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Protoplasmic astrocytoma

MedGen UID:
87268
Concept ID:
C0334580
Neoplastic Process
Synonyms: Astrocytoma, Protoplasmic; Protoplasmic Astrocytoma; Protoplasmic Astrocytomas
SNOMED CT: Protoplasmic astrocytoma (55094006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0016687
Orphanet: ORPHA251598

Definition

A rare variant of diffuse astrocytoma. It is predominantly composed of neoplastic astrocytes showing a small cell body with few, flaccid processes with a low content of glial filaments and scant GFAP expression. This lesion is not well defined and is considered by some authors as an occasional histopathological feature rather than a reproducibly identifiable variant. When occurring in children, this neoplasm may be difficult to separate from pilocytic juvenile astrocytoma. (Adapted from WHO) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProtoplasmic astrocytoma
Follow this link to review classifications for Protoplasmic astrocytoma in Orphanet.

Professional guidelines

PubMed

McKinnon C, Nandhabalan M, Murray SA, Plaha P
BMJ 2021 Jul 14;374:n1560. doi: 10.1136/bmj.n1560. PMID: 34261630
Ma R, Taphoorn MJB, Plaha P
J Neurol Neurosurg Psychiatry 2021 Oct;92(10):1103-1111. Epub 2021 Jun 23 doi: 10.1136/jnnp-2020-325334. PMID: 34162730
Morshed RA, Young JS, Hervey-Jumper SL, Berger MS
J Neurosurg Sci 2019 Aug;63(4):450-457. Epub 2019 Mar 27 doi: 10.23736/S0390-5616.19.04701-5. PMID: 30916536

Recent clinical studies

Etiology

Deguchi S, Oishi T, Mitsuya K, Kakuda Y, Endo M, Sugino T, Hayashi N
Sci Rep 2020 Jun 22;10(1):10113. doi: 10.1038/s41598-020-67244-7. PMID: 32572107Free PMC Article
Tay KL, Tsui A, Phal PM, Drummond KJ, Tress BM
Neuroradiology 2011 Jun;53(6):405-11. Epub 2010 Jul 20 doi: 10.1007/s00234-010-0741-2. PMID: 20644924
Prayson RA
Pathology 2010;42(5):426-31. doi: 10.3109/00313025.2010.493870. PMID: 20632818
Prayson RA
Hum Pathol 2004 Mar;35(3):317-21. doi: 10.1016/j.humpath.2003.09.010. PMID: 15017587
Prayson RA, Estes ML
Am J Clin Pathol 1995 Jun;103(6):705-9. doi: 10.1093/ajcp/103.6.705. PMID: 7785654

Diagnosis

Deguchi S, Oishi T, Mitsuya K, Kakuda Y, Endo M, Sugino T, Hayashi N
Sci Rep 2020 Jun 22;10(1):10113. doi: 10.1038/s41598-020-67244-7. PMID: 32572107Free PMC Article
Tay KL, Tsui A, Phal PM, Drummond KJ, Tress BM
Neuroradiology 2011 Jun;53(6):405-11. Epub 2010 Jul 20 doi: 10.1007/s00234-010-0741-2. PMID: 20644924
Manley S, Crooks D, Artingstall L, Buxton N, Appleton R, Riordan A, Cleary G, Pizer B
Pediatr Blood Cancer 2010 May;54(5):768-9. doi: 10.1002/pbc.22402. PMID: 20049933
Katsetos CD, Krishna L
Clin Neuropathol 1994 Nov-Dec;13(6):295-305. PMID: 7851044
J Neurooncol 1989 Sep;7(3):211-24. doi: 10.1007/BF00172914. PMID: 2795117

Therapy

Gump WC, Skjei KL, Karkare SN
Neurosurg Focus 2013 Jun;34(6):E1. doi: 10.3171/2013.3.FOCUS1348. PMID: 23724833

Prognosis

Deguchi S, Oishi T, Mitsuya K, Kakuda Y, Endo M, Sugino T, Hayashi N
Sci Rep 2020 Jun 22;10(1):10113. doi: 10.1038/s41598-020-67244-7. PMID: 32572107Free PMC Article
Gump WC, Skjei KL, Karkare SN
Neurosurg Focus 2013 Jun;34(6):E1. doi: 10.3171/2013.3.FOCUS1348. PMID: 23724833
Prayson RA
Hum Pathol 2004 Mar;35(3):317-21. doi: 10.1016/j.humpath.2003.09.010. PMID: 15017587
Prayson RA, Estes ML
Am J Clin Pathol 1995 Jun;103(6):705-9. doi: 10.1093/ajcp/103.6.705. PMID: 7785654
Gilles FH, Sobel E, Leviton A, Hedley-Whyte ET, Tavare CJ, Adelman LS, Sobel RA
J Neurooncol 1992 Jan;12(1):53-68. doi: 10.1007/BF00172457. PMID: 1541979

Clinical prediction guides

Deguchi S, Oishi T, Mitsuya K, Kakuda Y, Endo M, Sugino T, Hayashi N
Sci Rep 2020 Jun 22;10(1):10113. doi: 10.1038/s41598-020-67244-7. PMID: 32572107Free PMC Article
Gump WC, Skjei KL, Karkare SN
Neurosurg Focus 2013 Jun;34(6):E1. doi: 10.3171/2013.3.FOCUS1348. PMID: 23724833
Prayson RA
Pathology 2010;42(5):426-31. doi: 10.3109/00313025.2010.493870. PMID: 20632818
Prayson RA
Hum Pathol 2004 Mar;35(3):317-21. doi: 10.1016/j.humpath.2003.09.010. PMID: 15017587
J Neurooncol 1989 Sep;7(3):211-24. doi: 10.1007/BF00172914. PMID: 2795117

Supplemental Content

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