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Endometrial stromal tumor

MedGen UID:
87280
Concept ID:
C0334695
Neoplastic Process
Synonyms: Endometrial Stromal Tumor; Endometrial Stromal Tumors; Stromal Tumor, Endometrial; Stromal Tumors, Endometrial; Tumor, Endometrial Stromal; Tumors, Endometrial Stromal
SNOMED CT: Endometrial stromal tumor (446887007); Endometrial stromal tumor of uncertain behavior (68738004)
 
Monarch Initiative: MONDO:0003311

Definition

Neoplasms of the endometrial stroma that sometimes involve the myometrium. These tumors contain cells that may closely or remotely resemble the normal stromal cells. Endometrial stromal neoplasms are divided into three categories: (1) benign stromal nodules; (2) low-grade stromal sarcoma, or endolymphatic stromal myosis; and (3) malignant endometrial stromal sarcoma (sarcoma, endometrial stromal). [from MONDO]

Professional guidelines

PubMed

Gadducci A, Multinu F, De Vitis LA, Cosio S, Carinelli S, Aletti GD
Gynecol Oncol 2023 Apr;171:95-105. Epub 2023 Feb 24 doi: 10.1016/j.ygyno.2023.02.009. PMID: 36842409
Zhao W, Cui M, Zhang R, Shen X, Xiong X, Ji X, Tao L, Jia W, Pang L, Sun Z, Wang C, Zou H
BMC Cancer 2021 Sep 23;21(1):1047. doi: 10.1186/s12885-021-08781-w. PMID: 34556086Free PMC Article

Recent clinical studies

Etiology

Moore M, McCluggage WG
Int J Gynecol Pathol 2020 May;39(3):221-226. doi: 10.1097/PGP.0000000000000593. PMID: 30807369
Shukla PS, Mittal K
Arch Pathol Lab Med 2019 Jan;143(1):122-129. Epub 2018 Jul 2 doi: 10.5858/arpa.2017-0575-RA. PMID: 29965784
Yenicesu O, Tokmak A, Sirvan AL, Danisman N, Güngör T
J Exp Ther Oncol 2018 Nov;12(4):281-286. PMID: 30476382
Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397
Kondi-Pafiti A, Grapsa D, Kairi-Vassilatou E, Kontogianni-Katsarou K, Koliopoulos C, Botsis D
Eur J Gynaecol Oncol 2006;27(1):73-7. PMID: 16550975

Diagnosis

Gadducci A, Multinu F, De Vitis LA, Cosio S, Carinelli S, Aletti GD
Gynecol Oncol 2023 Apr;171:95-105. Epub 2023 Feb 24 doi: 10.1016/j.ygyno.2023.02.009. PMID: 36842409
Niu S, Zheng W
Semin Diagn Pathol 2022 May;39(3):201-212. Epub 2022 Jan 14 doi: 10.1053/j.semdp.2022.01.004. PMID: 35067405
Shukla PS, Mittal K
Arch Pathol Lab Med 2019 Jan;143(1):122-129. Epub 2018 Jul 2 doi: 10.5858/arpa.2017-0575-RA. PMID: 29965784
Conklin CM, Longacre TA
Adv Anat Pathol 2014 Nov;21(6):383-93. doi: 10.1097/PAP.0000000000000046. PMID: 25299308
Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397

Therapy

Holzmann C, Löning T, Bullerdiek J
Cancer Genet 2016 Jun;209(6):278-81. Epub 2016 Mar 8 doi: 10.1016/j.cancergen.2016.02.005. PMID: 27397601
Bakula-Zalewska E, Danska-Bidzinska A, Kowalewska M, Piascik A, Nasierowska-Guttmejer A, Bidzinski M
Ann Diagn Pathol 2014 Dec;18(6):329-32. Epub 2014 Aug 30 doi: 10.1016/j.anndiagpath.2014.08.009. PMID: 25257516
Pavlakis K, Messini I, Papadimitriou CA, Zagouri F, Yiannou P, Mavrelos D, Panoskaltis T
Eur J Gynaecol Oncol 2011;32(3):362-3. PMID: 21797138
Kasashima S, Kobayashi M, Yamada M, Oda Y
Pathol Int 2003 Sep;53(9):637-41. doi: 10.1046/j.1440-1827.2003.01525.x. PMID: 14507323
Schilder JM, Hurd WW, Roth LM, Sutton GP
Obstet Gynecol 1999 May;93(5 Pt 2):805-7. doi: 10.1016/s0029-7844(98)00332-9. PMID: 10912400

Prognosis

Gadducci A, Multinu F, De Vitis LA, Cosio S, Carinelli S, Aletti GD
Gynecol Oncol 2023 Apr;171:95-105. Epub 2023 Feb 24 doi: 10.1016/j.ygyno.2023.02.009. PMID: 36842409
Zhao W, Cui M, Zhang R, Shen X, Xiong X, Ji X, Tao L, Jia W, Pang L, Sun Z, Wang C, Zou H
BMC Cancer 2021 Sep 23;21(1):1047. doi: 10.1186/s12885-021-08781-w. PMID: 34556086Free PMC Article
Ganjoo KN
Curr Probl Cancer 2019 Aug;43(4):283-288. Epub 2019 Jun 14 doi: 10.1016/j.currproblcancer.2019.06.001. PMID: 31235185
Conklin CM, Longacre TA
Adv Anat Pathol 2014 Nov;21(6):383-93. doi: 10.1097/PAP.0000000000000046. PMID: 25299308
Su TF, Chao TK, Lee HS, Perng CL, Nieh S
Int J Surg Pathol 2014 Sep;22(6):559-63. Epub 2013 Oct 23 doi: 10.1177/1066896913506934. PMID: 24155223

Clinical prediction guides

Zhao W, Cui M, Zhang R, Shen X, Xiong X, Ji X, Tao L, Jia W, Pang L, Sun Z, Wang C, Zou H
BMC Cancer 2021 Sep 23;21(1):1047. doi: 10.1186/s12885-021-08781-w. PMID: 34556086Free PMC Article
Jia M, Sun PL, Gao H
Diagn Pathol 2019 Nov 18;14(1):129. doi: 10.1186/s13000-019-0909-y. PMID: 31739799Free PMC Article
Conklin CM, Longacre TA
Adv Anat Pathol 2014 Nov;21(6):383-93. doi: 10.1097/PAP.0000000000000046. PMID: 25299308
Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397
Fekete PS, Vellios F, Patterson BD
Int J Gynecol Pathol 1985;4(4):378-87. PMID: 4086162

Recent systematic reviews

Jia M, Sun PL, Gao H
Diagn Pathol 2019 Nov 18;14(1):129. doi: 10.1186/s13000-019-0909-y. PMID: 31739799Free PMC Article

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