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Microaneurysm

MedGen UID:
87161
•Concept ID:
C0333101
•
Pathologic Function
Synonym: Microaneurysms
SNOMED CT: Microaneurysm (87104008); MA-microaneurysm (87104008)

Definition

An aneurysm that is located within the system of small blood vessels, including capillaries, venules, and arterioles, that perfuse the body''s tissues. [from NCI]

Professional guidelines

PubMed

Diabetic Macular Edema Treatment with Bevacizumab Does Not Depend on the Retinal Nonperfusion Presence.
Sędziak-Marcinek B, Teper S, Chełmecka E, Wylęgała A, Marcinek M, Bas M, Wylęgała E
J Diabetes Res 2021;2021:6620122. Epub 2021 Feb 26 doi: 10.1155/2021/6620122. PMID: 33728349Free PMC Article
Microaneurysm detection in color eye fundus images for diabetic retinopathy screening.
Melo T, Mendonça AM, Campilho A
Comput Biol Med 2020 Nov;126:103995. Epub 2020 Sep 18 doi: 10.1016/j.compbiomed.2020.103995. PMID: 33007620
Clinical evaluation and treatment accuracy in diabetic macular edema using navigated laser photocoagulator NAVILAS.
Kozak I, Oster SF, Cortes MA, Dowell D, Hartmann K, Kim JS, Freeman WR
Ophthalmology 2011 Jun;118(6):1119-24. Epub 2011 Jan 26 doi: 10.1016/j.ophtha.2010.10.007. PMID: 21269701

Recent clinical studies

Etiology

The comparative effects of oral Chinese patent medicines in non-proliferative diabetic retinopathy: A Bayesian network meta-analysis of randomized controlled trials.
Liu Z, Chen Y, Jie C, Wang J, Deng Y, Hou X, Li Y, Cai W
Front Endocrinol (Lausanne) 2023;14:1144290. Epub 2023 Apr 3 doi: 10.3389/fendo.2023.1144290. PMID: 37077355Free PMC Article
Longitudinal Quantitative Ultrawide-field Fluorescein Angiography Dynamics in the RUBY Diabetic Macular Edema Study.
Sarici K, Yordi S, Martin A, Lunasco L, Mugnaini C, Chu K, Moini H, Vitti R, Srivastava SK, Ehlers JP
Ophthalmol Retina 2023 Jun;7(6):543-552. Epub 2023 Feb 2 doi: 10.1016/j.oret.2023.01.018. PMID: 36736895
Charcot-Bouchard aneurysms revisited: clinicopathologic correlations.
Magaki S, Chen Z, Haeri M, Williams CK, Khanlou N, Yong WH, Vinters HV
Mod Pathol 2021 Dec;34(12):2109-2121. Epub 2021 Jun 14 doi: 10.1038/s41379-021-00847-1. PMID: 34326486Free PMC Article
Microaneurysm Imaging Using Multiple En Face OCT Angiography Image Averaging: Morphology and Visualization.
Kaizu Y, Nakao S, Wada I, Arima M, Yamaguchi M, Ishikawa K, Akiyama M, Kishimoto J, Hisatomi T, Sonoda KH
Ophthalmol Retina 2020 Feb;4(2):175-186. Epub 2019 Sep 27 doi: 10.1016/j.oret.2019.09.010. PMID: 31753811
Epidemiological issues in diabetic retinopathy.
Scanlon PH, Aldington SJ, Stratton IM
Middle East Afr J Ophthalmol 2013 Oct-Dec;20(4):293-300. doi: 10.4103/0974-9233.120007. PMID: 24339678Free PMC Article

Diagnosis

Turnover of Microaneurysms After Intravitreal Injections of Faricimab for Diabetic Macular Edema.
Takamura Y, Yamada Y, Morioka M, Gozawa M, Matsumura T, Inatani M
Invest Ophthalmol Vis Sci 2023 Oct 3;64(13):31. doi: 10.1167/iovs.64.13.31. PMID: 37856112Free PMC Article
Longitudinal Quantitative Ultrawide-field Fluorescein Angiography Dynamics in the RUBY Diabetic Macular Edema Study.
Sarici K, Yordi S, Martin A, Lunasco L, Mugnaini C, Chu K, Moini H, Vitti R, Srivastava SK, Ehlers JP
Ophthalmol Retina 2023 Jun;7(6):543-552. Epub 2023 Feb 2 doi: 10.1016/j.oret.2023.01.018. PMID: 36736895
Algorithms for red lesion detection in Diabetic Retinopathy: A review.
Biyani RS, Patre BM
Biomed Pharmacother 2018 Nov;107:681-688. Epub 2018 Aug 18 doi: 10.1016/j.biopha.2018.07.175. PMID: 30130729
New insights into diabetic retinopathy by OCT angiography.
Liu G, Xu D, Wang F
Diabetes Res Clin Pract 2018 Aug;142:243-253. Epub 2018 Jun 4 doi: 10.1016/j.diabres.2018.05.043. PMID: 29879494
Emerging Issues for Optical Coherence Tomography.
Pierro L, Rabiolo A
Dev Ophthalmol 2017;60:28-37. Epub 2017 Apr 20 doi: 10.1159/000459723. PMID: 28427062

Therapy

Turnover of Microaneurysms After Intravitreal Injections of Faricimab for Diabetic Macular Edema.
Takamura Y, Yamada Y, Morioka M, Gozawa M, Matsumura T, Inatani M
Invest Ophthalmol Vis Sci 2023 Oct 3;64(13):31. doi: 10.1167/iovs.64.13.31. PMID: 37856112Free PMC Article
The Role of Laser Photocoagulation in Treating Diabetic Macular Edema in the Era of Intravitreal Drug Administration: A Descriptive Review.
Nozaki M, Ando R, Kimura T, Kato F, Yasukawa T
Medicina (Kaunas) 2023 Jul 17;59(7) doi: 10.3390/medicina59071319. PMID: 37512130Free PMC Article
The comparative effects of oral Chinese patent medicines in non-proliferative diabetic retinopathy: A Bayesian network meta-analysis of randomized controlled trials.
Liu Z, Chen Y, Jie C, Wang J, Deng Y, Hou X, Li Y, Cai W
Front Endocrinol (Lausanne) 2023;14:1144290. Epub 2023 Apr 3 doi: 10.3389/fendo.2023.1144290. PMID: 37077355Free PMC Article
Longitudinal Quantitative Ultrawide-field Fluorescein Angiography Dynamics in the RUBY Diabetic Macular Edema Study.
Sarici K, Yordi S, Martin A, Lunasco L, Mugnaini C, Chu K, Moini H, Vitti R, Srivastava SK, Ehlers JP
Ophthalmol Retina 2023 Jun;7(6):543-552. Epub 2023 Feb 2 doi: 10.1016/j.oret.2023.01.018. PMID: 36736895
PDGF-C mediates glomerular capillary repair.
Boor P, van Roeyen CR, Kunter U, Villa L, Bücher E, Hohenstein B, Hugo CP, Eriksson U, Satchell SC, Mathieson PW, Eitner F, Floege J, Ostendorf T
Am J Pathol 2010 Jul;177(1):58-69. Epub 2010 May 20 doi: 10.2353/ajpath.2010.091008. PMID: 20489153Free PMC Article

Prognosis

Quantitative Ultra-Widefield Angiographic Features and Associations with Diabetic Macular Edema.
Jiang AC, Srivastava SK, Hu M, Figueiredo N, Babiuch A, Boss JD, Reese JL, Ehlers JP
Ophthalmol Retina 2020 Jan;4(1):49-56. Epub 2019 Aug 28 doi: 10.1016/j.oret.2019.08.008. PMID: 31690541Free PMC Article
Hemorrhage and/or Microaneurysm Severity and Count in Ultrawide Field Images and Early Treatment Diabetic Retinopathy Study Photography.
Silva PS, El-Rami H, Barham R, Gupta A, Fleming A, van Hemert J, Cavallerano JD, Sun JK, Aiello LP
Ophthalmology 2017 Jul;124(7):970-976. Epub 2017 Mar 20 doi: 10.1016/j.ophtha.2017.02.012. PMID: 28336057
Phenotypes and biomarkers of diabetic retinopathy.
Cunha-Vaz J, Ribeiro L, Lobo C
Prog Retin Eye Res 2014 Jul;41:90-111. Epub 2014 Mar 26 doi: 10.1016/j.preteyeres.2014.03.003. PMID: 24680929
Epidemiological issues in diabetic retinopathy.
Scanlon PH, Aldington SJ, Stratton IM
Middle East Afr J Ophthalmol 2013 Oct-Dec;20(4):293-300. doi: 10.4103/0974-9233.120007. PMID: 24339678Free PMC Article
Ionizing radiation and the retina.
Archer DB, Gardiner TA
Curr Opin Ophthalmol 1994 Jun;5(3):59-65. doi: 10.1097/00055735-199406000-00011. PMID: 10147458

Clinical prediction guides

Longitudinal Quantitative Ultrawide-field Fluorescein Angiography Dynamics in the RUBY Diabetic Macular Edema Study.
Sarici K, Yordi S, Martin A, Lunasco L, Mugnaini C, Chu K, Moini H, Vitti R, Srivastava SK, Ehlers JP
Ophthalmol Retina 2023 Jun;7(6):543-552. Epub 2023 Feb 2 doi: 10.1016/j.oret.2023.01.018. PMID: 36736895
Retinopathy Analysis Based on Deep Convolution Neural Network.
Hatanaka Y
Adv Exp Med Biol 2020;1213:107-120. doi: 10.1007/978-3-030-33128-3_7. PMID: 32030666
Microaneurysm Imaging Using Multiple En Face OCT Angiography Image Averaging: Morphology and Visualization.
Kaizu Y, Nakao S, Wada I, Arima M, Yamaguchi M, Ishikawa K, Akiyama M, Kishimoto J, Hisatomi T, Sonoda KH
Ophthalmol Retina 2020 Feb;4(2):175-186. Epub 2019 Sep 27 doi: 10.1016/j.oret.2019.09.010. PMID: 31753811
Hemorrhage and/or Microaneurysm Severity and Count in Ultrawide Field Images and Early Treatment Diabetic Retinopathy Study Photography.
Silva PS, El-Rami H, Barham R, Gupta A, Fleming A, van Hemert J, Cavallerano JD, Sun JK, Aiello LP
Ophthalmology 2017 Jul;124(7):970-976. Epub 2017 Mar 20 doi: 10.1016/j.ophtha.2017.02.012. PMID: 28336057
Cerebral microbleeds: histopathological correlation of neuroimaging.
Shoamanesh A, Kwok CS, Benavente O
Cerebrovasc Dis 2011;32(6):528-34. Epub 2011 Nov 18 doi: 10.1159/000331466. PMID: 22104448

Recent systematic reviews

The comparative effects of oral Chinese patent medicines in non-proliferative diabetic retinopathy: A Bayesian network meta-analysis of randomized controlled trials.
Liu Z, Chen Y, Jie C, Wang J, Deng Y, Hou X, Li Y, Cai W
Front Endocrinol (Lausanne) 2023;14:1144290. Epub 2023 Apr 3 doi: 10.3389/fendo.2023.1144290. PMID: 37077355Free PMC Article
Effect of Chinese Patent Medicines on Ocular Fundus Signs and Vision in Calcium Dobesilate-Treated Persons With Non-Proliferative Diabetic Retinopathy: A Systematic Review and Meta-Analysis.
Zhang Y, An X, Duan L, Jin D, Duan Y, Zhou R, Zhang Y, Kang X, Lian F
Front Endocrinol (Lausanne) 2022;13:799337. Epub 2022 Mar 14 doi: 10.3389/fendo.2022.799337. PMID: 35370950Free PMC Article
Single herbal medicine for diabetic retinopathy.
Zhang HW, Zhang H, Grant SJ, Wan X, Li G
Cochrane Database Syst Rev 2018 Dec 19;12(12):CD007939. doi: 10.1002/14651858.CD007939.pub2. PMID: 30566763Free PMC Article
Cerebral microbleeds: histopathological correlation of neuroimaging.
Shoamanesh A, Kwok CS, Benavente O
Cerebrovasc Dis 2011;32(6):528-34. Epub 2011 Nov 18 doi: 10.1159/000331466. PMID: 22104448

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