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Thyroid gland diffuse sclerosing papillary carcinoma

MedGen UID:
87218
•Concept ID:
C0334330
•
Neoplastic Process
Synonyms: Diffuse Sclerosing Variant Thyroid Gland Papillary Carcinoma; Nonencapsulated sclerosing adenocarcinoma; Nonencapsulated Sclerosing Adenocarcinoma; nonencapsulated sclerosing adenocarcinoma; Nonencapsulated sclerosing carcinoma; Nonencapsulated Sclerosing Carcinoma; nonencapsulated sclerosing carcinoma; Nonencapsulated Sclerosing Neoplasm; nonencapsulated sclerosing neoplasm; Nonencapsulated Sclerosing Papillary Thyroid Carcinoma; nonencapsulated sclerosing papillary thyroid carcinoma; Nonencapsulated sclerosing tumor; Nonencapsulated Sclerosing Tumor; nonencapsulated sclerosing tumor; nonencapsulated sclerosing tumour; Papillary carcinoma, diffuse sclerosing; papillary carcinoma, diffuse sclerosing; Thyroid Gland Diffuse Sclerosing Papillary Carcinoma; thyroid gland diffuse sclerosing papillary carcinoma
SNOMED CT: Nonencapsulated sclerosing carcinoma (62681000); Nonencapsulated sclerosing adenocarcinoma (62681000); Nonencapsulated sclerosing tumor (62681000); Papillary carcinoma, diffuse sclerosing (62681000)
 
Monarch Initiative: MONDO:0003701

Definition

A morphologic variant of papillary carcinoma of the thyroid gland that more often affects young patients and commonly metastasizing to the lungs. It is characterized by a diffuse infiltration of the thyroid gland by malignant follicular cells, squamous metaplasia, stromal fibrosis, and lymphocytic infiltration. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid gland diffuse sclerosing papillary carcinoma

Professional guidelines

PubMed

Management of pediatric papillary thyroid cancer.
Pazaitou-Panayiotou K
Hell J Nucl Med 2023 May-Aug;26 Suppl:60-64. PMID: 37658567
Ultrasound, laboratory and histopathological insights in diagnosing papillary thyroid carcinoma in a paediatric population: a single centre follow-up study between 2000-2022.
Januś D, Wójcik M, Taczanowska-Niemczuk A, Kiszka-Wiłkojć A, Kujdowicz M, Czogała M, Górecki W, Starzyk JB
Front Endocrinol (Lausanne) 2023;14:1170971. Epub 2023 May 18 doi: 10.3389/fendo.2023.1170971. PMID: 37274328Free PMC Article
Thyroid nodules after high-dose external radiotherapy. Fine-needle aspiration cytology in diagnosis and management.
Pretorius HT, Katikineni M, Kinsella TJ, Barsky SH, Brennan MF, Chu EW, Robbins J
JAMA 1982 Jun 18;247(23):3217-20. PMID: 7087060

Recent clinical studies

Etiology

Management of pediatric papillary thyroid cancer.
Pazaitou-Panayiotou K
Hell J Nucl Med 2023 May-Aug;26 Suppl:60-64. PMID: 37658567
Ultrasound, laboratory and histopathological insights in diagnosing papillary thyroid carcinoma in a paediatric population: a single centre follow-up study between 2000-2022.
Januś D, Wójcik M, Taczanowska-Niemczuk A, Kiszka-Wiłkojć A, Kujdowicz M, Czogała M, Górecki W, Starzyk JB
Front Endocrinol (Lausanne) 2023;14:1170971. Epub 2023 May 18 doi: 10.3389/fendo.2023.1170971. PMID: 37274328Free PMC Article
Radioactive iodine does not improve overall survival for patients with aggressive variants of papillary thyroid carcinoma less than 2 cm.
Holoubek SA, MacKinney EC, Khokar AM, Kuchta KM, Winchester DJ, Prinz RA, Moo-Young TA
Surgery 2022 Jan;171(1):203-211. Epub 2021 Aug 10 doi: 10.1016/j.surg.2021.05.054. PMID: 34384604
Aggressive variants of papillary thyroid microcarcinoma are associated with high-risk features, but not decreased survival.
Holoubek SA, Yan H, Khokar AH, Kuchta KM, Winchester DJ, Prinz RA, Moo-Young TA
Surgery 2020 Jan;167(1):19-27. Epub 2019 Oct 16 doi: 10.1016/j.surg.2019.03.030. PMID: 31627846
Diffuse sclerosing variant of papillary carcinoma of the thyroid: ultrasound features with histopathological correlation.
Kwak JY, Kim EK, Hong SW, Oh KK, Kim MJ, Park CS, Cheong WY
Clin Radiol 2007 Apr;62(4):382-6. Epub 2007 Feb 7 doi: 10.1016/j.crad.2006.11.015. PMID: 17331834

Diagnosis

Management of pediatric papillary thyroid cancer.
Pazaitou-Panayiotou K
Hell J Nucl Med 2023 May-Aug;26 Suppl:60-64. PMID: 37658567
Aggressive variants of follicular cell-derived thyroid carcinoma: an overview.
Pizzimenti C, Fiorentino V, Ieni A, Martini M, Tuccari G, Lentini M, Fadda G
Endocrine 2022 Oct;78(1):1-12. Epub 2022 Jul 21 doi: 10.1007/s12020-022-03146-0. PMID: 35864338
Diffuse sclerosing variant of papillary thyroid carcinoma: ultrasonographic and clinicopathological features in children/adolescents and adults.
Wang Q, Chang Q, Zhang R, Sun C, Li L, Wang S, Wang Q, Li Z, Niu L
Clin Radiol 2022 May;77(5):e356-e362. Epub 2022 Feb 20 doi: 10.1016/j.crad.2022.01.051. PMID: 35197192
Diffuse sclerosing variant of papillary thyroid carcinoma--an update of its clinicopathological features and molecular biology.
Pillai S, Gopalan V, Smith RA, Lam AK
Crit Rev Oncol Hematol 2015 Apr;94(1):64-73. Epub 2014 Dec 18 doi: 10.1016/j.critrevonc.2014.12.001. PMID: 25577570
Sonographic and cytopathologic correlation of papillary thyroid carcinoma variants.
Lee JH, Shin JH, Lee HW, Oh YL, Hahn SY, Ko EY
J Ultrasound Med 2015 Jan;34(1):1-15. doi: 10.7863/ultra.34.1.1. PMID: 25542934

Therapy

Ultrasound, laboratory and histopathological insights in diagnosing papillary thyroid carcinoma in a paediatric population: a single centre follow-up study between 2000-2022.
Januś D, Wójcik M, Taczanowska-Niemczuk A, Kiszka-Wiłkojć A, Kujdowicz M, Czogała M, Górecki W, Starzyk JB
Front Endocrinol (Lausanne) 2023;14:1170971. Epub 2023 May 18 doi: 10.3389/fendo.2023.1170971. PMID: 37274328Free PMC Article
Radioactive iodine does not improve overall survival for patients with aggressive variants of papillary thyroid carcinoma less than 2 cm.
Holoubek SA, MacKinney EC, Khokar AM, Kuchta KM, Winchester DJ, Prinz RA, Moo-Young TA
Surgery 2022 Jan;171(1):203-211. Epub 2021 Aug 10 doi: 10.1016/j.surg.2021.05.054. PMID: 34384604
Aggressive variants of papillary thyroid microcarcinoma are associated with high-risk features, but not decreased survival.
Holoubek SA, Yan H, Khokar AH, Kuchta KM, Winchester DJ, Prinz RA, Moo-Young TA
Surgery 2020 Jan;167(1):19-27. Epub 2019 Oct 16 doi: 10.1016/j.surg.2019.03.030. PMID: 31627846
Aggressive variants of papillary thyroid microcarcinoma are associated with extrathyroidal spread and lymph-node metastases: a population-level analysis.
Kuo EJ, Goffredo P, Sosa JA, Roman SA
Thyroid 2013 Oct;23(10):1305-11. Epub 2013 Sep 14 doi: 10.1089/thy.2012.0563. PMID: 23600998Free PMC Article
Thyroid nodules after high-dose external radiotherapy. Fine-needle aspiration cytology in diagnosis and management.
Pretorius HT, Katikineni M, Kinsella TJ, Barsky SH, Brennan MF, Chu EW, Robbins J
JAMA 1982 Jun 18;247(23):3217-20. PMID: 7087060

Prognosis

Ultrasound, laboratory and histopathological insights in diagnosing papillary thyroid carcinoma in a paediatric population: a single centre follow-up study between 2000-2022.
Januś D, Wójcik M, Taczanowska-Niemczuk A, Kiszka-Wiłkojć A, Kujdowicz M, Czogała M, Górecki W, Starzyk JB
Front Endocrinol (Lausanne) 2023;14:1170971. Epub 2023 May 18 doi: 10.3389/fendo.2023.1170971. PMID: 37274328Free PMC Article
Aggressive variants of follicular cell-derived thyroid carcinoma: an overview.
Pizzimenti C, Fiorentino V, Ieni A, Martini M, Tuccari G, Lentini M, Fadda G
Endocrine 2022 Oct;78(1):1-12. Epub 2022 Jul 21 doi: 10.1007/s12020-022-03146-0. PMID: 35864338
Diffuse sclerosing variant of papillary thyroid carcinoma: major genetic alterations and prognostic implications.
Joung JY, Kim TH, Jeong DJ, Park SM, Cho YY, Jang HW, Jung YY, Oh YL, Yim HS, Kim YL, Chung JH, Ki CS, Kim SW
Histopathology 2016 Jul;69(1):45-53. Epub 2016 Jan 11 doi: 10.1111/his.12902. PMID: 26568156
Diffuse sclerosing variant of papillary thyroid carcinoma--an update of its clinicopathological features and molecular biology.
Pillai S, Gopalan V, Smith RA, Lam AK
Crit Rev Oncol Hematol 2015 Apr;94(1):64-73. Epub 2014 Dec 18 doi: 10.1016/j.critrevonc.2014.12.001. PMID: 25577570
Sonographic and cytopathologic correlation of papillary thyroid carcinoma variants.
Lee JH, Shin JH, Lee HW, Oh YL, Hahn SY, Ko EY
J Ultrasound Med 2015 Jan;34(1):1-15. doi: 10.7863/ultra.34.1.1. PMID: 25542934

Clinical prediction guides

Ultrasound, laboratory and histopathological insights in diagnosing papillary thyroid carcinoma in a paediatric population: a single centre follow-up study between 2000-2022.
Januś D, Wójcik M, Taczanowska-Niemczuk A, Kiszka-Wiłkojć A, Kujdowicz M, Czogała M, Górecki W, Starzyk JB
Front Endocrinol (Lausanne) 2023;14:1170971. Epub 2023 May 18 doi: 10.3389/fendo.2023.1170971. PMID: 37274328Free PMC Article
Diffuse sclerosing variant of papillary thyroid carcinoma: ultrasonographic and clinicopathological features in children/adolescents and adults.
Wang Q, Chang Q, Zhang R, Sun C, Li L, Wang S, Wang Q, Li Z, Niu L
Clin Radiol 2022 May;77(5):e356-e362. Epub 2022 Feb 20 doi: 10.1016/j.crad.2022.01.051. PMID: 35197192
Radioactive iodine does not improve overall survival for patients with aggressive variants of papillary thyroid carcinoma less than 2 cm.
Holoubek SA, MacKinney EC, Khokar AM, Kuchta KM, Winchester DJ, Prinz RA, Moo-Young TA
Surgery 2022 Jan;171(1):203-211. Epub 2021 Aug 10 doi: 10.1016/j.surg.2021.05.054. PMID: 34384604
Aggressive variants of papillary thyroid microcarcinoma are associated with high-risk features, but not decreased survival.
Holoubek SA, Yan H, Khokar AH, Kuchta KM, Winchester DJ, Prinz RA, Moo-Young TA
Surgery 2020 Jan;167(1):19-27. Epub 2019 Oct 16 doi: 10.1016/j.surg.2019.03.030. PMID: 31627846
Overview of surgical pathology of the thyroid gland.
Nishiyama RH
World J Surg 2000 Aug;24(8):898-906. doi: 10.1007/s002680010157. PMID: 10865033

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