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Diffuse Sclerosing Variant Thyroid Gland Papillary Carcinoma

MedGen UID:
87218
•Concept ID:
C0334330
•
Neoplastic Process
Synonyms: Nonencapsulated sclerosing adenocarcinoma; Nonencapsulated Sclerosing Adenocarcinoma; Nonencapsulated sclerosing carcinoma; Nonencapsulated Sclerosing Carcinoma; Nonencapsulated Sclerosing Neoplasm; Nonencapsulated Sclerosing Papillary Thyroid Carcinoma; Nonencapsulated sclerosing tumor; Nonencapsulated Sclerosing Tumor; Papillary carcinoma, diffuse sclerosing; Thyroid Gland Diffuse Sclerosing Papillary Carcinoma
SNOMED CT: Nonencapsulated sclerosing carcinoma (62681000); Nonencapsulated sclerosing adenocarcinoma (62681000); Nonencapsulated sclerosing tumor (62681000); Papillary carcinoma, diffuse sclerosing (62681000)

Definition

A morphologic variant of papillary carcinoma of the thyroid gland that more often affects young patients and commonly metastasizing to the lungs. It is characterized by a diffuse infiltration of the thyroid gland by malignant follicular cells, squamous metaplasia, stromal fibrosis, and lymphocytic infiltration. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse Sclerosing Variant Thyroid Gland Papillary Carcinoma

Professional guidelines

PubMed

Differential diagnosis of diffuse sclerotic thyroid papillary carcinoma and Hashimoto's thyroiditis using fine-needle aspiration cytology, BRAF(V600E) , and ultrasound elastography.
Wang X, Xu F, Gao J, Agyekum EA, Sun H, Zhang G, Li X, Xiang H, Hu S, Qian X
J Clin Ultrasound 2022 Sep;50(7):942-950. Epub 2022 Jul 2 doi: 10.1002/jcu.23260. PMID: 35779272Free PMC Article
Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.
Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A
Adv Ther 2020 Jul;37(7):3112-3128. Epub 2020 Jun 1 doi: 10.1007/s12325-020-01391-1. PMID: 32488657Free PMC Article
Surgical Management of Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma. Experience in 25 Patients.
Spinelli C, Strambi S, Bakkar S, Nosiglia A, Elia G, Bertocchini A, Calani C, Leoni M, Morganti R, Materazzi G
World J Surg 2020 Jan;44(1):155-162. doi: 10.1007/s00268-019-05230-5. PMID: 31605177

Recent clinical studies

Etiology

Thyroid Nodules and Follicular Cell-Derived Thyroid Carcinomas in Children.
Slack JC, Hollowell M, Barletta JA
Endocr Pathol 2023 Jun;34(2):165-175. Epub 2023 May 9 doi: 10.1007/s12022-023-09764-2. PMID: 37160531
Clinical Outcomes of Diffuse Sclerosing Variant Papillary Thyroid Carcinoma in Pediatric Patients.
Brady C, Manning SC, Rudzinski E, Paulson V, Wang X, Liu YJ, Parikh SR, Bonilla-Velez J, Hawkins DS, Dahl J
Laryngoscope 2022 May;132(5):1132-1138. Epub 2021 Oct 29 doi: 10.1002/lary.29926. PMID: 34713899
Prognostic significance of diffuse sclerosing variant papillary thyroid carcinoma: a systematic review and meta-analysis.
Vuong HG, Kondo T, Pham TQ, Oishi N, Mochizuki K, Nakazawa T, Hassell L, Katoh R
Eur J Endocrinol 2017 Apr;176(4):433-441. doi: 10.1530/EJE-16-0863. PMID: 28183787
Papillary thyroid carcinoma with different histological patterns.
Lin JD, Hsueh C, Huang BY
Chang Gung Med J 2011 Jan-Feb;34(1):23-34. PMID: 21392471
Aggressive variants of papillary thyroid carcinoma.
Silver CE, Owen RP, Rodrigo JP, Rinaldo A, Devaney KO, Ferlito A
Head Neck 2011 Jul;33(7):1052-9. Epub 2010 Sep 7 doi: 10.1002/hed.21494. PMID: 20824810

Diagnosis

Aggressive variants of follicular cell-derived thyroid carcinoma: an overview.
Pizzimenti C, Fiorentino V, Ieni A, Martini M, Tuccari G, Lentini M, Fadda G
Endocrine 2022 Oct;78(1):1-12. Epub 2022 Jul 21 doi: 10.1007/s12020-022-03146-0. PMID: 35864338
Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.
Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A
Adv Ther 2020 Jul;37(7):3112-3128. Epub 2020 Jun 1 doi: 10.1007/s12325-020-01391-1. PMID: 32488657Free PMC Article
Pediatric thyroid ultrasound: a radiologist's checklist.
Tritou I, Vakaki M, Sfakiotaki R, Kalaitzaki K, Raissaki M
Pediatr Radiol 2020 Apr;50(4):563-574. Epub 2020 Mar 12 doi: 10.1007/s00247-019-04602-2. PMID: 32166365
Sonographic and cytopathologic correlation of papillary thyroid carcinoma variants.
Lee JH, Shin JH, Lee HW, Oh YL, Hahn SY, Ko EY
J Ultrasound Med 2015 Jan;34(1):1-15. doi: 10.7863/ultra.34.1.1. PMID: 25542934
Papillary thyroid carcinoma variants.
Lloyd RV, Buehler D, Khanafshar E
Head Neck Pathol 2011 Mar;5(1):51-6. Epub 2011 Jan 8 doi: 10.1007/s12105-010-0236-9. PMID: 21221869Free PMC Article

Therapy

Radioactive iodine does not improve overall survival for patients with aggressive variants of papillary thyroid carcinoma less than 2 cm.
Holoubek SA, MacKinney EC, Khokar AM, Kuchta KM, Winchester DJ, Prinz RA, Moo-Young TA
Surgery 2022 Jan;171(1):203-211. Epub 2021 Aug 10 doi: 10.1016/j.surg.2021.05.054. PMID: 34384604
Aggressive variants of papillary thyroid microcarcinoma are associated with high-risk features, but not decreased survival.
Holoubek SA, Yan H, Khokar AH, Kuchta KM, Winchester DJ, Prinz RA, Moo-Young TA
Surgery 2020 Jan;167(1):19-27. Epub 2019 Oct 16 doi: 10.1016/j.surg.2019.03.030. PMID: 31627846
Prognostic significance of diffuse sclerosing variant papillary thyroid carcinoma: a systematic review and meta-analysis.
Vuong HG, Kondo T, Pham TQ, Oishi N, Mochizuki K, Nakazawa T, Hassell L, Katoh R
Eur J Endocrinol 2017 Apr;176(4):433-441. doi: 10.1530/EJE-16-0863. PMID: 28183787
Low expression of sodium iodide symporter expression in aggressive variants of papillary thyroid carcinoma.
Wei S, Gao M, Zhao C, Pan Y, Li H, Li J, Li X
Int J Clin Oncol 2014 Oct;19(5):800-4. Epub 2013 Oct 5 doi: 10.1007/s10147-013-0620-z. PMID: 24096868
Aggressive variants of papillary thyroid cancer: incidence, characteristics and predictors of survival among 43,738 patients.
Kazaure HS, Roman SA, Sosa JA
Ann Surg Oncol 2012 Jun;19(6):1874-80. Epub 2011 Nov 8 doi: 10.1245/s10434-011-2129-x. PMID: 22065195

Prognosis

Thyroid Nodules and Follicular Cell-Derived Thyroid Carcinomas in Children.
Slack JC, Hollowell M, Barletta JA
Endocr Pathol 2023 Jun;34(2):165-175. Epub 2023 May 9 doi: 10.1007/s12022-023-09764-2. PMID: 37160531
Aggressive variants of follicular cell-derived thyroid carcinoma: an overview.
Pizzimenti C, Fiorentino V, Ieni A, Martini M, Tuccari G, Lentini M, Fadda G
Endocrine 2022 Oct;78(1):1-12. Epub 2022 Jul 21 doi: 10.1007/s12020-022-03146-0. PMID: 35864338
Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.
Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A
Adv Ther 2020 Jul;37(7):3112-3128. Epub 2020 Jun 1 doi: 10.1007/s12325-020-01391-1. PMID: 32488657Free PMC Article
Diffuse sclerosing variant of papillary thyroid carcinoma--an update of its clinicopathological features and molecular biology.
Pillai S, Gopalan V, Smith RA, Lam AK
Crit Rev Oncol Hematol 2015 Apr;94(1):64-73. Epub 2014 Dec 18 doi: 10.1016/j.critrevonc.2014.12.001. PMID: 25577570
Sonographic and cytopathologic correlation of papillary thyroid carcinoma variants.
Lee JH, Shin JH, Lee HW, Oh YL, Hahn SY, Ko EY
J Ultrasound Med 2015 Jan;34(1):1-15. doi: 10.7863/ultra.34.1.1. PMID: 25542934

Clinical prediction guides

Diffuse sclerosing variant of papillary thyroid carcinoma: ultrasonographic and clinicopathological features in children/adolescents and adults.
Wang Q, Chang Q, Zhang R, Sun C, Li L, Wang S, Wang Q, Li Z, Niu L
Clin Radiol 2022 May;77(5):e356-e362. Epub 2022 Feb 20 doi: 10.1016/j.crad.2022.01.051. PMID: 35197192
Prognostic significance of diffuse sclerosing variant papillary thyroid carcinoma: a systematic review and meta-analysis.
Vuong HG, Kondo T, Pham TQ, Oishi N, Mochizuki K, Nakazawa T, Hassell L, Katoh R
Eur J Endocrinol 2017 Apr;176(4):433-441. doi: 10.1530/EJE-16-0863. PMID: 28183787
Variants of Papillary Thyroid Carcinoma: Multiple Faces of a Familiar Tumor.
Sak SD
Turk Patoloji Derg 2015;31 Suppl 1:34-47. doi: 10.5146/tjpath.2015.01313. PMID: 26177316
Papillary thyroid carcinoma with different histological patterns.
Lin JD, Hsueh C, Huang BY
Chang Gung Med J 2011 Jan-Feb;34(1):23-34. PMID: 21392471
Aggressive variants of papillary thyroid carcinoma.
Silver CE, Owen RP, Rodrigo JP, Rinaldo A, Devaney KO, Ferlito A
Head Neck 2011 Jul;33(7):1052-9. Epub 2010 Sep 7 doi: 10.1002/hed.21494. PMID: 20824810

Recent systematic reviews

Prognostic significance of diffuse sclerosing variant papillary thyroid carcinoma: a systematic review and meta-analysis.
Vuong HG, Kondo T, Pham TQ, Oishi N, Mochizuki K, Nakazawa T, Hassell L, Katoh R
Eur J Endocrinol 2017 Apr;176(4):433-441. doi: 10.1530/EJE-16-0863. PMID: 28183787

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