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Perivascular fibrosis

MedGen UID:
87194
•Concept ID:
C0334144
•
Pathologic Function
Synonym: Perivascular Fibrosis
SNOMED CT: Perivascular fibrosis (46283004)
 
HPO: HP:0032200

Definition

The presence of thick collagen bundles around blood vessels, often in an onion-skin type whorling pattern. [from HPO]

Professional guidelines

PubMed

Heart Failure With Preserved Ejection Fraction in Diabetes: Mechanisms and Management.
Meagher P, Adam M, Civitarese R, Bugyei-Twum A, Connelly KA
Can J Cardiol 2018 May;34(5):632-643. Epub 2018 Mar 2 doi: 10.1016/j.cjca.2018.02.026. PMID: 29731023
Evaluation of subclinical target organ damage for risk assessment and treatment in the hypertensive patients: left ventricular hypertrophy.
Agabiti-Rosei E, Muiesan ML, Salvetti M
J Am Soc Nephrol 2006 Apr;17(4 Suppl 2):S104-8. doi: 10.1681/ASN.2005121336. PMID: 16565230
Histopathologic improvement with lymphedema management, Léogâne, Haiti.
Wilson SF, Guarner J, Valme AL, Louis-Charles J, Jones TL, Addiss DG
Emerg Infect Dis 2004 Nov;10(11):1938-46. doi: 10.3201/eid1011.040548. PMID: 15550203Free PMC Article

Recent clinical studies

Etiology

Perivascular Fibrosis Is Mediated by a KLF10-IL-9 Signaling Axis in CD4+ T Cells.
Zhuang R, Chen J, Cheng HS, Assa C, Jamaiyar A, Pandey AK, Pérez-Cremades D, Zhang B, Tzani A, Khyrul Wara A, Plutzky J, Barrera V, Bhetariya P, Mitchell RN, Liu Z, Feinberg MW
Circ Res 2022 May 27;130(11):1662-1681. Epub 2022 Apr 20 doi: 10.1161/CIRCRESAHA.121.320420. PMID: 35440172Free PMC Article
Melatonin ameliorates PM(2.5) -induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis.
Jiang J, Liang S, Zhang J, Du Z, Xu Q, Duan J, Sun Z
J Pineal Res 2021 Jan;70(1):e12686. Epub 2020 Nov 16 doi: 10.1111/jpi.12686. PMID: 32730639Free PMC Article
CT-1 (Cardiotrophin-1)-Gal-3 (Galectin-3) Axis in Cardiac Fibrosis and Inflammation.
Martínez-Martínez E, Brugnolaro C, Ibarrola J, Ravassa S, Buonafine M, López B, Fernández-Celis A, Querejeta R, Santamaria E, Fernández-Irigoyen J, Rábago G, Moreno MU, Jaisser F, Díez J, González A, López-Andrés N
Hypertension 2019 Mar;73(3):602-611. doi: 10.1161/HYPERTENSIONAHA.118.11874. PMID: 30612490
Myocardial fibrosis in chronic kidney disease: potential benefits of torasemide.
López B, González A, Hermida N, Laviades C, Díez J
Kidney Int Suppl 2008 Dec;(111):S19-23. doi: 10.1038/ki.2008.512. PMID: 19034320
Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system.
Weber KT, Brilla CG
Circulation 1991 Jun;83(6):1849-65. doi: 10.1161/01.cir.83.6.1849. PMID: 1828192

Diagnosis

CT-1 (Cardiotrophin-1)-Gal-3 (Galectin-3) Axis in Cardiac Fibrosis and Inflammation.
Martínez-Martínez E, Brugnolaro C, Ibarrola J, Ravassa S, Buonafine M, López B, Fernández-Celis A, Querejeta R, Santamaria E, Fernández-Irigoyen J, Rábago G, Moreno MU, Jaisser F, Díez J, González A, López-Andrés N
Hypertension 2019 Mar;73(3):602-611. doi: 10.1161/HYPERTENSIONAHA.118.11874. PMID: 30612490
Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities.
Frangogiannis NG
Mol Aspects Med 2019 Feb;65:70-99. Epub 2018 Aug 2 doi: 10.1016/j.mam.2018.07.001. PMID: 30056242
Primary orbital eosinophilic angiocentric fibrosis with intranasal extension.
Karligkiotis A, Volpi L, Ferreli F, Cerati M, Kagkelari E, Meloni F, Castelnuovo P
Head Neck 2014 Jan;36(1):E8-E11. Epub 2013 Sep 11 doi: 10.1002/hed.23396. PMID: 23733241
Pulmonary hypertension in patients with interstitial lung diseases.
Ryu JH, Krowka MJ, Pellikka PA, Swanson KL, McGoon MD
Mayo Clin Proc 2007 Mar;82(3):342-50. doi: 10.4065/82.3.342. PMID: 17352370
Coronary microcirculation and cardiovascular pathology.
Garot P, Teiger E, Dupouy P, Aptecar E, Hittinger L, Dubois-Randé JL
Drugs 1999;59 Spec No:23-31. PMID: 10548389

Therapy

A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage.
Alexander MR, Hank S, Dale BL, Himmel L, Zhong X, Smart CD, Fehrenbach DJ, Chen Y, Prabakaran N, Tirado B, Centrella M, Ao M, Du L, Shyr Y, Levy D, Madhur MS
Circ Res 2022 Oct 14;131(9):731-747. Epub 2022 Sep 28 doi: 10.1161/CIRCRESAHA.121.320625. PMID: 36169218Free PMC Article
Cardiac fibrosis.
Frangogiannis NG
Cardiovasc Res 2021 May 25;117(6):1450-1488. doi: 10.1093/cvr/cvaa324. PMID: 33135058Free PMC Article
Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities.
Mettu PS, Allingham MJ, Cousins SW
Prog Retin Eye Res 2021 May;82:100906. Epub 2020 Oct 3 doi: 10.1016/j.preteyeres.2020.100906. PMID: 33022379Free PMC Article
Oxidative stress and cardiac hypertrophy: a review.
Maulik SK, Kumar S
Toxicol Mech Methods 2012 Jun;22(5):359-66. Epub 2012 Mar 20 doi: 10.3109/15376516.2012.666650. PMID: 22394344
Myocardial fibrosis in chronic kidney disease: potential benefits of torasemide.
López B, González A, Hermida N, Laviades C, Díez J
Kidney Int Suppl 2008 Dec;(111):S19-23. doi: 10.1038/ki.2008.512. PMID: 19034320

Prognosis

A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage.
Alexander MR, Hank S, Dale BL, Himmel L, Zhong X, Smart CD, Fehrenbach DJ, Chen Y, Prabakaran N, Tirado B, Centrella M, Ao M, Du L, Shyr Y, Levy D, Madhur MS
Circ Res 2022 Oct 14;131(9):731-747. Epub 2022 Sep 28 doi: 10.1161/CIRCRESAHA.121.320625. PMID: 36169218Free PMC Article
T-Cell-Derived miRNA-214 Mediates Perivascular Fibrosis in Hypertension.
Nosalski R, Siedlinski M, Denby L, McGinnigle E, Nowak M, Cat AND, Medina-Ruiz L, Cantini M, Skiba D, Wilk G, Osmenda G, Rodor J, Salmeron-Sanchez M, Graham G, Maffia P, Graham D, Baker AH, Guzik TJ
Circ Res 2020 Apr 10;126(8):988-1003. Epub 2020 Feb 17 doi: 10.1161/CIRCRESAHA.119.315428. PMID: 32065054Free PMC Article
CT-1 (Cardiotrophin-1)-Gal-3 (Galectin-3) Axis in Cardiac Fibrosis and Inflammation.
Martínez-Martínez E, Brugnolaro C, Ibarrola J, Ravassa S, Buonafine M, López B, Fernández-Celis A, Querejeta R, Santamaria E, Fernández-Irigoyen J, Rábago G, Moreno MU, Jaisser F, Díez J, González A, López-Andrés N
Hypertension 2019 Mar;73(3):602-611. doi: 10.1161/HYPERTENSIONAHA.118.11874. PMID: 30612490
Oxidative stress and cardiac hypertrophy: a review.
Maulik SK, Kumar S
Toxicol Mech Methods 2012 Jun;22(5):359-66. Epub 2012 Mar 20 doi: 10.3109/15376516.2012.666650. PMID: 22394344
Pulmonary hypertension in patients with interstitial lung diseases.
Ryu JH, Krowka MJ, Pellikka PA, Swanson KL, McGoon MD
Mayo Clin Proc 2007 Mar;82(3):342-50. doi: 10.4065/82.3.342. PMID: 17352370

Clinical prediction guides

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension.
Kumar R, Lee MH, Kassa B, Fonseca Balladares DC, Mickael C, Sanders L, Andruska A, Kumar M, Spiekerkoetter E, Bandeira A, Stenmark KR, Tuder RM, Graham BB
Clin Sci (Lond) 2023 Apr 26;137(8):617-631. doi: 10.1042/CS20220642. PMID: 37014925Free PMC Article
A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage.
Alexander MR, Hank S, Dale BL, Himmel L, Zhong X, Smart CD, Fehrenbach DJ, Chen Y, Prabakaran N, Tirado B, Centrella M, Ao M, Du L, Shyr Y, Levy D, Madhur MS
Circ Res 2022 Oct 14;131(9):731-747. Epub 2022 Sep 28 doi: 10.1161/CIRCRESAHA.121.320625. PMID: 36169218Free PMC Article
Trimetazidine Reduces Cardiac Fibrosis in Rats by Inhibiting NOX2-Mediated Endothelial-to-Mesenchymal Transition.
Chen X, Xia X, Dong T, Lin Z, Du L, Zhou H
Drug Des Devel Ther 2022;16:2517-2527. Epub 2022 Aug 3 doi: 10.2147/DDDT.S360283. PMID: 35946039Free PMC Article
Endothelial cell metabolic memory causes cardiovascular dysfunction in diabetes.
Yao Y, Song Q, Hu C, Da X, Yu Y, He Z, Xu C, Chen Q, Wang QK
Cardiovasc Res 2022 Jan 7;118(1):196-211. doi: 10.1093/cvr/cvab013. PMID: 33483741
A collagen-binding protein enables molecular imaging of kidney fibrosis in vivo.
Baues M, Klinkhammer BM, Ehling J, Gremse F, van Zandvoort MAMJ, Reutelingsperger CPM, Daniel C, Amann K, Bábíčková J, Kiessling F, Floege J, Lammers T, Boor P
Kidney Int 2020 Mar;97(3):609-614. Epub 2019 Sep 18 doi: 10.1016/j.kint.2019.08.029. PMID: 31784048Free PMC Article

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