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Fibrillary astrocytoma

MedGen UID:
87270
Concept ID:
C0334582
Neoplastic Process
Synonyms: Astrocytoma, Fibrillary; Fibrillary Astrocytoma; Fibrillary Astrocytomas
SNOMED CT: Fibrillary astrocytoma (71314006); Fibrous astrocytoma (71314006)
 
Monarch Initiative: MONDO:0016688
Orphanet: ORPHA251601

Definition

The most frequent histological variant of diffuse astrocytoma. It is predominantly composed of fibrillary neoplastic astrocytes. Nuclear atypia is a diagnostic criterion but mitotic activity, necrosis and microvascular proliferation are absent. The occasional or regional occurrence of gemistocytic neoplastic cells is compatible with the diagnosis of fibrillary astrocytoma. (WHO) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFibrillary astrocytoma
Follow this link to review classifications for Fibrillary astrocytoma in Orphanet.

Professional guidelines

PubMed

El Beltagy MA, Reda M, Enayet A, Zaghloul MS, Awad M, Zekri W, Taha H, El-Khateeb N
World Neurosurg 2016 May;89:525-34. Epub 2016 Feb 18 doi: 10.1016/j.wneu.2016.02.042. PMID: 26898488
Ghodsi M, Mortazavi A, Shahjouei S, Hanaei S, Esmaeili A, Nejat F, El Khashab M
Pediatr Neurosurg 2013;49(4):195-201. Epub 2014 May 22 doi: 10.1159/000362621. PMID: 24861884
Allen JC
Pediatr Neurosurg 2000 Mar;32(3):154-62. doi: 10.1159/000028922. PMID: 10867564

Recent clinical studies

Etiology

Andrews C, Prayson RA
Ann Diagn Pathol 2020 Jun;46:151519. Epub 2020 Apr 8 doi: 10.1016/j.anndiagpath.2020.151519. PMID: 32305004
Upadhyaya SA, Ghazwani Y, Wu S, Broniscer A, Boop FA, Gajjar A, Qaddoumi I
Pediatr Blood Cancer 2018 Jan;65(1) Epub 2017 Jul 14 doi: 10.1002/pbc.26717. PMID: 28708330Free PMC Article
Menon G, Nair S, Sudhir J, Rao BR, Krishnakumar K
Br J Neurosurg 2010 Oct;24(5):566-71. doi: 10.3109/02688691003777915. PMID: 20536292
Fisher PG, Breiter SN, Carson BS, Wharam MD, Williams JA, Weingart JD, Foer DR, Goldthwaite PT, Tihan T, Burger PC
Cancer 2000 Oct 1;89(7):1569-76. doi: 10.1002/1097-0142(20001001)89:7<1569::aid-cncr22>3.0.co;2-0. PMID: 11013373
Allen JC
Pediatr Neurosurg 2000 Mar;32(3):154-62. doi: 10.1159/000028922. PMID: 10867564

Diagnosis

Andrews C, Prayson RA
Ann Diagn Pathol 2020 Jun;46:151519. Epub 2020 Apr 8 doi: 10.1016/j.anndiagpath.2020.151519. PMID: 32305004
Prayson RA
Ann Diagn Pathol 2019 Dec;43:151411. Epub 2019 Oct 23 doi: 10.1016/j.anndiagpath.2019.151411. PMID: 31677487
Upadhyaya SA, Ghazwani Y, Wu S, Broniscer A, Boop FA, Gajjar A, Qaddoumi I
Pediatr Blood Cancer 2018 Jan;65(1) Epub 2017 Jul 14 doi: 10.1002/pbc.26717. PMID: 28708330Free PMC Article
Habek M, Brinar VV, Mubrin Z, Barun B, Zarković K
J Neurooncol 2007 Sep;84(2):175-7. Epub 2007 May 24 doi: 10.1007/s11060-007-9404-5. PMID: 17522784
Engelhard HH, Stelea A, Cochran EJ
Surg Neurol 2002 Aug;58(2):111-7; discussion 117. doi: 10.1016/s0090-3019(02)00751-6. PMID: 12453646

Therapy

El Beltagy MA, Reda M, Enayet A, Zaghloul MS, Awad M, Zekri W, Taha H, El-Khateeb N
World Neurosurg 2016 May;89:525-34. Epub 2016 Feb 18 doi: 10.1016/j.wneu.2016.02.042. PMID: 26898488
Massimino M, Spreafico F, Riva D, Biassoni V, Poggi G, Solero C, Gandola L, Genitori L, Modena P, Simonetti F, Potepan P, Casanova M, Meazza C, Clerici CA, Catania S, Sardi I, Giangaspero F
J Neurooncol 2010 Oct;100(1):65-71. Epub 2010 Feb 12 doi: 10.1007/s11060-010-0136-6. PMID: 20151174
Gururangan S, Fisher MJ, Allen JC, Herndon JE 2nd, Quinn JA, Reardon DA, Vredenburgh JJ, Desjardins A, Phillips PC, Watral MA, Krauser JM, Friedman AH, Friedman HS
Neuro Oncol 2007 Apr;9(2):161-8. Epub 2007 Mar 8 doi: 10.1215/15228517-2006-030. PMID: 17347491Free PMC Article
Suárez JC, Viano JC, Zunino S, Herrera EJ, Gomez J, Tramunt B, Marengo I, Hiramatzu E, Miras M, Pena M, Sonzini Astudillo B
Childs Nerv Syst 2006 Jul;22(7):679-84. Epub 2006 Jan 3 doi: 10.1007/s00381-005-0021-3. PMID: 16389565
Walter AW, Gajjar A, Reardon DA, Thompson SJ, Langston JW, Jones-Wallace D, Kun LE, Heideman RL
J Pediatr Hematol Oncol 2000 May-Jun;22(3):247-51. doi: 10.1097/00043426-200005000-00010. PMID: 10864056

Prognosis

Upadhyaya SA, Ghazwani Y, Wu S, Broniscer A, Boop FA, Gajjar A, Qaddoumi I
Pediatr Blood Cancer 2018 Jan;65(1) Epub 2017 Jul 14 doi: 10.1002/pbc.26717. PMID: 28708330Free PMC Article
Menon G, Nair S, Sudhir J, Rao BR, Krishnakumar K
Br J Neurosurg 2010 Oct;24(5):566-71. doi: 10.3109/02688691003777915. PMID: 20536292
Lymbouridou R, Soufla G, Chatzinikola AM, Vakis A, Spandidos DA
Eur J Cancer 2009 May;45(7):1294-1303. Epub 2009 Jan 27 doi: 10.1016/j.ejca.2008.12.028. PMID: 19179066
Engelhard HH, Stelea A, Cochran EJ
Surg Neurol 2002 Aug;58(2):111-7; discussion 117. doi: 10.1016/s0090-3019(02)00751-6. PMID: 12453646
Allen JC
Pediatr Neurosurg 2000 Mar;32(3):154-62. doi: 10.1159/000028922. PMID: 10867564

Clinical prediction guides

Sivakova I, Mraz P, Kubikova E, El Falougy H, Perzelova A
Bratisl Lek Listy 2021;122(6):367-370. doi: 10.4149/10.4149/BLL_2021_061. PMID: 34002608
Hashemi M, Bashi S, Zali A
Mol Biol Rep 2020 Jul;47(7):5461-5467. Epub 2020 Jul 4 doi: 10.1007/s11033-020-05636-8. PMID: 32623617
Andrews C, Prayson RA
Ann Diagn Pathol 2020 Jun;46:151519. Epub 2020 Apr 8 doi: 10.1016/j.anndiagpath.2020.151519. PMID: 32305004
Minehan KJ, Shaw EG, Scheithauer BW, Davis DL, Onofrio BM
J Neurosurg 1995 Oct;83(4):590-5. doi: 10.3171/jns.1995.83.4.0590. PMID: 7674006
Strong JA, Hatten HP Jr, Brown MT, Debatin JF, Friedman HS, Oakes WJ, Tien R
AJR Am J Roentgenol 1993 Aug;161(2):369-72. doi: 10.2214/ajr.161.2.8333380. PMID: 8333380

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