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Nail infection

MedGen UID:
87467
•Concept ID:
C0343026
•
Disease or Syndrome
Synonym: Nail infections
SNOMED CT: Infection of nail (238408000)
 
Monarch Initiative: MONDO:0024487

Definition

An infectious process affecting the nail. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNail infection

Professional guidelines

PubMed

Onychomycosis: Diagnosis, Treatment, and Prevention.
Beuscher TL, Kelechi TJ
J Wound Ostomy Continence Nurs 2019 Jul/Aug;46(4):333-335. doi: 10.1097/WON.0000000000000556. PMID: 31274864
Global perspectives for the management of onychomycosis.
Gupta AK, Mays RR, Versteeg SG, Piraccini BM, Takwale A, Shemer A, Babaev M, Grover C, Di Chiacchio NG, Taborda PRO, Taborda VBA, Shear NH, Piguet V, Tosti A
Int J Dermatol 2019 Oct;58(10):1118-1129. Epub 2018 Dec 25 doi: 10.1111/ijd.14346. PMID: 30585300
Onychomycosis: Treatment and prevention of recurrence.
Lipner SR, Scher RK
J Am Acad Dermatol 2019 Apr;80(4):853-867. Epub 2018 Jun 28 doi: 10.1016/j.jaad.2018.05.1260. PMID: 29959962

Recent clinical studies

Etiology

S1 Guideline onychomycosis.
Nenoff P, Reinel D, Mayser P, Abeck D, Bezold G, Bosshard PP, Brasch J, Daeschlein G, Effendy I, Ginter-Hanselmayer G, Gräser Y, Hamm G, Hengge U, Hipler UC, Höger P, Kargl A, Kolb-Mäurer A, Krüger C, Malisiewicz B, Mayer J, Ott H, Paasch U, Schaller M, Uhrlaß S, Zidane M
J Dtsch Dermatol Ges 2023 Jun;21(6):678-692. Epub 2023 May 22 doi: 10.1111/ddg.14988. PMID: 37212291
Onychomycosis: Treatment and prevention of recurrence.
Lipner SR, Scher RK
J Am Acad Dermatol 2019 Apr;80(4):853-867. Epub 2018 Jun 28 doi: 10.1016/j.jaad.2018.05.1260. PMID: 29959962
Onychomycosis: Clinical overview and diagnosis.
Lipner SR, Scher RK
J Am Acad Dermatol 2019 Apr;80(4):835-851. Epub 2018 Jun 28 doi: 10.1016/j.jaad.2018.03.062. PMID: 29959961
Fungal melanonychia.
Finch J, Arenas R, Baran R
J Am Acad Dermatol 2012 May;66(5):830-41. Epub 2012 Jan 17 doi: 10.1016/j.jaad.2010.11.018. PMID: 22257832
How should fungal nail infection be treated?
Drug Ther Bull 2008 Jan;46(1):3-8. doi: 10.1136/dtb.2007.12.0007. PMID: 18171727

Diagnosis

S1 Guideline onychomycosis.
Nenoff P, Reinel D, Mayser P, Abeck D, Bezold G, Bosshard PP, Brasch J, Daeschlein G, Effendy I, Ginter-Hanselmayer G, Gräser Y, Hamm G, Hengge U, Hipler UC, Höger P, Kargl A, Kolb-Mäurer A, Krüger C, Malisiewicz B, Mayer J, Ott H, Paasch U, Schaller M, Uhrlaß S, Zidane M
J Dtsch Dermatol Ges 2023 Jun;21(6):678-692. Epub 2023 May 22 doi: 10.1111/ddg.14988. PMID: 37212291
Onychomycosis: a review.
Gupta AK, Stec N, Summerbell RC, Shear NH, Piguet V, Tosti A, Piraccini BM
J Eur Acad Dermatol Venereol 2020 Sep;34(9):1972-1990. Epub 2020 Jun 5 doi: 10.1111/jdv.16394. PMID: 32239567
Onychomycosis: Treatment and prevention of recurrence.
Lipner SR, Scher RK
J Am Acad Dermatol 2019 Apr;80(4):853-867. Epub 2018 Jun 28 doi: 10.1016/j.jaad.2018.05.1260. PMID: 29959962
Onychomycosis: Clinical overview and diagnosis.
Lipner SR, Scher RK
J Am Acad Dermatol 2019 Apr;80(4):835-851. Epub 2018 Jun 28 doi: 10.1016/j.jaad.2018.03.062. PMID: 29959961
Fungal melanonychia.
Finch J, Arenas R, Baran R
J Am Acad Dermatol 2012 May;66(5):830-41. Epub 2012 Jan 17 doi: 10.1016/j.jaad.2010.11.018. PMID: 22257832

Therapy

S1 Guideline onychomycosis.
Nenoff P, Reinel D, Mayser P, Abeck D, Bezold G, Bosshard PP, Brasch J, Daeschlein G, Effendy I, Ginter-Hanselmayer G, Gräser Y, Hamm G, Hengge U, Hipler UC, Höger P, Kargl A, Kolb-Mäurer A, Krüger C, Malisiewicz B, Mayer J, Ott H, Paasch U, Schaller M, Uhrlaß S, Zidane M
J Dtsch Dermatol Ges 2023 Jun;21(6):678-692. Epub 2023 May 22 doi: 10.1111/ddg.14988. PMID: 37212291
Efinaconazole in Onychomycosis.
Gupta AK, Talukder M
Am J Clin Dermatol 2022 Mar;23(2):207-218. Epub 2021 Dec 13 doi: 10.1007/s40257-021-00660-1. PMID: 34902110
Onychomycosis: a review.
Gupta AK, Stec N, Summerbell RC, Shear NH, Piguet V, Tosti A, Piraccini BM
J Eur Acad Dermatol Venereol 2020 Sep;34(9):1972-1990. Epub 2020 Jun 5 doi: 10.1111/jdv.16394. PMID: 32239567
Onychomycosis: Treatment and prevention of recurrence.
Lipner SR, Scher RK
J Am Acad Dermatol 2019 Apr;80(4):853-867. Epub 2018 Jun 28 doi: 10.1016/j.jaad.2018.05.1260. PMID: 29959962
Transungual permeation: current insights.
Bhuptani RS, Deshpande KM, Patravale VB
Drug Deliv Transl Res 2016 Aug;6(4):426-39. doi: 10.1007/s13346-015-0259-6. PMID: 26419676

Prognosis

Pharmacotherapy for onychomycosis: new and emerging treatments.
Lipner SR
Expert Opin Pharmacother 2019 Apr;20(6):725-735. Epub 2019 Jan 28 doi: 10.1080/14656566.2019.1571039. PMID: 30689469
Onychomycosis: Treatment and prevention of recurrence.
Lipner SR, Scher RK
J Am Acad Dermatol 2019 Apr;80(4):853-867. Epub 2018 Jun 28 doi: 10.1016/j.jaad.2018.05.1260. PMID: 29959962
Fungal melanonychia.
Finch J, Arenas R, Baran R
J Am Acad Dermatol 2012 May;66(5):830-41. Epub 2012 Jan 17 doi: 10.1016/j.jaad.2010.11.018. PMID: 22257832
Onychomycosis: diagnosis and definition of cure.
Scher RK, Tavakkol A, Sigurgeirsson B, Hay RJ, Joseph WS, Tosti A, Fleckman P, Ghannoum M, Armstrong DG, Markinson BC, Elewski BE
J Am Acad Dermatol 2007 Jun;56(6):939-44. Epub 2007 Feb 16 doi: 10.1016/j.jaad.2006.12.019. PMID: 17307276
Epidemiology and ecology of onychomycosis.
Summerbell RC
Dermatology 1997;194 Suppl 1:32-6. doi: 10.1159/000246182. PMID: 9154399

Clinical prediction guides

Reflectance confocal microscopy for the diagnosis of skin infections and infestations.
Pimenta R, Soares-de-Almeida L, Arzberger E, Ferreira J, Leal-Filipe P, Bastos PM, Oliveira AL
Dermatol Online J 2020 Mar 15;26(3) PMID: 32609438
Secukinumab Therapy for Netherton Syndrome.
Luchsinger I, Knöpfel N, Theiler M, Bonnet des Claustres M, Barbieux C, Schwieger-Briel A, Brunner C, Donghi D, Buettcher M, Meier-Schiesser B, Hovnanian A, Weibel L
JAMA Dermatol 2020 Aug 1;156(8):907-911. doi: 10.1001/jamadermatol.2020.1019. PMID: 32459284Free PMC Article
Antifungal susceptibility patterns of yeasts and filamentous fungi isolated from nail infection.
Ataides FS, Chaul MH, El Essal FE, Costa CR, Souza LK, Fernandes OF, Silva MR
J Eur Acad Dermatol Venereol 2012 Dec;26(12):1479-85. Epub 2011 Nov 3 doi: 10.1111/j.1468-3083.2011.04315.x. PMID: 22049990
Onychomycosis: diagnosis and definition of cure.
Scher RK, Tavakkol A, Sigurgeirsson B, Hay RJ, Joseph WS, Tosti A, Fleckman P, Ghannoum M, Armstrong DG, Markinson BC, Elewski BE
J Am Acad Dermatol 2007 Jun;56(6):939-44. Epub 2007 Feb 16 doi: 10.1016/j.jaad.2006.12.019. PMID: 17307276
Dermatophilus congolensis human infection.
Towersey L, Martins Ede C, Londero AT, Hay RJ, Soares Filho PJ, Takiya CM, Martins CC, Gompertz OF
J Am Acad Dermatol 1993 Aug;29(2 Pt 2):351-4. doi: 10.1016/0190-9622(93)70194-x. PMID: 8340513

Recent systematic reviews

Race reporting and representation in onychomycosis clinical trials: A systematic review.
Chang MJ, Qiu Y, Lipner SR
Mycoses 2021 Aug;64(8):954-966. Epub 2021 Mar 13 doi: 10.1111/myc.13262. PMID: 33655595
A systematic review and meta-analysis on the epidemiology, casual agents and demographic characteristics of onychomycosis in Iran.
Rafat Z, Hashemi SJ, Saboor-Yaraghi AA, Pouragha B, Taheriniya A, Moosavi A, Roohi B, Arjmand R, Moradi A, Daie-Ghazvini R, Basiri S
J Mycol Med 2019 Sep;29(3):265-272. Epub 2019 Jul 5 doi: 10.1016/j.mycmed.2019.05.004. PMID: 31285126

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