ann Clin Lab Sci 2018 Mar;48(2):205-207. PMID: 29678848
Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects.
Nehlig A, Daval JL, Debry G
Brain Res Brain Res Rev 1992 May-Aug;17(2):139-70. doi: 10.1016/0165-0173(92)90012-b. PMID: 1356551
Glucagon and the circulation.
Farah AE
Pharmacol Rev 1983 Sep;35(3):181-217. PMID: 6318231

Therapy

Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S
J Clin Endocrinol Metab 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. PMID: 36740954
MIB-626, an Oral Formulation of a Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and its Metabolome in Middle-Aged and Older Adults.
Pencina KM, Lavu S, Dos Santos M, Beleva YM, Cheng M, Livingston D, Bhasin S
J Gerontol A Biol Sci Med Sci 2023 Jan 26;78(1):90-96. doi: 10.1093/gerona/glac049. PMID: 35182418
Therapeutic Effects of Mesenchymal Stem Cells Expressing Erythropoietin on Cancer-Related Anemia in Mice Model.
Estiri M, Estiri B, Fallah A, Aghazadeh M, Sedaqati A, Abdollahi A, Rabienia M, Mortazavidehkordi N, Farjadfar A
Curr Gene Ther 2022;22(5):406-416. doi: 10.2174/1566523222666220405134136. PMID: 35382717
Effects of glycine on metabolic syndrome components: a review.
Imenshahidi M, Hossenzadeh H
J Endocrinol Invest 2022 May;45(5):927-939. Epub 2022 Jan 11 doi: 10.1007/s40618-021-01720-3. PMID: 35013990
Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects.
Nehlig A, Daval JL, Debry G
Brain Res Brain Res Rev 1992 May-Aug;17(2):139-70. doi: 10.1016/0165-0173(92)90012-b. PMID: 1356551

Prognosis

Increased Extracellular ATP in Plasma of Rheumatoid Arthritis Patients Activates CD8(+)T Cells.
Tripathy A, Padhan P, Swain N, Raghav SK, Gupta B
Arch Med Res 2021 May;52(4):423-433. Epub 2021 Feb 1 doi: 10.1016/j.arcmed.2020.12.010. PMID: 33541740
Serum and pulmonary uric acid in pulmonary arterial hypertension.
Savale L, Akagi S, Tu L, Cumont A, Thuillet R, Phan C, Le Vely B, Berrebeh N, Huertas A, Jaïs X, Cottin V, Chaouat A, Tromeur C, Boucly A, Jutant EM, Mercier O, Fadel E, Montani D, Sitbon O, Humbert M, Tamura Y, Guignabert C
Eur Respir J 2021 Aug;58(2) Epub 2021 Aug 5 doi: 10.1183/13993003.00332-2020. PMID: 33446602
Uric acid and the cardio-renal effects of SGLT2 inhibitors.
Bailey CJ
Diabetes Obes Metab 2019 Jun;21(6):1291-1298. Epub 2019 Mar 15 doi: 10.1111/dom.13670. PMID: 30762288
Circulating antioxidants and Alzheimer disease prevention: a Mendelian randomization study.
Williams DM, Hägg S, Pedersen NL
Am J Clin Nutr 2019 Jan 1;109(1):90-98. doi: 10.1093/ajcn/nqy225. PMID: 30596810Free PMC Article
Labile (borderline) hypertension--new aspects of a common disorder.
Kuchel O, Cuche JL, Hamet P, Tolis G, Messerli FH, Barbeau A, Boucher R, Genest J
Angiology 1975 Sep;26(8):619-31. doi: 10.1177/000331977502600805. PMID: 233754

Clinical prediction guides

Increased circulating uric acid aggravates heart failure via impaired fatty acid metabolism.
Lou B, Wu H, Ott H, Bennewitz K, Wang C, Poschet G, Liu H, Yuan Z, Kroll J, She J
J Transl Med 2023 Mar 16;21(1):199. doi: 10.1186/s12967-023-04050-5. PMID: 36927819Free PMC Article
Pentoxifylline as a therapeutic option for pre-eclampsia: a study on its placental effects.
Broekhuizen M, de Vries R, Smits MAW, Dik WA, Schoenmakers S, Koch BCP, Merkus D, Reiss IKM, Danser AHJ, Simons SHP, Hitzerd E
Br J Pharmacol 2022 Nov;179(22):5074-5088. Epub 2022 Aug 5 doi: 10.1111/bph.15931. PMID: 35861684Free PMC Article
Clinical Pharmacokinetic and Pharmacodynamic Profile of Idelalisib.
Ramanathan S, Jin F, Sharma S, Kearney BP
Clin Pharmacokinet 2016 Jan;55(1):33-45. doi: 10.1007/s40262-015-0304-0. PMID: 26242379
Why does ticagrelor induce dyspnea?
Cattaneo M, Faioni EM
Thromb Haemost 2012 Dec;108(6):1031-6. Epub 2012 Oct 16 doi: 10.1160/TH12-08-0547. PMID: 23070079
Glucagon and the circulation.
Farah AE
Pharmacol Rev 1983 Sep;35(3):181-217. PMID: 6318231

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...