U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

High urinary gonadotropin level

MedGen UID:
871135
•Concept ID:
C4025606
•
Finding
HPO: HP:0003492

Definition

An elevated concentration of a gonadotropin hormone (stimulating hormone or luteinizing hormone) in the urine, consistent with the diagnosis of primary hypogonadism. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh urinary gonadotropin level

Professional guidelines

PubMed

Diagnostic value of urinary luteinizing hormone levels in the monitoring of precocious puberty treatment.
Yüce Ö, Bideci A, Çelik N, Çamurdan O, Cinaz P
Arch Endocrinol Metab 2020 Apr;64(2):121-127. Epub 2020 Mar 27 doi: 10.20945/2359-3997000000212. PMID: 32236310Free PMC Article
Premature ovarian failure: diagnosis and treatment.
Slopień R, Warenik-Szymankiewicz A
Clin Exp Obstet Gynecol 2014;41(6):659-61. PMID: 25551958
Urinary gonadotropin fragment (UGF) measurements in the diagnosis and management of ovarian cancer.
Cole LA, Nam JH
Yale J Biol Med 1989 Jul-Aug;62(4):367-78. PMID: 2596125Free PMC Article

Recent clinical studies

Etiology

Phase II, Open-Label Clinical Trial of Urinary-Derived Human Chorionic Gonadotropin/Epidermal Growth Factor for Life-Threatening Acute Graft-versus-Host Disease.
Holtan SG, Hoeschen A, Cao Q, Ustun C, Betts BC, Jurdi NE, Maakaron J, Rashidi A, Miller JS, Wagner JE, Blazar BR, Jacobson PA, Panoskaltsis-Mortari A, Weisdorf DJ, MacMillan ML
Transplant Cell Ther 2023 Aug;29(8):509.e1-509.e8. Epub 2023 Jun 4 doi: 10.1016/j.jtct.2023.05.021. PMID: 37279855Free PMC Article
Autoimmune Thyroiditis Attenuates Cardiometabolic Effects of Cabergoline in Young Women With Hyperprolactinemia.
Krysiak R, Kowalcze K, Okopień B
J Clin Pharmacol 2023 Aug;63(8):886-894. Epub 2023 May 8 doi: 10.1002/jcph.2245. PMID: 37042432
Persistently elevated β-human chorionic gonadotropin level after vacuum-assisted uterine aspiration: a case report.
Sinha A, Patterson B
J Med Case Rep 2022 Jul 17;16(1):279. doi: 10.1186/s13256-022-03511-7. PMID: 35842706Free PMC Article
Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age.
Steiner AZ, Pritchard D, Stanczyk FZ, Kesner JS, Meadows JW, Herring AH, Baird DD
JAMA 2017 Oct 10;318(14):1367-1376. doi: 10.1001/jama.2017.14588. PMID: 29049585Free PMC Article
Biomarker development, from bench to bedside.
Stenman UH
Crit Rev Clin Lab Sci 2016;53(2):69-86. Epub 2015 Aug 18 doi: 10.3109/10408363.2015.1075468. PMID: 26287282

Diagnosis

Sex hormones influence survival of patients with metastatic urothelial carcinoma undergoing immune checkpoint therapy.
Lindner AK, Lackner F, Tymoszuk P, Barth DA, Seeber A, Kocher F, Toth B, Hochleitner M, Pichler M, Pichler R
Biol Sex Differ 2023 Jun 5;14(1):38. doi: 10.1186/s13293-023-00522-x. PMID: 37277835Free PMC Article
Autoimmune Thyroiditis Attenuates Cardiometabolic Effects of Cabergoline in Young Women With Hyperprolactinemia.
Krysiak R, Kowalcze K, Okopień B
J Clin Pharmacol 2023 Aug;63(8):886-894. Epub 2023 May 8 doi: 10.1002/jcph.2245. PMID: 37042432
Persistently elevated β-human chorionic gonadotropin level after vacuum-assisted uterine aspiration: a case report.
Sinha A, Patterson B
J Med Case Rep 2022 Jul 17;16(1):279. doi: 10.1186/s13256-022-03511-7. PMID: 35842706Free PMC Article
Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age.
Steiner AZ, Pritchard D, Stanczyk FZ, Kesner JS, Meadows JW, Herring AH, Baird DD
JAMA 2017 Oct 10;318(14):1367-1376. doi: 10.1001/jama.2017.14588. PMID: 29049585Free PMC Article
Biomarker development, from bench to bedside.
Stenman UH
Crit Rev Clin Lab Sci 2016;53(2):69-86. Epub 2015 Aug 18 doi: 10.3109/10408363.2015.1075468. PMID: 26287282

Therapy

Changes in bone and mineral homeostasis after short-term androgen deprivation therapy with or without androgen receptor signalling inhibitor - substudy of a single-centre, double blind, randomised, placebo-controlled phase 2 trial.
David K, Devos G, Narinx N, Antonio L, Devlies W, Deboel L, Schollaert D, Eisenhauer A, Cavalier E, Vanderschueren D, Claessens F, Joniau S, Decallonne B
EBioMedicine 2023 Nov;97:104817. Epub 2023 Oct 5 doi: 10.1016/j.ebiom.2023.104817. PMID: 37804569Free PMC Article
Phase II, Open-Label Clinical Trial of Urinary-Derived Human Chorionic Gonadotropin/Epidermal Growth Factor for Life-Threatening Acute Graft-versus-Host Disease.
Holtan SG, Hoeschen A, Cao Q, Ustun C, Betts BC, Jurdi NE, Maakaron J, Rashidi A, Miller JS, Wagner JE, Blazar BR, Jacobson PA, Panoskaltsis-Mortari A, Weisdorf DJ, MacMillan ML
Transplant Cell Ther 2023 Aug;29(8):509.e1-509.e8. Epub 2023 Jun 4 doi: 10.1016/j.jtct.2023.05.021. PMID: 37279855Free PMC Article
Autoimmune Thyroiditis Attenuates Cardiometabolic Effects of Cabergoline in Young Women With Hyperprolactinemia.
Krysiak R, Kowalcze K, Okopień B
J Clin Pharmacol 2023 Aug;63(8):886-894. Epub 2023 May 8 doi: 10.1002/jcph.2245. PMID: 37042432
Androgen Suppression Therapy Is Associated with Lower Recurrence of Non-muscle-invasive Bladder Cancer.
Wu SC, Kwon D, Jue JS, Chen FV, Velasquez Escobar MC, Punnen S, Parekh DJ, Ritch CR, Gonzalgo ML
Eur Urol Focus 2021 Jan;7(1):142-147. Epub 2019 May 15 doi: 10.1016/j.euf.2019.04.021. PMID: 31103602
Interaction between diet- and exercise-lifestyle and phthalates exposure on sex hormone levels.
Zhang J, Yin W, Li P, Hu C, Wang L, Li T, Gao E, Hou J, Wang G, Wang X, Wang L, Yu Z, Yuan J
J Hazard Mater 2019 May 5;369:290-298. Epub 2019 Feb 6 doi: 10.1016/j.jhazmat.2019.02.011. PMID: 30780025

Prognosis

Changes in bone and mineral homeostasis after short-term androgen deprivation therapy with or without androgen receptor signalling inhibitor - substudy of a single-centre, double blind, randomised, placebo-controlled phase 2 trial.
David K, Devos G, Narinx N, Antonio L, Devlies W, Deboel L, Schollaert D, Eisenhauer A, Cavalier E, Vanderschueren D, Claessens F, Joniau S, Decallonne B
EBioMedicine 2023 Nov;97:104817. Epub 2023 Oct 5 doi: 10.1016/j.ebiom.2023.104817. PMID: 37804569Free PMC Article
Sex hormones influence survival of patients with metastatic urothelial carcinoma undergoing immune checkpoint therapy.
Lindner AK, Lackner F, Tymoszuk P, Barth DA, Seeber A, Kocher F, Toth B, Hochleitner M, Pichler M, Pichler R
Biol Sex Differ 2023 Jun 5;14(1):38. doi: 10.1186/s13293-023-00522-x. PMID: 37277835Free PMC Article
Reproducibility and Refinement of Urinary LH in the Screening of Progressive Puberty in Girls.
Zung A, Nachmany A, Burundukov E, Glaser T, Straussman S
J Clin Endocrinol Metab 2022 Mar 24;107(4):e1673-e1678. doi: 10.1210/clinem/dgab806. PMID: 34758085
Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age.
Steiner AZ, Pritchard D, Stanczyk FZ, Kesner JS, Meadows JW, Herring AH, Baird DD
JAMA 2017 Oct 10;318(14):1367-1376. doi: 10.1001/jama.2017.14588. PMID: 29049585Free PMC Article
Biomarker development, from bench to bedside.
Stenman UH
Crit Rev Clin Lab Sci 2016;53(2):69-86. Epub 2015 Aug 18 doi: 10.3109/10408363.2015.1075468. PMID: 26287282

Clinical prediction guides

Sex hormones influence survival of patients with metastatic urothelial carcinoma undergoing immune checkpoint therapy.
Lindner AK, Lackner F, Tymoszuk P, Barth DA, Seeber A, Kocher F, Toth B, Hochleitner M, Pichler M, Pichler R
Biol Sex Differ 2023 Jun 5;14(1):38. doi: 10.1186/s13293-023-00522-x. PMID: 37277835Free PMC Article
Reproducibility and Refinement of Urinary LH in the Screening of Progressive Puberty in Girls.
Zung A, Nachmany A, Burundukov E, Glaser T, Straussman S
J Clin Endocrinol Metab 2022 Mar 24;107(4):e1673-e1678. doi: 10.1210/clinem/dgab806. PMID: 34758085
Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age.
Steiner AZ, Pritchard D, Stanczyk FZ, Kesner JS, Meadows JW, Herring AH, Baird DD
JAMA 2017 Oct 10;318(14):1367-1376. doi: 10.1001/jama.2017.14588. PMID: 29049585Free PMC Article
WITHDRAWN: Recombinant versus urinary follicle stimulating hormone for ovarian stimulation in assisted reproduction cycles.
Daya S, Gunby J
Cochrane Database Syst Rev 2007 Jul 18;2006(3):CD002810. doi: 10.1002/14651858.CD002810.pub2. PMID: 17636708Free PMC Article
Recombinant versus urinary follicle stimulating hormone for ovarian stimulation in assisted reproduction cycles.
Daya S, Gunby J
Cochrane Database Syst Rev 2000;(4):CD002810. doi: 10.1002/14651858.CD002810. PMID: 11034767

Recent systematic reviews

WITHDRAWN: Recombinant versus urinary follicle stimulating hormone for ovarian stimulation in assisted reproduction cycles.
Daya S, Gunby J
Cochrane Database Syst Rev 2007 Jul 18;2006(3):CD002810. doi: 10.1002/14651858.CD002810.pub2. PMID: 17636708Free PMC Article
Recombinant versus urinary follicle stimulating hormone for ovarian stimulation in assisted reproduction cycles.
Daya S, Gunby J
Cochrane Database Syst Rev 2000;(4):CD002810. doi: 10.1002/14651858.CD002810. PMID: 11034767
Ovulation induction with urinary follicle stimulating hormone versus human menopausal gonadotropin for clomiphene-resistant polycystic ovary syndrome.
Hughes E, Collins J, Vandekerckhove P
Cochrane Database Syst Rev 2000;1996(2):CD000087. doi: 10.1002/14651858.CD000087. PMID: 10796690Free PMC Article
WITHDRAWN: Ovulation induction with urinary follicle stimulating hormone versus human menopausal gonadotropin for clomiphene-resistant polycystic ovary syndrome.
Hughes E, Collins J, Vandekerckhove P
Cochrane Database Syst Rev 1996 Apr 22;(1):CD000087. doi: 10.1002/14651858.CD000087. PMID: 17636586

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...