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Liver sarcoma

MedGen UID:
87522
•Concept ID:
C0345906
•
Neoplastic Process
Synonyms: Hepatic Sarcoma; hepatic sarcoma; Liver Sarcoma; liver sarcoma; Sarcoma of liver; Sarcoma of Liver; sarcoma of liver; Sarcoma of the Liver; sarcoma of the liver
SNOMED CT: Sarcoma of liver (254601002)
 
Monarch Initiative: MONDO:0002397

Definition

A malignant soft tissue neoplasm that arises from the liver. Representative examples include angiosarcoma, undifferentiated (embryonal) sarcoma, rhabdomyosarcoma, and leiomyosarcoma. [from NCI]

Professional guidelines

PubMed

Surgical and oncological results after surgical treatment of patients diagnosed with sarcoma liver metastases.
González-Abós S, Molina Santos V, Homs Samsó R, Martín Arnau B, Rodríguez Blanco M, González López JA, López-Pousa A, Moral Duarte A, Sánchez-Cabús S
Cir Esp (Engl Ed) 2023 Feb;101(2):80-89. Epub 2022 Jul 25 doi: 10.1016/j.cireng.2022.07.009. PMID: 35901963
Surgical Treatment and Chemotherapy of Adult Primary Liver Sarcoma: Experiences from a Single Hospital in China.
Zhou F, Huang HZ, Zhou MT, Han SL
Dig Surg 2019;36(1):46-52. Epub 2018 Jan 18 doi: 10.1159/000486454. PMID: 29346784

Recent clinical studies

Etiology

The association between infectious agents and breast cancer: a review of the epidemiologic evidence.
Brantley KD, Tamimi RM
Breast Cancer Res Treat 2024 Sep;207(2):235-252. Epub 2024 Jul 6 doi: 10.1007/s10549-024-07388-6. PMID: 38971906
Primary sarcoma of the liver: A nationwide analysis of a rare mesenchymal tumor.
Finney N, Tran T, Hasjim BJ, Jakowatz J, Chiao E, Eng O, Wolf R, Jutric Z, Yamamoto M, Tran TB
J Surg Oncol 2024 Feb;129(2):358-364. Epub 2023 Oct 5 doi: 10.1002/jso.27477. PMID: 37796036
Undifferentiated sarcoma of the liver: Multicenter international experience of the Cooperative Soft-Tissue Sarcoma Group and Polish Paediatric Solid Tumor Group.
Murawski M, Scheer M, Leuschner I, Stefanowicz J, Bonar J, Dembowska-Bagińska B, Kaliciński P, Koscielniak E, Czauderna P, Fuchs J
Pediatr Blood Cancer 2020 Nov;67(11):e28598. Epub 2020 Jul 24 doi: 10.1002/pbc.28598. PMID: 32706511
Characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver: A report from the National Cancer Database.
Shi Y, Rojas Y, Zhang W, Beierle EA, Doski JJ, Goldfarb M, Goldin AB, Gow KW, Langer M, Meyers RL, Nuchtern JG, Vasudevan SA
Pediatr Blood Cancer 2017 Apr;64(4) Epub 2016 Oct 26 doi: 10.1002/pbc.26272. PMID: 27781381Free PMC Article
Liver transplantation for primary or metastatic sarcoma to the liver.
Husted TL, Neff G, Thomas MJ, Gross TG, Woodle ES, Buell JF
Am J Transplant 2006 Feb;6(2):392-7. doi: 10.1111/j.1600-6143.2005.01179.x. PMID: 16426326

Diagnosis

Adult primary liver sarcoma: systematic review.
Martins ACA, Costa Neto DCD, Silva JDDE, Moraes YM, LeÃo CS, Martins C
Rev Col Bras Cir 2020;47:e20202647. Epub 2020 Nov 30 doi: 10.1590/0100-6991e-20202647. PMID: 33263653
Undifferentiated sarcoma of the liver: Multicenter international experience of the Cooperative Soft-Tissue Sarcoma Group and Polish Paediatric Solid Tumor Group.
Murawski M, Scheer M, Leuschner I, Stefanowicz J, Bonar J, Dembowska-Bagińska B, Kaliciński P, Koscielniak E, Czauderna P, Fuchs J
Pediatr Blood Cancer 2020 Nov;67(11):e28598. Epub 2020 Jul 24 doi: 10.1002/pbc.28598. PMID: 32706511
Surgical Treatment and Chemotherapy of Adult Primary Liver Sarcoma: Experiences from a Single Hospital in China.
Zhou F, Huang HZ, Zhou MT, Han SL
Dig Surg 2019;36(1):46-52. Epub 2018 Jan 18 doi: 10.1159/000486454. PMID: 29346784
Characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver: A report from the National Cancer Database.
Shi Y, Rojas Y, Zhang W, Beierle EA, Doski JJ, Goldfarb M, Goldin AB, Gow KW, Langer M, Meyers RL, Nuchtern JG, Vasudevan SA
Pediatr Blood Cancer 2017 Apr;64(4) Epub 2016 Oct 26 doi: 10.1002/pbc.26272. PMID: 27781381Free PMC Article
Pitfalls in a sonographic diagnosis of liver abscess in children.
Chuang CC, Wu SF, Chen AC, Tsai MF, Lin CY, Chen W
Pediatr Neonatol 2012 Apr;53(2):98-104. Epub 2012 Mar 3 doi: 10.1016/j.pedneo.2012.01.006. PMID: 22503256

Therapy

Successful use of transarterial radioembolization with yttrium-90 (TARE-Y90) in two children with hepatoblastoma.
Aguado A, Dunn SP, Averill LW, Chikwava KR, Gresh R, Rabinowitz D, Katzenstein HM
Pediatr Blood Cancer 2020 Sep;67(9):e28421. Epub 2020 Jun 30 doi: 10.1002/pbc.28421. PMID: 32603027
Surgical Treatment and Chemotherapy of Adult Primary Liver Sarcoma: Experiences from a Single Hospital in China.
Zhou F, Huang HZ, Zhou MT, Han SL
Dig Surg 2019;36(1):46-52. Epub 2018 Jan 18 doi: 10.1159/000486454. PMID: 29346784
A single-institution retrospective cases series of childhood undifferentiated embryonal liver sarcoma (UELS): success of combined therapy and the use of orthotopic liver transplant.
Plant AS, Busuttil RW, Rana A, Nelson SD, Auerbach M, Federman NC
J Pediatr Hematol Oncol 2013 Aug;35(6):451-5. doi: 10.1097/MPH.0b013e318271c948. PMID: 23138115
A case of undifferentiated embryonic liver sarcoma mimicking cystic hydatid disease in an endemic region of the world.
Oral A, Yigiter M, Demirci E, Yildirim ZK, Kantarci M, Salman AB
J Pediatr Surg 2011 Nov;46(11):e5-9. doi: 10.1016/j.jpedsurg.2011.07.006. PMID: 22075370
Childhood undifferentiated embryonal liver sarcoma: clinical features and immunohistochemistry analysis.
Wei ZG, Tang LF, Chen ZM, Tang HF, Li MJ
J Pediatr Surg 2008 Oct;43(10):1912-9. doi: 10.1016/j.jpedsurg.2008.06.016. PMID: 18926232

Prognosis

Primary sarcoma of the liver: A nationwide analysis of a rare mesenchymal tumor.
Finney N, Tran T, Hasjim BJ, Jakowatz J, Chiao E, Eng O, Wolf R, Jutric Z, Yamamoto M, Tran TB
J Surg Oncol 2024 Feb;129(2):358-364. Epub 2023 Oct 5 doi: 10.1002/jso.27477. PMID: 37796036
Adult primary liver sarcoma: systematic review.
Martins ACA, Costa Neto DCD, Silva JDDE, Moraes YM, LeÃo CS, Martins C
Rev Col Bras Cir 2020;47:e20202647. Epub 2020 Nov 30 doi: 10.1590/0100-6991e-20202647. PMID: 33263653
Undifferentiated sarcoma of the liver: Multicenter international experience of the Cooperative Soft-Tissue Sarcoma Group and Polish Paediatric Solid Tumor Group.
Murawski M, Scheer M, Leuschner I, Stefanowicz J, Bonar J, Dembowska-Bagińska B, Kaliciński P, Koscielniak E, Czauderna P, Fuchs J
Pediatr Blood Cancer 2020 Nov;67(11):e28598. Epub 2020 Jul 24 doi: 10.1002/pbc.28598. PMID: 32706511
Surgical Treatment and Chemotherapy of Adult Primary Liver Sarcoma: Experiences from a Single Hospital in China.
Zhou F, Huang HZ, Zhou MT, Han SL
Dig Surg 2019;36(1):46-52. Epub 2018 Jan 18 doi: 10.1159/000486454. PMID: 29346784
Characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver: A report from the National Cancer Database.
Shi Y, Rojas Y, Zhang W, Beierle EA, Doski JJ, Goldfarb M, Goldin AB, Gow KW, Langer M, Meyers RL, Nuchtern JG, Vasudevan SA
Pediatr Blood Cancer 2017 Apr;64(4) Epub 2016 Oct 26 doi: 10.1002/pbc.26272. PMID: 27781381Free PMC Article

Clinical prediction guides

Primary sarcoma of the liver: A nationwide analysis of a rare mesenchymal tumor.
Finney N, Tran T, Hasjim BJ, Jakowatz J, Chiao E, Eng O, Wolf R, Jutric Z, Yamamoto M, Tran TB
J Surg Oncol 2024 Feb;129(2):358-364. Epub 2023 Oct 5 doi: 10.1002/jso.27477. PMID: 37796036
Selective portal embolization combined with chemotherapy treatment in non-resectable liver tumors reduces tumor volume and generates contralateral compensating hypertrophy allowing for a full resection while avoiding liver transplantation.
Serradilla J, Bueno A, Hernández F, Andrés AM, López-Santamaría M
Cir Pediatr 2021 Apr 1;34(2):95-99. PMID: 33826263
Undifferentiated sarcoma of the liver: Multicenter international experience of the Cooperative Soft-Tissue Sarcoma Group and Polish Paediatric Solid Tumor Group.
Murawski M, Scheer M, Leuschner I, Stefanowicz J, Bonar J, Dembowska-Bagińska B, Kaliciński P, Koscielniak E, Czauderna P, Fuchs J
Pediatr Blood Cancer 2020 Nov;67(11):e28598. Epub 2020 Jul 24 doi: 10.1002/pbc.28598. PMID: 32706511
Lethal mass mimicking myxoma in the heart.
Soo WM, Pang YH, Poh KK
Asian Cardiovasc Thorac Ann 2014 Oct;22(8):962-4. Epub 2013 Nov 13 doi: 10.1177/0218492313488896. PMID: 24887828
Synthesis, characterization and antiproliferative activity of 1,2-naphthoquinone and its derivatives.
Shukla S, Srivastava RS, Shrivastava SK, Sodhi A, Kumar P
Appl Biochem Biotechnol 2012 Jul;167(5):1430-45. Epub 2012 Jan 19 doi: 10.1007/s12010-012-9551-9. PMID: 22258648

Recent systematic reviews

Adult primary liver sarcoma: systematic review.
Martins ACA, Costa Neto DCD, Silva JDDE, Moraes YM, LeÃo CS, Martins C
Rev Col Bras Cir 2020;47:e20202647. Epub 2020 Nov 30 doi: 10.1590/0100-6991e-20202647. PMID: 33263653

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