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Polyclonal elevation of IgM

MedGen UID:
871141
Concept ID:
C4025612
Finding
HPO: HP:0003459

Definition

A heterogeneous increase in IgM immunoglobulins characterized by a diffuse band on serum electrophoresis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolyclonal elevation of IgM

Conditions with this feature

Classic Hodgkin lymphoma
MedGen UID:
9283
Concept ID:
C0019829
Neoplastic Process
Classic Hodgkin lymphoma is a lymph node cancer of germinal center B-cell origin. Hodgkin lymphoma tumors consist of a minority of malignant cells, known as 'Reed-Sternberg' (RS) cells, mixed with reactive lymphocytes and other benign inflammatory cells. A defining feature of RS cells is the presence of 2 nuclei (summary by Salipante et al., 2009).
Macroglobulinemia, Waldenstrom, 1
MedGen UID:
320546
Concept ID:
C1835192
Disease or Syndrome
Waldenstrom macroglobulinemia (WM) is a malignant B-cell neoplasm characterized by lymphoplasmacytic infiltration of the bone marrow and hypersecretion of monoclonal immunoglobulin M (IgM) protein (review by Vijay and Gertz, 2007). The importance of genetic factors is suggested by the observation of familial clustering of WM (McMaster, 2003). Whereas WM is rare, an asymptomatic elevation of monoclonal IgM protein, termed 'IgM monoclonal gammopathy of undetermined significance' (IgM MGUS) is more common. Patients with IgM MGUS can progress to develop WM, at the rate of 1.5% to 2% per year (Kyle et al., 2003). Genetic Heterogeneity of Waldenstrom Macroglobulinemia A locus for susceptibility to Waldenstrom macroglobulinemia (WM2; 610430) has been mapped to chromosome 4q.

Professional guidelines

PubMed

Kiprov DD, Miller RG
Artif Organs 1985 Feb;9(1):47-52. doi: 10.1111/j.1525-1594.1985.tb04346.x. PMID: 3994551

Recent clinical studies

Etiology

Spielmann G, Agha N, Kunz H, Simpson RJ, Crucian B, Mehta S, Laughlin M, Campbell J
J Appl Physiol (1985) 2019 Feb 1;126(2):469-476. Epub 2018 Nov 29 doi: 10.1152/japplphysiol.00789.2018. PMID: 30496712Free PMC Article
Chernova NG, Soboleva NP, Mariina SA, Sidorova YV, Sinitsyna MN, Dvirnyk VN, Badmazhapova DS, Vinogradova YE, Zvonkov EE, Savchenko VG
Ter Arkh 2018 Aug 17;90(7):51-56. doi: 10.26442/terarkh201890751-56. PMID: 30701922
Welte T, Dellinger RP, Ebelt H, Ferrer M, Opal SM, Singer M, Vincent JL, Werdan K, Martin-Loeches I, Almirall J, Artigas A, Ignacio Ayestarán J, Nuding S, Ferrer R, Sirgo Rodríguez G, Shankar-Hari M, Álvarez-Lerma F, Riessen R, Sirvent JM, Kluge S, Zacharowski K, Bonastre Mora J, Lapp H, Wöbker G, Achtzehn U, Brealey D, Kempa A, Sánchez García M, Brederlau J, Kochanek M, Reschreiter HP, Wise MP, Belohradsky BH, Bobenhausen I, Dälken B, Dubovy P, Langohr P, Mayer M, Schüttrumpf J, Wartenberg-Demand A, Wippermann U, Wolf D, Torres A
Intensive Care Med 2018 Apr;44(4):438-448. Epub 2018 Apr 9 doi: 10.1007/s00134-018-5143-7. PMID: 29632995Free PMC Article
Bosch EP, Smith BE
Med Clin North Am 1993 Jan;77(1):125-39. doi: 10.1016/s0025-7125(16)30276-0. PMID: 8380479
Dowling PC, Bosch VV, Cook SD, Chmel H
J Neurol Sci 1982 Dec;57(2-3):435-40. doi: 10.1016/0022-510x(82)90047-8. PMID: 7161628

Diagnosis

Wei L, Qian W, Fang ZX, Mei GD, Feng ZW, Hui YC
Jpn J Infect Dis 2022 Sep 22;75(5):454-460. Epub 2022 Mar 31 doi: 10.7883/yoken.JJID.2021.795. PMID: 35354706
Chernova NG, Soboleva NP, Mariina SA, Sidorova YV, Sinitsyna MN, Dvirnyk VN, Badmazhapova DS, Vinogradova YE, Zvonkov EE, Savchenko VG
Ter Arkh 2018 Aug 17;90(7):51-56. doi: 10.26442/terarkh201890751-56. PMID: 30701922
Bosch EP, Smith BE
Med Clin North Am 1993 Jan;77(1):125-39. doi: 10.1016/s0025-7125(16)30276-0. PMID: 8380479
Perreault C, Boileau J, Gyger M, de Bellefeuille C, D'Angelo G, Belanger R, Lacombe M, Lavallee R, Bonny Y, Paquin M
Eur J Haematol 1989 Apr;42(4):361-7. doi: 10.1111/j.1600-0609.1989.tb01226.x. PMID: 2785931
Dalakas MC
Ann Neurol 1986 Jun;19(6):545-54. doi: 10.1002/ana.410190605. PMID: 3014995

Therapy

Gan C, Howard MD, Mulcahy A, Yazdabadi A
BMJ Case Rep 2022 Apr 7;15(4) doi: 10.1136/bcr-2021-247780. PMID: 35393272Free PMC Article
Kurokawa Y, Koike K, Kaida Y, Ito S, Chiba H, Urae K, Moriyama T, Nakamura N, Imai T, Shibata R, Hazama T, Wakasugi D, Okuda S, Fukami K
CEN Case Rep 2019 Aug;8(3):205-211. Epub 2019 Mar 29 doi: 10.1007/s13730-019-00394-4. PMID: 30927247Free PMC Article
Welte T, Dellinger RP, Ebelt H, Ferrer M, Opal SM, Singer M, Vincent JL, Werdan K, Martin-Loeches I, Almirall J, Artigas A, Ignacio Ayestarán J, Nuding S, Ferrer R, Sirgo Rodríguez G, Shankar-Hari M, Álvarez-Lerma F, Riessen R, Sirvent JM, Kluge S, Zacharowski K, Bonastre Mora J, Lapp H, Wöbker G, Achtzehn U, Brealey D, Kempa A, Sánchez García M, Brederlau J, Kochanek M, Reschreiter HP, Wise MP, Belohradsky BH, Bobenhausen I, Dälken B, Dubovy P, Langohr P, Mayer M, Schüttrumpf J, Wartenberg-Demand A, Wippermann U, Wolf D, Torres A
Intensive Care Med 2018 Apr;44(4):438-448. Epub 2018 Apr 9 doi: 10.1007/s00134-018-5143-7. PMID: 29632995Free PMC Article
von Gersdorff Jørgensen L, Sigh J, Kania PW, Holten-Andersen L, Buchmann K, Clark T, Rasmussen JS, Einer-Jensen K, Lorenzen N
PLoS One 2012;7(11):e48129. Epub 2012 Nov 7 doi: 10.1371/journal.pone.0048129. PMID: 23144852Free PMC Article
Canoso RT, de Oliveira RM, Nixon RA
Biol Psychiatry 1990 Apr 15;27(8):863-70. doi: 10.1016/0006-3223(90)90467-g. PMID: 1970485

Prognosis

Chernova NG, Soboleva NP, Mariina SA, Sidorova YV, Sinitsyna MN, Dvirnyk VN, Badmazhapova DS, Vinogradova YE, Zvonkov EE, Savchenko VG
Ter Arkh 2018 Aug 17;90(7):51-56. doi: 10.26442/terarkh201890751-56. PMID: 30701922
Sun P, Juskevicius R
Diagn Pathol 2012 Aug 19;7:107. doi: 10.1186/1746-1596-7-107. PMID: 22901769Free PMC Article
Bosch EP, Smith BE
Med Clin North Am 1993 Jan;77(1):125-39. doi: 10.1016/s0025-7125(16)30276-0. PMID: 8380479
Israël-Biet D, Labrousse F, Tourani JM, Sors H, Andrieu JM, Even P
J Allergy Clin Immunol 1992 Jan;89(1 Pt 1):68-75. doi: 10.1016/s0091-6749(05)80042-9. PMID: 1346148
Dalakas MC
Ann Neurol 1986 Jun;19(6):545-54. doi: 10.1002/ana.410190605. PMID: 3014995

Clinical prediction guides

Spielmann G, Agha N, Kunz H, Simpson RJ, Crucian B, Mehta S, Laughlin M, Campbell J
J Appl Physiol (1985) 2019 Feb 1;126(2):469-476. Epub 2018 Nov 29 doi: 10.1152/japplphysiol.00789.2018. PMID: 30496712Free PMC Article
Chernova NG, Soboleva NP, Mariina SA, Sidorova YV, Sinitsyna MN, Dvirnyk VN, Badmazhapova DS, Vinogradova YE, Zvonkov EE, Savchenko VG
Ter Arkh 2018 Aug 17;90(7):51-56. doi: 10.26442/terarkh201890751-56. PMID: 30701922
Sun P, Juskevicius R
Diagn Pathol 2012 Aug 19;7:107. doi: 10.1186/1746-1596-7-107. PMID: 22901769Free PMC Article
Hopper JE, Sequeira W, Martellotto J, Papagiannes E, Perna L, Skosey JL
J Clin Immunol 1989 Jul;9(4):338-50. doi: 10.1007/BF00918666. PMID: 2504765
Gleicher N, el-Roeiy A, Confino E, Friberg J
Obstet Gynecol 1987 Jul;70(1):115-22. PMID: 3110710

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