Papillon-Lefèvre syndrome- MedGen UID:
- 45306
- •Concept ID:
- C0030360
- •
- Disease or Syndrome
Papillion-Lefevre syndrome (PALS) is an autosomal recessive disorder characterized by palmoplantar keratoderma, periodontitis, and premature loss of dentition (summary by Lefevre et al., 2001).
Haim-Munk syndrome- MedGen UID:
- 344539
- •Concept ID:
- C1855627
- •
- Disease or Syndrome
Haim-Munk syndrome is an autosomal recessive disorder characterized by palmoplantar keratoderma, severe periodonitis, arachnodactyly, acroosteolysis, atrophic changes of the nails, and a radiographic deformity of the fingers (summary by Hart et al., 2000).
Periodontitis, aggressive 1- MedGen UID:
- 1644602
- •Concept ID:
- C4551681
- •
- Disease or Syndrome
Aggressive periodontitis, which may be generalized or localized, is characterized by severe and protracted gingival infections, leading to tooth loss. Amounts of microbial deposits are generally inconsistent with the severity of periodontal tissue destruction and the progression of attachment and bone loss may be self arresting (American Academy of Periodontology, 2000). The term 'aggressive periodontitis' replaced the terms 'early-onset,' 'prepubertal,' or 'juvenile periodontitis' at a 1999 International workshop for a classification of periodontal disease and conditions, where it was decided that the classification terminology should not be age dependent or require knowledge of rates of progression (Armitage, 1999).
Genetic Heterogeneity of Aggressive Periodontitis
Aggressive periodontitis-2 (608526) has been mapped to chromosome 1q25.