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Abnormal fundus morphology

MedGen UID:
871316
Concept ID:
C4025804
Anatomical Abnormality
Synonym: Abnormality of the fundus
 
HPO: HP:0001098

Definition

Any structural abnormality of the fundus of the eye. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal fundus morphology

Conditions with this feature

Prolonged electroretinal response suppression 2
MedGen UID:
1841088
Concept ID:
C5830452
Finding
Prolonged electroretinal response suppression-2 (PERRS2), also referred to as bradyopsia-2, is an autosomal recessive childhood-onset retinopathy characterized by markedly delayed dark and light adaptation, mild photophobia, difficulty seeing moving objects, moderately reduced visual acuity, normal color vision, normal fundi, and reduced rod and cone responses with prolonged recovery on electrophysiologic assessment (summary by Michaelides et al., 2010).

Professional guidelines

PubMed

Ho CPS, Lai TYY
Indian J Ophthalmol 2018 Dec;66(12):1727-1735. doi: 10.4103/ijo.IJO_975_18. PMID: 30451173Free PMC Article
Tack J, Camilleri M
Curr Opin Pharmacol 2018 Dec;43:111-117. Epub 2018 Sep 21 doi: 10.1016/j.coph.2018.08.015. PMID: 30245474
Anantharaman G, Sheth J, Bhende M, Narayanan R, Natarajan S, Rajendran A, Manayath G, Sen P, Biswas R, Banker A, Gupta C
Indian J Ophthalmol 2018 Jul;66(7):896-908. doi: 10.4103/ijo.IJO_1136_17. PMID: 29941728Free PMC Article

Recent clinical studies

Etiology

Birtel J, von Landenberg C, Gliem M, Gliem C, Reimann J, Kunz WS, Herrmann P, Betz C, Caswell R, Nesbitt V, Kornblum C, Charbel Issa P
Ophthalmol Retina 2022 Jan;6(1):65-79. Epub 2021 Jul 10 doi: 10.1016/j.oret.2021.02.017. PMID: 34257060
Birtel J, Gliem M, Herrmann P, MacLaren RE, Bolz HJ, Charbel Issa P
Ophthalmol Retina 2020 May;4(5):523-529. Epub 2020 Mar 5 doi: 10.1016/j.oret.2019.12.008. PMID: 32147488
Akkaya S
Int Ophthalmol 2018 Oct;38(5):2239-2246. Epub 2017 Aug 1 doi: 10.1007/s10792-017-0666-4. PMID: 28766279
Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR; Beckman Initiative for Macular Research Classification Committee
Ophthalmology 2013 Apr;120(4):844-51. Epub 2013 Jan 16 doi: 10.1016/j.ophtha.2012.10.036. PMID: 23332590
Ophthalmology 1991 May;98(5 Suppl):786-806. PMID: 2062513

Diagnosis

Cheung CMG, Lee WK, Koizumi H, Dansingani K, Lai TYY, Freund KB
Eye (Lond) 2019 Jan;33(1):14-33. Epub 2018 Jul 11 doi: 10.1038/s41433-018-0158-4. PMID: 29995841Free PMC Article
Pichi F, Aggarwal K, Neri P, Salvetti P, Lembo A, Nucci P, Gemmy Cheung CM, Gupta V
Indian J Ophthalmol 2018 Dec;66(12):1716-1726. doi: 10.4103/ijo.IJO_893_18. PMID: 30451172Free PMC Article
Akkaya S
Int Ophthalmol 2018 Oct;38(5):2239-2246. Epub 2017 Aug 1 doi: 10.1007/s10792-017-0666-4. PMID: 28766279
Rabiolo A, De Vitis LA, Sacconi R, Carnevali A, Querques L, Bandello F, Querques G
Dev Ophthalmol 2017;60:50-55. Epub 2017 Apr 20 doi: 10.1159/000459689. PMID: 28427064
Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR; Beckman Initiative for Macular Research Classification Committee
Ophthalmology 2013 Apr;120(4):844-51. Epub 2013 Jan 16 doi: 10.1016/j.ophtha.2012.10.036. PMID: 23332590

Therapy

Greenstein VC, Lima de Carvalho JR Jr, Parmann R, Amaro-Quireza L, Lee W, Hood DC, Tsang SH, Sparrow JR
Invest Ophthalmol Vis Sci 2020 Sep 1;61(11):41. doi: 10.1167/iovs.61.11.41. PMID: 32976563Free PMC Article
Ho CPS, Lai TYY
Indian J Ophthalmol 2018 Dec;66(12):1727-1735. doi: 10.4103/ijo.IJO_975_18. PMID: 30451173Free PMC Article
Tack J, Camilleri M
Curr Opin Pharmacol 2018 Dec;43:111-117. Epub 2018 Sep 21 doi: 10.1016/j.coph.2018.08.015. PMID: 30245474
Ophthalmology 1991 May;98(5 Suppl):786-806. PMID: 2062513
Lambert R, André C, Moulinier B, Bugnon B
Digestion 1978;17(2):159-67. doi: 10.1159/000198106. PMID: 414953

Prognosis

Nichani P, Micieli JA
Ophthalmol Retina 2021 May;5(5):429-437. Epub 2020 Aug 26 doi: 10.1016/j.oret.2020.08.016. PMID: 32860958
van Dijk EHC, Schellevis RL, Breukink MB, Mohabati D, Dijkman G, Keunen JEE, Yzer S, den Hollander AI, Hoyng CB, de Jong EK, Boon CJF
Retina 2019 Feb;39(2):398-407. doi: 10.1097/IAE.0000000000001966. PMID: 29190234
Rabiolo A, De Vitis LA, Sacconi R, Carnevali A, Querques L, Bandello F, Querques G
Dev Ophthalmol 2017;60:50-55. Epub 2017 Apr 20 doi: 10.1159/000459689. PMID: 28427064
Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR; Beckman Initiative for Macular Research Classification Committee
Ophthalmology 2013 Apr;120(4):844-51. Epub 2013 Jan 16 doi: 10.1016/j.ophtha.2012.10.036. PMID: 23332590
Witmer MT, Margo CE, Drucker M
Surv Ophthalmol 2010 Sep-Oct;55(5):403-28. Epub 2010 Jul 10 doi: 10.1016/j.survophthal.2010.01.002. PMID: 20621322

Clinical prediction guides

Gus PI, Donis KC, Marinho D, Martins TF, de Souza CFM, Carloto RB, Leivas G, Schwartz IVD
Ophthalmic Genet 2021 Feb;42(1):71-74. Epub 2020 Sep 17 doi: 10.1080/13816810.2020.1821384. PMID: 32940091
de Oliveira DR, Ventura CV, Esporcatte BLB, Gracitelli CPB, Dias NC, Ventura LO, Belfort R Jr, Rolim-de-Moura C
J Glaucoma 2019 Apr;28(4):313-317. doi: 10.1097/IJG.0000000000001150. PMID: 30531188
van Dijk EHC, Schellevis RL, Breukink MB, Mohabati D, Dijkman G, Keunen JEE, Yzer S, den Hollander AI, Hoyng CB, de Jong EK, Boon CJF
Retina 2019 Feb;39(2):398-407. doi: 10.1097/IAE.0000000000001966. PMID: 29190234
Sergott RC
J Neuroophthalmol 2014 Sep;34 Suppl:S24-8. doi: 10.1097/WNO.0000000000000164. PMID: 25133967
Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR; Beckman Initiative for Macular Research Classification Committee
Ophthalmology 2013 Apr;120(4):844-51. Epub 2013 Jan 16 doi: 10.1016/j.ophtha.2012.10.036. PMID: 23332590

Recent systematic reviews

Hou X, Guo Y, Liu J, Li S, Fan W, Lin M, Rokohl AC, Heindl LM
Curr Eye Res 2021 Jul;46(7):913-918. Epub 2021 Jan 22 doi: 10.1080/02713683.2020.1853779. PMID: 33478254
Meng L, Zhao X, Zhang W, Wang D, Chen Y
Acta Ophthalmol 2021 Nov;99(7):e1176-e1189. Epub 2021 Jan 9 doi: 10.1111/aos.14730. PMID: 33421324
Schneider M, Molnar A, Angeli O, Szabo D, Bernath F, Hajdu D, Gombocz E, Mate B, Jiling B, Nagy BV, Nagy ZZ, Peto T, Papp A
Acta Ophthalmol 2021 May;99(3):e310-e318. Epub 2020 Aug 24 doi: 10.1111/aos.14592. PMID: 32833328
Akkaya S
Int Ophthalmol 2018 Oct;38(5):2239-2246. Epub 2017 Aug 1 doi: 10.1007/s10792-017-0666-4. PMID: 28766279
Borooah S, Collins C, Wright A, Dhillon B
Br J Ophthalmol 2009 Mar;93(3):284-9. Epub 2008 Dec 19 doi: 10.1136/bjo.2008.150151. PMID: 19098033

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