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Abnormal circulating leptin concentration

MedGen UID:
870878
•Concept ID:
C4025339
•
Finding
Synonym: Abnormality of circulating leptin level
 
HPO: HP:0004361

Definition

An abnormal concentration of leptin in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating leptin concentration

Professional guidelines

PubMed

Circulating Levels of Nesfatin-1 and Spexin in Children with Prader-Willi Syndrome during Growth Hormone Treatment and Dietary Intervention.
Gajewska J, Szamotulska K, Klemarczyk W, Chełchowska M, Strucińska M, Ambroszkiewicz J
Nutrients 2023 Mar 1;15(5) doi: 10.3390/nu15051240. PMID: 36904239Free PMC Article
Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy.
Grosso S, Luisi S, Mostardini R, Matera M, Barlocco EG, Casarosa E, Balestri P, Petraglia F
Neuroendocrinology 2011;93(3):159-64. Epub 2010 Oct 27 doi: 10.1159/000321664. PMID: 20980729

Recent clinical studies

Etiology

Circulating Levels of Nesfatin-1 and Spexin in Children with Prader-Willi Syndrome during Growth Hormone Treatment and Dietary Intervention.
Gajewska J, Szamotulska K, Klemarczyk W, Chełchowska M, Strucińska M, Ambroszkiewicz J
Nutrients 2023 Mar 1;15(5) doi: 10.3390/nu15051240. PMID: 36904239Free PMC Article
Leptin, Obesity, and Hypertension: A Review of Pathogenetic Mechanisms.
Lu SC, Akanji AO
Metab Syndr Relat Disord 2020 Nov;18(9):399-405. Epub 2020 Sep 1 doi: 10.1089/met.2020.0065. PMID: 32876506
Circulating leptin and bone mineral density in rheumatoid arthritis.
Aguilar-Chavez EA, Gamez-Nava JI, Lopez-Olivo MA, Galvan-Melendres S, Corona-Sanchez EG, Loaiza-Cardenas CA, Celis A, Cardona-Muñoz EG, Gonzalez-Lopez L
J Rheumatol 2009 Mar;36(3):512-6. Epub 2009 Jan 22 doi: 10.3899/jrheum.080196. PMID: 19208597
Adiponectin and leptin concentrations in dichorionic twins with discordant and concordant growth.
Mazaki-Tovi S, Kanety H, Pariente C, Hemi R, Yinon Y, Wiser A, Schiff E, Sivan E
J Clin Endocrinol Metab 2009 Mar;94(3):892-8. Epub 2008 Dec 9 doi: 10.1210/jc.2008-2118. PMID: 19066299
Androgens and coronary artery disease.
Wu FC, von Eckardstein A
Endocr Rev 2003 Apr;24(2):183-217. doi: 10.1210/er.2001-0025. PMID: 12700179

Diagnosis

The characteristics of elevated blood pressure in abdominal obesity correspond to primary hypertension: a cross-sectional study.
Taurio J, Hautaniemi EJ, Koskela JK, Eräranta A, Hämäläinen M, Tikkakoski A, Kettunen JA, Kähönen M, Niemelä O, Moilanen E, Mustonen J, Pörsti I
BMC Cardiovasc Disord 2023 Mar 27;23(1):161. doi: 10.1186/s12872-023-03150-w. PMID: 36973671Free PMC Article
Effects of DHEA on metabolic and endocrine functions of adipose tissue.
Karbowska J, Kochan Z
Horm Mol Biol Clin Investig 2013 Aug;14(2):65-74. doi: 10.1515/hmbci-2013-0009. PMID: 25436721
Circulating levels of adiponectin and leptin at 23-25 weeks of pregnancy in women with impaired placentation and in those with established fetal growth restriction.
Savvidou MD, Sotiriadis A, Kaihura C, Nicolaides KH, Sattar N
Clin Sci (Lond) 2008 Oct;115(7):219-24. doi: 10.1042/CS20070409. PMID: 18211260
Clinical aspects of leptin.
Sinha MK, Caro JF
Vitam Horm 1998;54:1-30. doi: 10.1016/s0083-6729(08)60919-x. PMID: 9529971
Comparison of leptin protein levels in Prader-Willi syndrome and control individuals.
Butler MG, Moore J, Morawiecki A, Nicolson M
Am J Med Genet 1998 Jan 6;75(1):7-12. PMID: 9450849Free PMC Article

Therapy

Circulating Levels of Nesfatin-1 and Spexin in Children with Prader-Willi Syndrome during Growth Hormone Treatment and Dietary Intervention.
Gajewska J, Szamotulska K, Klemarczyk W, Chełchowska M, Strucińska M, Ambroszkiewicz J
Nutrients 2023 Mar 1;15(5) doi: 10.3390/nu15051240. PMID: 36904239Free PMC Article
Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy.
Grosso S, Luisi S, Mostardini R, Matera M, Barlocco EG, Casarosa E, Balestri P, Petraglia F
Neuroendocrinology 2011;93(3):159-64. Epub 2010 Oct 27 doi: 10.1159/000321664. PMID: 20980729
Circulating adipocytokines in non-diabetic and Type 1 diabetic children: relationship to insulin therapy, glycaemic control and pubertal development.
Celi F, Bini V, Papi F, Santilli E, Castellani MS, Ferretti A, Mencacci M, Berioli MG, De Giorgi G, Falorni A
Diabet Med 2006 Jun;23(6):660-5. doi: 10.1111/j.1464-5491.2006.01823.x. PMID: 16759309
Androgens and coronary artery disease.
Wu FC, von Eckardstein A
Endocr Rev 2003 Apr;24(2):183-217. doi: 10.1210/er.2001-0025. PMID: 12700179
Fructose, weight gain, and the insulin resistance syndrome.
Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ
Am J Clin Nutr 2002 Nov;76(5):911-22. doi: 10.1093/ajcn/76.5.911. PMID: 12399260

Prognosis

Circulating Osteonectin and Adipokine Profiles in Relation to Metabolically Healthy Obesity in Chinese Children: Findings From BCAMS.
Fu J, Li Y, Esangbedo IC, Li G, Feng D, Li L, Xu L, Han L, Li M, Li C, Gao S, Li M, Willi SM
J Am Heart Assoc 2018 Dec 4;7(23):e009169. doi: 10.1161/JAHA.118.009169. PMID: 30571596Free PMC Article
Circulating levels of adiponectin and leptin at 23-25 weeks of pregnancy in women with impaired placentation and in those with established fetal growth restriction.
Savvidou MD, Sotiriadis A, Kaihura C, Nicolaides KH, Sattar N
Clin Sci (Lond) 2008 Oct;115(7):219-24. doi: 10.1042/CS20070409. PMID: 18211260
Leptin and cellular and innate immunity in abstinent alcoholics and controls.
Motivala SJ, Dang J, Obradovic T, Meadows GG, Butch AW, Irwin MR
Alcohol Clin Exp Res 2003 Nov;27(11):1819-24. doi: 10.1097/01.ALC.0000093741.21492.02. PMID: 14634499
Temporal patterns of circulating leptin levels in lean and obese adolescents: relationships to insulin, growth hormone, and free fatty acids rhythmicity.
Heptulla R, Smitten A, Teague B, Tamborlane WV, Ma YZ, Caprio S
J Clin Endocrinol Metab 2001 Jan;86(1):90-6. doi: 10.1210/jcem.86.1.7136. PMID: 11231983
Clinical aspects of leptin.
Sinha MK, Caro JF
Vitam Horm 1998;54:1-30. doi: 10.1016/s0083-6729(08)60919-x. PMID: 9529971

Clinical prediction guides

Circulating Levels of Nesfatin-1 and Spexin in Children with Prader-Willi Syndrome during Growth Hormone Treatment and Dietary Intervention.
Gajewska J, Szamotulska K, Klemarczyk W, Chełchowska M, Strucińska M, Ambroszkiewicz J
Nutrients 2023 Mar 1;15(5) doi: 10.3390/nu15051240. PMID: 36904239Free PMC Article
Leptin and reproductive dysfunction in obese men.
Almabhouh FA, Md Mokhtar AH, Malik IA, Aziz NAAA, Durairajanayagam D, Singh HJ
Andrologia 2020 Feb;52(1):e13433. Epub 2019 Nov 27 doi: 10.1111/and.13433. PMID: 31773771
Androgens and coronary artery disease.
Wu FC, von Eckardstein A
Endocr Rev 2003 Apr;24(2):183-217. doi: 10.1210/er.2001-0025. PMID: 12700179
Fructose, weight gain, and the insulin resistance syndrome.
Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ
Am J Clin Nutr 2002 Nov;76(5):911-22. doi: 10.1093/ajcn/76.5.911. PMID: 12399260
Clinical aspects of leptin.
Sinha MK, Caro JF
Vitam Horm 1998;54:1-30. doi: 10.1016/s0083-6729(08)60919-x. PMID: 9529971

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