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Neurotrophic keratopathy

MedGen UID:
87384
Concept ID:
C0339296
Disease or Syndrome
Synonym: Neurotrophic keratitis
SNOMED CT: Anesthetic keratopathy (128080005); Neurotrophic keratopathy (128080005); Neuroparalytic keratopathy (128080005); Neurotrophic keratitis (128080005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0015290
Orphanet: ORPHA137596

Definition

Neurotrophic keratopathy is a rare degenerative disease of the cornea characterized by reduction or loss of corneal sensitivity that can be asymptomatic or present with red-eye and, during the early stages of the disease, a minor decrease in visual acuity. It eventually leads to loss of vision. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurotrophic keratopathy
Follow this link to review classifications for Neurotrophic keratopathy in Orphanet.

Professional guidelines

PubMed

Coco G, Piccotti G, Romano V, Ferro Desideri L, Vagge A, Traverso CE, Pellegrini M, Bruscolini A, Marenco M, Giannaccare G
Drugs Today (Barc) 2023 Mar;59(3):113-123. doi: 10.1358/dot.2023.59.3.3521858. PMID: 36847622
Okada Y, Reinach PS, Kitano A, Shirai K, Kao WW, Saika S
Histol Histopathol 2010 Jun;25(6):771-80. doi: 10.14670/HH-25.771. PMID: 20376784
Lambiase A, Rama P, Aloe L, Bonini S
Curr Opin Ophthalmol 1999 Aug;10(4):270-6. doi: 10.1097/00055735-199908000-00009. PMID: 10621535

Recent clinical studies

Etiology

Neurotrophic Keratopathy Study Group
Ocul Surf 2023 Oct;30:129-138. Epub 2023 Sep 4 doi: 10.1016/j.jtos.2023.09.001. PMID: 37666470
Kristan J, Kang JJ
Curr Opin Ophthalmol 2021 Jul 1;32(4):315-318. doi: 10.1097/ICU.0000000000000769. PMID: 33989233
Agarwal R, Nagpal R, Todi V, Sharma N
Surv Ophthalmol 2021 Jan-Feb;66(1):2-19. Epub 2020 Oct 13 doi: 10.1016/j.survophthal.2020.10.004. PMID: 33058926
Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, Foster CS, Affeldt J, Seedor JA, Afshari NA, Chao W, Allegretti M, Mantelli F, Dana R
Ophthalmology 2020 Jan;127(1):14-26. Epub 2019 Aug 26 doi: 10.1016/j.ophtha.2019.08.020. PMID: 31585826
Dua HS, Said DG, Messmer EM, Rolando M, Benitez-Del-Castillo JM, Hossain PN, Shortt AJ, Geerling G, Nubile M, Figueiredo FC, Rauz S, Mastropasqua L, Rama P, Baudouin C
Prog Retin Eye Res 2018 Sep;66:107-131. Epub 2018 Apr 23 doi: 10.1016/j.preteyeres.2018.04.003. PMID: 29698813

Diagnosis

NaPier E, Camacho M, McDevitt TF, Sweeney AR
Ann Med 2022 Dec;54(1):666-673. doi: 10.1080/07853890.2022.2045035. PMID: 35243932Free PMC Article
Yu FX, Lee PSY, Yang L, Gao N, Zhang Y, Ljubimov AV, Yang E, Zhou Q, Xie L
Prog Retin Eye Res 2022 Jul;89:101039. Epub 2022 Jan 4 doi: 10.1016/j.preteyeres.2021.101039. PMID: 34991965Free PMC Article
Kristan J, Kang JJ
Curr Opin Ophthalmol 2021 Jul 1;32(4):315-318. doi: 10.1097/ICU.0000000000000769. PMID: 33989233
Agarwal R, Nagpal R, Todi V, Sharma N
Surv Ophthalmol 2021 Jan-Feb;66(1):2-19. Epub 2020 Oct 13 doi: 10.1016/j.survophthal.2020.10.004. PMID: 33058926
Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, Foster CS, Affeldt J, Seedor JA, Afshari NA, Chao W, Allegretti M, Mantelli F, Dana R
Ophthalmology 2020 Jan;127(1):14-26. Epub 2019 Aug 26 doi: 10.1016/j.ophtha.2019.08.020. PMID: 31585826

Therapy

Kristan J, Kang JJ
Curr Opin Ophthalmol 2021 Jul 1;32(4):315-318. doi: 10.1097/ICU.0000000000000769. PMID: 33989233
Yeung A, Dwarakanathan S
Dis Mon 2021 May;67(5):101135. Epub 2021 Feb 4 doi: 10.1016/j.disamonth.2021.101135. PMID: 33551178
Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, Foster CS, Affeldt J, Seedor JA, Afshari NA, Chao W, Allegretti M, Mantelli F, Dana R
Ophthalmology 2020 Jan;127(1):14-26. Epub 2019 Aug 26 doi: 10.1016/j.ophtha.2019.08.020. PMID: 31585826
Di Zazzo A, Coassin M, Varacalli G, Galvagno E, De Vincentis A, Bonini S
Ocul Surf 2019 Oct;17(4):619-623. Epub 2019 Sep 14 doi: 10.1016/j.jtos.2019.09.002. PMID: 31526824
Dua HS, Said DG, Messmer EM, Rolando M, Benitez-Del-Castillo JM, Hossain PN, Shortt AJ, Geerling G, Nubile M, Figueiredo FC, Rauz S, Mastropasqua L, Rama P, Baudouin C
Prog Retin Eye Res 2018 Sep;66:107-131. Epub 2018 Apr 23 doi: 10.1016/j.preteyeres.2018.04.003. PMID: 29698813

Prognosis

Liu CY, Arteaga AC, Fung SE, Cortina MS, Leyngold IM, Aakalu VK
Ocul Surf 2021 Apr;20:163-172. Epub 2021 Feb 26 doi: 10.1016/j.jtos.2021.02.010. PMID: 33647470Free PMC Article
Ruiz-Lozano RE, Hernandez-Camarena JC, Loya-Garcia D, Merayo-Lloves J, Rodriguez-Garcia A
Ocul Surf 2021 Jan;19:224-240. Epub 2020 Oct 3 doi: 10.1016/j.jtos.2020.09.007. PMID: 33022412
Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, Foster CS, Affeldt J, Seedor JA, Afshari NA, Chao W, Allegretti M, Mantelli F, Dana R
Ophthalmology 2020 Jan;127(1):14-26. Epub 2019 Aug 26 doi: 10.1016/j.ophtha.2019.08.020. PMID: 31585826
Bonini S, Rama P, Olzi D, Lambiase A
Eye (Lond) 2003 Nov;17(8):989-95. doi: 10.1038/sj.eye.6700616. PMID: 14631406
Pushker N, Dada T, Vajpayee RB, Gupta V, Aggrawal T, Titiyal JS
CLAO J 2001 Apr;27(2):100-7. PMID: 11352446

Clinical prediction guides

Saini M, Kalia A, Jain AK, Gaba S, Malhotra C, Gupta A, Soni T, Saini K, Gupta PC, Singh M
PLoS One 2023;18(11):e0294756. Epub 2023 Nov 28 doi: 10.1371/journal.pone.0294756. PMID: 38015881Free PMC Article
Castillo-Macías A, Arreola-Martínez JE, Loya-García D, Valdez-García JE
Int Ophthalmol 2023 Sep;43(9):3257-3262. Epub 2023 May 4 doi: 10.1007/s10792-023-02726-x. PMID: 37140835Free PMC Article
Di Zazzo A, Coassin M, Varacalli G, Galvagno E, De Vincentis A, Bonini S
Ocul Surf 2019 Oct;17(4):619-623. Epub 2019 Sep 14 doi: 10.1016/j.jtos.2019.09.002. PMID: 31526824
Hsu HY, Modi D
Eye Contact Lens 2015 Sep;41(5):314-7. doi: 10.1097/ICL.0000000000000133. PMID: 25828513
Bikbova G, Oshitari T, Tawada A, Yamamoto S
Curr Diabetes Rev 2012 Jul 1;8(4):294-302. doi: 10.2174/157339912800840479. PMID: 22587515

Recent systematic reviews

Roumeau S, Dutheil F, Sapin V, Baker JS, Watson SL, Pereira B, Chiambaretta F, Navel V
Graefes Arch Clin Exp Ophthalmol 2022 Aug;260(8):2623-2637. Epub 2022 Mar 7 doi: 10.1007/s00417-022-05602-z. PMID: 35254511
Park JK, Charlson ES, Leyngold I, Kossler AL
Ophthalmic Plast Reconstr Surg 2020 Sep/Oct;36(5):431-437. doi: 10.1097/IOP.0000000000001583. PMID: 31923091

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