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Haemophilus influenzae infection

MedGen UID:
87592
•Concept ID:
C0348321
•
Disease or Syndrome
Synonyms: Haemophilus influenzae Infection; Haemophilus influenzae Infections; Infection, Haemophilus influenzae
SNOMED CT: Haemophilus influenzae infection (91428005)

Definition

An infection that is caused by the organism Hemophilus influenza. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHaemophilus influenzae infection

Professional guidelines

PubMed

Evaluation and management of infants and young children with fever.
Luszczak M
Am Fam Physician 2001 Oct 1;64(7):1219-26. PMID: 11601804
Cephazolin treatment of pneumonia in the elderly.
Castleton B, Goodwin CS, Stirling J, Pitcher-Wilmott R, Elton A
Age Ageing 1976 Aug;5(3):181-7. doi: 10.1093/ageing/5.3.181. PMID: 973593

Recent clinical studies

Etiology

Extensively drug-resistant Haemophilus influenzae - emergence, epidemiology, risk factors, and regimen.
Su PY, Huang AH, Lai CH, Lin HF, Lin TM, Ho CH
BMC Microbiol 2020 Apr 28;20(1):102. doi: 10.1186/s12866-020-01785-9. PMID: 32345232Free PMC Article
Invasive Nontypeable Haemophilus influenzae Infection Among Adults With HIV in Metropolitan Atlanta, Georgia, 2008-2018.
Collins LF, Havers FP, Tunali A, Thomas S, Clennon JA, Wiley Z, Tobin-D'Angelo M, Parrott T, Read TD, Satola SW, Petit RA 3rd, Farley MM
JAMA 2019 Dec 24;322(24):2399-2410. doi: 10.1001/jama.2019.18800. PMID: 31860046Free PMC Article
Risk of invasive Haemophilus influenzae infection during pregnancy and association with adverse fetal outcomes.
Collins S, Ramsay M, Slack MP, Campbell H, Flynn S, Litt D, Ladhani SN
JAMA 2014 Mar 19;311(11):1125-32. doi: 10.1001/jama.2014.1878. PMID: 24643602
Haemophilus influenzae infection and Guillain-Barré syndrome.
Mori M, Kuwabara S, Miyake M, Noda M, Kuroki H, Kanno H, Ogawara K, Hattori T
Brain 2000 Oct;123 ( Pt 10):2171-8. doi: 10.1093/brain/123.10.2171. PMID: 11004133
Haemophilus influenzae: then and now.
Jordens JZ, Slack MP
Eur J Clin Microbiol Infect Dis 1995 Nov;14(11):935-48. doi: 10.1007/BF01691374. PMID: 8654443

Diagnosis

Invasive Haemophilus influenzae Infection in Patients With Cancer.
Singh V, Nanjappa S, Pabbathi S, Greene JN
Cancer Control 2017 Jan;24(1):66-71. doi: 10.1177/107327481702400111. PMID: 28178716
Non-Type b Haemophilus influenzae Invasive Infections in North Dakota and South Dakota, 2013-2015.
Antony S, Kaushik A, Mauriello C, Chatterjee A
J Pediatric Infect Dis Soc 2017 Sep 1;6(3):281-284. doi: 10.1093/jpids/piw053. PMID: 27656134
The role of cytomegalovirus, Haemophilus influenzae and Epstein Barr virus in Guillain Barre syndrome.
Nafissi S, Vahabi Z, Sadeghi Ghahar M, Amirzargar AA, Naderi S
Acta Med Iran 2013 Jul 13;51(6):372-6. PMID: 23852841
Invasive Haemophilus influenzae serotype e and f disease, England and Wales.
Ladhani SN, Collins S, Vickers A, Litt DJ, Crawford C, Ramsay ME, Slack MP
Emerg Infect Dis 2012 May;18(5):725-32. doi: 10.3201/eid1805.111738. PMID: 22515912Free PMC Article
Evaluation and management of infants and young children with fever.
Luszczak M
Am Fam Physician 2001 Oct 1;64(7):1219-26. PMID: 11601804

Therapy

Extensively drug-resistant Haemophilus influenzae - emergence, epidemiology, risk factors, and regimen.
Su PY, Huang AH, Lai CH, Lin HF, Lin TM, Ho CH
BMC Microbiol 2020 Apr 28;20(1):102. doi: 10.1186/s12866-020-01785-9. PMID: 32345232Free PMC Article
Invasive Haemophilus influenzae Infection in Patients With Cancer.
Singh V, Nanjappa S, Pabbathi S, Greene JN
Cancer Control 2017 Jan;24(1):66-71. doi: 10.1177/107327481702400111. PMID: 28178716
Interleukin-22 protects against non-typeable Haemophilus influenzae infection: alteration during chronic obstructive pulmonary disease.
Sharan R, Perez-Cruz M, Kervoaze G, Gosset P, Weynants V, Godfroid F, Hermand P, Trottein F, Pichavant M, Gosset P
Mucosal Immunol 2017 Jan;10(1):139-149. Epub 2016 May 4 doi: 10.1038/mi.2016.40. PMID: 27143304
Necrotising fasciitis complicating Haemophilus influenzae type b epiglottitis in an adult.
Chalmers C
J Laryngol Otol 2010 Jul;124(7):807-9. Epub 2009 Nov 23 doi: 10.1017/S0022215109992076. PMID: 19930753
Effect of dirithromycin on Haemophilus influenzae infection of the respiratory mucosa.
Rutman A, Dowling R, Wills P, Feldman C, Cole PJ, Wilson R
Antimicrob Agents Chemother 1998 Apr;42(4):772-8. doi: 10.1128/AAC.42.4.772. PMID: 9559781Free PMC Article

Prognosis

Nontypeable Haemophilus influenzae Infection Impedes Pseudomonas aeruginosa Colonization and Persistence in Mouse Respiratory Tract.
Lindgren NR, Novak L, Hunt BC, McDaniel MS, Swords WE
Infect Immun 2022 Feb 17;90(2):e0056821. Epub 2021 Nov 15 doi: 10.1128/IAI.00568-21. PMID: 34780275Free PMC Article
Extensively drug-resistant Haemophilus influenzae - emergence, epidemiology, risk factors, and regimen.
Su PY, Huang AH, Lai CH, Lin HF, Lin TM, Ho CH
BMC Microbiol 2020 Apr 28;20(1):102. doi: 10.1186/s12866-020-01785-9. PMID: 32345232Free PMC Article
Invasive Nontypeable Haemophilus influenzae Infection Among Adults With HIV in Metropolitan Atlanta, Georgia, 2008-2018.
Collins LF, Havers FP, Tunali A, Thomas S, Clennon JA, Wiley Z, Tobin-D'Angelo M, Parrott T, Read TD, Satola SW, Petit RA 3rd, Farley MM
JAMA 2019 Dec 24;322(24):2399-2410. doi: 10.1001/jama.2019.18800. PMID: 31860046Free PMC Article
Infections in "noninfectious" lung diseases.
Fitzpatrick ME, Sethi S, Daley CL, Ray P, Beck JM, Gingo MR
Ann Am Thorac Soc 2014 Aug;11 Suppl 4(Suppl 4):S221-6. doi: 10.1513/AnnalsATS.201401-041PL. PMID: 25148428Free PMC Article
Risk of invasive Haemophilus influenzae infection during pregnancy and association with adverse fetal outcomes.
Collins S, Ramsay M, Slack MP, Campbell H, Flynn S, Litt D, Ladhani SN
JAMA 2014 Mar 19;311(11):1125-32. doi: 10.1001/jama.2014.1878. PMID: 24643602

Clinical prediction guides

Fetal Loss and Preterm Birth Caused by Intraamniotic Haemophilus influenzae Infection, New Zealand.
Hills T, Sharpe C, Wong T, Cutfield T, Lee A, McBride S, Rogers M, Soh MC, Taylor A, Taylor S, Thomas M
Emerg Infect Dis 2022 Sep;28(9):1749-1754. doi: 10.3201/eid2809.220313. PMID: 35997306Free PMC Article
Nontypeable Haemophilus influenzae Infection Impedes Pseudomonas aeruginosa Colonization and Persistence in Mouse Respiratory Tract.
Lindgren NR, Novak L, Hunt BC, McDaniel MS, Swords WE
Infect Immun 2022 Feb 17;90(2):e0056821. Epub 2021 Nov 15 doi: 10.1128/IAI.00568-21. PMID: 34780275Free PMC Article
Extensively drug-resistant Haemophilus influenzae - emergence, epidemiology, risk factors, and regimen.
Su PY, Huang AH, Lai CH, Lin HF, Lin TM, Ho CH
BMC Microbiol 2020 Apr 28;20(1):102. doi: 10.1186/s12866-020-01785-9. PMID: 32345232Free PMC Article
Toll-like receptor 4 gene (TLR4), but not TLR2, polymorphisms modify the risk of tonsillar disease due to Streptococcus pyogenes and Haemophilus influenzae.
Liadaki K, Petinaki E, Skoulakis C, Tsirevelou P, Klapsa D, Germenis AE, Speletas M
Clin Vaccine Immunol 2011 Feb;18(2):217-22. Epub 2010 Dec 15 doi: 10.1128/CVI.00460-10. PMID: 21159925Free PMC Article
Analysis of invasive Haemophilus influenzae infections after extensive vaccination against H. influenzae type b.
Campos J, Hernando M, Román F, Pérez-Vázquez M, Aracil B, Oteo J, Lázaro E, de Abajo F; Group of Invasive Haemophilus Infections of the Autonomous Community of Madrid, Spain,
J Clin Microbiol 2004 Feb;42(2):524-9. doi: 10.1128/JCM.42.2.524-529.2004. PMID: 14766811Free PMC Article

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