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Abnormal conjunctiva morphology

MedGen UID:
871353
Concept ID:
C4025847
Anatomical Abnormality
Synonym: Abnormality of the conjunctiva
 
HPO: HP:0000502

Definition

An abnormality of the conjunctiva. [from HPO]

Conditions with this feature

Malignant atrophic papulosis
MedGen UID:
113138
Concept ID:
C0221011
Disease or Syndrome
Malignant atrophic papulosis (MAP) is a rare, chronic, thrombo-obliterative vasculopathy characterized by papular skin lesions with central porcelain-white atrophy and a surrounding teleangiectatic rim. Systemic lesions may affect the gastrointestinal tract and the central nervous system (CNS) and are potentially lethal.
Dermatopathia pigmentosa reticularis
MedGen UID:
98037
Concept ID:
C0406778
Congenital Abnormality
Dermatopathia pigmentosa reticularis (DPR) is a rare heritable disorder consisting of a triad of cutaneous findings including reticulate hyperpigmentation, noncicatricial alopecia, and onychodystrophy. Variable features include adermatoglyphia, hypohidrosis or hyperhidrosis, and palmoplantar hyperkeratosis (Heimer et al., 1992).
Ring dermoid of cornea
MedGen UID:
357922
Concept ID:
C1867155
Disease or Syndrome
Ring dermoid of cornea (RDC) is an autosomal dominant condition characterized by bilateral annular limbal dermoids with corneal and conjunctival extension (summary by Xia et al., 2004).
Familial pterygium of the conjunctiva
MedGen UID:
356779
Concept ID:
C1867441
Disease or Syndrome
Pterygium of the conjunctive refers to a wing-shaped thickening in the bulbar conjunctiva. The process begins near one corner of the eye, most commonly the inner canthus. The progressive head is typically fleshy and can infiltrate the cornea and block vision. Surgical excision is curative, although recurrence may occur after surgical removal (summary by Hecht and Shoptaugh, 1990).
White sponge nevus 1
MedGen UID:
860363
Concept ID:
C4011926
Disease or Syndrome
White sponge nevus is a rare autosomal dominant disorder of noncornifying squamous epithelial differentiation that presents clinically as white, soft, thick plaques of the oral mucosa. Less frequently, the mucous membranes of the nose, esophagus, genitalia, and rectum are involved. Histopathologic features, including epithelial thickening, parakeratosis, extensive vacuolization of the suprabasal keratinocytes, and compact aggregates of keratin intermediate filaments in the upper spinus layers resemble those found in epidermal disorders shown to be associated with keratin defects (summary by Richard et al., 1995). Genetic Heterogeneity of White Sponge Nevus White sponge nevus-2 (WSN2; 615785) is caused by mutation in the KRT13 gene (148065) on chromosome 17q21.

Professional guidelines

PubMed

Periman LM, Perez VL, Saban DR, Lin MC, Neri P
J Ocul Pharmacol Ther 2020 Apr;36(3):137-146. Epub 2020 Mar 12 doi: 10.1089/jop.2019.0060. PMID: 32175799Free PMC Article
Malhotra R, Hernández-Martın A, Oji V
Br J Ophthalmol 2018 May;102(5):586-592. Epub 2017 Nov 3 doi: 10.1136/bjophthalmol-2017-310615. PMID: 29101124
Hovanesian JA, Starr CE, Vroman DT, Mah FS, Gomes JAP, Farid M, Shamie N, Davidson RS, John T, Holland EJ, Kim T; ASCRS Cornea Clinical Committee
J Cataract Refract Surg 2017 Mar;43(3):405-419. doi: 10.1016/j.jcrs.2017.03.002. PMID: 28410726

Recent clinical studies

Etiology

He S, Wu Z
Ophthalmic Res 2022;65(5):481-492. Epub 2022 Apr 11 doi: 10.1159/000523878. PMID: 35405677
Agarwal R, Nagpal R, Todi V, Sharma N
Surv Ophthalmol 2021 Jan-Feb;66(1):2-19. Epub 2020 Oct 13 doi: 10.1016/j.survophthal.2020.10.004. PMID: 33058926
Maxia C, Murtas D, Isola M, Tamma R, Zucca I, Piras F, Ribatti D, Diana A, Perra MT
Mol Vis 2018;24:853-866. Epub 2018 Dec 29 PMID: 30713424Free PMC Article
Ma J, Rubin BK, Voynow JA
Chest 2018 Jul;154(1):169-176. Epub 2017 Nov 21 doi: 10.1016/j.chest.2017.11.008. PMID: 29170036
Ritch R, Schlötzer-Schrehardt U
Surv Ophthalmol 2001 Jan-Feb;45(4):265-315. doi: 10.1016/s0039-6257(00)00196-x. PMID: 11166342

Diagnosis

Gündüz AK, Mirzayev I, Okcu Heper A, Kuzu I, Gahramanli Z, Cansiz Ersöz C, Gündüz ÖÖ, Ataoğlu Ö
Eye (Lond) 2023 Apr;37(5):925-937. Epub 2022 Dec 13 doi: 10.1038/s41433-022-02339-1. PMID: 36513855Free PMC Article
He S, Wu Z
Ophthalmic Res 2022;65(5):481-492. Epub 2022 Apr 11 doi: 10.1159/000523878. PMID: 35405677
Agarwal R, Nagpal R, Todi V, Sharma N
Surv Ophthalmol 2021 Jan-Feb;66(1):2-19. Epub 2020 Oct 13 doi: 10.1016/j.survophthal.2020.10.004. PMID: 33058926
Ritch R, Schlötzer-Schrehardt U
Surv Ophthalmol 2001 Jan-Feb;45(4):265-315. doi: 10.1016/s0039-6257(00)00196-x. PMID: 11166342
Robin JB, Schanzlin DJ, Verity SM, Barron BA, Arffa RC, Suarez E, Kaufman HE
Surv Ophthalmol 1986 Jul-Aug;31(1):1-36. doi: 10.1016/0039-6257(86)90049-4. PMID: 3529467

Therapy

Periman LM, Perez VL, Saban DR, Lin MC, Neri P
J Ocul Pharmacol Ther 2020 Apr;36(3):137-146. Epub 2020 Mar 12 doi: 10.1089/jop.2019.0060. PMID: 32175799Free PMC Article
Saglik A, Koyuncu I, Yalcin H, Adibelli FM, Gonel A, Toptan M
Arq Bras Oftalmol 2020 Jan-Feb;83(1):5-10. doi: 10.5935/0004-2749.20200001. PMID: 31531547
Meneghim RLFS, Satto LH, Natsuaki KL, Oliveira AC, Padovani CR, Viveiros MMH, Schellini SA
Arq Bras Oftalmol 2019 Jun 27;82(5):372-376. doi: 10.5935/0004-2749.20190075. PMID: 31271569
Looi K, Evans DJ, Garratt LW, Ang S, Hillas JK, Kicic A, Simpson SJ
Paediatr Respir Rev 2019 Aug;31:82-88. Epub 2018 Dec 1 doi: 10.1016/j.prrv.2018.11.003. PMID: 31103368
Malhotra R, Hernández-Martın A, Oji V
Br J Ophthalmol 2018 May;102(5):586-592. Epub 2017 Nov 3 doi: 10.1136/bjophthalmol-2017-310615. PMID: 29101124

Prognosis

Palewski M, Budnik A, Konopińska J
Int J Environ Res Public Health 2022 Sep 9;19(18) doi: 10.3390/ijerph191811357. PMID: 36141628Free PMC Article
He S, Wu Z
Ophthalmic Res 2022;65(5):481-492. Epub 2022 Apr 11 doi: 10.1159/000523878. PMID: 35405677
Odze R
Dig Dis Sci 2018 Aug;63(8):2042-2051. doi: 10.1007/s10620-018-5151-z. PMID: 29998421
Hovanesian JA, Starr CE, Vroman DT, Mah FS, Gomes JAP, Farid M, Shamie N, Davidson RS, John T, Holland EJ, Kim T; ASCRS Cornea Clinical Committee
J Cataract Refract Surg 2017 Mar;43(3):405-419. doi: 10.1016/j.jcrs.2017.03.002. PMID: 28410726
Ritch R, Schlötzer-Schrehardt U
Surv Ophthalmol 2001 Jan-Feb;45(4):265-315. doi: 10.1016/s0039-6257(00)00196-x. PMID: 11166342

Clinical prediction guides

Di Zazzo A, Cutrupi F, De Antoniis MG, Ricci M, Esposito G, Antonini M, Coassin M, Micera A, Perrella E, Bonini S
Invest Ophthalmol Vis Sci 2023 Dec 1;64(15):17. doi: 10.1167/iovs.64.15.17. PMID: 38095906Free PMC Article
Tan J, Vollmer-Conna U, Tat L, Coroneo M
Ophthalmic Res 2019;61(4):199-203. Epub 2018 Oct 31 doi: 10.1159/000493544. PMID: 30380559
Odze R
Dig Dis Sci 2018 Aug;63(8):2042-2051. doi: 10.1007/s10620-018-5151-z. PMID: 29998421
Ma J, Rubin BK, Voynow JA
Chest 2018 Jul;154(1):169-176. Epub 2017 Nov 21 doi: 10.1016/j.chest.2017.11.008. PMID: 29170036
Hovanesian JA, Starr CE, Vroman DT, Mah FS, Gomes JAP, Farid M, Shamie N, Davidson RS, John T, Holland EJ, Kim T; ASCRS Cornea Clinical Committee
J Cataract Refract Surg 2017 Mar;43(3):405-419. doi: 10.1016/j.jcrs.2017.03.002. PMID: 28410726

Recent systematic reviews

Aljahdali F, Khayyat W, BinYamin AT, Al-Qahtani SA, Alghamdi MD, Alsudais AS, Alalgum HA, Bin Helayel H, AlMutlak M
BMJ Open Ophthalmol 2024 Apr 1;9(1) doi: 10.1136/bmjophth-2023-001621. PMID: 38565231Free PMC Article
Zein H, Ismail A, Abdelmongy M, Elsherif S, Hassanen A, Muhammad B, Assaf F, Elsehili A, Negida A, Yamane S, Abdel-Daim MM, Kadonosono K
Curr Pharm Des 2018;24(35):4197-4204. doi: 10.2174/1381612824666181001161352. PMID: 30277146
Lan A, Xiao F, Wang Y, Luo Z, Cao Q
Oncotarget 2017 Jun 20;8(25):41487-41497. doi: 10.18632/oncotarget.17195. PMID: 28489563Free PMC Article

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