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Protoplasmic astrocytoma

MedGen UID:
87268
Concept ID:
C0334580
Neoplastic Process
Synonyms: Astrocytoma, Protoplasmic; Protoplasmic Astrocytoma; Protoplasmic Astrocytomas
SNOMED CT: Protoplasmic astrocytoma (55094006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0016687
Orphanet: ORPHA251598

Definition

A rare variant of diffuse astrocytoma. It is predominantly composed of neoplastic astrocytes showing a small cell body with few, flaccid processes with a low content of glial filaments and scant GFAP expression. This lesion is not well defined and is considered by some authors as an occasional histopathological feature rather than a reproducibly identifiable variant. When occurring in children, this neoplasm may be difficult to separate from pilocytic juvenile astrocytoma. (Adapted from WHO) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProtoplasmic astrocytoma
Follow this link to review classifications for Protoplasmic astrocytoma in Orphanet.

Professional guidelines

PubMed

Czarnywojtek A, Borowska M, Dyrka K, Van Gool S, Sawicka-Gutaj N, Moskal J, Kościński J, Graczyk P, Hałas T, Lewandowska AM, Czepczyński R, Ruchała M
Pharmacology 2023;108(5):423-431. Epub 2023 Jul 17 doi: 10.1159/000531319. PMID: 37459849
McKinnon C, Nandhabalan M, Murray SA, Plaha P
BMJ 2021 Jul 14;374:n1560. doi: 10.1136/bmj.n1560. PMID: 34261630
Ma R, Taphoorn MJB, Plaha P
J Neurol Neurosurg Psychiatry 2021 Oct;92(10):1103-1111. Epub 2021 Jun 23 doi: 10.1136/jnnp-2020-325334. PMID: 34162730

Recent clinical studies

Etiology

Deguchi S, Oishi T, Mitsuya K, Kakuda Y, Endo M, Sugino T, Hayashi N
Sci Rep 2020 Jun 22;10(1):10113. doi: 10.1038/s41598-020-67244-7. PMID: 32572107Free PMC Article
Liubinas SV, D'Abaco GM, Moffat BM, Gonzales M, Feleppa F, Nowell CJ, Gorelik A, Drummond KJ, O'Brien TJ, Kaye AH, Morokoff AP
Epilepsia 2014 Sep;55(9):1438-43. Epub 2014 Jun 5 doi: 10.1111/epi.12662. PMID: 24903073
Tay KL, Tsui A, Phal PM, Drummond KJ, Tress BM
Neuroradiology 2011 Jun;53(6):405-11. Epub 2010 Jul 20 doi: 10.1007/s00234-010-0741-2. PMID: 20644924
Prayson RA, Estes ML
Am J Clin Pathol 1995 Jun;103(6):705-9. doi: 10.1093/ajcp/103.6.705. PMID: 7785654
Gilles FH, Sobel E, Leviton A, Hedley-Whyte ET, Tavare CJ, Adelman LS, Sobel RA
J Neurooncol 1992 Jan;12(1):53-68. doi: 10.1007/BF00172457. PMID: 1541979

Diagnosis

Deguchi S, Oishi T, Mitsuya K, Kakuda Y, Endo M, Sugino T, Hayashi N
Sci Rep 2020 Jun 22;10(1):10113. doi: 10.1038/s41598-020-67244-7. PMID: 32572107Free PMC Article
Tay KL, Tsui A, Phal PM, Drummond KJ, Tress BM
Neuroradiology 2011 Jun;53(6):405-11. Epub 2010 Jul 20 doi: 10.1007/s00234-010-0741-2. PMID: 20644924
Brown WD, Tavaré CJ, Sobel EL, Gilles FH
Neurosurgery 1995 Jun;36(6):1093-6. doi: 10.1227/00006123-199506000-00004. PMID: 7643986
Katsetos CD, Krishna L
Clin Neuropathol 1994 Nov-Dec;13(6):295-305. PMID: 7851044
J Neurooncol 1989 Sep;7(3):211-24. doi: 10.1007/BF00172914. PMID: 2795117

Therapy

Gump WC, Skjei KL, Karkare SN
Neurosurg Focus 2013 Jun;34(6):E1. doi: 10.3171/2013.3.FOCUS1348. PMID: 23724833

Prognosis

Deguchi S, Oishi T, Mitsuya K, Kakuda Y, Endo M, Sugino T, Hayashi N
Sci Rep 2020 Jun 22;10(1):10113. doi: 10.1038/s41598-020-67244-7. PMID: 32572107Free PMC Article
Gump WC, Skjei KL, Karkare SN
Neurosurg Focus 2013 Jun;34(6):E1. doi: 10.3171/2013.3.FOCUS1348. PMID: 23724833
Prayson RA
Hum Pathol 2004 Mar;35(3):317-21. doi: 10.1016/j.humpath.2003.09.010. PMID: 15017587
Prayson RA, Estes ML
Am J Clin Pathol 1995 Jun;103(6):705-9. doi: 10.1093/ajcp/103.6.705. PMID: 7785654
Gilles FH, Sobel E, Leviton A, Hedley-Whyte ET, Tavare CJ, Adelman LS, Sobel RA
J Neurooncol 1992 Jan;12(1):53-68. doi: 10.1007/BF00172457. PMID: 1541979

Clinical prediction guides

Deguchi S, Oishi T, Mitsuya K, Kakuda Y, Endo M, Sugino T, Hayashi N
Sci Rep 2020 Jun 22;10(1):10113. doi: 10.1038/s41598-020-67244-7. PMID: 32572107Free PMC Article
Gump WC, Skjei KL, Karkare SN
Neurosurg Focus 2013 Jun;34(6):E1. doi: 10.3171/2013.3.FOCUS1348. PMID: 23724833
Prayson RA
Hum Pathol 2004 Mar;35(3):317-21. doi: 10.1016/j.humpath.2003.09.010. PMID: 15017587
Prayson RA, Estes ML
Am J Clin Pathol 1995 Jun;103(6):705-9. doi: 10.1093/ajcp/103.6.705. PMID: 7785654
J Neurooncol 1989 Sep;7(3):211-24. doi: 10.1007/BF00172914. PMID: 2795117

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