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Indeterminate colitis

MedGen UID:
87418
•Concept ID:
C0341332
•
Disease or Syndrome
Synonyms: Colitis of Indeterminate Type; colitis of indeterminate type; indeterminate colitis
SNOMED CT: Indeterminate colitis (235746007)
 
Monarch Initiative: MONDO:0006038

Definition

It describes patients in whom a diagnosis of ulcerative colitis or Crohn's disease cannot be made based on standard clinical testing, including colonoscopy, imaging, laboratory tests, and biopsy. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIndeterminate colitis

Professional guidelines

PubMed

Role of the combination of biologics and/or small molecules in the treatment of patients with inflammatory bowel disease.
Balderramo D
World J Gastroenterol 2022 Dec 21;28(47):6743-6751. doi: 10.3748/wjg.v28.i47.6743. PMID: 36620336Free PMC Article
Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview.
M'Koma AE
Medicina (Kaunas) 2022 Apr 21;58(5) doi: 10.3390/medicina58050567. PMID: 35629984Free PMC Article
Review article: Indeterminate colitis--definition, diagnosis and management.
Tremaine WJ
Aliment Pharmacol Ther 2007 Jan 1;25(1):13-7. doi: 10.1111/j.1365-2036.2006.03159.x. PMID: 17229217

Recent clinical studies

Etiology

Role of the combination of biologics and/or small molecules in the treatment of patients with inflammatory bowel disease.
Balderramo D
World J Gastroenterol 2022 Dec 21;28(47):6743-6751. doi: 10.3748/wjg.v28.i47.6743. PMID: 36620336Free PMC Article
Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview.
M'Koma AE
Medicina (Kaunas) 2022 Apr 21;58(5) doi: 10.3390/medicina58050567. PMID: 35629984Free PMC Article
The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM; COLORS in IBD Study Group and NEOPICS
Gastroenterology 2014 Nov;147(5):990-1007.e3. Epub 2014 Jul 21 doi: 10.1053/j.gastro.2014.07.023. PMID: 25058236Free PMC Article
Indeterminate colitis.
Mitchell PJ, Rabau MY, Haboubi NY
Tech Coloproctol 2007 Jun;11(2):91-6. Epub 2007 May 25 doi: 10.1007/s10151-007-0337-y. PMID: 17510748
Inflammatory bowel disease.
Chutkan RK
Prim Care 2001 Sep;28(3):539-56, vi. doi: 10.1016/s0095-4543(05)70052-x. PMID: 11483443

Diagnosis

Role of the combination of biologics and/or small molecules in the treatment of patients with inflammatory bowel disease.
Balderramo D
World J Gastroenterol 2022 Dec 21;28(47):6743-6751. doi: 10.3748/wjg.v28.i47.6743. PMID: 36620336Free PMC Article
Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview.
M'Koma AE
Medicina (Kaunas) 2022 Apr 21;58(5) doi: 10.3390/medicina58050567. PMID: 35629984Free PMC Article
Clinical presentation of Crohn's, ulcerative colitis, and indeterminate colitis: Symptoms, extraintestinal manifestations, and disease phenotypes.
Yu YR, Rodriguez JR
Semin Pediatr Surg 2017 Dec;26(6):349-355. Epub 2017 Oct 5 doi: 10.1053/j.sempedsurg.2017.10.003. PMID: 29126502
The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM; COLORS in IBD Study Group and NEOPICS
Gastroenterology 2014 Nov;147(5):990-1007.e3. Epub 2014 Jul 21 doi: 10.1053/j.gastro.2014.07.023. PMID: 25058236Free PMC Article
Indeterminate colitis.
Mitchell PJ, Rabau MY, Haboubi NY
Tech Coloproctol 2007 Jun;11(2):91-6. Epub 2007 May 25 doi: 10.1007/s10151-007-0337-y. PMID: 17510748

Therapy

Role of the combination of biologics and/or small molecules in the treatment of patients with inflammatory bowel disease.
Balderramo D
World J Gastroenterol 2022 Dec 21;28(47):6743-6751. doi: 10.3748/wjg.v28.i47.6743. PMID: 36620336Free PMC Article
A Comprehensive Approach to Pouch Disorders.
Quinn KP, Lightner AL, Faubion WA, Raffals LE
Inflamm Bowel Dis 2019 Feb 21;25(3):460-471. doi: 10.1093/ibd/izy267. PMID: 30124882
Probiotics for inflammatory bowel diseases: a promising adjuvant treatment.
Coqueiro AY, Raizel R, Bonvini A, Tirapegui J, Rogero MM
Int J Food Sci Nutr 2019 Feb;70(1):20-29. Epub 2018 May 28 doi: 10.1080/09637486.2018.1477123. PMID: 29804478
Inflammatory bowel disease.
Fatahzadeh M
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 Nov;108(5):e1-10. doi: 10.1016/j.tripleo.2009.07.035. PMID: 19836703
Inflammatory bowel disease.
Chutkan RK
Prim Care 2001 Sep;28(3):539-56, vi. doi: 10.1016/s0095-4543(05)70052-x. PMID: 11483443

Prognosis

A Comprehensive Approach to Pouch Disorders.
Quinn KP, Lightner AL, Faubion WA, Raffals LE
Inflamm Bowel Dis 2019 Feb 21;25(3):460-471. doi: 10.1093/ibd/izy267. PMID: 30124882
Allergic and Immunologic Perspectives of Inflammatory Bowel Disease.
Clarke K, Chintanaboina J
Clin Rev Allergy Immunol 2019 Oct;57(2):179-193. doi: 10.1007/s12016-018-8690-3. PMID: 29754190
The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM; COLORS in IBD Study Group and NEOPICS
Gastroenterology 2014 Nov;147(5):990-1007.e3. Epub 2014 Jul 21 doi: 10.1053/j.gastro.2014.07.023. PMID: 25058236Free PMC Article
Is indeterminate colitis determinable?
Tremaine WJ
Curr Gastroenterol Rep 2012 Apr;14(2):162-5. doi: 10.1007/s11894-012-0244-x. PMID: 22314810
Crohn's disease, ulcerative colitis or indeterminate colitis--how important is it to differentiate?
Geboes K
Acta Gastroenterol Belg 2001 Apr-Jun;64(2):197-200. PMID: 11475135

Clinical prediction guides

Reporting Colonic Biopsies in Patients With Inflammatory Bowel Disease; a Practical Approach.
Haboubi N
Inflamm Bowel Dis 2019 Mar 14;25(4):679-684. doi: 10.1093/ibd/izy288. PMID: 30256953
The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM; COLORS in IBD Study Group and NEOPICS
Gastroenterology 2014 Nov;147(5):990-1007.e3. Epub 2014 Jul 21 doi: 10.1053/j.gastro.2014.07.023. PMID: 25058236Free PMC Article
Endoscopy in inflammatory bowel disease.
Carter D, Lang A, Eliakim R
Minerva Gastroenterol Dietol 2013 Sep;59(3):273-84. PMID: 23867947
Is indeterminate colitis determinable?
Tremaine WJ
Curr Gastroenterol Rep 2012 Apr;14(2):162-5. doi: 10.1007/s11894-012-0244-x. PMID: 22314810
Indeterminate colitis.
Guindi M, Riddell RH
J Clin Pathol 2004 Dec;57(12):1233-44. doi: 10.1136/jcp.2003.015214. PMID: 15563659Free PMC Article

Recent systematic reviews

MEFV Mutations in IBD Patients: A Systematic Review and Meta- analysis.
Papadopoulos VP, Antoniadou C, Ritis K, Skendros P
J Gastrointestin Liver Dis 2022 Mar 19;31(1):85-97. doi: 10.15403/jgld-4070. PMID: 35306551
COVID-19 and Outcomes in Patients With Inflammatory Bowel Disease: Systematic Review and Meta-Analysis.
Tripathi K, Godoy Brewer G, Thu Nguyen M, Singh Y, Saleh Ismail M, Sauk JS, Parian AM, Limketkai BN
Inflamm Bowel Dis 2022 Aug 1;28(8):1265-1279. doi: 10.1093/ibd/izab236. PMID: 34718595Free PMC Article
Rectal stump management in inflammatory bowel disease: a cohort study, systematic review and proportional analysis of perioperative complications.
Lawday S, Leaning M, Flannery O, Summers S, Antoniou GA, Goodhand J, Bethune R, Antoniou SA
Tech Coloproctol 2020 Jul;24(7):671-684. Epub 2020 Mar 31 doi: 10.1007/s10151-020-02188-8. PMID: 32236745
Outcome of Ileal Pouch-anal Anastomosis in Patients With Indeterminate Colitis: A Systematic Review and Meta-analysis.
Emile SH, Gilshtein H, Wexner SD
J Crohns Colitis 2020 Jul 30;14(7):1010-1020. doi: 10.1093/ecco-jcc/jjaa002. PMID: 31912129
Serological antibodies in inflammatory bowel disease: a systematic review.
Prideaux L, De Cruz P, Ng SC, Kamm MA
Inflamm Bowel Dis 2012 Jul;18(7):1340-55. Epub 2011 Nov 8 doi: 10.1002/ibd.21903. PMID: 22069240

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