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Symptom Flare Up

MedGen UID:
875730
Concept ID:
C4042866
Sign or Symptom
Synonyms: Acute Symptom Flare; Acute Symptom Flares; Flare Up, Symptom; Flare Ups, Symptom; Flare-up, Symptom; Flare-ups, Symptom; Flareup, Symptom; Flareups, Symptom; Flaring Up, Symptom; Symptom Flare Ups; Symptom Flare, Acute; Symptom Flare-up; Symptom Flare-ups; Symptom Flareup; Symptom Flareups; Symptom Flaring Up

Definition

A transient exacerbation of symptoms of an existing disease or condition. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSymptom Flare Up

Professional guidelines

PubMed

Wuyts M, Hermans F, Breuls S, Everaerts S, Derom E, Janssens W, Demeyer H, Troosters T
Physiotherapy 2024 Jun;123:81-90. Epub 2023 Oct 5 doi: 10.1016/j.physio.2023.09.003. PMID: 38295552
Celli BR, Fabbri LM, Aaron SD, Agusti A, Brook RD, Criner GJ, Franssen FME, Humbert M, Hurst JR, Montes de Oca M, Pantoni L, Papi A, Rodriguez-Roisin R, Sethi S, Stolz D, Torres A, Vogelmeier CF, Wedzicha JA
Am J Respir Crit Care Med 2023 May 1;207(9):1134-1144. doi: 10.1164/rccm.202209-1795CI. PMID: 36701677Free PMC Article
Lee JS, Oh JS, Hong S, Kim YG, Lee CK, Yoo B
Int J Rheum Dis 2020 Aug;23(8):1076-1081. Epub 2020 Jul 6 doi: 10.1111/1756-185X.13888. PMID: 33021334

Recent clinical studies

Etiology

Helget LN, Mikuls TR
Rheum Dis Clin North Am 2022 Nov;48(4):891-906. doi: 10.1016/j.rdc.2022.06.009. PMID: 36333002Free PMC Article
Afinogenova Y, Danve A, Neogi T
Curr Opin Rheumatol 2022 Mar 1;34(2):118-124. doi: 10.1097/BOR.0000000000000861. PMID: 34907116Free PMC Article
Dalbeth N, Gosling AL, Gaffo A, Abhishek A
Lancet 2021 May 15;397(10287):1843-1855. Epub 2021 Mar 30 doi: 10.1016/S0140-6736(21)00569-9. PMID: 33798500
Rousset L, Halioua B
Int J Dermatol 2018 Oct;57(10):1165-1172. Epub 2018 May 4 doi: 10.1111/ijd.14032. PMID: 29729012
Ko FW, Chan KP, Hui DS, Goddard JR, Shaw JG, Reid DW, Yang IA
Respirology 2016 Oct;21(7):1152-65. Epub 2016 Mar 30 doi: 10.1111/resp.12780. PMID: 27028990Free PMC Article

Diagnosis

Celli BR, Fabbri LM, Aaron SD, Agusti A, Brook RD, Criner GJ, Franssen FME, Humbert M, Hurst JR, Montes de Oca M, Pantoni L, Papi A, Rodriguez-Roisin R, Sethi S, Stolz D, Torres A, Vogelmeier CF, Wedzicha JA
Am J Respir Crit Care Med 2023 May 1;207(9):1134-1144. doi: 10.1164/rccm.202209-1795CI. PMID: 36701677Free PMC Article
Leung C, Sin DD
Chest 2022 Feb;161(2):330-344. Epub 2021 Oct 6 doi: 10.1016/j.chest.2021.09.036. PMID: 34626594
Dalbeth N, Gosling AL, Gaffo A, Abhishek A
Lancet 2021 May 15;397(10287):1843-1855. Epub 2021 Mar 30 doi: 10.1016/S0140-6736(21)00569-9. PMID: 33798500
Thanou A, Jupe E, Purushothaman M, Niewold TB, Munroe ME
J Autoimmun 2021 May;119:102615. Epub 2021 Feb 22 doi: 10.1016/j.jaut.2021.102615. PMID: 33631651Free PMC Article
Ko FW, Chan KP, Hui DS, Goddard JR, Shaw JG, Reid DW, Yang IA
Respirology 2016 Oct;21(7):1152-65. Epub 2016 Mar 30 doi: 10.1111/resp.12780. PMID: 27028990Free PMC Article

Therapy

Helget LN, Mikuls TR
Rheum Dis Clin North Am 2022 Nov;48(4):891-906. doi: 10.1016/j.rdc.2022.06.009. PMID: 36333002Free PMC Article
Mullens W, Dauw J, Martens P, Verbrugge FH, Nijst P, Meekers E, Tartaglia K, Chenot F, Moubayed S, Dierckx R, Blouard P, Troisfontaines P, Derthoo D, Smolders W, Bruckers L, Droogne W, Ter Maaten JM, Damman K, Lassus J, Mebazaa A, Filippatos G, Ruschitzka F, Dupont M; ADVOR Study Group
N Engl J Med 2022 Sep 29;387(13):1185-1195. Epub 2022 Aug 27 doi: 10.1056/NEJMoa2203094. PMID: 36027559
Papi A, Chipps BE, Beasley R, Panettieri RA Jr, Israel E, Cooper M, Dunsire L, Jeynes-Ellis A, Johnsson E, Rees R, Cappelletti C, Albers FC
N Engl J Med 2022 Jun 2;386(22):2071-2083. Epub 2022 May 15 doi: 10.1056/NEJMoa2203163. PMID: 35569035
Afinogenova Y, Danve A, Neogi T
Curr Opin Rheumatol 2022 Mar 1;34(2):118-124. doi: 10.1097/BOR.0000000000000861. PMID: 34907116Free PMC Article
Dalbeth N, Gosling AL, Gaffo A, Abhishek A
Lancet 2021 May 15;397(10287):1843-1855. Epub 2021 Mar 30 doi: 10.1016/S0140-6736(21)00569-9. PMID: 33798500

Prognosis

Zhang S, Han X, Liu W, Wen Q, Wang J
Arch Gynecol Obstet 2023 Jul;308(1):63-71. Epub 2022 Aug 1 doi: 10.1007/s00404-022-06718-7. PMID: 35913558
Bacharier LB, Maspero JF, Katelaris CH, Fiocchi AG, Gagnon R, de Mir I, Jain N, Sher LD, Mao X, Liu D, Zhang Y, Khan AH, Kapoor U, Khokhar FA, Rowe PJ, Deniz Y, Ruddy M, Laws E, Patel N, Weinreich DM, Yancopoulos GD, Amin N, Mannent LP, Lederer DJ, Hardin M; Liberty Asthma VOYAGE Investigators
N Engl J Med 2021 Dec 9;385(24):2230-2240. doi: 10.1056/NEJMoa2106567. PMID: 34879449
Thanou A, Jupe E, Purushothaman M, Niewold TB, Munroe ME
J Autoimmun 2021 May;119:102615. Epub 2021 Feb 22 doi: 10.1016/j.jaut.2021.102615. PMID: 33631651Free PMC Article
Suzuki A, Kondoh Y, Brown KK, Johkoh T, Kataoka K, Fukuoka J, Kimura T, Matsuda T, Yokoyama T, Fukihara J, Ando M, Tanaka T, Hashimoto N, Sakamoto K, Hasegawa Y
Respirology 2020 May;25(5):525-534. Epub 2019 Aug 19 doi: 10.1111/resp.13682. PMID: 31426125
Lightstone L, Hladunewich MA
Semin Nephrol 2017 Jul;37(4):347-353. doi: 10.1016/j.semnephrol.2017.05.006. PMID: 28711073

Clinical prediction guides

Celli BR, Fabbri LM, Aaron SD, Agusti A, Brook RD, Criner GJ, Franssen FME, Humbert M, Hurst JR, Montes de Oca M, Pantoni L, Papi A, Rodriguez-Roisin R, Sethi S, Stolz D, Torres A, Vogelmeier CF, Wedzicha JA
Am J Respir Crit Care Med 2023 May 1;207(9):1134-1144. doi: 10.1164/rccm.202209-1795CI. PMID: 36701677Free PMC Article
Ayoub I, Wolf BJ, Geng L, Song H, Khatiwada A, Tsao BP, Oates JC, Rovin BH
Kidney Int 2022 Feb;101(2):379-389. Epub 2021 Dec 3 doi: 10.1016/j.kint.2021.11.014. PMID: 34871620Free PMC Article
Bachelez H, Choon SE, Marrakchi S, Burden AD, Tsai TF, Morita A, Navarini AA, Zheng M, Xu J, Turki H, Anadkat MJ, Rajeswari S, Hua H, Vulcu SD, Hall D, Tetzlaff K, Thoma C, Lebwohl MG; Effisayil 1 Trial Investigators
N Engl J Med 2021 Dec 23;385(26):2431-2440. doi: 10.1056/NEJMoa2111563. PMID: 34936739
Bacharier LB, Maspero JF, Katelaris CH, Fiocchi AG, Gagnon R, de Mir I, Jain N, Sher LD, Mao X, Liu D, Zhang Y, Khan AH, Kapoor U, Khokhar FA, Rowe PJ, Deniz Y, Ruddy M, Laws E, Patel N, Weinreich DM, Yancopoulos GD, Amin N, Mannent LP, Lederer DJ, Hardin M; Liberty Asthma VOYAGE Investigators
N Engl J Med 2021 Dec 9;385(24):2230-2240. doi: 10.1056/NEJMoa2106567. PMID: 34879449
Thanou A, Jupe E, Purushothaman M, Niewold TB, Munroe ME
J Autoimmun 2021 May;119:102615. Epub 2021 Feb 22 doi: 10.1016/j.jaut.2021.102615. PMID: 33631651Free PMC Article

Recent systematic reviews

Zhang S, Han X, Liu W, Wen Q, Wang J
Arch Gynecol Obstet 2023 Jul;308(1):63-71. Epub 2022 Aug 1 doi: 10.1007/s00404-022-06718-7. PMID: 35913558
Kim LHY, Saleh C, Whalen-Browne A, O'Byrne PM, Chu DK
JAMA 2021 Jun 22;325(24):2466-2479. doi: 10.1001/jama.2021.7872. PMID: 34009257Free PMC Article
van Zuuren EJ, Fedorowicz Z, Christensen R, Lavrijsen A, Arents BWM
Cochrane Database Syst Rev 2017 Feb 6;2(2):CD012119. doi: 10.1002/14651858.CD012119.pub2. PMID: 28166390Free PMC Article
Schwendicke F, Göstemeyer G
BMJ Open 2017 Feb 1;7(2):e013115. doi: 10.1136/bmjopen-2016-013115. PMID: 28148534Free PMC Article
Richette P, Doherty M, Pascual E, Barskova V, Becce F, Castañeda-Sanabria J, Coyfish M, Guillo S, Jansen TL, Janssens H, Lioté F, Mallen C, Nuki G, Perez-Ruiz F, Pimentao J, Punzi L, Pywell T, So A, Tausche AK, Uhlig T, Zavada J, Zhang W, Tubach F, Bardin T
Ann Rheum Dis 2017 Jan;76(1):29-42. Epub 2016 Jul 25 doi: 10.1136/annrheumdis-2016-209707. PMID: 27457514

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