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Rectosigmoid junction neoplasm

MedGen UID:
87517
•Concept ID:
C0345873
•
Neoplastic Process
Synonyms: Neoplasm of rectosigmoid junction; Neoplasm of Rectosigmoid Junction; neoplasm of rectosigmoid junction; Neoplasm of the Rectosigmoid Junction; neoplasm of the rectosigmoid junction; rectosigmoid junction neoplasm; rectosigmoid junction neoplasm (disease); rectosigmoid junction tumor; rectosigmoid junction tumour; Rectosigmoid Neoplasm; rectosigmoid neoplasm; Rectosigmoid Tumor; rectosigmoid tumor; rectosigmoid tumour; Tumor of rectosigmoid junction; Tumor of Rectosigmoid Junction; tumor of rectosigmoid junction; Tumor of the Rectosigmoid Junction; tumor of the rectosigmoid junction; tumour of rectosigmoid junction; tumour of the rectosigmoid junction
SNOMED CT: Neoplasm of rectosigmoid junction (126848003); Tumor of rectosigmoid junction (126848003)
 
Monarch Initiative: MONDO:0002423

Definition

A benign or malignant neoplasm that affects the rectosigmoid region. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Rectosigmoid adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms. [from NCI]

Professional guidelines

PubMed

Comparative Effectiveness of Neoadjuvant Chemoradiation Versus Upfront Surgery in the Management of Recto-Sigmoid Junction Cancer.
Venigalla S, Chowdhry AK, Wojcieszynski AP, Lukens JN, Plastaras JP, Metz JM, Ben-Josef E, Mahmoud NN, Reiss KA, Shabason JE
Clin Colorectal Cancer 2018 Sep;17(3):e557-e568. Epub 2018 May 17 doi: 10.1016/j.clcc.2018.05.005. PMID: 29910004Free PMC Article
Colorectal cancer incidence and survival by sub-site and stage of diagnosis: a population-based study at the advent of national screening.
McDevitt J, Comber H, Walsh PM
Ir J Med Sci 2017 Feb;186(1):113-121. Epub 2016 Oct 18 doi: 10.1007/s11845-016-1513-8. PMID: 27752924
Colonic mucosal gene expression and genotype in irritable bowel syndrome patients with normal or elevated fecal bile acid excretion.
Camilleri M, Carlson P, Acosta A, Busciglio I
Am J Physiol Gastrointest Liver Physiol 2015 Jul 1;309(1):G10-20. Epub 2015 Apr 30 doi: 10.1152/ajpgi.00080.2015. PMID: 25930081Free PMC Article

Recent clinical studies

Etiology

Protein-truncating and rare missense variants in ATM and CHEK2 and associations with cancer in UK Biobank whole-exome sequence data.
Mukhtar TK, Wilcox N, Dennis J, Yang X, Naven M, Mavaddat N, Perry JRB, Gardner E, Easton DF
J Med Genet 2024 Oct 23;61(11):1016-1022. doi: 10.1136/jmg-2024-110127. PMID: 39209703Free PMC Article
Short Term Outcome of Laparoscopic Anterior Resection for Rectal Carcinoma.
Afrin T, Naznin KN, Habib MA, Ferdaus AM, Parveen F, Harun-Ar-Rashid M
Mymensingh Med J 2023 Oct;32(4):1028-1032. PMID: 37777897
Higher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer.
Holowatyj AN, Ose J, Gigic B, Lin T, Ulvik A, Geijsen AJMR, Brezina S, Kiblawi R, van Roekel EH, Baierl A, Böhm J, Bours MJL, Brenner H, Breukink SO, Chang-Claude J, de Wilt JHW, Grady WM, Grünberger T, Gumpenberger T, Herpel E, Hoffmeister M, Keulen ETP, Kok DE, Koole JL, Kosma K, Kouwenhoven EA, Kvalheim G, Li CI, Schirmacher P, Schrotz-King P, Singer MC, van Duijnhoven FJB, van Halteren HK, Vickers K, Vogelaar FJ, Warby CA, Wesselink E, Ueland PM, Ulrich AB, Schneider M, Habermann N, Kampman E, Weijenberg MP, Gsur A, Ulrich CM
Am J Clin Nutr 2022 Aug 4;116(2):303-313. doi: 10.1093/ajcn/nqac090. PMID: 35394006Free PMC Article
Rectal NETs and rectosigmoid junction NETs may need to be treated differently.
Cai W, Ge W, Hu H, Mao J
Cancer Med 2020 Feb;9(3):971-979. Epub 2019 Dec 16 doi: 10.1002/cam4.2779. PMID: 31840409Free PMC Article
Cancer risks in aluminum reduction plant workers: a review.
Gibbs GW, Labrèche F
J Occup Environ Med 2014 May;56(5 Suppl):S40-59. doi: 10.1097/JOM.0000000000000003. PMID: 24806725Free PMC Article

Diagnosis

Short Term Outcome of Laparoscopic Anterior Resection for Rectal Carcinoma.
Afrin T, Naznin KN, Habib MA, Ferdaus AM, Parveen F, Harun-Ar-Rashid M
Mymensingh Med J 2023 Oct;32(4):1028-1032. PMID: 37777897
Rectal actinomycosis mimicking malignancy.
Rajpoot A, Gowda C, Monappa V, Rodrigues G
Acta Chir Belg 2021 Feb;121(1):74-75. Epub 2021 Jan 19 doi: 10.1080/00015458.2020.1841487. PMID: 33461413
Rectal NETs and rectosigmoid junction NETs may need to be treated differently.
Cai W, Ge W, Hu H, Mao J
Cancer Med 2020 Feb;9(3):971-979. Epub 2019 Dec 16 doi: 10.1002/cam4.2779. PMID: 31840409Free PMC Article
Preoperative localization of distal colorectal tumours.
Bayrak S, Kinaci E, Ozakay A, Bektas CT, Yardimci AH, Arslan E, Sevinc MM, Bektas H
Ann Ital Chir 2016;87:595-600. PMID: 28070031
Rectal cancer in pregnancy: a diagnostic and therapeutic challenge.
Toosi M, Moaddabshoar L, Malek-Hosseini SA, Sasani MR, Mokhtari M, Mohammadianpanah M
J Egypt Natl Canc Inst 2014 Sep;26(3):175-9. Epub 2014 Apr 13 doi: 10.1016/j.jnci.2014.03.003. PMID: 25150133

Therapy

A postsurgical prognostic nomogram for patients with lymph node positive rectosigmoid junction adenocarcinoma.
Yanlong W, Yunxiao W, Yibing W
BMC Gastroenterol 2023 May 18;23(1):159. doi: 10.1186/s12876-023-02810-7. PMID: 37202718Free PMC Article
Postoperative Venous Thromboembolism in Colon and Rectal Cancer: Do Tumor Location and Operation Matter?
McKenna NP, Bews KA, Behm KT, Habermann EB, Cima RR
J Am Coll Surg 2023 Apr 1;236(4):658-665. Epub 2023 Jan 9 doi: 10.1097/XCS.0000000000000537. PMID: 36728394
Perspectives on modes of labour and delivery after different modalities of surgery for bowel endometriosis.
Gallagher B, Mallick R, Odejinmi F, Hosni MM
J Obstet Gynaecol 2022 Jul;42(5):1443-1447. Epub 2021 Dec 29 doi: 10.1080/01443615.2021.1997957. PMID: 34964412
The location-based resect and discard strategy for diminutive colorectal polyps: a prospective clinical study.
Taghiakbari M, Pohl H, Djinbachian R, Barkun A, Marques P, Bouin M, Deslandres E, Panzini B, Bouchard S, Weber A, von Renteln D
Endoscopy 2022 Apr;54(4):354-363. Epub 2021 Aug 26 doi: 10.1055/a-1546-9169. PMID: 34448185
Adenocarcinomas of the upper third of the rectum and the rectosigmoid junction seem to have similar prognosis as colon cancers even without radiotherapy, SAKK 40/87.
Käser SA, Froelicher J, Li Q, Müller S, Metzger U, Castiglione M, Laffer UT, Maurer CA
Langenbecks Arch Surg 2015 Aug;400(6):675-82. Epub 2014 Aug 28 doi: 10.1007/s00423-014-1243-1. PMID: 25163656

Prognosis

Postoperative Venous Thromboembolism in Colon and Rectal Cancer: Do Tumor Location and Operation Matter?
McKenna NP, Bews KA, Behm KT, Habermann EB, Cima RR
J Am Coll Surg 2023 Apr 1;236(4):658-665. Epub 2023 Jan 9 doi: 10.1097/XCS.0000000000000537. PMID: 36728394
Adult and Elderly Risk Factors of Mortality in 23,614 Emergently Admitted Patients with Rectal or Rectosigmoid Junction Malignancy.
Levy L, Smiley A, Latifi R
Int J Environ Res Public Health 2022 Jul 27;19(15) doi: 10.3390/ijerph19159203. PMID: 35954556Free PMC Article
Rectal NETs and rectosigmoid junction NETs may need to be treated differently.
Cai W, Ge W, Hu H, Mao J
Cancer Med 2020 Feb;9(3):971-979. Epub 2019 Dec 16 doi: 10.1002/cam4.2779. PMID: 31840409Free PMC Article
Primary Colonic Lymphoma.
Won RP, Lin MYC, Williams JL, Petrie BA
J Gastrointest Surg 2018 Feb;22(2):361-362. Epub 2017 Nov 29 doi: 10.1007/s11605-017-3472-4. PMID: 29188491
Rectal cancer in pregnancy: a diagnostic and therapeutic challenge.
Toosi M, Moaddabshoar L, Malek-Hosseini SA, Sasani MR, Mokhtari M, Mohammadianpanah M
J Egypt Natl Canc Inst 2014 Sep;26(3):175-9. Epub 2014 Apr 13 doi: 10.1016/j.jnci.2014.03.003. PMID: 25150133

Clinical prediction guides

Protein-truncating and rare missense variants in ATM and CHEK2 and associations with cancer in UK Biobank whole-exome sequence data.
Mukhtar TK, Wilcox N, Dennis J, Yang X, Naven M, Mavaddat N, Perry JRB, Gardner E, Easton DF
J Med Genet 2024 Oct 23;61(11):1016-1022. doi: 10.1136/jmg-2024-110127. PMID: 39209703Free PMC Article
Emergency and Elective Colorectal Cancer-Relationship between Clinical Factors, Tumor Topography and Surgical Strategies: A Cohort Study.
Coman IS, Vital RC, Coman VE, Burleanu C, Liţescu M, Florea CG, Cristian DA, Gorecki GP, Radu PA, Pleşea IE, Erchid A, Grigorean VT
Medicina (Kaunas) 2024 May 29;60(6) doi: 10.3390/medicina60060898. PMID: 38929515Free PMC Article
Short Term Outcome of Laparoscopic Anterior Resection for Rectal Carcinoma.
Afrin T, Naznin KN, Habib MA, Ferdaus AM, Parveen F, Harun-Ar-Rashid M
Mymensingh Med J 2023 Oct;32(4):1028-1032. PMID: 37777897
Adult and Elderly Risk Factors of Mortality in 23,614 Emergently Admitted Patients with Rectal or Rectosigmoid Junction Malignancy.
Levy L, Smiley A, Latifi R
Int J Environ Res Public Health 2022 Jul 27;19(15) doi: 10.3390/ijerph19159203. PMID: 35954556Free PMC Article
Rectal NETs and rectosigmoid junction NETs may need to be treated differently.
Cai W, Ge W, Hu H, Mao J
Cancer Med 2020 Feb;9(3):971-979. Epub 2019 Dec 16 doi: 10.1002/cam4.2779. PMID: 31840409Free PMC Article

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