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Symptom Flare Up

MedGen UID:
875730
•Concept ID:
C4042866
•
Sign or Symptom
Synonyms: Acute Symptom Flare; Acute Symptom Flares; Flare Up, Symptom; Flare Ups, Symptom; Flare-up, Symptom; Flare-ups, Symptom; Flareup, Symptom; Flareups, Symptom; Flaring Up, Symptom; Symptom Flare Ups; Symptom Flare, Acute; Symptom Flare-up; Symptom Flare-ups; Symptom Flareup; Symptom Flareups; Symptom Flaring Up

Definition

A transient exacerbation of symptoms of an existing disease or condition. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSymptom Flare Up

Professional guidelines

PubMed

Differential Diagnosis of Suspected Chronic Obstructive Pulmonary Disease Exacerbations in the Acute Care Setting: Best Practice.
Celli BR, Fabbri LM, Aaron SD, Agusti A, Brook RD, Criner GJ, Franssen FME, Humbert M, Hurst JR, Montes de Oca M, Pantoni L, Papi A, Rodriguez-Roisin R, Sethi S, Stolz D, Torres A, Vogelmeier CF, Wedzicha JA
Am J Respir Crit Care Med 2023 May 1;207(9):1134-1144. doi: 10.1164/rccm.202209-1795CI. PMID: 36701677Free PMC Article
Voiding dysfunctions in patients with non-Hunner's ulcer interstitial cystitis/bladder pain syndrome do not affect long-term treatment outcome.
Yu WR, Chang WC, Kuo HC
Int J Clin Pract 2021 Sep;75(9):e14372. Epub 2021 May 29 doi: 10.1111/ijcp.14372. PMID: 33998747
Six-month flare risk after discontinuing long-term methotrexate treatment in patients having rheumatoid arthritis with low disease activity.
Lee JS, Oh JS, Hong S, Kim YG, Lee CK, Yoo B
Int J Rheum Dis 2020 Aug;23(8):1076-1081. Epub 2020 Jul 6 doi: 10.1111/1756-185X.13888. PMID: 33021334

Recent clinical studies

Etiology

Update on gout management: what is old and what is new.
Afinogenova Y, Danve A, Neogi T
Curr Opin Rheumatol 2022 Mar 1;34(2):118-124. doi: 10.1097/BOR.0000000000000861. PMID: 34907116Free PMC Article
Gout.
Dalbeth N, Gosling AL, Gaffo A, Abhishek A
Lancet 2021 May 15;397(10287):1843-1855. Epub 2021 Mar 30 doi: 10.1016/S0140-6736(21)00569-9. PMID: 33798500
Inpatient management of acute decompensated heart failure.
Raj L, Maidman SD, Adhyaru BB
Postgrad Med J 2020 Jan;96(1131):33-42. Epub 2019 Sep 12 doi: 10.1136/postgradmedj-2019-136742. PMID: 31515438
Stress and psoriasis.
Rousset L, Halioua B
Int J Dermatol 2018 Oct;57(10):1165-1172. Epub 2018 May 4 doi: 10.1111/ijd.14032. PMID: 29729012
Acute exacerbation of COPD.
Ko FW, Chan KP, Hui DS, Goddard JR, Shaw JG, Reid DW, Yang IA
Respirology 2016 Oct;21(7):1152-65. Epub 2016 Mar 30 doi: 10.1111/resp.12780. PMID: 27028990Free PMC Article

Diagnosis

Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout.
Cipolletta E, Tata LJ, Nakafero G, Avery AJ, Mamas MA, Abhishek A
JAMA 2022 Aug 2;328(5):440-450. doi: 10.1001/jama.2022.11390. PMID: 35916846Free PMC Article
Asthma-COPD Overlap: What Are the Important Questions?
Leung C, Sin DD
Chest 2022 Feb;161(2):330-344. Epub 2021 Oct 6 doi: 10.1016/j.chest.2021.09.036. PMID: 34626594
Gout.
Dalbeth N, Gosling AL, Gaffo A, Abhishek A
Lancet 2021 May 15;397(10287):1843-1855. Epub 2021 Mar 30 doi: 10.1016/S0140-6736(21)00569-9. PMID: 33798500
Clinical disease activity and flare in SLE: Current concepts and novel biomarkers.
Thanou A, Jupe E, Purushothaman M, Niewold TB, Munroe ME
J Autoimmun 2021 May;119:102615. Epub 2021 Feb 22 doi: 10.1016/j.jaut.2021.102615. PMID: 33631651Free PMC Article
Acute exacerbation of COPD.
Ko FW, Chan KP, Hui DS, Goddard JR, Shaw JG, Reid DW, Yang IA
Respirology 2016 Oct;21(7):1152-65. Epub 2016 Mar 30 doi: 10.1111/resp.12780. PMID: 27028990Free PMC Article

Therapy

Acetazolamide in Acute Decompensated Heart Failure with Volume Overload.
Mullens W, Dauw J, Martens P, Verbrugge FH, Nijst P, Meekers E, Tartaglia K, Chenot F, Moubayed S, Dierckx R, Blouard P, Troisfontaines P, Derthoo D, Smolders W, Bruckers L, Droogne W, Ter Maaten JM, Damman K, Lassus J, Mebazaa A, Filippatos G, Ruschitzka F, Dupont M; ADVOR Study Group
N Engl J Med 2022 Sep 29;387(13):1185-1195. Epub 2022 Aug 27 doi: 10.1056/NEJMoa2203094. PMID: 36027559
Albuterol-Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma.
Papi A, Chipps BE, Beasley R, Panettieri RA Jr, Israel E, Cooper M, Dunsire L, Jeynes-Ellis A, Johnsson E, Rees R, Cappelletti C, Albers FC
N Engl J Med 2022 Jun 2;386(22):2071-2083. Epub 2022 May 15 doi: 10.1056/NEJMoa2203163. PMID: 35569035
Update on gout management: what is old and what is new.
Afinogenova Y, Danve A, Neogi T
Curr Opin Rheumatol 2022 Mar 1;34(2):118-124. doi: 10.1097/BOR.0000000000000861. PMID: 34907116Free PMC Article
Trial of Spesolimab for Generalized Pustular Psoriasis.
Bachelez H, Choon SE, Marrakchi S, Burden AD, Tsai TF, Morita A, Navarini AA, Zheng M, Xu J, Turki H, Anadkat MJ, Rajeswari S, Hua H, Vulcu SD, Hall D, Tetzlaff K, Thoma C, Lebwohl MG; Effisayil 1 Trial Investigators
N Engl J Med 2021 Dec 23;385(26):2431-2440. doi: 10.1056/NEJMoa2111563. PMID: 34936739
Gout.
Dalbeth N, Gosling AL, Gaffo A, Abhishek A
Lancet 2021 May 15;397(10287):1843-1855. Epub 2021 Mar 30 doi: 10.1016/S0140-6736(21)00569-9. PMID: 33798500

Prognosis

Pregnancy in patients with systemic lupus erythematosus: a systematic review.
Zhang S, Han X, Liu W, Wen Q, Wang J
Arch Gynecol Obstet 2023 Jul;308(1):63-71. Epub 2022 Aug 1 doi: 10.1007/s00404-022-06718-7. PMID: 35913558
Clinical Course and Characteristics of Generalized Pustular Psoriasis.
Choon SE, Navarini AA, Pinter A
Am J Clin Dermatol 2022 Jan;23(Suppl 1):21-29. Epub 2022 Jan 21 doi: 10.1007/s40257-021-00654-z. PMID: 35061227Free PMC Article
Dupilumab in Children with Uncontrolled Moderate-to-Severe Asthma.
Bacharier LB, Maspero JF, Katelaris CH, Fiocchi AG, Gagnon R, de Mir I, Jain N, Sher LD, Mao X, Liu D, Zhang Y, Khan AH, Kapoor U, Khokhar FA, Rowe PJ, Deniz Y, Ruddy M, Laws E, Patel N, Weinreich DM, Yancopoulos GD, Amin N, Mannent LP, Lederer DJ, Hardin M; Liberty Asthma VOYAGE Investigators
N Engl J Med 2021 Dec 9;385(24):2230-2240. doi: 10.1056/NEJMoa2106567. PMID: 34879449
Clinical disease activity and flare in SLE: Current concepts and novel biomarkers.
Thanou A, Jupe E, Purushothaman M, Niewold TB, Munroe ME
J Autoimmun 2021 May;119:102615. Epub 2021 Feb 22 doi: 10.1016/j.jaut.2021.102615. PMID: 33631651Free PMC Article
Acute exacerbations of fibrotic interstitial lung diseases.
Suzuki A, Kondoh Y, Brown KK, Johkoh T, Kataoka K, Fukuoka J, Kimura T, Matsuda T, Yokoyama T, Fukihara J, Ando M, Tanaka T, Hashimoto N, Sakamoto K, Hasegawa Y
Respirology 2020 May;25(5):525-534. Epub 2019 Aug 19 doi: 10.1111/resp.13682. PMID: 31426125

Clinical prediction guides

Pregnancy in patients with systemic lupus erythematosus: a systematic review.
Zhang S, Han X, Liu W, Wen Q, Wang J
Arch Gynecol Obstet 2023 Jul;308(1):63-71. Epub 2022 Aug 1 doi: 10.1007/s00404-022-06718-7. PMID: 35913558
A secondary analysis of the Belimumab International Study in Lupus Nephritis trial examined effects of belimumab on kidney outcomes and preservation of kidney function in patients with lupus nephritis.
Rovin BH, Furie R, Teng YKO, Contreras G, Malvar A, Yu X, Ji B, Green Y, Gonzalez-Rivera T, Bass D, Gilbride J, Tang CH, Roth DA
Kidney Int 2022 Feb;101(2):403-413. Epub 2021 Sep 22 doi: 10.1016/j.kint.2021.08.027. PMID: 34560137
Trial of Spesolimab for Generalized Pustular Psoriasis.
Bachelez H, Choon SE, Marrakchi S, Burden AD, Tsai TF, Morita A, Navarini AA, Zheng M, Xu J, Turki H, Anadkat MJ, Rajeswari S, Hua H, Vulcu SD, Hall D, Tetzlaff K, Thoma C, Lebwohl MG; Effisayil 1 Trial Investigators
N Engl J Med 2021 Dec 23;385(26):2431-2440. doi: 10.1056/NEJMoa2111563. PMID: 34936739
Dupilumab in Children with Uncontrolled Moderate-to-Severe Asthma.
Bacharier LB, Maspero JF, Katelaris CH, Fiocchi AG, Gagnon R, de Mir I, Jain N, Sher LD, Mao X, Liu D, Zhang Y, Khan AH, Kapoor U, Khokhar FA, Rowe PJ, Deniz Y, Ruddy M, Laws E, Patel N, Weinreich DM, Yancopoulos GD, Amin N, Mannent LP, Lederer DJ, Hardin M; Liberty Asthma VOYAGE Investigators
N Engl J Med 2021 Dec 9;385(24):2230-2240. doi: 10.1056/NEJMoa2106567. PMID: 34879449
Clinical disease activity and flare in SLE: Current concepts and novel biomarkers.
Thanou A, Jupe E, Purushothaman M, Niewold TB, Munroe ME
J Autoimmun 2021 May;119:102615. Epub 2021 Feb 22 doi: 10.1016/j.jaut.2021.102615. PMID: 33631651Free PMC Article

Recent systematic reviews

Impact of Antifibrotic Therapy on Mortality and Acute Exacerbation in Idiopathic Pulmonary Fibrosis: A Systematic Review and Meta-Analysis.
Petnak T, Lertjitbanjong P, Thongprayoon C, Moua T
Chest 2021 Nov;160(5):1751-1763. Epub 2021 Jul 2 doi: 10.1016/j.chest.2021.06.049. PMID: 34217681
Triple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma: A Systematic Review and Meta-analysis.
Kim LHY, Saleh C, Whalen-Browne A, O'Byrne PM, Chu DK
JAMA 2021 Jun 22;325(24):2466-2479. doi: 10.1001/jama.2021.7872. PMID: 34009257Free PMC Article
Interventions for cutaneous disease in systemic lupus erythematosus.
Hannon CW, McCourt C, Lima HC, Chen S, Bennett C
Cochrane Database Syst Rev 2021 Mar 9;3(3):CD007478. doi: 10.1002/14651858.CD007478.pub2. PMID: 33687069Free PMC Article
Emollients and moisturisers for eczema.
van Zuuren EJ, Fedorowicz Z, Christensen R, Lavrijsen A, Arents BWM
Cochrane Database Syst Rev 2017 Feb 6;2(2):CD012119. doi: 10.1002/14651858.CD012119.pub2. PMID: 28166390Free PMC Article
2016 updated EULAR evidence-based recommendations for the management of gout.
Richette P, Doherty M, Pascual E, Barskova V, Becce F, Castañeda-Sanabria J, Coyfish M, Guillo S, Jansen TL, Janssens H, Lioté F, Mallen C, Nuki G, Perez-Ruiz F, Pimentao J, Punzi L, Pywell T, So A, Tausche AK, Uhlig T, Zavada J, Zhang W, Tubach F, Bardin T
Ann Rheum Dis 2017 Jan;76(1):29-42. Epub 2016 Jul 25 doi: 10.1136/annrheumdis-2016-209707. PMID: 27457514

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