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HIV wasting syndrome

MedGen UID:
87476
•Concept ID:
C0343755
•
Disease or Syndrome
Synonyms: AIDS Wasting Syndrome; HIV Wasting Disease; HIV Wasting Syndrome; Slim Disease; Wasting Disease, HIV; Wasting Syndrome, AIDS; Wasting Syndrome, HIV
SNOMED CT: Acquired immunodeficiency syndrome wasting syndrome (1260096003); AIDS (acquired immunodeficiency syndrome) wasting syndrome (1260096003); Slim disease (1260096003); Wasting syndrome due to acquired immunodeficiency syndrome (1260096003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005797
Orphanet: ORPHA90081

Definition

A rare condition associated with acquired immunodeficiency syndrome (AIDS) and characterized by unwanted weight loss (involving both fat and muscle) of more than ten percent of body weight, with either diarrhea or weakness and fever which have lasted at least 30 days and are not related to an infection. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHIV wasting syndrome

Professional guidelines

PubMed

Management of HIV wasting syndrome: a consensus conference.
Kotler D, Wanke C
J Acquir Immune Defic Syndr 2004 Dec 1;37 Suppl 5:S261. doi: 10.1097/01.qai.0000144380.01727.6f. PMID: 15722868
HIV wasting syndrome: treatment update.
Balog DL, Epstein ME, Amodio-Groton MI
Ann Pharmacother 1998 Apr;32(4):446-58. doi: 10.1345/aph.17072. PMID: 9562141
Treatment for HIV wasting syndrome.
Cat LK, Coleman RL
Ann Pharmacother 1994 May;28(5):595-7. PMID: 8068997

Recent clinical studies

Etiology

Definition, Burden, and Predictors of HIV-Associated Wasting and Low Weight in the OPERA Cohort.
Wohlfeiler MB, Weber RP, Brunet L, Siddiqui J, Harbour M, Phillips AL, Hayward B, Fusco JS, Hsu RK, Fusco GP
AIDS Res Hum Retroviruses 2023 Dec;39(12):636-643. Epub 2023 Aug 18 doi: 10.1089/AID.2023.0048. PMID: 37489298Free PMC Article
Long-term impact of HIV wasting on physical function.
Erlandson KM, Li X, Abraham AG, Margolick JB, Lake JE, Palella FJ Jr, Koletar SL, Brown TT
AIDS 2016 Jan 28;30(3):445-54. doi: 10.1097/QAD.0000000000000932. PMID: 26760233Free PMC Article
Challenges of malnutrition care among HIV-infected children on antiretroviral treatment in Africa.
Jesson J, Leroy V
Med Mal Infect 2015 May;45(5):149-56. Epub 2015 Apr 7 doi: 10.1016/j.medmal.2015.03.002. PMID: 25861689
Growth hormone and HIV infection: contribution to disease manifestations and clinical implications.
Falutz J
Best Pract Res Clin Endocrinol Metab 2011 Jun;25(3):517-29. doi: 10.1016/j.beem.2010.11.001. PMID: 21663844
Testosterone therapy in HIV wasting syndrome: systematic review and meta-analysis.
Kong A, Edmonds P
Lancet Infect Dis 2002 Nov;2(11):692-9. doi: 10.1016/s1473-3099(02)00441-3. PMID: 12409050

Diagnosis

Definition, Burden, and Predictors of HIV-Associated Wasting and Low Weight in the OPERA Cohort.
Wohlfeiler MB, Weber RP, Brunet L, Siddiqui J, Harbour M, Phillips AL, Hayward B, Fusco JS, Hsu RK, Fusco GP
AIDS Res Hum Retroviruses 2023 Dec;39(12):636-643. Epub 2023 Aug 18 doi: 10.1089/AID.2023.0048. PMID: 37489298Free PMC Article
Challenges of malnutrition care among HIV-infected children on antiretroviral treatment in Africa.
Jesson J, Leroy V
Med Mal Infect 2015 May;45(5):149-56. Epub 2015 Apr 7 doi: 10.1016/j.medmal.2015.03.002. PMID: 25861689
Pharmacologic management of human immunodeficiency virus wasting syndrome.
Badowski M, Pandit NS
Pharmacotherapy 2014 Aug;34(8):868-81. Epub 2014 Apr 30 doi: 10.1002/phar.1431. PMID: 24782295
HIV-associated wasting in the HAART era: guidelines for assessment, diagnosis, and treatment.
Polsky B, Kotler D, Steinhart C
AIDS Patient Care STDS 2001 Aug;15(8):411-23. doi: 10.1089/108729101316914412. PMID: 11522215
Wasting in cancer.
Tisdale MJ
J Nutr 1999 Jan;129(1S Suppl):243S-246S. doi: 10.1093/jn/129.1.243S. PMID: 9915907

Therapy

HIV enteropathy and 'Slim disease': Historical and current perspectives.
Kapembwa MS, Batman PA, Fleming SC, Griffin GE
Int J Infect Dis 2024 Feb;139:86-91. Epub 2023 Dec 4 doi: 10.1016/j.ijid.2023.11.037. PMID: 38052315
Are cannabinoids effective for HIV wasting syndrome?
Núñez A, Núñez C, Corsi O, Rada G
Medwave 2017 Dec 22;17(9):e7107. doi: 10.5867/medwave.2017.09.7107. PMID: 29272264
Mecasermin.
Keating GM
BioDrugs 2008;22(3):177-88. doi: 10.2165/00063030-200822030-00004. PMID: 18481900
Testosterone therapy in HIV wasting syndrome: systematic review and meta-analysis.
Kong A, Edmonds P
Lancet Infect Dis 2002 Nov;2(11):692-9. doi: 10.1016/s1473-3099(02)00441-3. PMID: 12409050
Thalidomide. A surprising recovery.
Stirling D, Sherman M, Strauss S
J Am Pharm Assoc (Wash) 1997 May-Jun;NS37(3):306-13. PMID: 9170807

Prognosis

Definition, Burden, and Predictors of HIV-Associated Wasting and Low Weight in the OPERA Cohort.
Wohlfeiler MB, Weber RP, Brunet L, Siddiqui J, Harbour M, Phillips AL, Hayward B, Fusco JS, Hsu RK, Fusco GP
AIDS Res Hum Retroviruses 2023 Dec;39(12):636-643. Epub 2023 Aug 18 doi: 10.1089/AID.2023.0048. PMID: 37489298Free PMC Article
Bone loss in patients with HIV infection.
Paccou J, Viget N, Legrout-Gérot I, Yazdanpanah Y, Cortet B
Joint Bone Spine 2009 Dec;76(6):637-41. doi: 10.1016/j.jbspin.2009.10.003. PMID: 19945322
Nutrition and HIV infection.
Salomon J, De TP, Melchior JC
Br J Nutr 2002 Jan;87 Suppl 1:S111-9. doi: 10.1079/bjn2001464. PMID: 11895147
Acquired immunodeficiency syndrome wasting, functional performance, and quality of life.
Roubenoff R
Am J Manag Care 2000 Sep;6(9):1003-16. PMID: 11184062
Treatment guidelines for HIV-associated wasting.
Nemechek PM, Polsky B, Gottlieb MS
Mayo Clin Proc 2000 Apr;75(4):386-94. doi: 10.4065/75.4.386. PMID: 10761494

Clinical prediction guides

Definition, Burden, and Predictors of HIV-Associated Wasting and Low Weight in the OPERA Cohort.
Wohlfeiler MB, Weber RP, Brunet L, Siddiqui J, Harbour M, Phillips AL, Hayward B, Fusco JS, Hsu RK, Fusco GP
AIDS Res Hum Retroviruses 2023 Dec;39(12):636-643. Epub 2023 Aug 18 doi: 10.1089/AID.2023.0048. PMID: 37489298Free PMC Article
Mecasermin.
Keating GM
BioDrugs 2008;22(3):177-88. doi: 10.2165/00063030-200822030-00004. PMID: 18481900
Role of recombinant human growth hormone in HIV-associated wasting and cachexia: pathophysiology and rationale for treatment.
Gelato M, McNurlan M, Freedland E
Clin Ther 2007 Nov;29(11):2269-88. doi: 10.1016/j.clinthera.2007.11.004. PMID: 18158071
Nutrition and HIV infection: review of weight loss and wasting in the era of highly active antiretroviral therapy from the nutrition for healthy living cohort.
Mangili A, Murman DH, Zampini AM, Wanke CA
Clin Infect Dis 2006 Mar 15;42(6):836-42. Epub 2006 Feb 7 doi: 10.1086/500398. PMID: 16477562
Body composition and nutritional parameters in HIV and AIDS patients.
Salomon J, de Truchis P, Melchior JC
Clin Chem Lab Med 2002 Dec;40(12):1329-33. doi: 10.1515/CCLM.2002.229. PMID: 12553439

Recent systematic reviews

Weight loss and mortality in people living with HIV: a systematic review and meta-analysis.
Cordeiro SA, Lopes TCP, Boechat AL, Gonçalves RL
BMC Infect Dis 2024 Jan 2;24(1):34. doi: 10.1186/s12879-023-08889-3. PMID: 38166819Free PMC Article
Magnitude of underweight, wasting and stunting among HIV positive children in East Africa: A systematic review and meta-analysis.
Abate BB, Aragie TG, Tesfaw G
PLoS One 2020;15(9):e0238403. Epub 2020 Sep 17 doi: 10.1371/journal.pone.0238403. PMID: 32941443Free PMC Article
Pharmacologic management of human immunodeficiency virus wasting syndrome.
Badowski M, Pandit NS
Pharmacotherapy 2014 Aug;34(8):868-81. Epub 2014 Apr 30 doi: 10.1002/phar.1431. PMID: 24782295
Efficacy of selected treatments of HIV wasting: a systematic review and meta-analysis.
Moyle GJ, Schoelles K, Fahrbach K, Frame D, James K, Scheye R, Cure-Bolt N
J Acquir Immune Defic Syndr 2004 Dec 1;37 Suppl 5:S262-76. doi: 10.1097/01.qai.0000144381.09350.5b. PMID: 15722869
Testosterone therapy in HIV wasting syndrome: systematic review and meta-analysis.
Kong A, Edmonds P
Lancet Infect Dis 2002 Nov;2(11):692-9. doi: 10.1016/s1473-3099(02)00441-3. PMID: 12409050

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