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Sleep-wake disorder

MedGen UID:: 875755
•Concept ID:: C4042891
•: Mental or Behavioral Dysfunction

Synonyms:	Disorder, Sleep Wake; Disorders, Sleep Wake; Sleep Wake Disorder; Sleep Wake Disorders; Wake Disorder, Sleep; Wake Disorders, Sleep

Monarch Initiative:	MONDO:0003406

Definition

Abnormal sleep-wake schedule or pattern associated with the circadian rhythm which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle. These can include dyssomnias such as circadian rhythm disorders, hypersomnia, and sleep apnea and parasomnias such as bruxism and rapid eye movement sleep disorder. [from MONDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSleep-wake disorder

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of nervous system
        Sleep-wake disorder
        Dyssomnia
        Circadian rhythm sleep disorder
        Circadian rhythm sleep disorder, jet lag type
        Circadian rhythm sleep disorder, shift work type
        Early chronotype
        Late chronotype
        Shortened sleep phase
        Sleep-wake inversion
        Sleep-wake schedule disorder, delayed phase type
        Sleep deprivation
        Sleep Disorders, Intrinsic
        Disorder of excessive somnolence
        Periodic limb movement disorder
        Restless legs
        Sleep apnea
        Sleep disorder, initiating and maintaining sleep
        Parasomnia
        Disturbance during transitions between sleep and wake states
        Abnormal hypnagogia
        Abnormal hypnopompia
        Exploding head syndrome
        Dream anxiety disorder
        Nocturnal paroxysmal dystonia
        NREM parasomnia
        Sexsomnia
        Sleep terror
        REM parasomnia
        Nightmare disorder
        REM Sleep Parasomnias
        REM sleep behavior disorder
        Sleep paralysis
        Sleep Arousal Disorders
        Somnambulism
        Sleep Bruxism

Professional guidelines

PubMed

Research progress in the prevention and treatment of insomnia with classical prescriptions.

Shi X, Chen L, Li W, Wang R
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2023 Oct 28;48(10):1494-1505. doi: 10.11817/j.issn.1672-7347.2023.230200. PMID: 38432879 Free PMC Article

Use of Actigraphy for the Evaluation of Sleep Disorders and Circadian Rhythm Sleep-Wake Disorders: An American Academy of Sleep Medicine Clinical Practice Guideline.

Smith MT, McCrae CS, Cheung J, Martin JL, Harrod CG, Heald JL, Carden KA
J Clin Sleep Med 2018 Jul 15;14(7):1231-1237. doi: 10.5664/jcsm.7230. PMID: 29991437 Free PMC Article

Diagnosis and Treatment of Non-24-h Sleep-Wake Disorder in the Blind.

Emens JS, Eastman CI
Drugs 2017 Apr;77(6):637-650. doi: 10.1007/s40265-017-0707-3. PMID: 28229310

See all (15)

Recent clinical studies

Etiology

Sleep-wake disorders in veterans with opioid use disorder: Prevalence and comorbidities.

Celik M, Cosentino D, Fuehrlein B
Sleep Health 2023 Dec;9(6):889-892. Epub 2023 Jul 10 doi: 10.1016/j.sleh.2023.05.012. PMID: 37438174

Circadian Rhythm Disturbances in the Blind.

Hartley S, Dauvilliers Y, Quera-Salva MA
Curr Neurol Neurosci Rep 2018 Aug 6;18(10):65. doi: 10.1007/s11910-018-0876-9. PMID: 30083814

Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.

Sletten TL, Magee M, Murray JM, Gordon CJ, Lovato N, Kennaway DJ, Gwini SM, Bartlett DJ, Lockley SW, Lack LC, Grunstein RR, Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group
PLoS Med 2018 Jun;15(6):e1002587. Epub 2018 Jun 18 doi: 10.1371/journal.pmed.1002587. PMID: 29912983 Free PMC Article

Impacts of shift work on sleep and circadian rhythms.

Boivin DB, Boudreau P
Pathol Biol (Paris) 2014 Oct;62(5):292-301. Epub 2014 Sep 20 doi: 10.1016/j.patbio.2014.08.001. PMID: 25246026

Excessive sleepiness: under-recognized and essential marker for sleep/wake disorder management.

Roth T, Bogan RK, Culpepper L, Doghramji K, Doghramji P, Drake C, Grauke JH, Knoepflmacher P, Sateia M, Silvershein D, Thorpy MJ
Curr Med Res Opin 2010 Dec;26 Suppl 2:S3-24; quiz S25-7. doi: 10.1185/03007995.2010.532544. PMID: 21077746

See all (50)

Diagnosis

Non-24-hour Sleep-Wake Rhythm Disorder.

Abbott SM
Neurol Clin 2019 Aug;37(3):545-552. Epub 2019 Apr 30 doi: 10.1016/j.ncl.2019.03.002. PMID: 31256788

Use of Actigraphy for the Evaluation of Sleep Disorders and Circadian Rhythm Sleep-Wake Disorders: An American Academy of Sleep Medicine Clinical Practice Guideline.

Smith MT, McCrae CS, Cheung J, Martin JL, Harrod CG, Heald JL, Carden KA
J Clin Sleep Med 2018 Jul 15;14(7):1231-1237. doi: 10.5664/jcsm.7230. PMID: 29991437 Free PMC Article

Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.

Diagnosis and Treatment of Non-24-h Sleep-Wake Disorder in the Blind.

Emens JS, Eastman CI
Drugs 2017 Apr;77(6):637-650. doi: 10.1007/s40265-017-0707-3. PMID: 28229310

Exploding head syndrome.

Sharpless BA
Sleep Med Rev 2014 Dec;18(6):489-93. Epub 2014 Mar 13 doi: 10.1016/j.smrv.2014.03.001. PMID: 24703829

See all (68)

Therapy

Circadian Rhythm Disturbances in the Blind.

Hartley S, Dauvilliers Y, Quera-Salva MA
Curr Neurol Neurosci Rep 2018 Aug 6;18(10):65. doi: 10.1007/s11910-018-0876-9. PMID: 30083814

Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.

Diagnosis and Treatment of Non-24-h Sleep-Wake Disorder in the Blind.

Emens JS, Eastman CI
Drugs 2017 Apr;77(6):637-650. doi: 10.1007/s40265-017-0707-3. PMID: 28229310

Impacts of shift work on sleep and circadian rhythms.

Boivin DB, Boudreau P
Pathol Biol (Paris) 2014 Oct;62(5):292-301. Epub 2014 Sep 20 doi: 10.1016/j.patbio.2014.08.001. PMID: 25246026

Tasimelteon: first global approval.

Dhillon S, Clarke M
Drugs 2014 Mar;74(4):505-11. doi: 10.1007/s40265-014-0200-1. PMID: 24610704

See all (49)

Prognosis

Major depressive episode with insomnia and excessive daytime sleepiness: A more homogeneous and severe subtype of depression.

Maruani J, Boiret C, Leseur J, Romier A, Bazin B, Stern E, Lejoyeux M, Geoffroy PA
Psychiatry Res 2023 Dec;330:115603. Epub 2023 Nov 11 doi: 10.1016/j.psychres.2023.115603. PMID: 37979319

Light-based methods for predicting circadian phase in delayed sleep-wake phase disorder.

Murray JM, Magee M, Sletten TL, Gordon C, Lovato N, Ambani K, Bartlett DJ, Kennaway DJ, Lack LC, Grunstein RR, Lockley SW, Rajaratnam SMW, Phillips AJK
Sci Rep 2021 May 25;11(1):10878. doi: 10.1038/s41598-021-89924-8. PMID: 34035333 Free PMC Article

Fibromyalgia, sleep disturbance and menopause: Is there a relationship? A literature review.

Dias RCA, Kulak Junior J, Ferreira da Costa EH, Nisihara RM
Int J Rheum Dis 2019 Nov;22(11):1961-1971. Epub 2019 Oct 14 doi: 10.1111/1756-185X.13713. PMID: 31612618

Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers.

Talih F, Gebara NY, Andary FS, Mondello S, Kobeissy F, Ferri R
Sleep Med Rev 2018 Oct;41:133-140. Epub 2018 Feb 13 doi: 10.1016/j.smrv.2018.02.002. PMID: 29534856

Impacts of shift work on sleep and circadian rhythms.

Boivin DB, Boudreau P
Pathol Biol (Paris) 2014 Oct;62(5):292-301. Epub 2014 Sep 20 doi: 10.1016/j.patbio.2014.08.001. PMID: 25246026

See all (18)

Clinical prediction guides

Recent insights into the pathophysiology of narcolepsy type 1.

Vringer M, Zhou J, Gool JK, Bijlenga D, Lammers GJ, Fronczek R, Schinkelshoek MS
Sleep Med Rev 2024 Dec;78:101993. Epub 2024 Aug 15 doi: 10.1016/j.smrv.2024.101993. PMID: 39241492

Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers.

Talih F, Gebara NY, Andary FS, Mondello S, Kobeissy F, Ferri R
Sleep Med Rev 2018 Oct;41:133-140. Epub 2018 Feb 13 doi: 10.1016/j.smrv.2018.02.002. PMID: 29534856

The Development of Sleep Medicine: A Historical Sketch.

Schulz H, Salzarulo P
J Clin Sleep Med 2016 Jul 15;12(7):1041-52. doi: 10.5664/jcsm.5946. PMID: 27250813 Free PMC Article

Impacts of shift work on sleep and circadian rhythms.

Boivin DB, Boudreau P
Pathol Biol (Paris) 2014 Oct;62(5):292-301. Epub 2014 Sep 20 doi: 10.1016/j.patbio.2014.08.001. PMID: 25246026

Tasimelteon: a melatonin receptor agonist for non-24-hour sleep-wake disorder.

Johnsa JD, Neville MW
Ann Pharmacother 2014 Dec;48(12):1636-41. Epub 2014 Sep 9 doi: 10.1177/1060028014550476. PMID: 25204464

See all (29)

Recent systematic reviews

Sex Differences in Insomnia and Circadian Rhythm Disorders: A Systematic Review.

Pajėdienė E, Urbonavičiūtė V, Ramanauskaitė V, Strazdauskas L, Stefani A
Medicina (Kaunas) 2024 Mar 13;60(3) doi: 10.3390/medicina60030474. PMID: 38541200 Free PMC Article

Social and circadian rhythm dysregulation and suicide: A systematic review and meta-analysis.

Walsh RFL, Maddox MA, Smith LT, Liu RT, Alloy LB
Neurosci Biobehav Rev 2024 Mar;158:105560. Epub 2024 Jan 23 doi: 10.1016/j.neubiorev.2024.105560. PMID: 38272337 Free PMC Article

See all (2)

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Sleep-wake disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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