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Abnormal cartilage morphology

MedGen UID:
871202
•Concept ID:
C4025680
•
Anatomical Abnormality
Synonym: Abnormality of cartilage morphology
 
HPO: HP:0002763

Definition

Any morphological abnormality of cartilage. [from HPO]

Professional guidelines

PubMed

Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis.
Hodgkinson T, Kelly DC, Curtin CM, O'Brien FJ
Nat Rev Rheumatol 2022 Feb;18(2):67-84. Epub 2021 Dec 21 doi: 10.1038/s41584-021-00724-w. PMID: 34934171
Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis.
Hu W, Chen Y, Dou C, Dong S
Ann Rheum Dis 2021 Apr;80(4):413-422. Epub 2020 Nov 6 doi: 10.1136/annrheumdis-2020-218089. PMID: 33158879Free PMC Article
Pathogenesis and management of pain in osteoarthritis.
Dieppe PA, Lohmander LS
Lancet 2005 Mar 12-18;365(9463):965-73. doi: 10.1016/S0140-6736(05)71086-2. PMID: 15766999

Recent clinical studies

Etiology

Quantitative MRI evaluation of articular cartilage in patients with meniscus tear.
Chen E, Hou W, Wang H, Li J, Lin Y, Liu H, Du M, Li L, Wang X, Yang J, Yang R, Zhou C, Chen P, Zeng M, Yao Q, Chen W
Front Endocrinol (Lausanne) 2022;13:911893. Epub 2022 Jul 29 doi: 10.3389/fendo.2022.911893. PMID: 35966082Free PMC Article
FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis.
Matsuzaki T, Alvarez-Garcia O, Mokuda S, Nagira K, Olmer M, Gamini R, Miyata K, Akasaki Y, Su AI, Asahara H, Lotz MK
Sci Transl Med 2018 Feb 14;10(428) doi: 10.1126/scitranslmed.aan0746. PMID: 29444976Free PMC Article
Spreader Grafts in Functional Rhinoplasty.
Kim L, Papel ID
Facial Plast Surg 2016 Feb;32(1):29-35. Epub 2016 Feb 10 doi: 10.1055/s-0035-1570127. PMID: 26862961
Histology and pathology of the human intervertebral disc.
Roberts S, Evans H, Trivedi J, Menage J
J Bone Joint Surg Am 2006 Apr;88 Suppl 2:10-4. doi: 10.2106/JBJS.F.00019. PMID: 16595436
Composition and dynamics of articular cartilage: structure, function, and maintaining healthy state.
Cohen NP, Foster RJ, Mow VC
J Orthop Sports Phys Ther 1998 Oct;28(4):203-15. doi: 10.2519/jospt.1998.28.4.203. PMID: 9785256

Diagnosis

Auricular reconstruction.
Cubitt JJ, Chang LY, Liang D, Vandervord J, Marucci DD
J Paediatr Child Health 2019 May;55(5):512-517. Epub 2019 Mar 28 doi: 10.1111/jpc.14444. PMID: 30920067
Alar Rim Deformities.
Totonchi A, Guyuron B
Clin Plast Surg 2016 Jan;43(1):127-34. doi: 10.1016/j.cps.2015.09.014. PMID: 26616701
Congenital laryngeal stenosis.
Schroeder JW Jr, Holinger LD
Otolaryngol Clin North Am 2008 Oct;41(5):865-75, viii. doi: 10.1016/j.otc.2008.04.015. PMID: 18775338
Neuro-osteology.
Kjaer I
Crit Rev Oral Biol Med 1998;9(2):224-44. doi: 10.1177/10454411980090020501. PMID: 9603237
Tarsal coalition.
Kulik SA Jr, Clanton TO
Foot Ankle Int 1996 May;17(5):286-96. doi: 10.1177/107110079601700509. PMID: 8734800

Therapy

The role of the sirtuin family in cartilage and osteoarthritis: molecular mechanisms and therapeutic targets.
Sun K, Wu Y, Zeng Y, Xu J, Wu L, Li M, Shen B
Arthritis Res Ther 2022 Dec 31;24(1):286. doi: 10.1186/s13075-022-02983-8. PMID: 36585687Free PMC Article
Thalidomide and neurotrophism.
Soper JR, Bonar SF, O'Sullivan DJ, McCredie J, Willert HG
Skeletal Radiol 2019 Apr;48(4):517-525. Epub 2018 Oct 19 doi: 10.1007/s00256-018-3086-2. PMID: 30341712Free PMC Article
Paediatric Tracheomalacia.
Hysinger EB, Panitch HB
Paediatr Respir Rev 2016 Jan;17:9-15. Epub 2015 Mar 17 doi: 10.1016/j.prrv.2015.03.002. PMID: 25962857
Acetabular labrum.
Blankenbaker DG, Tuite MJ
Magn Reson Imaging Clin N Am 2013 Feb;21(1):21-33. Epub 2012 Oct 13 doi: 10.1016/j.mric.2012.09.006. PMID: 23168180
Magnetic resonance imaging of the lumbar spine in people without back pain.
Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, Ross JS
N Engl J Med 1994 Jul 14;331(2):69-73. doi: 10.1056/NEJM199407143310201. PMID: 8208267

Prognosis

MRI-based T(1rho) and T(2) cartilage compositional imaging in osteoarthritis: what have we learned and what is needed to apply it clinically and in a trial setting?
Link TM, Joseph GB, Li X
Skeletal Radiol 2023 Nov;52(11):2137-2147. Epub 2023 Mar 31 doi: 10.1007/s00256-023-04310-x. PMID: 37000230
Discoid lateral meniscus: current concepts.
Tapasvi S, Shekhar A, Eriksson K
J ISAKOS 2021 Jan;6(1):14-21. Epub 2020 Sep 16 doi: 10.1136/jisakos-2017-000162. PMID: 33833041
Histology and pathology of the human intervertebral disc.
Roberts S, Evans H, Trivedi J, Menage J
J Bone Joint Surg Am 2006 Apr;88 Suppl 2:10-4. doi: 10.2106/JBJS.F.00019. PMID: 16595436
Neuro-osteology.
Kjaer I
Crit Rev Oral Biol Med 1998;9(2):224-44. doi: 10.1177/10454411980090020501. PMID: 9603237
Microtia.
Tanzer RC
Clin Plast Surg 1978 Jul;5(3):317-36. PMID: 359217

Clinical prediction guides

MRI-based T(1rho) and T(2) cartilage compositional imaging in osteoarthritis: what have we learned and what is needed to apply it clinically and in a trial setting?
Link TM, Joseph GB, Li X
Skeletal Radiol 2023 Nov;52(11):2137-2147. Epub 2023 Mar 31 doi: 10.1007/s00256-023-04310-x. PMID: 37000230
The MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) 2.0 Knee Score and Atlas.
Schreiner MM, Raudner M, Marlovits S, Bohndorf K, Weber M, Zalaudek M, Röhrich S, Szomolanyi P, Filardo G, Windhager R, Trattnig S
Cartilage 2021 Dec;13(1_suppl):571S-587S. Epub 2019 Aug 17 doi: 10.1177/1947603519865308. PMID: 31422674Free PMC Article
Thalidomide and neurotrophism.
Soper JR, Bonar SF, O'Sullivan DJ, McCredie J, Willert HG
Skeletal Radiol 2019 Apr;48(4):517-525. Epub 2018 Oct 19 doi: 10.1007/s00256-018-3086-2. PMID: 30341712Free PMC Article
FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis.
Matsuzaki T, Alvarez-Garcia O, Mokuda S, Nagira K, Olmer M, Gamini R, Miyata K, Akasaki Y, Su AI, Asahara H, Lotz MK
Sci Transl Med 2018 Feb 14;10(428) doi: 10.1126/scitranslmed.aan0746. PMID: 29444976Free PMC Article
Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis.
Peterfy CG, Guermazi A, Zaim S, Tirman PF, Miaux Y, White D, Kothari M, Lu Y, Fye K, Zhao S, Genant HK
Osteoarthritis Cartilage 2004 Mar;12(3):177-90. doi: 10.1016/j.joca.2003.11.003. PMID: 14972335

Recent systematic reviews

The correlation between the lumbar disc MRI high-intensity zone and discogenic low back pain: a systematic review and meta-analysis.
Yang L, Li W, Yang Y, Zhao H, Yu X
J Orthop Surg Res 2023 Oct 7;18(1):758. doi: 10.1186/s13018-023-04187-5. PMID: 37805519Free PMC Article
How does the cam morphology develop in athletes? A systematic review and meta-analysis.
Pettit M, Doran C, Singh Y, Saito M, Sunil Kumar KH, Khanduja V
Osteoarthritis Cartilage 2021 Aug;29(8):1117-1129. Epub 2021 May 11 doi: 10.1016/j.joca.2021.02.572. PMID: 33989785
Management of Sigmoid Sinus Associated Pulsatile Tinnitus: A Systematic Review of the Literature.
Wang AC, Nelson AN, Pino C, Svider PF, Hong RS, Chan E
Otol Neurotol 2017 Dec;38(10):1390-1396. doi: 10.1097/MAO.0000000000001612. PMID: 29135862
Discoid Lateral Meniscus.
Dai WL, Zhang H, Zhou AG, Zhang G, Zhang J
J Knee Surg 2017 Nov;30(9):854-862. Epub 2017 Jan 23 doi: 10.1055/s-0036-1598021. PMID: 28114702
Systematic review of the concurrent and predictive validity of MRI biomarkers in OA.
Hunter DJ, Zhang W, Conaghan PG, Hirko K, Menashe L, Li L, Reichmann WM, Losina E
Osteoarthritis Cartilage 2011 May;19(5):557-88. Epub 2011 Mar 23 doi: 10.1016/j.joca.2010.10.029. PMID: 21396463Free PMC Article

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