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Benign phyllodes tumor

MedGen UID:: 87254
•Concept ID:: C0334501
•: Neoplastic Process

Synonyms:	Benign Cystosarcoma Phyllodes; Benign cystosarcoma phyllodes; benign cystosarcoma phyllodes; Benign Phyllodes Neoplasm; benign phyllodes neoplasm; Benign Phyllodes Tumor; benign phyllodes tumor; Cystosarcoma phyllodes, benign; Phyllodes tumor, benign; phyllodes tumor, benign
SNOMED CT:	Benign phyllodes tumor (16566002); Benign cystosarcoma phyllodes (16566002); Phyllodes tumor, benign (16566002); Cystosarcoma phyllodes, benign (16566002)

Monarch Initiative:	MONDO:0037002

Definition

A benign, circumscribed fibroepithelial neoplasm arising from the breast and rarely the prostate gland. It is characterized by the presence of epithelial structures which are arranged in clefts and by a hypercellular mesenchymal stroma which is organized in leaf-like structures. There is no evidence of cellular atypia or sarcomatous features. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign phyllodes tumor

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Neoplasm by Special Category
        Benign neoplasm
        Benign phyllodes tumor
        Benign breast phyllodes tumor
        Benign prostate phyllodes tumor
        Benign Vulvar Phyllodes Tumor

Professional guidelines

PubMed

Diagnosis, characteristics, and treatment of breast carcinomas within benign fibroepithelial tumors.

Saimura M, Koga K, Anan K, Mitsuyama S, Tamiya S
Breast Cancer 2018 Jul;25(4):470-478. Epub 2018 Feb 19 doi: 10.1007/s12282-018-0847-7. PMID: 29460095

Proliferating activity in differential diagnosis of benign phyllodes tumor and cellular fibroadenomas: is it helpful?

Kaya R, Pestereli HE, Erdogan G, Gülkesen KH, Karaveli S
Pathol Oncol Res 2001;7(3):213-6. doi: 10.1007/BF03032352. PMID: 11692149

The treatment and prognosis of patients with phyllodes tumor of the breast: an analysis of 170 cases.

Reinfuss M, Mituś J, Duda K, Stelmach A, Ryś J, Smolak K
Cancer 1996 Mar 1;77(5):910-6. doi: 10.1002/(sici)1097-0142(19960301)77:5<910::aid-cncr16>3.0.co;2-6. PMID: 8608483

See all (6)

Recent clinical studies

Etiology

Logistic regression analysis of ultrasound findings in predicting the malignant and benign phyllodes tumor of breast.

Li T, Li Y, Yang Y, Li J, Hu Z, Wang L, Pu W, Wei T, Lu M
PLoS One 2022;17(3):e0265952. Epub 2022 Mar 24 doi: 10.1371/journal.pone.0265952. PMID: 35325009 Free PMC Article

Benign Phyllodes Tumor in Children: A Study of 8 Cases and Review of the Literature.

Hafeez S, Balarezo F, Ricci A Jr
J Pediatr Hematol Oncol 2020 Jul;42(5):e388-e391. doi: 10.1097/MPH.0000000000001501. PMID: 31107366

Percutaneous removal of benign phyllodes tumor of the breast: An alternative to surgery.

Graña López L, Vázquez Caruncho M, Villares Armas Á
Breast J 2018 Nov;24(6):1035-1037. Epub 2018 Sep 24 doi: 10.1111/tbj.13122. PMID: 30251456

Fibroepithelial lesions; The WHO spectrum.

Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536

Benign Phyllodes Tumor of the Breast Diagnosed After Ultrasound-Guided Vacuum-Assisted Biopsy: Surgical Excision or Wait-and-Watch?

Ouyang Q, Li S, Tan C, Zeng Y, Zhu L, Song E, Chen K, Su F
Ann Surg Oncol 2016 Apr;23(4):1129-34. Epub 2015 Nov 17 doi: 10.1245/s10434-015-4990-5. PMID: 26577125

See all (34)

Diagnosis

Benign Phyllodes Tumor in Children: A Study of 8 Cases and Review of the Literature.

Hafeez S, Balarezo F, Ricci A Jr
J Pediatr Hematol Oncol 2020 Jul;42(5):e388-e391. doi: 10.1097/MPH.0000000000001501. PMID: 31107366

Percutaneous removal of benign phyllodes tumor of the breast: An alternative to surgery.

Graña López L, Vázquez Caruncho M, Villares Armas Á
Breast J 2018 Nov;24(6):1035-1037. Epub 2018 Sep 24 doi: 10.1111/tbj.13122. PMID: 30251456

Diagnosis, characteristics, and treatment of breast carcinomas within benign fibroepithelial tumors.

Saimura M, Koga K, Anan K, Mitsuyama S, Tamiya S
Breast Cancer 2018 Jul;25(4):470-478. Epub 2018 Feb 19 doi: 10.1007/s12282-018-0847-7. PMID: 29460095

Fibroepithelial lesions; The WHO spectrum.

Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536

Benign Phyllodes Tumor of the Breast Diagnosed After Ultrasound-Guided Vacuum-Assisted Biopsy: Surgical Excision or Wait-and-Watch?

Ouyang Q, Li S, Tan C, Zeng Y, Zhu L, Song E, Chen K, Su F
Ann Surg Oncol 2016 Apr;23(4):1129-34. Epub 2015 Nov 17 doi: 10.1245/s10434-015-4990-5. PMID: 26577125

See all (51)

Therapy

Malignant Phyllodes Tumor Recurrence in the Pleural Cavity via the Deep Inferior Epigastric Perforator Flap and Internal Mammary Vessel Bundle: A Case Report.

Fang CL, Hsu CH, Tu CW
Ann Plast Surg 2019 Jun;82(6):618-621. doi: 10.1097/SAP.0000000000001795. PMID: 30882414

Cellular fibroepithelial lesions of the breast: A long term follow up study.

Yasir S, Nassar A, Jimenez RE, Jenkins SM, Hartmann LC, Degnim AC, Frost M, Visscher DW
Ann Diagn Pathol 2018 Aug;35:85-91. Epub 2018 Jan 10 doi: 10.1016/j.anndiagpath.2018.01.005. PMID: 30029048

A Case of Benign Phyllodes Tumor in a Transgender Woman Receiving Cross-Sex Hormones.

Richards SM, Pine-Twaddell ED, Ioffe OB, Bellavance EC
Int J Surg Pathol 2018 Jun;26(4):356-359. Epub 2017 Nov 23 doi: 10.1177/1066896917743011. PMID: 29169272

Benign Phyllodes Tumor of the Breast Diagnosed After Ultrasound-Guided Vacuum-Assisted Biopsy: Surgical Excision or Wait-and-Watch?

Ouyang Q, Li S, Tan C, Zeng Y, Zhu L, Song E, Chen K, Su F
Ann Surg Oncol 2016 Apr;23(4):1129-34. Epub 2015 Nov 17 doi: 10.1245/s10434-015-4990-5. PMID: 26577125

Interobserver variability by pathologists in the distinction between cellular fibroadenomas and phyllodes tumors.

Lawton TJ, Acs G, Argani P, Farshid G, Gilcrease M, Goldstein N, Koerner F, Rowe JJ, Sanders M, Shah SS, Reynolds C
Int J Surg Pathol 2014 Dec;22(8):695-8. Epub 2014 Aug 26 doi: 10.1177/1066896914548763. PMID: 25161205 Free PMC Article

See all (5)

Prognosis

Factors effective on recurrence and metastasis in phyllodes tumors.

Altiok M, Kurt F
Niger J Clin Pract 2022 Apr;25(4):425-431. doi: 10.4103/njcp.njcp_1374_21. PMID: 35439900

Logistic regression analysis of ultrasound findings in predicting the malignant and benign phyllodes tumor of breast.

Li T, Li Y, Yang Y, Li J, Hu Z, Wang L, Pu W, Wei T, Lu M
PLoS One 2022;17(3):e0265952. Epub 2022 Mar 24 doi: 10.1371/journal.pone.0265952. PMID: 35325009 Free PMC Article

Benign Phyllodes Tumor in Children: A Study of 8 Cases and Review of the Literature.

Hafeez S, Balarezo F, Ricci A Jr
J Pediatr Hematol Oncol 2020 Jul;42(5):e388-e391. doi: 10.1097/MPH.0000000000001501. PMID: 31107366

Fibroepithelial lesions; The WHO spectrum.

Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536

Benign Phyllodes Tumor of the Breast Diagnosed After Ultrasound-Guided Vacuum-Assisted Biopsy: Surgical Excision or Wait-and-Watch?

Ouyang Q, Li S, Tan C, Zeng Y, Zhu L, Song E, Chen K, Su F
Ann Surg Oncol 2016 Apr;23(4):1129-34. Epub 2015 Nov 17 doi: 10.1245/s10434-015-4990-5. PMID: 26577125

See all (25)

Clinical prediction guides

Logistic regression analysis of ultrasound findings in predicting the malignant and benign phyllodes tumor of breast.

Li T, Li Y, Yang Y, Li J, Hu Z, Wang L, Pu W, Wei T, Lu M
PLoS One 2022;17(3):e0265952. Epub 2022 Mar 24 doi: 10.1371/journal.pone.0265952. PMID: 35325009 Free PMC Article

Benign and borderline phyllodes tumors of the breast: Clinicopathologic analysis of 205 cases with emphasis on the surgical margin status and local recurrence rate.

Genco IS, Purohit V, Hackman K, Ferreira L, Tugertimur B, Hajiyeva S
Ann Diagn Pathol 2021 Apr;51:151708. Epub 2021 Jan 22 doi: 10.1016/j.anndiagpath.2021.151708. PMID: 33513547

Benign Phyllodes Tumor in Children: A Study of 8 Cases and Review of the Literature.

Hafeez S, Balarezo F, Ricci A Jr
J Pediatr Hematol Oncol 2020 Jul;42(5):e388-e391. doi: 10.1097/MPH.0000000000001501. PMID: 31107366

Fibroepithelial lesions; The WHO spectrum.

Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536

Benign Phyllodes Tumor of the Breast Diagnosed After Ultrasound-Guided Vacuum-Assisted Biopsy: Surgical Excision or Wait-and-Watch?

Ouyang Q, Li S, Tan C, Zeng Y, Zhu L, Song E, Chen K, Su F
Ann Surg Oncol 2016 Apr;23(4):1129-34. Epub 2015 Nov 17 doi: 10.1245/s10434-015-4990-5. PMID: 26577125

See all (20)

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Benign phyllodes tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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