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Malignant Optic Nerve Neoplasm

MedGen UID:
87553
•Concept ID:
C0346323
•
Neoplastic Process
Synonyms: Malignant Optic Nerve Tumor; Optic Nerve Tumor, Malignant; Tumor, Malignant, Optic Nerve; Tumor, Optic Nerve, Malignant
SNOMED CT: Malignant tumor of optic nerve (363498002)

Definition

A primary or metastatic malignant neoplasm that affects the optic nerve. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Optic Nerve Neoplasm

Professional guidelines

PubMed

Current treatment of optic nerve gliomas.
Farazdaghi MK, Katowitz WR, Avery RA
Curr Opin Ophthalmol 2019 Sep;30(5):356-363. doi: 10.1097/ICU.0000000000000587. PMID: 31246635Free PMC Article
SIOPE - Brain tumor group consensus guideline on craniospinal target volume delineation for high-precision radiotherapy.
Ajithkumar T, Horan G, Padovani L, Thorp N, Timmermann B, Alapetite C, Gandola L, Ramos M, Van Beek K, Christiaens M, Lassen-Ramshad Y, Magelssen H, Nilsson K, Saran F, Rombi B, Kortmann R, Janssens GO; SIOPE BTG Radiotherapy Group
Radiother Oncol 2018 Aug;128(2):192-197. Epub 2018 May 2 doi: 10.1016/j.radonc.2018.04.016. PMID: 29729847
Pituitary incidentaloma: an endocrine society clinical practice guideline.
Freda PU, Beckers AM, Katznelson L, Molitch ME, Montori VM, Post KD, Vance ML; Endocrine Society
J Clin Endocrinol Metab 2011 Apr;96(4):894-904. doi: 10.1210/jc.2010-1048. PMID: 21474686Free PMC Article

Recent clinical studies

Etiology

Neurological malignancies in neurofibromatosis type 1.
Eoli M, Saletti V, Finocchiaro G
Curr Opin Oncol 2019 Nov;31(6):554-561. doi: 10.1097/CCO.0000000000000576. PMID: 31436563
Hemangioblastoma of the optic nerve.
McGrath LA, Mudhar HS, Salvi SM
Surv Ophthalmol 2019 Mar-Apr;64(2):175-184. Epub 2018 Oct 13 doi: 10.1016/j.survophthal.2018.10.002. PMID: 30321570
Optic Pathway Gliomas in Neurofibromatosis Type 1.
Campen CJ, Gutmann DH
J Child Neurol 2018 Jan;33(1):73-81. doi: 10.1177/0883073817739509. PMID: 29246098Free PMC Article
Neurofibromatosis type 1.
Gutmann DH, Ferner RE, Listernick RH, Korf BR, Wolters PL, Johnson KJ
Nat Rev Dis Primers 2017 Feb 23;3:17004. doi: 10.1038/nrdp.2017.4. PMID: 28230061
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696

Diagnosis

Optic nerve sheath meningioma.
Douglas VP, Douglas KAA, Cestari DM
Curr Opin Ophthalmol 2020 Nov;31(6):455-461. doi: 10.1097/ICU.0000000000000700. PMID: 33009076
Diagnostic error and neuro-ophthalmology.
Stunkel L, Newman NJ, Biousse V
Curr Opin Neurol 2019 Feb;32(1):62-67. doi: 10.1097/WCO.0000000000000635. PMID: 30516641Free PMC Article
Hemangioblastoma of the optic nerve.
McGrath LA, Mudhar HS, Salvi SM
Surv Ophthalmol 2019 Mar-Apr;64(2):175-184. Epub 2018 Oct 13 doi: 10.1016/j.survophthal.2018.10.002. PMID: 30321570
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Second chances.
Nagia L, Doyle JI, Hackney JR, Vaphiades MS, Kline LB, Levin MH
Surv Ophthalmol 2015 Nov-Dec;60(6):596-9. Epub 2015 Jun 14 doi: 10.1016/j.survophthal.2015.06.002. PMID: 26079932

Therapy

A phase II trial of selumetinib in children with recurrent optic pathway and hypothalamic low-grade glioma without NF1: a Pediatric Brain Tumor Consortium study.
Fangusaro J, Onar-Thomas A, Poussaint TY, Wu S, Ligon AH, Lindeman N, Campagne O, Banerjee A, Gururangan S, Kilburn LB, Goldman S, Qaddoumi I, Baxter P, Vezina G, Bregman C, Patay Z, Jones JY, Stewart CF, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Neuro Oncol 2021 Oct 1;23(10):1777-1788. doi: 10.1093/neuonc/noab047. PMID: 33631016Free PMC Article
Current treatment of optic nerve gliomas.
Farazdaghi MK, Katowitz WR, Avery RA
Curr Opin Ophthalmol 2019 Sep;30(5):356-363. doi: 10.1097/ICU.0000000000000587. PMID: 31246635Free PMC Article
Interventions for orbital lymphangioma.
Patel SR, Rosenberg JB, Barmettler A
Cochrane Database Syst Rev 2019 May 15;5(5):CD013000. doi: 10.1002/14651858.CD013000.pub2. PMID: 31094450Free PMC Article
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591

Prognosis

A phase II trial of selumetinib in children with recurrent optic pathway and hypothalamic low-grade glioma without NF1: a Pediatric Brain Tumor Consortium study.
Fangusaro J, Onar-Thomas A, Poussaint TY, Wu S, Ligon AH, Lindeman N, Campagne O, Banerjee A, Gururangan S, Kilburn LB, Goldman S, Qaddoumi I, Baxter P, Vezina G, Bregman C, Patay Z, Jones JY, Stewart CF, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Neuro Oncol 2021 Oct 1;23(10):1777-1788. doi: 10.1093/neuonc/noab047. PMID: 33631016Free PMC Article
Optic nerve sheath meningioma.
Douglas VP, Douglas KAA, Cestari DM
Curr Opin Ophthalmol 2020 Nov;31(6):455-461. doi: 10.1097/ICU.0000000000000700. PMID: 33009076
Neurological malignancies in neurofibromatosis type 1.
Eoli M, Saletti V, Finocchiaro G
Curr Opin Oncol 2019 Nov;31(6):554-561. doi: 10.1097/CCO.0000000000000576. PMID: 31436563
Optic Nerve Hemangioblastoma: Review.
Darbari S, Meena RK, Sawarkar D, Doddamani RS
World Neurosurg 2019 Aug;128:211-215. Epub 2019 May 1 doi: 10.1016/j.wneu.2019.04.224. PMID: 31054346
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696

Clinical prediction guides

Hypofractionated stereotactic irradiation for optic nerve glioma.
Zagirov RI, Trunin YY, Serova NK, Pronin IN, Antipina NA, Golanov AV
Zh Vopr Neirokhir Im N N Burdenko 2022;86(5):74-80. doi: 10.17116/neiro20228605174. PMID: 36252196
Neurological malignancies in neurofibromatosis type 1.
Eoli M, Saletti V, Finocchiaro G
Curr Opin Oncol 2019 Nov;31(6):554-561. doi: 10.1097/CCO.0000000000000576. PMID: 31436563
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Primary optic nerve tumours.
Wilhelm H
Curr Opin Neurol 2009 Feb;22(1):11-8. doi: 10.1097/WCO.0b013e32831fd9f5. PMID: 19155759
Pathological optic-disc cupping.
Piette SD, Sergott RC
Curr Opin Ophthalmol 2006 Feb;17(1):1-6. doi: 10.1097/01.icu.0000193072.17122.f3. PMID: 16436917

Recent systematic reviews

Treatment and prophylaxis of radiation optic neuropathy: A systematic review and meta-analysis.
Yu CW, Joarder I, Micieli JA
Eur J Ophthalmol 2022 Nov;32(6):3129-3141. Epub 2022 Mar 9 doi: 10.1177/11206721221085409. PMID: 35262423
Paraneoplastic ocular syndrome: a pandora's box of underlying malignancies.
Sarkar P, Mehtani A, Gandhi HC, Bhalla JS, Tapariya S
Eye (Lond) 2022 Jul;36(7):1355-1367. Epub 2021 Aug 3 doi: 10.1038/s41433-021-01676-x. PMID: 34345027Free PMC Article
A systematic review of ongoing clinical trials in optic pathway gliomas.
Hill CS, Devesa SC, Ince W, Borg A, Aquilina K
Childs Nerv Syst 2020 Sep;36(9):1869-1886. Epub 2020 Jun 18 doi: 10.1007/s00381-020-04724-1. PMID: 32556546Free PMC Article
Interventions for orbital lymphangioma.
Patel SR, Rosenberg JB, Barmettler A
Cochrane Database Syst Rev 2019 May 15;5(5):CD013000. doi: 10.1002/14651858.CD013000.pub2. PMID: 31094450Free PMC Article
Modern Management of Meningiomas Compressing the Optic Nerve: A Systematic Review.
Hénaux PL, Bretonnier M, Le Reste PJ, Morandi X
World Neurosurg 2018 Oct;118:e677-e686. Epub 2018 Aug 3 doi: 10.1016/j.wneu.2018.07.020. PMID: 30010062

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