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Abnormal motor neuron morphology

MedGen UID:
871226
Concept ID:
C4025707
Anatomical Abnormality
Synonym: Abnormal shape of motor neuron
 
HPO: HP:0002450

Definition

Any structural anomaly that affects the motor neuron. [from HPO]

Professional guidelines

PubMed

McCray BA, Scherer SS
Neurotherapeutics 2021 Oct;18(4):2269-2285. Epub 2021 Oct 4 doi: 10.1007/s13311-021-01099-2. PMID: 34606075Free PMC Article
Ross CA, Tabrizi SJ
Lancet Neurol 2011 Jan;10(1):83-98. doi: 10.1016/S1474-4422(10)70245-3. PMID: 21163446
Leigh RJ, Ramat S
Curr Opin Neurol 1999 Feb;12(1):21-7. doi: 10.1097/00019052-199902000-00004. PMID: 10097880

Recent clinical studies

Etiology

McCray BA, Scherer SS
Neurotherapeutics 2021 Oct;18(4):2269-2285. Epub 2021 Oct 4 doi: 10.1007/s13311-021-01099-2. PMID: 34606075Free PMC Article
Mckee AC, Daneshvar DH
Handb Clin Neurol 2015;127:45-66. doi: 10.1016/B978-0-444-52892-6.00004-0. PMID: 25702209Free PMC Article
Eisen A, Kiernan M, Mitsumoto H, Swash M
J Neurol Neurosurg Psychiatry 2014 Nov;85(11):1232-8. Epub 2014 Mar 19 doi: 10.1136/jnnp-2013-307135. PMID: 24648037
Noreau A, Dion PA, Rouleau GA
Exp Cell Res 2014 Jul 1;325(1):18-26. Epub 2014 Mar 11 doi: 10.1016/j.yexcr.2014.02.021. PMID: 24631291
Albin RL, Young AB, Penney JB
Trends Neurosci 1989 Oct;12(10):366-75. doi: 10.1016/0166-2236(89)90074-x. PMID: 2479133

Diagnosis

Tetter S, Arseni D, Murzin AG, Buhidma Y, Peak-Chew SY, Garringer HJ, Newell KL, Vidal R, Apostolova LG, Lashley T, Ghetti B, Ryskeldi-Falcon B
Nature 2024 Jan;625(7994):345-351. Epub 2023 Dec 6 doi: 10.1038/s41586-023-06801-2. PMID: 38057661Free PMC Article
Toupenet Marchesi L, Leblanc M, Stevanin G
Cells 2021 Jul 2;10(7) doi: 10.3390/cells10071678. PMID: 34359848Free PMC Article
Margolis SS, Sell GL, Zbinden MA, Bird LM
Neurotherapeutics 2015 Jul;12(3):641-50. doi: 10.1007/s13311-015-0361-y. PMID: 26040994Free PMC Article
Eisen A, Kiernan M, Mitsumoto H, Swash M
J Neurol Neurosurg Psychiatry 2014 Nov;85(11):1232-8. Epub 2014 Mar 19 doi: 10.1136/jnnp-2013-307135. PMID: 24648037
Bodensteiner JB
Semin Pediatr Neurol 2008 Mar;15(1):10-20. doi: 10.1016/j.spen.2008.01.003. PMID: 18342256

Therapy

De Gioia R, Citterio G, Abati E, Nizzardo M, Bresolin N, Comi GP, Corti S, Rizzo F
Mol Neurobiol 2020 Dec;57(12):5121-5129. Epub 2020 Aug 27 doi: 10.1007/s12035-020-02081-3. PMID: 32856204Free PMC Article
Cacabelos R
Int J Mol Sci 2017 Mar 4;18(3) doi: 10.3390/ijms18030551. PMID: 28273839Free PMC Article
Menke RA, Agosta F, Grosskreutz J, Filippi M, Turner MR
Neurotherapeutics 2017 Jan;14(1):11-23. doi: 10.1007/s13311-016-0484-9. PMID: 27752938Free PMC Article
Margolis SS, Sell GL, Zbinden MA, Bird LM
Neurotherapeutics 2015 Jul;12(3):641-50. doi: 10.1007/s13311-015-0361-y. PMID: 26040994Free PMC Article
Fisone G, Bezard E
Int Rev Neurobiol 2011;98:95-122. doi: 10.1016/B978-0-12-381328-2.00004-3. PMID: 21907084

Prognosis

Mckee AC, Daneshvar DH
Handb Clin Neurol 2015;127:45-66. doi: 10.1016/B978-0-444-52892-6.00004-0. PMID: 25702209Free PMC Article
Viollet L, Melki J
Handb Clin Neurol 2013;113:1395-411. doi: 10.1016/B978-0-444-59565-2.00010-1. PMID: 23622363
McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS, Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW, Cantu RC
Brain 2013 Jan;136(Pt 1):43-64. Epub 2012 Dec 2 doi: 10.1093/brain/aws307. PMID: 23208308Free PMC Article
Ross CA, Tabrizi SJ
Lancet Neurol 2011 Jan;10(1):83-98. doi: 10.1016/S1474-4422(10)70245-3. PMID: 21163446
Armour JA
Exp Physiol 2008 Feb;93(2):165-76. Epub 2007 Nov 2 doi: 10.1113/expphysiol.2007.041178. PMID: 17981929

Clinical prediction guides

Huin V, Coarelli G, Guemy C, Boluda S, Debs R, Mochel F, Stojkovic T, Grabli D, Maisonobe T, Gaymard B, Lenglet T, Tard C, Davion JB, Sablonnière B, Monin ML, Ewenczyk C, Viala K, Charles P, Le Ber I, Reilly MM, Houlden H, Cortese A, Seilhean D, Brice A, Durr A
Brain 2022 Jun 30;145(6):2121-2132. doi: 10.1093/brain/awab449. PMID: 34927205
Ruffoli R, Biagioni F, Busceti CL, Gaglione A, Ryskalin L, Gambardella S, Frati A, Fornai F
Histol Histopathol 2017 Nov;32(11):1115-1123. Epub 2017 Apr 11 doi: 10.14670/HH-11-895. PMID: 28397197
Dugger BN, Dickson DW
Cold Spring Harb Perspect Biol 2017 Jul 5;9(7) doi: 10.1101/cshperspect.a028035. PMID: 28062563Free PMC Article
Perrot R, Eyer J
Brain Res Bull 2009 Oct 28;80(4-5):282-95. Epub 2009 Jun 17 doi: 10.1016/j.brainresbull.2009.06.004. PMID: 19539727
Mamoli A, Nemni R, Camerlingo M, Quattrini A, Castro L, Lorenzetti I, Canal N
Acta Neurol Scand 1992 Feb;85(2):110-5. doi: 10.1111/j.1600-0404.1992.tb04008.x. PMID: 1315474

Recent systematic reviews

Erro R, Schneider SA, Stamelou M, Quinn NP, Bhatia KP
J Neurol Neurosurg Psychiatry 2016 Mar;87(3):319-23. Epub 2015 May 19 doi: 10.1136/jnnp-2014-310256. PMID: 25991401
Annane D, Orlikowski D, Chevret S
Cochrane Database Syst Rev 2014 Dec 13;2014(12):CD001941. doi: 10.1002/14651858.CD001941.pub3. PMID: 25503955Free PMC Article
Annane D, Orlikowski D, Chevret S, Chevrolet JC, Raphaël JC
Cochrane Database Syst Rev 2007 Oct 17;(4):CD001941. doi: 10.1002/14651858.CD001941.pub2. PMID: 17943762

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