U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Intestinal cancer

MedGen UID:
87562
Concept ID:
C0346627
Neoplastic Process
Synonyms: Cancer of Intestines; Cancer of the Intestines; Cancer, Intestinal; Cancer, Intestines; Cancers, Intestinal; Cancers, Intestines; Intestinal Cancer; Intestinal Cancers; Intestines Cancer; Intestines Cancers
SNOMED CT: Cancer of intestine (363508008); Malignant neoplasm of intestine (363508008); CA - Cancer of intestine (363508008); Intestinal cancer (363508008); Cancer of bowel (363508008); CA - Cancer of bowel (363508008); Malignant tumor of intestine (363508008)
 
Monarch Initiative: MONDO:0005814

Definition

A primary or metastatic malignant neoplasm involving the small intestine, large intestine, or both. Representative examples are carcinomas, lymphomas, and sarcomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntestinal cancer

Professional guidelines

PubMed

Fei Y, Ma Y, Zhang H, Li H, Feng G, Fang J
J Nanobiotechnology 2022 Sep 29;20(1):430. doi: 10.1186/s12951-022-01517-3. PMID: 36175955Free PMC Article
Menahem B, Alves A, Regimbeau JM, Sabbagh C
J Visc Surg 2019 Dec;156(6):507-514. Epub 2019 Aug 21 doi: 10.1016/j.jviscsurg.2019.07.009. PMID: 31445799
de Bree E, Rovers KP, Stamatiou D, Souglakos J, Michelakis D, de Hingh IH
Acta Oncol 2018 Jun;57(6):712-722. Epub 2018 Jan 30 doi: 10.1080/0284186X.2018.1433321. PMID: 29381126

Recent clinical studies

Etiology

Cavestro GM, Mannucci A, Balaguer F, Hampel H, Kupfer SS, Repici A, Sartore-Bianchi A, Seppälä TT, Valentini V, Boland CR, Brand RE, Buffart TE, Burke CA, Caccialanza R, Cannizzaro R, Cascinu S, Cercek A, Crosbie EJ, Danese S, Dekker E, Daca-Alvarez M, Deni F, Dominguez-Valentin M, Eng C, Goel A, Guillem JG, Houwen BBSL, Kahi C, Kalady MF, Kastrinos F, Kühn F, Laghi L, Latchford A, Liska D, Lynch P, Malesci A, Mauri G, Meldolesi E, Møller P, Monahan KJ, Möslein G, Murphy CC, Nass K, Ng K, Oliani C, Papaleo E, Patel SG, Puzzono M, Remo A, Ricciardiello L, Ripamonti CI, Siena S, Singh SK, Stadler ZK, Stanich PP, Syngal S, Turi S, Urso ED, Valle L, Vanni VS, Vilar E, Vitellaro M, You YN, Yurgelun MB, Zuppardo RA, Stoffel EM; Associazione Italiana Familiarità Ereditarietà Tumori; Collaborative Group of the Americas on Inherited Gastrointestinal Cancer; European Hereditary Tumour Group, and the International Society for Gastrointestinal Hereditary Tumours
Clin Gastroenterol Hepatol 2023 Mar;21(3):581-603.e33. Epub 2022 Dec 20 doi: 10.1016/j.cgh.2022.12.006. PMID: 36549470
Friedberg S, Rubin DT
Gastroenterol Clin North Am 2022 Jun;51(2):369-379. Epub 2022 Apr 22 doi: 10.1016/j.gtc.2021.12.011. PMID: 35595420
Al-Ishaq RK, Overy AJ, Büsselberg D
Biomolecules 2020 Jan 8;10(1) doi: 10.3390/biom10010105. PMID: 31936288Free PMC Article
Fu T, Coulter S, Yoshihara E, Oh TG, Fang S, Cayabyab F, Zhu Q, Zhang T, Leblanc M, Liu S, He M, Waizenegger W, Gasser E, Schnabl B, Atkins AR, Yu RT, Knight R, Liddle C, Downes M, Evans RM
Cell 2019 Feb 21;176(5):1098-1112.e18. doi: 10.1016/j.cell.2019.01.036. PMID: 30794774Free PMC Article
Schulz-Heddergott R, Stark N, Edmunds SJ, Li J, Conradi LC, Bohnenberger H, Ceteci F, Greten FR, Dobbelstein M, Moll UM
Cancer Cell 2018 Aug 13;34(2):298-314.e7. doi: 10.1016/j.ccell.2018.07.004. PMID: 30107178Free PMC Article

Diagnosis

Cavestro GM, Mannucci A, Balaguer F, Hampel H, Kupfer SS, Repici A, Sartore-Bianchi A, Seppälä TT, Valentini V, Boland CR, Brand RE, Buffart TE, Burke CA, Caccialanza R, Cannizzaro R, Cascinu S, Cercek A, Crosbie EJ, Danese S, Dekker E, Daca-Alvarez M, Deni F, Dominguez-Valentin M, Eng C, Goel A, Guillem JG, Houwen BBSL, Kahi C, Kalady MF, Kastrinos F, Kühn F, Laghi L, Latchford A, Liska D, Lynch P, Malesci A, Mauri G, Meldolesi E, Møller P, Monahan KJ, Möslein G, Murphy CC, Nass K, Ng K, Oliani C, Papaleo E, Patel SG, Puzzono M, Remo A, Ricciardiello L, Ripamonti CI, Siena S, Singh SK, Stadler ZK, Stanich PP, Syngal S, Turi S, Urso ED, Valle L, Vanni VS, Vilar E, Vitellaro M, You YN, Yurgelun MB, Zuppardo RA, Stoffel EM; Associazione Italiana Familiarità Ereditarietà Tumori; Collaborative Group of the Americas on Inherited Gastrointestinal Cancer; European Hereditary Tumour Group, and the International Society for Gastrointestinal Hereditary Tumours
Clin Gastroenterol Hepatol 2023 Mar;21(3):581-603.e33. Epub 2022 Dec 20 doi: 10.1016/j.cgh.2022.12.006. PMID: 36549470
Fei Y, Ma Y, Zhang H, Li H, Feng G, Fang J
J Nanobiotechnology 2022 Sep 29;20(1):430. doi: 10.1186/s12951-022-01517-3. PMID: 36175955Free PMC Article
Llach J, Pellisé M, Monahan K
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101790. Epub 2022 Mar 26 doi: 10.1016/j.bpg.2022.101790. PMID: 35988964
Friedberg S, Rubin DT
Gastroenterol Clin North Am 2022 Jun;51(2):369-379. Epub 2022 Apr 22 doi: 10.1016/j.gtc.2021.12.011. PMID: 35595420
Gammon A, Jasperson K, Kohlmann W, Burt RW
Best Pract Res Clin Gastroenterol 2009;23(2):219-31. doi: 10.1016/j.bpg.2009.02.007. PMID: 19414148Free PMC Article

Therapy

Monahan KJ, Swinyard O, Latchford A
Cancer Prev Res (Phila) 2023 Aug 1;16(8):421-427. doi: 10.1158/1940-6207.CAPR-22-0500. PMID: 37001883
Fei Y, Ma Y, Zhang H, Li H, Feng G, Fang J
J Nanobiotechnology 2022 Sep 29;20(1):430. doi: 10.1186/s12951-022-01517-3. PMID: 36175955Free PMC Article
Al-Ishaq RK, Overy AJ, Büsselberg D
Biomolecules 2020 Jan 8;10(1) doi: 10.3390/biom10010105. PMID: 31936288Free PMC Article
Hor T
J Visc Surg 2018 Jun;155 Suppl 1:S49-S55. Epub 2018 May 30 doi: 10.1016/j.jviscsurg.2018.04.006. PMID: 29857942
Davidson M, Chau I
Expert Opin Biol Ther 2016 Oct;16(10):1197-207. Epub 2016 Jul 25 doi: 10.1080/14712598.2016.1213233. PMID: 27409159

Prognosis

Huang J, Chan SC, Fung YC, Mak FY, Lok V, Zhang L, Lin X, Lucero-Prisno DE 3rd, Xu W, Zheng ZJ, Elcarte E, Withers M, Wong MCS; NCD Global Health Research Group, Association of Pacific Rim Universities
Gastroenterology 2023 Sep;165(3):600-612. Epub 2023 Jun 3 doi: 10.1053/j.gastro.2023.05.043. PMID: 37277079
Llach J, Pellisé M, Monahan K
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101790. Epub 2022 Mar 26 doi: 10.1016/j.bpg.2022.101790. PMID: 35988964
Al-Ishaq RK, Overy AJ, Büsselberg D
Biomolecules 2020 Jan 8;10(1) doi: 10.3390/biom10010105. PMID: 31936288Free PMC Article
Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH
Nature 2017 Apr 19;544(7650):372-376. doi: 10.1038/nature22056. PMID: 28425994
Gammon A, Jasperson K, Kohlmann W, Burt RW
Best Pract Res Clin Gastroenterol 2009;23(2):219-31. doi: 10.1016/j.bpg.2009.02.007. PMID: 19414148Free PMC Article

Clinical prediction guides

Huang J, Chan SC, Fung YC, Mak FY, Lok V, Zhang L, Lin X, Lucero-Prisno DE 3rd, Xu W, Zheng ZJ, Elcarte E, Withers M, Wong MCS; NCD Global Health Research Group, Association of Pacific Rim Universities
Gastroenterology 2023 Sep;165(3):600-612. Epub 2023 Jun 3 doi: 10.1053/j.gastro.2023.05.043. PMID: 37277079
Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH
Nature 2017 Apr 19;544(7650):372-376. doi: 10.1038/nature22056. PMID: 28425994
Gammon A, Jasperson K, Kohlmann W, Burt RW
Best Pract Res Clin Gastroenterol 2009;23(2):219-31. doi: 10.1016/j.bpg.2009.02.007. PMID: 19414148Free PMC Article
Wolfrum F, Vogel I, Fändrich F, Kalthoff H
Langenbecks Arch Surg 2005 Sep;390(5):430-41. Epub 2005 Jul 1 doi: 10.1007/s00423-005-0558-3. PMID: 15991048
Zeuzem S
Int J Colorectal Dis 2000 Apr;15(2):59-82. doi: 10.1007/s003840050236. PMID: 10855547

Recent systematic reviews

Hintzen KFH, Grote J, Wintjens AGWE, Lubbers T, Eussen MMM, van Schooten FJ, Bouvy ND, Peeters A
BJS Open 2021 Mar 5;5(2) doi: 10.1093/bjsopen/zrab013. PMID: 33855362Free PMC Article
Uchino M, Ikeuchi H, Hata K, Minagawa T, Horio Y, Kuwahara R, Nakamura S, Watanabe K, Saruta M, Fujii T, Kobayashi T, Sugimoto K, Hirai F, Esaki M, Hiraoka S, Matsuoka K, Shinzaki S, Matsuura M, Inoue N, Nakase H, Watanabe M
J Gastroenterol Hepatol 2021 Feb;36(2):329-336. Epub 2020 Sep 30 doi: 10.1111/jgh.15229. PMID: 32865278
Lo B, Zhao M, Vind I, Burisch J
Clin Gastroenterol Hepatol 2021 Jun;19(6):1117-1138.e19. Epub 2020 Aug 13 doi: 10.1016/j.cgh.2020.08.015. PMID: 32801010
Musio D, De Felice F, Raffetto N, Tombolini V
Radiat Oncol 2014 Jan 28;9:39. doi: 10.1186/1748-717X-9-39. PMID: 24472223Free PMC Article
Pedersen N, Duricova D, Elkjaer M, Gamborg M, Munkholm P, Jess T
Am J Gastroenterol 2010 Jul;105(7):1480-7. Epub 2010 Mar 23 doi: 10.1038/ajg.2009.760. PMID: 20332773

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...