U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Congenital varicella syndrome

MedGen UID:
87473
•Concept ID:
C0343560
•
Disease or Syndrome
Synonyms: Fetal effects of Chickenpox; Fetal effects of varicella zoster virus; Fetal varicella infection; Fetal varicella zoster syndrome; Varicella Embryopathy
SNOMED CT: Congenital varicella syndrome (277644009)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0017372
Orphanet: ORPHA291

Definition

A rare acquired developmental anomaly syndrome characterized by skin, neurological, ocular, limbs and growth defects secondary to maternal Varicella-Zoster Virus (VZV) infection. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCongenital varicella syndrome

Professional guidelines

PubMed

Management of varicella-zoster virus primary infection during pregnancy: A national survey of practice.
Benoit G, Etchemendigaray C, Nguyen-Xuan HT, Vauloup-Fellous C, Ayoubi JM, Picone O
J Clin Virol 2015 Nov;72:4-10. Epub 2015 Jul 26 doi: 10.1016/j.jcv.2015.07.301. PMID: 26356985
Varicella and the pregnant woman: prevention and management.
Daley AJ, Thorpe S, Garland SM
Aust N Z J Obstet Gynaecol 2008 Feb;48(1):26-33. doi: 10.1111/j.1479-828X.2007.00797.x. PMID: 18275568
Management of varicella-zoster contact and infection in pregnancy using a standardized varicella-zoster ELISA test.
Enders G
Postgrad Med J 1985;61 Suppl 4:23-30. PMID: 3014475

Recent clinical studies

Etiology

Varicella in the fetus and newborn.
Smith CK, Arvin AM
Semin Fetal Neonatal Med 2009 Aug;14(4):209-17. Epub 2008 Dec 19 doi: 10.1016/j.siny.2008.11.008. PMID: 19097954
The congenital varicella syndrome.
Sauerbrei A, Wutzler P
J Perinatol 2000 Dec;20(8 Pt 1):548-54. doi: 10.1038/sj.jp.7200457. PMID: 11190597
Pediatric Horner syndrome.
Jeffery AR, Ellis FJ, Repka MX, Buncic JR
J AAPOS 1998 Jun;2(3):159-67. doi: 10.1016/s1091-8531(98)90008-8. PMID: 10532753
Varicella and pregnancy.
Dufour P, de Bièvre P, Vinatier D, Tordjeman N, Da Lage B, Vanhove J, Monnier JC
Eur J Obstet Gynecol Reprod Biol 1996 Jun;66(2):119-23. doi: 10.1016/0301-2115(96)02395-0. PMID: 8735731
Congenital varicella syndrome.
Hajdi G, Mészner Z, Nyerges G, Büky B, Simon M
Infection 1986 Jul-Aug;14(4):177-80. doi: 10.1007/BF01645259. PMID: 3019895

Diagnosis

Common Skin Conditions in Children: Neonatal Skin Lesions.
Rayala BZ, Morrell DS
FP Essent 2017 Feb;453:11-17. PMID: 28196316
Congenital and perinatally-acquired infections in resource-constrained settings.
Madrid L, Varo R, Sitoe A, Bassat Q
Expert Rev Anti Infect Ther 2016 Sep;14(9):845-61. Epub 2016 Jul 31 doi: 10.1080/14787210.2016.1215913. PMID: 27442227
The congenital varicella syndrome.
Sauerbrei A, Wutzler P
J Perinatol 2000 Dec;20(8 Pt 1):548-54. doi: 10.1038/sj.jp.7200457. PMID: 11190597
Pediatric Horner syndrome.
Jeffery AR, Ellis FJ, Repka MX, Buncic JR
J AAPOS 1998 Jun;2(3):159-67. doi: 10.1016/s1091-8531(98)90008-8. PMID: 10532753
Varicella and pregnancy.
Dufour P, de Bièvre P, Vinatier D, Tordjeman N, Da Lage B, Vanhove J, Monnier JC
Eur J Obstet Gynecol Reprod Biol 1996 Jun;66(2):119-23. doi: 10.1016/0301-2115(96)02395-0. PMID: 8735731

Therapy

The role of VariZIG in pregnancy.
Bapat P, Koren G
Expert Rev Vaccines 2013 Nov;12(11):1243-8. Epub 2013 Oct 4 doi: 10.1586/14760584.2013.844651. PMID: 24093779
Varicella-zoster virus: Prevention through vaccination.
Gnann JW Jr
Clin Obstet Gynecol 2012 Jun;55(2):560-70. doi: 10.1097/GRF.0b013e3182510b67. PMID: 22510639
Varicella in the fetus and newborn.
Smith CK, Arvin AM
Semin Fetal Neonatal Med 2009 Aug;14(4):209-17. Epub 2008 Dec 19 doi: 10.1016/j.siny.2008.11.008. PMID: 19097954
Varicella and the pregnant woman: prevention and management.
Daley AJ, Thorpe S, Garland SM
Aust N Z J Obstet Gynaecol 2008 Feb;48(1):26-33. doi: 10.1111/j.1479-828X.2007.00797.x. PMID: 18275568
Chickenpox in pregnancy: revisited.
Tan MP, Koren G
Reprod Toxicol 2006 May;21(4):410-20. Epub 2005 Jun 23 doi: 10.1016/j.reprotox.2005.04.011. PMID: 15979274

Prognosis

Congenital Varicella Syndrome.
Kodur VV, Hegde DG
Indian Pediatr 2016 Mar;53(3):269. PMID: 27029702
Congenital varicella syndrome: A systematic review.
Ahn KH, Park YJ, Hong SC, Lee EH, Lee JS, Oh MJ, Kim HJ
J Obstet Gynaecol 2016 Jul;36(5):563-6. Epub 2016 Mar 10 doi: 10.3109/01443615.2015.1127905. PMID: 26965725
Frequency of congenital varicella syndrome in a prospective cohort of 347 pregnant women.
Harger JH, Ernest JM, Thurnau GR, Moawad A, Thom E, Landon MB, Paul R, Miodovnik M, Dombrowski M, Sibai B, Van Dorsten P, McNellis D; National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units
Obstet Gynecol 2002 Aug;100(2):260-5. doi: 10.1016/s0029-7844(02)02059-8. PMID: 12151147
Varicella infection in pregnancy.
McCarter-Spaulding DE
J Obstet Gynecol Neonatal Nurs 2001 Nov-Dec;30(6):667-73. doi: 10.1111/j.1552-6909.2001.tb00014.x. PMID: 11724203
Congenital varicella syndrome as an unusual cause of congenital malformation: report of one case.
Huang CS, Lin SP, Chiu NC, Hung HY
Acta Paediatr Taiwan 2001 Jul-Aug;42(4):239-42. PMID: 11550414

Clinical prediction guides

Management of varicella-zoster virus primary infection during pregnancy: A national survey of practice.
Benoit G, Etchemendigaray C, Nguyen-Xuan HT, Vauloup-Fellous C, Ayoubi JM, Picone O
J Clin Virol 2015 Nov;72:4-10. Epub 2015 Jul 26 doi: 10.1016/j.jcv.2015.07.301. PMID: 26356985
Varicella vaccination in Japan: necessity of implementing a routine vaccination program.
Ozaki T
J Infect Chemother 2013 Apr;19(2):188-95. Epub 2013 Mar 13 doi: 10.1007/s10156-013-0577-x. PMID: 23483311
Varicella-zoster virus infections in pregnancy.
Sauerbrei A
Intervirology 1998;41(4-5):191-6. doi: 10.1159/000024935. PMID: 10213895
Varicella and pregnancy.
Dufour P, de Bièvre P, Vinatier D, Tordjeman N, Da Lage B, Vanhove J, Monnier JC
Eur J Obstet Gynecol Reprod Biol 1996 Jun;66(2):119-23. doi: 10.1016/0301-2115(96)02395-0. PMID: 8735731
Intrauterine infection with varicella-zoster virus after maternal varicella.
Paryani SG, Arvin AM
N Engl J Med 1986 Jun 12;314(24):1542-6. doi: 10.1056/NEJM198606123142403. PMID: 3012334

Recent systematic reviews

Congenital varicella syndrome: A systematic review.
Ahn KH, Park YJ, Hong SC, Lee EH, Lee JS, Oh MJ, Kim HJ
J Obstet Gynaecol 2016 Jul;36(5):563-6. Epub 2016 Mar 10 doi: 10.3109/01443615.2015.1127905. PMID: 26965725

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...