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Malignant Neoplasm, Uncertain Whether Primary or Metastatic

MedGen UID:
87196
Concept ID:
C0334224
Neoplastic Process
Synonyms: Malignant tumor - uncertain whether primary or metastatic; Neoplasm, malignant, uncertain whether primary or metastatic; Unclassified tumor, malignant, uncertain whether primary or metastatic
SNOMED CT: Neoplasm, malignant, uncertain whether primary or metastatic (6219000); Unclassified tumor, malignant, uncertain whether primary or metastatic (6219000); Malignant tumor - uncertain whether primary or metastatic (6219000)

Definition

A malignant neoplasm in which the examined tissue can not be determined with certainty if it represents the primary site of tumor growth or tumor spread from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Neoplasm, Uncertain Whether Primary or Metastatic

Professional guidelines

PubMed

Cervantes A, Adam R, Roselló S, Arnold D, Normanno N, Taïeb J, Seligmann J, De Baere T, Osterlund P, Yoshino T, Martinelli E; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Jan;34(1):10-32. Epub 2022 Oct 25 doi: 10.1016/j.annonc.2022.10.003. PMID: 36307056
Barkun AN, Almadi M, Kuipers EJ, Laine L, Sung J, Tse F, Leontiadis GI, Abraham NS, Calvet X, Chan FKL, Douketis J, Enns R, Gralnek IM, Jairath V, Jensen D, Lau J, Lip GYH, Loffroy R, Maluf-Filho F, Meltzer AC, Reddy N, Saltzman JR, Marshall JK, Bardou M
Ann Intern Med 2019 Dec 3;171(11):805-822. Epub 2019 Oct 22 doi: 10.7326/M19-1795. PMID: 31634917Free PMC Article
Vuurberg G, Hoorntje A, Wink LM, van der Doelen BFW, van den Bekerom MP, Dekker R, van Dijk CN, Krips R, Loogman MCM, Ridderikhof ML, Smithuis FF, Stufkens SAS, Verhagen EALM, de Bie RA, Kerkhoffs GMMJ
Br J Sports Med 2018 Aug;52(15):956. Epub 2018 Mar 7 doi: 10.1136/bjsports-2017-098106. PMID: 29514819

Recent clinical studies

Etiology

Schrag D, Shi Q, Weiser MR, Gollub MJ, Saltz LB, Musher BL, Goldberg J, Al Baghdadi T, Goodman KA, McWilliams RR, Farma JM, George TJ, Kennecke HF, Shergill A, Montemurro M, Nelson GD, Colgrove B, Gordon V, Venook AP, O'Reilly EM, Meyerhardt JA, Dueck AC, Basch E, Chang GJ, Mamon HJ
N Engl J Med 2023 Jul 27;389(4):322-334. Epub 2023 Jun 4 doi: 10.1056/NEJMoa2303269. PMID: 37272534
Yuan S, Chen J, Ruan X, Sun Y, Zhang K, Wang X, Li X, Gill D, Burgess S, Giovannucci E, Larsson SC
Elife 2023 Feb 2;12 doi: 10.7554/eLife.84051. PMID: 36727839Free PMC Article
Aminian A, Wilson R, Al-Kurd A, Tu C, Milinovich A, Kroh M, Rosenthal RJ, Brethauer SA, Schauer PR, Kattan MW, Brown JC, Berger NA, Abraham J, Nissen SE
JAMA 2022 Jun 28;327(24):2423-2433. doi: 10.1001/jama.2022.9009. PMID: 35657620Free PMC Article
Catto JWF, Khetrapal P, Ricciardi F, Ambler G, Williams NR, Al-Hammouri T, Khan MS, Thurairaja R, Nair R, Feber A, Dixon S, Nathan S, Briggs T, Sridhar A, Ahmad I, Bhatt J, Charlesworth P, Blick C, Cumberbatch MG, Hussain SA, Kotwal S, Koupparis A, McGrath J, Noon AP, Rowe E, Vasdev N, Hanchanale V, Hagan D, Brew-Graves C, Kelly JD; iROC Study Team
JAMA 2022 Jun 7;327(21):2092-2103. doi: 10.1001/jama.2022.7393. PMID: 35569079Free PMC Article
Tosello G, Torloni MR, Mota BS, Neeman T, Riera R
Cochrane Database Syst Rev 2018 Mar 15;3(3):CD011276. doi: 10.1002/14651858.CD011276.pub2. PMID: 29542106Free PMC Article

Diagnosis

Kurian AW, Abrahamse P, Furgal A, Ward KC, Hamilton AS, Hodan R, Tocco R, Liu L, Berek JS, Hoang L, Yussuf A, Susswein L, Esplin ED, Slavin TP, Gomez SL, Hofer TP, Katz SJ
JAMA 2023 Jul 3;330(1):43-51. doi: 10.1001/jama.2023.9526. PMID: 37276540Free PMC Article
Qiao H, Tan XR, Li H, Li JY, Chen XZ, Li YQ, Li WF, Tang LL, Zhou GQ, Zhang Y, Liang YL, He QM, Zhao Y, Huang SY, Gong S, Li Q, Ye ML, Chen KL, Sun Y, Ma J, Liu N
JAMA Oncol 2022 Sep 1;8(9):1301-1309. doi: 10.1001/jamaoncol.2022.2810. PMID: 35834269Free PMC Article
Russo TA, Marr CM
Clin Microbiol Rev 2019 Jun 19;32(3) Epub 2019 May 15 doi: 10.1128/CMR.00001-19. PMID: 31092506Free PMC Article
Tosello G, Torloni MR, Mota BS, Neeman T, Riera R
Cochrane Database Syst Rev 2018 Mar 15;3(3):CD011276. doi: 10.1002/14651858.CD011276.pub2. PMID: 29542106Free PMC Article
Jin X, Ruiz Beguerie J, Sze DM, Chan GC
Cochrane Database Syst Rev 2016 Apr 5;4(4):CD007731. doi: 10.1002/14651858.CD007731.pub3. PMID: 27045603Free PMC Article

Therapy

Rantala ES, Hernberg MM, Piperno-Neumann S, Grossniklaus HE, Kivelä TT
Prog Retin Eye Res 2022 Sep;90:101041. Epub 2022 Jan 6 doi: 10.1016/j.preteyeres.2022.101041. PMID: 34999237
Hoyle AP, Ali A, James ND, Cook A, Parker CC, de Bono JS, Attard G, Chowdhury S, Cross WR, Dearnaley DP, Brawley CD, Gilson C, Ingleby F, Gillessen S, Aebersold DM, Jones RJ, Matheson D, Millman R, Mason MD, Ritchie AWS, Russell M, Douis H, Parmar MKB, Sydes MR, Clarke NW; STAMPEDE Investigators
Eur Urol 2019 Dec;76(6):719-728. Epub 2019 Aug 23 doi: 10.1016/j.eururo.2019.08.006. PMID: 31447077
Lim CED, Ng RWC, Cheng NCL, Zhang GS, Chen H
Cochrane Database Syst Rev 2019 Jul 2;7(7):CD007689. doi: 10.1002/14651858.CD007689.pub4. PMID: 31264709Free PMC Article
Tosello G, Torloni MR, Mota BS, Neeman T, Riera R
Cochrane Database Syst Rev 2018 Mar 15;3(3):CD011276. doi: 10.1002/14651858.CD011276.pub2. PMID: 29542106Free PMC Article
Jin X, Ruiz Beguerie J, Sze DM, Chan GC
Cochrane Database Syst Rev 2016 Apr 5;4(4):CD007731. doi: 10.1002/14651858.CD007731.pub3. PMID: 27045603Free PMC Article

Prognosis

Zaorsky NG, Wang X, Garrett SM, Lehrer EJ, Lin C, DeGraff DJ, Spratt DE, Trifiletti DM, Kishan AU, Showalter TN, Park HS, Yang JT, Chinchilli VM, Wang M
Int J Cancer 2022 Jan 1;150(1):132-141. Epub 2021 Aug 27 doi: 10.1002/ijc.33744. PMID: 34287840Free PMC Article
Wong MCS, Huang J, Chan PSF, Choi P, Lao XQ, Chan SM, Teoh A, Liang P
JAMA Netw Open 2021 Jul 1;4(7):e2118457. doi: 10.1001/jamanetworkopen.2021.18457. PMID: 34309666Free PMC Article
Ripollés-Melchor J, Ramírez-Rodríguez JM, Casans-Francés R, Aldecoa C, Abad-Motos A, Logroño-Egea M, García-Erce JA, Camps-Cervantes Á, Ferrando-Ortolá C, Suarez de la Rica A, Cuellar-Martínez A, Marmaña-Mezquita S, Abad-Gurumeta A, Calvo-Vecino JM; POWER Study Investigators Group for the Spanish Perioperative Audit and Research Network (REDGERM)
JAMA Surg 2019 Aug 1;154(8):725-736. doi: 10.1001/jamasurg.2019.0995. PMID: 31066889Free PMC Article
Cagney DN, Martin AM, Catalano PJ, Redig AJ, Lin NU, Lee EQ, Wen PY, Dunn IF, Bi WL, Weiss SE, Haas-Kogan DA, Alexander BM, Aizer AA
Neuro Oncol 2017 Oct 19;19(11):1511-1521. doi: 10.1093/neuonc/nox077. PMID: 28444227Free PMC Article
Dominguez-Ventura A, Nichols FC 3rd
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Clinical prediction guides

Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
Raunig DL, Schmid AM, Miller CG, Walovitch RC, O'Connor M, Noever K, Hristova I, O'Neal M, Brueggenwerth G, Ford RR
Ther Innov Regul Sci 2021 Nov;55(6):1122-1138. Epub 2021 Jul 9 doi: 10.1007/s43441-021-00317-5. PMID: 34244987
Dunne EM, Sahgal A, Lo SS, Bergman A, Kosztyla R, Dea N, Chang EL, Chang UK, Chao ST, Faruqi S, Ghia AJ, Redmond KJ, Soltys SG, Liu MC
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Recent systematic reviews

Gaebe K, Li AY, Park A, Parmar A, Lok BH, Sahgal A, Chan KKW, Erickson AW, Das S
Lancet Oncol 2022 Jul;23(7):931-939. Epub 2022 May 26 doi: 10.1016/S1470-2045(22)00271-6. PMID: 35644163
Lim CED, Ng RWC, Cheng NCL, Zhang GS, Chen H
Cochrane Database Syst Rev 2019 Jul 2;7(7):CD007689. doi: 10.1002/14651858.CD007689.pub4. PMID: 31264709Free PMC Article
Tosello G, Torloni MR, Mota BS, Neeman T, Riera R
Cochrane Database Syst Rev 2018 Mar 15;3(3):CD011276. doi: 10.1002/14651858.CD011276.pub2. PMID: 29542106Free PMC Article
Kumar A, Weber MH, Gokaslan Z, Wolinsky JP, Schmidt M, Rhines L, Fehlings MG, Laufer I, Sciubba DM, Clarke MJ, Sundaresan N, Verlaan JJ, Sahgal A, Chou D, Fisher CG
Clin Spine Surg 2017 May;30(4):156-163. doi: 10.1097/BSD.0000000000000528. PMID: 28437329
Jin X, Ruiz Beguerie J, Sze DM, Chan GC
Cochrane Database Syst Rev 2016 Apr 5;4(4):CD007731. doi: 10.1002/14651858.CD007731.pub3. PMID: 27045603Free PMC Article

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