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Abnormal paranasal sinus morphology

MedGen UID:
871377
•Concept ID:
C4025873
•
Anatomical Abnormality
Synonyms: Abnormality of the paranasal sinuses; Abnormality of the sinuses; Abnormality of the sinuses of the head
 
HPO: HP:0000245

Definition

Abnormality of the paranasal (cranial) sinuses, which are air-filled spaces that are located within the bones of the skull and face and communicate with the nasal cavity. They comprise the maxillary sinuses, the frontal sinuses, the ethmoid sinuses, and the sphenoid sinuses. [from HPO]

Conditions with this feature

Aplasia cutis congenita-intestinal lymphangiectasia syndrome
MedGen UID:
349241
•Concept ID:
C1859753
•
Disease or Syndrome
An extremely rare association syndrome, described in only two brothers to date (one of which died at 2 months of age), characterized by aplasia cutis congenita of the vertex and generalized edema (as well as hypoproteinemia and lymphopenia) due to intestinal lymphangiectasia. There have been no further descriptions in the literature since 1985.
See: Condition Record
Aplasia cutis congenita-intestinal lymphangiectasia syndrome

Professional guidelines

PubMed

Sinonasal Neuroendocrine Neoplasms: Current Challenges and Advances in Diagnosis and Treatment, with a Focus on Olfactory Neuroblastoma.
Bell D
Head Neck Pathol 2018 Mar;12(1):22-30. Epub 2018 Feb 9 doi: 10.1007/s12105-018-0887-5. PMID: 29427030Free PMC Article
Nasal polyposis: an overview of differential diagnosis and treatment.
Cingi C, Demirbas D, Ural A
Recent Pat Inflamm Allergy Drug Discov 2011 Sep;5(3):241-52. doi: 10.2174/187221311797264900. PMID: 21834752
Sinonasal disease in cystic fibrosis: clinical characteristics, diagnosis, and management.
Gysin C, Alothman GA, Papsin BC
Pediatr Pulmonol 2000 Dec;30(6):481-9. doi: 10.1002/1099-0496(200012)30:6<481::aid-ppul8>3.0.co;2-n. PMID: 11109061

Recent clinical studies

Etiology

Nasal Cavity and Paranasal Sinus Diseases Affecting Orbit.
Samil KS, Yasar C, Ercan A, Hanifi B, Hilal K
J Craniofac Surg 2015 Jun;26(4):e348-51. doi: 10.1097/SCS.0000000000001827. PMID: 26080260
Maxillary sinus aplasia.
Chrcanovic BR, Freire-Maia B
Oral Maxillofac Surg 2010 Sep;14(3):187-91. doi: 10.1007/s10006-009-0200-6. PMID: 20091417
The Arrhinias.
Tessier P, Ciminello FS, Wolfe SA
Scand J Plast Reconstr Surg Hand Surg 2009;43(4):177-96. doi: 10.1080/02844310802517259. PMID: 19401938
Phaeohyphomycosis.
Kumar KK, Hallikeri K
Indian J Pathol Microbiol 2008 Oct-Dec;51(4):556-8. doi: 10.4103/0377-4929.43761. PMID: 19008596
Maxillary sinus hypoplasia.
Erdem T, Aktas D, Erdem G, Miman MC, Ozturan O
Rhinology 2002 Sep;40(3):150-3. PMID: 12357716

Diagnosis

Venous Abnormalities Leading to Tinnitus: Imaging Evaluation.
Reardon MA, Raghavan P
Neuroimaging Clin N Am 2016 May;26(2):237-45. Epub 2016 Mar 5 doi: 10.1016/j.nic.2015.12.006. PMID: 27154606
Primary ciliary dyskinesia in adults.
Honoré I, Burgel PR
Rev Mal Respir 2016 Feb;33(2):165-89. Epub 2015 Dec 1 doi: 10.1016/j.rmr.2015.10.743. PMID: 26654126
What do we know about rhinogenic headache? The otolaryngologist’s challenge.
Mehle ME
Otolaryngol Clin North Am 2014 Apr;47(2):255-64. Epub 2014 Jan 10 doi: 10.1016/j.otc.2013.10.006. PMID: 24680492
Maxillary sinus aplasia.
Chrcanovic BR, Freire-Maia B
Oral Maxillofac Surg 2010 Sep;14(3):187-91. doi: 10.1007/s10006-009-0200-6. PMID: 20091417
The Arrhinias.
Tessier P, Ciminello FS, Wolfe SA
Scand J Plast Reconstr Surg Hand Surg 2009;43(4):177-96. doi: 10.1080/02844310802517259. PMID: 19401938

Therapy

Sphenoid sinuses: pneumatisation and anatomical variants-what the radiologist needs to know and report to avoid intraoperative complications.
Cellina M, Gibelli D, Floridi C, Toluian T, Valenti Pittino C, Martinenghi C, Oliva G
Surg Radiol Anat 2020 Sep;42(9):1013-1024. Epub 2020 May 11 doi: 10.1007/s00276-020-02490-y. PMID: 32394118
Revisiting major anatomical risk factors of maxillary sinus lift and soft tissue graft harvesting for dental implant surgeons.
Iwanaga J, Tanaka T, Ibaragi S, Okui T, Hamaguchi J, Min S, Tubbs RS
Surg Radiol Anat 2020 Sep;42(9):1025-1031. Epub 2020 Apr 10 doi: 10.1007/s00276-020-02468-w. PMID: 32277256
Bacteriology and treatment of infections in the upper and lower airways in patients with primary ciliary dyskinesia: adressing the paranasal sinuses.
Alanin MC
Dan Med J 2017 May;64(5) PMID: 28552099
Pathological mechanisms and clinical features of eosinophilic chronic rhinosinusitis in the Japanese population.
Takeno S, Hirakawa K, Ishino T
Allergol Int 2010 Sep;59(3):247-256. Epub 2010 Jun 25 doi: 10.2332/allergolint.10-RAI-0202. PMID: 20567131
Allergic fungal sinusitis: pathophysiology, diagnosis and management.
Schubert MS
Med Mycol 2009;47 Suppl 1:S324-30. Epub 2009 Mar 27 doi: 10.1080/13693780802314809. PMID: 19330659

Prognosis

Magnetic Resonance Imaging of Pulmonary and Paranasal Sinus Abnormalities in Children with Primary Ciliary Dyskinesia Compared to Children with Cystic Fibrosis.
Wucherpfennig L, Wuennemann F, Eichinger M, Schmitt N, Seitz A, Baumann I, Roehmel JF, Stahl M, Hämmerling S, Chung J, Schenk JP, Alrajab A, Kauczor HU, Mall MA, Wielpütz MO, Sommerburg O
Ann Am Thorac Soc 2024 Mar;21(3):438-448. doi: 10.1513/AnnalsATS.202305-453OC. PMID: 38206973
Primary ciliary dyskinesia in adults.
Honoré I, Burgel PR
Rev Mal Respir 2016 Feb;33(2):165-89. Epub 2015 Dec 1 doi: 10.1016/j.rmr.2015.10.743. PMID: 26654126
Maxillary sinus aplasia.
Chrcanovic BR, Freire-Maia B
Oral Maxillofac Surg 2010 Sep;14(3):187-91. doi: 10.1007/s10006-009-0200-6. PMID: 20091417
The Arrhinias.
Tessier P, Ciminello FS, Wolfe SA
Scand J Plast Reconstr Surg Hand Surg 2009;43(4):177-96. doi: 10.1080/02844310802517259. PMID: 19401938
Maxillary sinus hypoplasia.
Erdem T, Aktas D, Erdem G, Miman MC, Ozturan O
Rhinology 2002 Sep;40(3):150-3. PMID: 12357716

Clinical prediction guides

Immunological Features of Paranasal Sinus Mucosa in Patients with Graves' Orbitopathy.
Lu Y, Wu Y, Huang Y, Fang S, Li Y, Sun J, Zhou H
Front Endocrinol (Lausanne) 2020;11:621321. Epub 2021 Feb 10 doi: 10.3389/fendo.2020.621321. PMID: 33643223Free PMC Article
Maxillary sinus septa: a systematic review.
Maestre-Ferrín L, Galán-Gil S, Rubio-Serrano M, Peñarrocha-Diago M, Peñarrocha-Oltra D
Med Oral Patol Oral Cir Bucal 2010 Mar 1;15(2):e383-6. doi: 10.4317/medoral.15.e383. PMID: 19767706
Orbital syndromes.
Bhatti MT
Semin Neurol 2007 Jul;27(3):269-87. doi: 10.1055/s-2007-979685. PMID: 17577868
Mucociliary transport in chronic rhinosinusitis.
Baroody FM
Clin Allergy Immunol 2007;20:103-19. PMID: 17534048
Ciliary dyskinesia in the nose and paranasal sinuses.
Jorissen M, Bertrand B, Eloy P
Acta Otorhinolaryngol Belg 1997;51(4):353-66. PMID: 9444381

Recent systematic reviews

Infraorbital canal variants and its clinical and surgical implications. A systematic review.
Orellana-Donoso M, Romero-Zucchino D, Fuentes-Abarca A, Aravena-Ríos P, Sanchis-Gimeno J, Konschake M, Nova-Baeza P, Valenzuela-Fuenzalida JJ
Surg Radiol Anat 2024 Jul;46(7):1027-1046. Epub 2024 Apr 29 doi: 10.1007/s00276-024-03348-3. PMID: 38684553
Anatomical variations and abnormalities of the maxillary region and clinical implications: A systematic review and metaanalysis.
Valenzuela-Fuenzalida JJ, Baez-Flores B, Sepúlveda RÁ, Medina CM, Pérez R, López E, Sanchis J, Orellana Donoso M, Silva JL, Rodriguez MC, Iwanaga J
Medicine (Baltimore) 2023 Sep 22;102(38):e34510. doi: 10.1097/MD.0000000000034510. PMID: 37747000Free PMC Article
Ectopic ACTH-secreting pituitary adenoma of the sphenoid sinus: case report of endoscopic endonasal resection and systematic review of the literature.
Seltzer J, Lucas J, Commins D, Lerner O, Lerner A, Carmichael JD, Zada G
Neurosurg Focus 2015 Feb;38(2):E10. doi: 10.3171/2014.10.FOCUS14685. PMID: 25639312
Maxillary sinus septa: a systematic review.
Maestre-Ferrín L, Galán-Gil S, Rubio-Serrano M, Peñarrocha-Diago M, Peñarrocha-Oltra D
Med Oral Patol Oral Cir Bucal 2010 Mar 1;15(2):e383-6. doi: 10.4317/medoral.15.e383. PMID: 19767706
Do chronic changes in nasal airflow have any physiological or pathological effect on the nose and paranasal sinuses? A systematic review.
Boyce J, Eccles R
Clin Otolaryngol 2006 Feb;31(1):15-9. doi: 10.1111/j.1749-4486.2006.01125.x. PMID: 16441795

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