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Congenital varicella syndrome

MedGen UID:
87473
Concept ID:
C0343560
Disease or Syndrome
Synonyms: Fetal effects of Chickenpox; Fetal effects of varicella zoster virus; Fetal varicella infection; Fetal varicella zoster syndrome; Varicella Embryopathy
SNOMED CT: Congenital varicella syndrome (277644009)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0017372
Orphanet: ORPHA291

Definition

A rare acquired developmental anomaly syndrome characterized by skin, neurological, ocular, limbs and growth defects secondary to maternal Varicella-Zoster Virus (VZV) infection. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCongenital varicella syndrome

Professional guidelines

PubMed

Benoit G, Etchemendigaray C, Nguyen-Xuan HT, Vauloup-Fellous C, Ayoubi JM, Picone O
J Clin Virol 2015 Nov;72:4-10. Epub 2015 Jul 26 doi: 10.1016/j.jcv.2015.07.301. PMID: 26356985
Daley AJ, Thorpe S, Garland SM
Aust N Z J Obstet Gynaecol 2008 Feb;48(1):26-33. doi: 10.1111/j.1479-828X.2007.00797.x. PMID: 18275568
Enders G
Postgrad Med J 1985;61 Suppl 4:23-30. PMID: 3014475

Recent clinical studies

Etiology

Teutsch SM, Nunez CA, Morris A, Eslick GD, Elliott EJ
Commun Dis Intell (2018) 2023 Aug 24;47 doi: 10.33321/cdi.2023.47.46. PMID: 37817313
Smith CK, Arvin AM
Semin Fetal Neonatal Med 2009 Aug;14(4):209-17. Epub 2008 Dec 19 doi: 10.1016/j.siny.2008.11.008. PMID: 19097954
Tan MP, Koren G
Reprod Toxicol 2006 May;21(4):410-20. Epub 2005 Jun 23 doi: 10.1016/j.reprotox.2005.04.011. PMID: 15979274
Sauerbrei A, Wutzler P
J Perinatol 2000 Dec;20(8 Pt 1):548-54. doi: 10.1038/sj.jp.7200457. PMID: 11190597
Jeffery AR, Ellis FJ, Repka MX, Buncic JR
J AAPOS 1998 Jun;2(3):159-67. doi: 10.1016/s1091-8531(98)90008-8. PMID: 10532753

Diagnosis

Rayala BZ, Morrell DS
FP Essent 2017 Feb;453:11-17. PMID: 28196316
Madrid L, Varo R, Sitoe A, Bassat Q
Expert Rev Anti Infect Ther 2016 Sep;14(9):845-61. Epub 2016 Jul 31 doi: 10.1080/14787210.2016.1215913. PMID: 27442227
Tan MP, Koren G
Reprod Toxicol 2006 May;21(4):410-20. Epub 2005 Jun 23 doi: 10.1016/j.reprotox.2005.04.011. PMID: 15979274
Sauerbrei A, Wutzler P
J Perinatol 2000 Dec;20(8 Pt 1):548-54. doi: 10.1038/sj.jp.7200457. PMID: 11190597
Jeffery AR, Ellis FJ, Repka MX, Buncic JR
J AAPOS 1998 Jun;2(3):159-67. doi: 10.1016/s1091-8531(98)90008-8. PMID: 10532753

Therapy

Bapat P, Koren G
Expert Rev Vaccines 2013 Nov;12(11):1243-8. Epub 2013 Oct 4 doi: 10.1586/14760584.2013.844651. PMID: 24093779
Lamont RF, Sobel JD, Carrington D, Mazaki-Tovi S, Kusanovic JP, Vaisbuch E, Romero R
BJOG 2011 Sep;118(10):1155-62. Epub 2011 May 18 doi: 10.1111/j.1471-0528.2011.02983.x. PMID: 21585641Free PMC Article
Smith CK, Arvin AM
Semin Fetal Neonatal Med 2009 Aug;14(4):209-17. Epub 2008 Dec 19 doi: 10.1016/j.siny.2008.11.008. PMID: 19097954
Daley AJ, Thorpe S, Garland SM
Aust N Z J Obstet Gynaecol 2008 Feb;48(1):26-33. doi: 10.1111/j.1479-828X.2007.00797.x. PMID: 18275568
Tan MP, Koren G
Reprod Toxicol 2006 May;21(4):410-20. Epub 2005 Jun 23 doi: 10.1016/j.reprotox.2005.04.011. PMID: 15979274

Prognosis

Teutsch SM, Nunez CA, Morris A, McGregor S, King J, Brotherton JM, Novakovic D, Booy R, Jones CA, Rawlinson W, Thorley BR, Elliott EJ
Commun Dis Intell (2018) 2020 Aug 17;44 doi: 10.33321/cdi.2020.44.60. PMID: 32829700
Kodur VV, Hegde DG
Indian Pediatr 2016 Mar;53(3):269. PMID: 27029702
Ahn KH, Park YJ, Hong SC, Lee EH, Lee JS, Oh MJ, Kim HJ
J Obstet Gynaecol 2016 Jul;36(5):563-6. Epub 2016 Mar 10 doi: 10.3109/01443615.2015.1127905. PMID: 26965725
Harger JH, Ernest JM, Thurnau GR, Moawad A, Thom E, Landon MB, Paul R, Miodovnik M, Dombrowski M, Sibai B, Van Dorsten P, McNellis D; National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units
Obstet Gynecol 2002 Aug;100(2):260-5. doi: 10.1016/s0029-7844(02)02059-8. PMID: 12151147
McCarter-Spaulding DE
J Obstet Gynecol Neonatal Nurs 2001 Nov-Dec;30(6):667-73. doi: 10.1111/j.1552-6909.2001.tb00014.x. PMID: 11724203

Clinical prediction guides

Trotta M, Borchi B, Niccolai A, Venturini E, Giaché S, Sterrantino G, Colao MG, Rossolini GM, Bartoloni A, Zammarchi L
Infection 2018 Oct;46(5):693-699. Epub 2018 May 15 doi: 10.1007/s15010-018-1150-4. PMID: 29766472
Benoit G, Etchemendigaray C, Nguyen-Xuan HT, Vauloup-Fellous C, Ayoubi JM, Picone O
J Clin Virol 2015 Nov;72:4-10. Epub 2015 Jul 26 doi: 10.1016/j.jcv.2015.07.301. PMID: 26356985
Ozaki T
J Infect Chemother 2013 Apr;19(2):188-95. Epub 2013 Mar 13 doi: 10.1007/s10156-013-0577-x. PMID: 23483311
Dufour P, de Bièvre P, Vinatier D, Tordjeman N, Da Lage B, Vanhove J, Monnier JC
Eur J Obstet Gynecol Reprod Biol 1996 Jun;66(2):119-23. doi: 10.1016/0301-2115(96)02395-0. PMID: 8735731
Paryani SG, Arvin AM
N Engl J Med 1986 Jun 12;314(24):1542-6. doi: 10.1056/NEJM198606123142403. PMID: 3012334

Recent systematic reviews

Ahn KH, Park YJ, Hong SC, Lee EH, Lee JS, Oh MJ, Kim HJ
J Obstet Gynaecol 2016 Jul;36(5):563-6. Epub 2016 Mar 10 doi: 10.3109/01443615.2015.1127905. PMID: 26965725

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