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Malignant fibrous histiocytoma

MedGen UID:
87248
Concept ID:
C0334463
Neoplastic Process
Synonyms: Malignant fibrohistiocytic tumors; Undifferentiated pleomorphic sarcoma
SNOMED CT: Malignant fibrous histiocytoma (34360000); Malignant fibroxanthoma (34360000); Malignant fibrous histiocytoma (443439001); Undifferentiated high grade pleomorphic sarcoma (34360000); Fibrous histiocytoma, malignant (34360000); Fibroxanthoma, malignant (34360000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0002142
Orphanet: ORPHA2023

Definition

An aggressive sarcoma of soft tissues or bone that can arise from any part of the body, clinically presenting as swelling, mass, pain, pathological fracture and occasional systemic features and is characterized by high local recurrence and significant metastasis. [from ORDO]

Professional guidelines

PubMed

Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Soleymani T, Aasi SZ, Novoa R, Hollmig ST
Dermatol Clin 2019 Jul;37(3):253-259. Epub 2019 Apr 16 doi: 10.1016/j.det.2019.02.001. PMID: 31084719
Huang H, Li D, Wang X, Wu Y, Liu S, Xu Z
J Cancer Res Ther 2017;13(4):660-663. doi: 10.4103/jcrt.JCRT_29_17. PMID: 28901310

Recent clinical studies

Etiology

Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Soleymani T, Aasi SZ, Novoa R, Hollmig ST
Dermatol Clin 2019 Jul;37(3):253-259. Epub 2019 Apr 16 doi: 10.1016/j.det.2019.02.001. PMID: 31084719
Skubitz KM, D'Adamo DR
Mayo Clin Proc 2007 Nov;82(11):1409-32. doi: 10.4065/82.11.1409. PMID: 17976362
Patel SR
Curr Treat Options Oncol 2000 Aug;1(3):258-61. doi: 10.1007/s11864-000-0037-6. PMID: 12057168
Stadler FJ, Scott GA, Brown MD
Semin Cutan Med Surg 1998 Jun;17(2):141-52. doi: 10.1016/s1085-5629(98)80007-2. PMID: 9669607

Diagnosis

Saleh JS, Whittington CP, Bresler SC, Patel RM
Surg Pathol Clin 2024 Mar;17(1):153-158. Epub 2023 Aug 5 doi: 10.1016/j.path.2023.06.007. PMID: 38278604
Berkeley R, Andrei V, Saifuddin A
Skeletal Radiol 2021 Aug;50(8):1491-1511. Epub 2021 Jan 7 doi: 10.1007/s00256-020-03692-6. PMID: 33410967
Soleymani T, Aasi SZ, Novoa R, Hollmig ST
Dermatol Clin 2019 Jul;37(3):253-259. Epub 2019 Apr 16 doi: 10.1016/j.det.2019.02.001. PMID: 31084719
Withers AH, Brougham ND, Barber RM, Tan ST
J Plast Reconstr Aesthet Surg 2011 Nov;64(11):e273-8. Epub 2011 Jun 12 doi: 10.1016/j.bjps.2011.05.004. PMID: 21664889
Fisher C
Virchows Arch 2004 Sep;445(3):215-23. Epub 2004 Jun 2 doi: 10.1007/s00428-004-1038-9. PMID: 15173943

Therapy

Skubitz KM, D'Adamo DR
Mayo Clin Proc 2007 Nov;82(11):1409-32. doi: 10.4065/82.11.1409. PMID: 17976362
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171
Patel SR
Curr Treat Options Oncol 2000 Aug;1(3):258-61. doi: 10.1007/s11864-000-0037-6. PMID: 12057168
Masaoka A, Yamakawa Y, Niwa H, Fukai I, Saito Y, Tokudome S, Nakahara K, Fujii Y
Eur J Cardiothorac Surg 1994;8(5):251-3. doi: 10.1016/1010-7940(94)90155-4. PMID: 8043287
Springfield D
Clin Orthop Relat Res 1993 Apr;(289):50-7. PMID: 8472432

Prognosis

Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171
Patel SR
Curr Treat Options Oncol 2000 Aug;1(3):258-61. doi: 10.1007/s11864-000-0037-6. PMID: 12057168
Stadler FJ, Scott GA, Brown MD
Semin Cutan Med Surg 1998 Jun;17(2):141-52. doi: 10.1016/s1085-5629(98)80007-2. PMID: 9669607
Masaoka A, Yamakawa Y, Niwa H, Fukai I, Saito Y, Tokudome S, Nakahara K, Fujii Y
Eur J Cardiothorac Surg 1994;8(5):251-3. doi: 10.1016/1010-7940(94)90155-4. PMID: 8043287
Springfield D
Clin Orthop Relat Res 1993 Apr;(289):50-7. PMID: 8472432

Clinical prediction guides

Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Soleymani T, Aasi SZ, Novoa R, Hollmig ST
Dermatol Clin 2019 Jul;37(3):253-259. Epub 2019 Apr 16 doi: 10.1016/j.det.2019.02.001. PMID: 31084719
Li YR, Akbari E, Tretiakova MS, Hart J, Akbari M, Urbanski SJ, Gao ZH
Am J Surg Pathol 2008 Aug;32(8):1144-58. doi: 10.1097/PAS.0b013e3181659791. PMID: 18545143
Nascimento AG
Semin Diagn Pathol 2001 Nov;18(4):263-6. PMID: 11757866
Masaoka A, Yamakawa Y, Niwa H, Fukai I, Saito Y, Tokudome S, Nakahara K, Fujii Y
Eur J Cardiothorac Surg 1994;8(5):251-3. doi: 10.1016/1010-7940(94)90155-4. PMID: 8043287

Recent systematic reviews

Ørholt M, Abebe K, Aaberg F, Rasmussen LE, Daugaard S, Loya AC, Herly M, Vester-Glowinski PV
Am J Dermatopathol 2022 Dec 1;44(12):913-920. doi: 10.1097/DAD.0000000000002305. PMID: 36395448
Konarski W, Poboży T, Hordowicz M, Śliwczyński A, Kotela I, Krakowiak J, Kotela A
Int J Environ Res Public Health 2022 Jul 29;19(15) doi: 10.3390/ijerph19159282. PMID: 35954639Free PMC Article
Zhurakivska K, Troiano G, Montella M, Lo Muzio L, Fiorillo L, Cervino G, Cicciù M, D'Amico C, Rullo R, Laino G, Di Stasio D, Laino L
Int J Environ Res Public Health 2020 Feb 23;17(4) doi: 10.3390/ijerph17041426. PMID: 32102165Free PMC Article
Neuwirth MG, Song Y, Sinnamon AJ, Fraker DL, Zager JS, Karakousis GC
Ann Surg Oncol 2017 Dec;24(13):3803-3810. Epub 2017 Oct 11 doi: 10.1245/s10434-017-6109-7. PMID: 29022281
Li YR, Akbari E, Tretiakova MS, Hart J, Akbari M, Urbanski SJ, Gao ZH
Am J Surg Pathol 2008 Aug;32(8):1144-58. doi: 10.1097/PAS.0b013e3181659791. PMID: 18545143

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