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Skin Smooth Muscle Neoplasm

MedGen UID:
87532
•Concept ID:
C0346062
•
Neoplastic Process
Synonyms: Cutaneous Neoplasm of Smooth Muscle Origin; Cutaneous Smooth Muscle Neoplasm; Cutaneous Tumor of Smooth Muscle Origin; Skin Neoplasm of Smooth Muscle Origin; Skin tumor of smooth muscle origin; Skin Tumor of Smooth Muscle Origin; Smooth Muscle Skin Neoplasm
SNOMED CT: Skin tumor of smooth muscle origin (254765000)

Definition

A smooth muscle neoplasm occurring in the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Smooth Muscle Neoplasm

Professional guidelines

PubMed

Top 10 Differential Diagnoses for Desmoplastic Melanoma.
Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737Free PMC Article
Leiomyosarcoma and Pleomorphic Dermal Sarcoma: Guidelines for Diagnosis and Treatment.
Llombart B, Serra-Guillén C, Requena C, Alsina M, Morgado-Carrasco D, Machado I, Sanmartín O
Actas Dermosifiliogr (Engl Ed) 2019 Jan-Feb;110(1):4-11. Epub 2018 Nov 5 doi: 10.1016/j.ad.2018.06.012. PMID: 30409380
Dermatomyofibromas presenting in pediatric patients: clinicopathologic characteristics and differential diagnosis.
Tardío JC, Azorín D, Hernández-Núñez A, Guzmán A, Torrelo A, Herráiz M, Espinosa P, Moreno A, Granados R, Colmenero I
J Cutan Pathol 2011 Dec;38(12):967-72. Epub 2011 Jul 14 doi: 10.1111/j.1600-0560.2011.01739.x. PMID: 21752049

Recent clinical studies

Etiology

Hereditary leiomyomatosis and renal cell carcinoma syndrome associated uterine smooth muscle tumors: Bridging morphology and clinical screening.
Garg K, Rabban J
Genes Chromosomes Cancer 2021 Mar;60(3):210-216. Epub 2020 Nov 18 doi: 10.1002/gcc.22905. PMID: 33099845
Cutaneous leiomyosarcoma: dermal and subcutaneous.
Wong GN, Webb A, Gyorki D, McCormack C, Tran P, Ngan SY, Slavin J, Henderson MA
Australas J Dermatol 2020 Aug;61(3):243-249. Epub 2020 Jun 14 doi: 10.1111/ajd.13307. PMID: 32537765
Cutaneous Smooth Muscle Tumors: A Review.
Lau SK, Koh SS
Adv Anat Pathol 2018 Jul;25(4):282-290. doi: 10.1097/PAP.0000000000000188. PMID: 29649005
PEComa: what do we know so far?
Hornick JL, Fletcher CD
Histopathology 2006 Jan;48(1):75-82. doi: 10.1111/j.1365-2559.2005.02316.x. PMID: 16359539
Infantile myofibromatosis.
Chung EB, Enzinger FM
Cancer 1981 Oct 15;48(8):1807-18. doi: 10.1002/1097-0142(19811015)48:8<1807::aid-cncr2820480818>3.0.co;2-g. PMID: 7284977

Diagnosis

Myointimoma of the penis.
Cito G, Santi R, Gemma L, Galli IC, Cocci A, Carini M, Minervini A, Nesi G
Int J Impot Res 2021 Sep;33(6):583-586. Epub 2020 Jun 2 doi: 10.1038/s41443-020-0316-7. PMID: 32488208
Leiomyosarcoma and Pleomorphic Dermal Sarcoma: Guidelines for Diagnosis and Treatment.
Llombart B, Serra-Guillén C, Requena C, Alsina M, Morgado-Carrasco D, Machado I, Sanmartín O
Actas Dermosifiliogr (Engl Ed) 2019 Jan-Feb;110(1):4-11. Epub 2018 Nov 5 doi: 10.1016/j.ad.2018.06.012. PMID: 30409380
Multiple dermatomyofibromas.
Lima LAF, Lisboa GM, Silva Filho EAD, Rabelo G
An Bras Dermatol 2018 Mar;93(2):268-270. doi: 10.1590/abd1806-4841.20186748. PMID: 29723353Free PMC Article
Cutaneous Smooth Muscle Tumors: A Review.
Lau SK, Koh SS
Adv Anat Pathol 2018 Jul;25(4):282-290. doi: 10.1097/PAP.0000000000000188. PMID: 29649005
Lymphangioleiomyomatosis: A review.
Hohman DW, Noghrehkar D, Ratnayake S
Eur J Intern Med 2008 Jul;19(5):319-24. Epub 2007 Dec 26 doi: 10.1016/j.ejim.2007.10.015. PMID: 18549932

Therapy

Multikinase inhibitor sorafenib induces skin toxicities in tumor-bearing mice.
Tian A, Lu H, Zhang J, Fu S, Jiang Z, Lam W, Guan F, Chen L, Feng L, Cheng Y
Cancer Chemother Pharmacol 2018 Jun;81(6):1025-1033. Epub 2018 Apr 9 doi: 10.1007/s00280-018-3575-y. PMID: 29633006
Lymphangioleiomyomatosis: A review.
Hohman DW, Noghrehkar D, Ratnayake S
Eur J Intern Med 2008 Jul;19(5):319-24. Epub 2007 Dec 26 doi: 10.1016/j.ejim.2007.10.015. PMID: 18549932
Glomeruloid hemangioma.
Yuri T, Yamazaki F, Takasu K, Shikata N, Tsubura A
Pathol Int 2008 Jun;58(6):390-5. doi: 10.1111/j.1440-1827.2008.02241.x. PMID: 18477219
Kaposi's sarcoma - still an enigma.
Babál P, Péc J
J Eur Acad Dermatol Venereol 2003 Jul;17(4):377-80. doi: 10.1046/j.1468-3083.2003.00746.x. PMID: 12834444
Final report on the safety assessment of Ammonium, Potassium, and Sodium Persulfate.
Pang S, Fiume MZ
Int J Toxicol 2001;20 Suppl 3:7-21. doi: 10.1080/10915810152630710. PMID: 11766134

Prognosis

Top 10 Differential Diagnoses for Desmoplastic Melanoma.
Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737Free PMC Article
Primary cutaneous and subcutaneous leiomyosarcomas: evolution and prognostic factors.
Aneiros-Fernandez J, Antonio Retamero J, Husein-Elahmed H, Ovalle F, Aneiros-Cachaza J
Eur J Dermatol 2016 Jan-Feb;26(1):9-12. doi: 10.1684/ejd.2015.2681. PMID: 26678649
Glomeruloid hemangioma.
Yuri T, Yamazaki F, Takasu K, Shikata N, Tsubura A
Pathol Int 2008 Jun;58(6):390-5. doi: 10.1111/j.1440-1827.2008.02241.x. PMID: 18477219
PEComa: what do we know so far?
Hornick JL, Fletcher CD
Histopathology 2006 Jan;48(1):75-82. doi: 10.1111/j.1365-2559.2005.02316.x. PMID: 16359539
Infantile myofibromatosis.
Chung EB, Enzinger FM
Cancer 1981 Oct 15;48(8):1807-18. doi: 10.1002/1097-0142(19811015)48:8<1807::aid-cncr2820480818>3.0.co;2-g. PMID: 7284977

Clinical prediction guides

Clinicopathological and molecular characteristics of fumarate hydratase-deficient uterine smooth muscle tumors: a single-center study of 52 cases.
Li H, Yang W, Tu X, Yu L, Huang D, Cheng Y, Chang B, Tang S, Ge H, Bao L, Zhou X, Bi R
Hum Pathol 2022 Aug;126:136-145. Epub 2022 May 31 doi: 10.1016/j.humpath.2022.05.016. PMID: 35659509
Leiomyosarcoma and Pleomorphic Dermal Sarcoma: Guidelines for Diagnosis and Treatment.
Llombart B, Serra-Guillén C, Requena C, Alsina M, Morgado-Carrasco D, Machado I, Sanmartín O
Actas Dermosifiliogr (Engl Ed) 2019 Jan-Feb;110(1):4-11. Epub 2018 Nov 5 doi: 10.1016/j.ad.2018.06.012. PMID: 30409380
Cutaneous/subcutaneous mesenchymal proliferations of the breast.
Orta LY, Beyda JN, Desman GT
Semin Diagn Pathol 2017 Sep;34(5):470-478. Epub 2017 May 30 doi: 10.1053/j.semdp.2017.05.005. PMID: 28662996
PEComa: what do we know so far?
Hornick JL, Fletcher CD
Histopathology 2006 Jan;48(1):75-82. doi: 10.1111/j.1365-2559.2005.02316.x. PMID: 16359539
Cutaneous angiolipoleiomyoma.
Fitzpatrick JE, Mellette JR Jr, Hwang RJ, Golitz LE, Zaim MT, Clemons D
J Am Acad Dermatol 1990 Dec;23(6 Pt 1):1093-8. doi: 10.1016/0190-9622(90)70339-j. PMID: 2273108

Recent systematic reviews

Immunohistochemical Characteristics of Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: A Systematic Review and Meta-Analysis.
Ørholt M, Abebe K, Aaberg F, Rasmussen LE, Daugaard S, Loya AC, Herly M, Vester-Glowinski PV
Am J Dermatopathol 2022 Dec 1;44(12):913-920. doi: 10.1097/DAD.0000000000002305. PMID: 36395448

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