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Abnormal renal glomerulus morphology

MedGen UID:: 871392
•Concept ID:: C4025889
•: Anatomical Abnormality

Synonyms:	Abnormality of renal glomerulus morphology; Morphologic abnormality of the renal glomerulus

HPO:	HP:0000095

Definition

A structural anomaly of the glomerulus. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal renal glomerulus morphology

Abnormality of the urinary system
- Abnormality of the upper urinary tract
  - Abnormality of the kidney
    - Abnormal renal morphology
      - Abnormal nephron morphology
        Abnormal renal corpuscle morphology
        Abnormal renal glomerulus morphology
        Abnormal glomerular capillary morphology
        Abnormal glomerular capillary lumen morphology
        Deflation of the glomerular tuft
        Glomerular capillary collapse
        Glomerular capillary congestion
        Glomerular capillary microaneurysm
        Glomerular fibrin thrombus
        Glomerular hyaline pseudothrombus
        Glomerular karyhorrhectic debris
        Glomerular lipoprotein thrombus
        Abnormal glomerular endothelial cell morphology
        Glomerular endothelial tubuloreticular inclusion
        Glomerular endotheliosis
        Loss of glomerular endothelial cell fenestration
        Glomerular capillary wall duplication with cellular interposition
        Glomerular capillary wall duplication without cellular interposition
        Glomerular endocapillary hypercellularity
        Glomerular endocapillary leukocyte hypercellularity
        Glomerular fibrinoid necrosis
        Thickening of glomerular capillary wall
        Abnormal glomerular mesangium morphology
        Abnormal glomerular mesangial cellularity
        Mesangial cell loss
        Mesangial hypercellularity
        Abnormal glomerular mesangial matrix morphology
        Global mesangial sclerosis
        Mesangial matrix expansion
        Mesangiolysis
        Nodular mesangiosclerosis
        Diffuse mesangial sclerosis
        Mesangial fibril deposition
        Mesangial amyloid deposition
        Mesangial fibrillary deposits
        Mesangial immunotactoid deposits
        Mesangial microfibril deposition
        Mesangial hyaline deposition
        Mesangial Immune complex deposition
        Paramesangial deposits
        Glomerular deposits
        Glomerular C3 deposition
        Glomerular capillary wire loop deposits
        Glomerular subendothelial electron-dense deposits
        Glomerular subepithelial deposits
        Abnormal glomerular basement membrane morphology
        Fibrillar glomerular subepithelial deposits
        Glomerular hyaline subepithelial deposits
        Glomerular subepithelial immune-complex deposits
        IgA deposition in the glomerulus
        Glomerular extracapillary hypercellularity
        Glomerular sclerosis
        Focal segmental glomerulosclerosis
        Chronic rejection of renal transplant
        Focal Segmental Glomerulosclerosis Cellular Variant
        Focal Segmental Glomerulosclerosis Collapsing Variant
        Focal Segmental Glomerulosclerosis Perihilar Variant
        Focal Segmental Glomerulosclerosis Tip Lesion Variant
        Focal Segmental Glomerulosclerosis, Not Otherwise Specified
        HIV-associated nephropathy
        Inherited focal segmental glomerulosclerosis
        Obesity Related Glomerulopathy
        Primary focal segmental glomerulosclerosis
        Secondary Focal Segmental Glomerulosclerosis
        Global glomerulosclerosis
        Glomerular obsolescence
        Segmental glomerulosclerosis
        Perihilar segmental glomerulosclerosis
        Segmental glomerulosclerosis away from the vascular and tubular poles
        Tip variant segmental glomerulosclerosis
        Glomerulomegaly
        Glomerulopathy
        Collapsing Glomerulopathy
        Glomerulocystic Disease
        Idiopathic Membranous Glomerulopathy
        Membranous Nephropathy - Secondary
        Primary Collapsing Glomerulopathy
        Secondary Collapsing Glomerulopathy
        Tip Lesion Glomerulopathy
        Lobular glomerulopathy
        Multiple glomerular cysts
        Obliterative abnormality of the renal glomerulus
        Glomerular hyalinosis
        Glomerular hyalinosis at the tubular pole
        Glomerular hyalinosis away from the vascular and tubular poles
        Perihilar glomerular hyalinosis
        Renal juxtaglomerular cell hypertrophy/hyperplasia

Conditions with this feature

Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome

MedGen UID:: 1373459
•Concept ID:: C4317151
•: Disease or Syndrome

Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome is an autosomal dominant disorder characterized by these 4 features, which begin in early childhood and are progressive (summary by Moalem et al., 2015).

See: Condition Record

Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome

Professional guidelines

PubMed

Membranoproliferative glomerulonephritis: no longer the same disease and may need very different treatment.

Noris M, Daina E, Remuzzi G
Nephrol Dial Transplant 2023 Feb 13;38(2):283-290. doi: 10.1093/ndt/gfab281. PMID: 34596686

Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.

Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W, Gribouval O, Boyer O, Revy P, Jobst-Schwan T, Schmidt JM, Lawson JA, Schanze D, Ashraf S, Ullmann JFP, Hoogstraten CA, Boddaert N, Collinet B, Martin G, Liger D, Lovric S, Furlano M, Guerrera IC, Sanchez-Ferras O, Hu JF, Boschat AC, Sanquer S, Menten B, Vergult S, De Rocker N, Airik M, Hermle T, Shril S, Widmeier E, Gee HY, Choi WI, Sadowski CE, Pabst WL, Warejko JK, Daga A, Basta T, Matejas V, Scharmann K, Kienast SD, Behnam B, Beeson B, Begtrup A, Bruce M, Ch'ng GS, Lin SP, Chang JH, Chen CH, Cho MT, Gaffney PM, Gipson PE, Hsu CH, Kari JA, Ke YY, Kiraly-Borri C, Lai WM, Lemyre E, Littlejohn RO, Masri A, Moghtaderi M, Nakamura K, Ozaltin F, Praet M, Prasad C, Prytula A, Roeder ER, Rump P, Schnur RE, Shiihara T, Sinha MD, Soliman NA, Soulami K, Sweetser DA, Tsai WH, Tsai JD, Topaloglu R, Vester U, Viskochil DH, Vatanavicharn N, Waxler JL, Wierenga KJ, Wolf MTF, Wong SN, Leidel SA, Truglio G, Dedon PC, Poduri A, Mane S, Lifton RP, Bouchard M, Kannu P, Chitayat D, Magen D, Callewaert B, van Tilbeurgh H, Zenker M, Antignac C, Hildebrandt F
Nat Genet 2017 Oct;49(10):1529-1538. Epub 2017 Aug 14 doi: 10.1038/ng.3933. PMID: 28805828 Free PMC Article

Recent progress in the pathophysiology and treatment of FSGS recurrence.

Cravedi P, Kopp JB, Remuzzi G
Am J Transplant 2013 Feb;13(2):266-74. Epub 2013 Jan 11 doi: 10.1111/ajt.12045. PMID: 23312002 Free PMC Article

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Recent clinical studies

Etiology

IgA Nephropathy: Core Curriculum 2021.

Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883

Familial hematuria: A review.

Plevová P, Gut J, Janda J
Medicina (Kaunas) 2017;53(1):1-10. Epub 2017 Jan 31 doi: 10.1016/j.medici.2017.01.002. PMID: 28236514

Tsuboi N, Utsunomiya Y, Hosoya T
Nephrol Dial Transplant 2013 Nov;28 Suppl 4:iv108-13. Epub 2013 Jul 17 doi: 10.1093/ndt/gft258. PMID: 23868145

Safety in glomerular numbers.

Schreuder MF
Pediatr Nephrol 2012 Oct;27(10):1881-7. Epub 2012 Apr 25 doi: 10.1007/s00467-012-2169-x. PMID: 22532329 Free PMC Article

Infantile nephrotic syndrome.

George CR, Hickman RO, Stricker GE
Clin Nephrol 1976 Jan;5(1):20-4. PMID: 765027

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Diagnosis

Membranoproliferative glomerulonephritis: no longer the same disease and may need very different treatment.

Noris M, Daina E, Remuzzi G
Nephrol Dial Transplant 2023 Feb 13;38(2):283-290. doi: 10.1093/ndt/gfab281. PMID: 34596686

Immunoglobulin A nephropathy in paediatrics: An up-to-date.

Paranhos RM, De Souza Figueiredo GA, De Abreu GR, Ferreira GC, Fonseca GG, Simões E Silva AC
Nephrology (Carlton) 2022 Apr;27(4):307-317. Epub 2021 Oct 29 doi: 10.1111/nep.13987. PMID: 34676611

IgA Nephropathy: Core Curriculum 2021.

Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883

Familial hematuria: A review.

Plevová P, Gut J, Janda J
Medicina (Kaunas) 2017;53(1):1-10. Epub 2017 Jan 31 doi: 10.1016/j.medici.2017.01.002. PMID: 28236514

Interstitial nephritis.

Dixon AJ, Winearls CG, Dunnill MS
J Clin Pathol 1981 Jun;34(6):616-24. doi: 10.1136/jcp.34.6.616. PMID: 7251904 Free PMC Article

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Therapy

IgA Nephropathy: Core Curriculum 2021.

Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883

Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors.

DeFronzo RA, Reeves WB, Awad AS
Nat Rev Nephrol 2021 May;17(5):319-334. Epub 2021 Feb 5 doi: 10.1038/s41581-021-00393-8. PMID: 33547417

Connexin 43: a New Therapeutic Target Against Chronic Kidney Disease.

Prakoura N, Kavvadas P, Chadjichristos CE
Cell Physiol Biochem 2018;49(3):985. Epub 2018 Sep 7 doi: 10.1159/000493230. PMID: 30196298

Anti-glomerular basement membrane antibodies.

Silvariño R, Noboa O, Cervera R
Isr Med Assoc J 2014 Nov;16(11):727-32. PMID: 25558706

Infantile nephrotic syndrome.

George CR, Hickman RO, Stricker GE
Clin Nephrol 1976 Jan;5(1):20-4. PMID: 765027

See all (211)

Prognosis

Membranoproliferative glomerulonephritis: no longer the same disease and may need very different treatment.

Noris M, Daina E, Remuzzi G
Nephrol Dial Transplant 2023 Feb 13;38(2):283-290. doi: 10.1093/ndt/gfab281. PMID: 34596686

IgA Nephropathy: Core Curriculum 2021.

Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883

Podocytopathies.

Kopp JB, Anders HJ, Susztak K, Podestà MA, Remuzzi G, Hildebrandt F, Romagnani P
Nat Rev Dis Primers 2020 Aug 13;6(1):68. doi: 10.1038/s41572-020-0196-7. PMID: 32792490 Free PMC Article

Nail-patella syndrome.

Witzgall R
Pflugers Arch 2017 Aug;469(7-8):927-936. Epub 2017 Jul 5 doi: 10.1007/s00424-017-2013-z. PMID: 28681095

Pathophysiology of proteinuria.

D'Amico G, Bazzi C
Kidney Int 2003 Mar;63(3):809-25. doi: 10.1046/j.1523-1755.2003.00840.x. PMID: 12631062

See all (300)

Clinical prediction guides

Immunoglobulin A nephropathy in paediatrics: An up-to-date.

Paranhos RM, De Souza Figueiredo GA, De Abreu GR, Ferreira GC, Fonseca GG, Simões E Silva AC
Nephrology (Carlton) 2022 Apr;27(4):307-317. Epub 2021 Oct 29 doi: 10.1111/nep.13987. PMID: 34676611

IgA Nephropathy: Core Curriculum 2021.

Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883

Familial hematuria: A review.

Plevová P, Gut J, Janda J
Medicina (Kaunas) 2017;53(1):1-10. Epub 2017 Jan 31 doi: 10.1016/j.medici.2017.01.002. PMID: 28236514

Pathophysiology of proteinuria.

D'Amico G, Bazzi C
Kidney Int 2003 Mar;63(3):809-25. doi: 10.1046/j.1523-1755.2003.00840.x. PMID: 12631062

Glomerulonephritis.

Remuzzi G, Zoja C, Bertani T
Curr Opin Nephrol Hypertens 1993 May;2(3):465-74. doi: 10.1097/00041552-199305000-00015. PMID: 7922207

See all (408)