U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Benign Skin Fibroblastic Neoplasm

MedGen UID:
87602
•Concept ID:
C0349526
•
Neoplastic Process
Synonyms: Benign Cutaneous Fibroblastic Neoplasm; Benign Cutaneous Fibroblastic Tumor; Benign Cutaneous Fibrocytic Neoplasm; Benign Cutaneous Fibrous Neoplasm; Benign Cutaneous Fibrous Tissue Neoplasm; Benign Fibrous Tissue Neoplasm of Skin; Benign Fibrous Tissue Skin Neoplasm; Benign Fibrous Tissue Skin Tumor; Benign Fibrous Tissue Tumor of Skin

Definition

A benign neoplasm arising from the dermis. It is characterized by the presence of neoplastic fibroblasts without malignant characteristics. [from NCI]

Professional guidelines

PubMed

Treatment Options for Multinucleate Cell Angiohistiocytoma: A Case Series and Review of the Literature.
Taibo A, Padin CP, Losada JDP, Fonseca E
J Cutan Med Surg 2023 May-Jun;27(3):219-225. Epub 2023 Mar 16 doi: 10.1177/12034754231163539. PMID: 36927096
Diagnosis and differential diagnosis of dermatofibrosarcoma protuberans: Utility of high-resolution dynamic contrast-enhanced (DCE) MRI.
Yu Q, Zhu Y, Huang R, Li Y, Song L, Zhang X, Tang M, Gu Q, Li P, Zhou N, Li Y
Skin Res Technol 2022 Sep;28(5):651-663. Epub 2022 May 31 doi: 10.1111/srt.13164. PMID: 35639715Free PMC Article
Dermatofibrosarcoma Protuberans: The Current State of Multidisciplinary Management.
Ramirez-Fort MK, Meier-Schiesser B, Niaz MJ, Niaz MO, Feily A, Fort M, Lange CS, Caba D
Skinmed 2020;18(5):288-293. Epub 2020 Oct 1 PMID: 33160438

Recent clinical studies

Etiology

Fibroblastic and Myofibroblastic Soft-Tissue Tumors: Imaging Spectrum and Radiologic-Pathologic Correlation.
Haseli S, Mansoori B, Christensen D, Abadi A, Pooyan A, Shomal Zadeh F, Mau B, Khalili N, Murphey M, Chalian M
Radiographics 2023 Aug;43(8):e230005. doi: 10.1148/rg.230005. PMID: 37440448
Intramuscular Eyelid Myxoma.
Liu CK, Williamson JE 3rd, Milman T, Lally SE, Shields CL
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):e180-e183. Epub 2022 Jul 4 doi: 10.1097/IOP.0000000000002236. PMID: 35793663
Fibrohistiocytic Tumors.
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503
Molecular pathology of skin neoplasms of the head and neck.
Kraft S, Granter SR
Arch Pathol Lab Med 2014 Jun;138(6):759-87. doi: 10.5858/arpa.2013-0157-RA. PMID: 24878016
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Diagnosis

Gene fusions in superficial mesenchymal neoplasms: Emerging entities and useful diagnostic adjuncts.
Fischer GM, Papke DJ Jr
Semin Diagn Pathol 2023 Jul;40(4):246-257. Epub 2023 Apr 25 doi: 10.1053/j.semdp.2023.04.014. PMID: 37156707
Atypical Fibroxanthoma.
Chapman LW, Yu SS, Arron ST
Semin Cutan Med Surg 2019 Mar 1;38(1):E65-E66. doi: 10.12788/j.sder.2019.008. PMID: 31051027
Histologic Mimics of Basal Cell Carcinoma.
Stanoszek LM, Wang GY, Harms PW
Arch Pathol Lab Med 2017 Nov;141(11):1490-1502. doi: 10.5858/arpa.2017-0222-RA. PMID: 29072946
Fibrohistiocytic Tumors.
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503
Atypical fibroxanthoma.
Ziemer M
J Dtsch Dermatol Ges 2012 Aug;10(8):537-50. Epub 2012 Jun 19 doi: 10.1111/j.1610-0387.2012.07980.x. PMID: 22709412

Therapy

When to suspect a non-melanoma skin cancer.
Smith H, Wernham A, Patel A
BMJ 2020 Mar 11;368:m692. doi: 10.1136/bmj.m692. PMID: 32161002
Molecular pathology of skin neoplasms of the head and neck.
Kraft S, Granter SR
Arch Pathol Lab Med 2014 Jun;138(6):759-87. doi: 10.5858/arpa.2013-0157-RA. PMID: 24878016
Cutaneous cryosurgery.
Zimmerman EE, Crawford P
Am Fam Physician 2012 Dec 15;86(12):1118-24. PMID: 23316984
Infantile digital fibromatosis.
Taylor HO, Gellis SE, Schmidt BA, Upton J, Rogers GF
Ann Plast Surg 2008 Oct;61(4):472-6. doi: 10.1097/SAP.0b013e31816d8236. PMID: 18812724
Cutaneous lesions: benign and malignant.
Padgett JK
Facial Plast Surg Clin North Am 2005 May;13(2):195-202, v. doi: 10.1016/j.fsc.2004.11.006. PMID: 15817400

Prognosis

Fibroblastic and Myofibroblastic Soft-Tissue Tumors: Imaging Spectrum and Radiologic-Pathologic Correlation.
Haseli S, Mansoori B, Christensen D, Abadi A, Pooyan A, Shomal Zadeh F, Mau B, Khalili N, Murphey M, Chalian M
Radiographics 2023 Aug;43(8):e230005. doi: 10.1148/rg.230005. PMID: 37440448
Intramuscular Eyelid Myxoma.
Liu CK, Williamson JE 3rd, Milman T, Lally SE, Shields CL
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):e180-e183. Epub 2022 Jul 4 doi: 10.1097/IOP.0000000000002236. PMID: 35793663
Nail tumors.
Richert B, Lecerf P, Caucanas M, André J
Clin Dermatol 2013 Sep-Oct;31(5):602-17. doi: 10.1016/j.clindermatol.2013.06.014. PMID: 24079590
Cutaneous paraneoplasia.
Ramos-E-Silva M, Carvalho JC, Carneiro SC
Clin Dermatol 2011 Sep-Oct;29(5):541-7. doi: 10.1016/j.clindermatol.2010.09.022. PMID: 21855730
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Clinical prediction guides

Fibroblastic and Myofibroblastic Soft-Tissue Tumors: Imaging Spectrum and Radiologic-Pathologic Correlation.
Haseli S, Mansoori B, Christensen D, Abadi A, Pooyan A, Shomal Zadeh F, Mau B, Khalili N, Murphey M, Chalian M
Radiographics 2023 Aug;43(8):e230005. doi: 10.1148/rg.230005. PMID: 37440448
Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review.
Seifi G, Kalantari Y, Etesami I
J Dtsch Dermatol Ges 2022 Dec;20(12):1569-1579. Epub 2022 Dec 4 doi: 10.1111/ddg.14888. PMID: 36464809
Miliary fibromas in tuberous sclerosis complex.
Cartron AM, Buccine D, Treichel AM, Lee CR, Moss J, Darling TN
J Eur Acad Dermatol Venereol 2021 May;35(5):1226-1229. Epub 2021 Feb 23 doi: 10.1111/jdv.17161. PMID: 33565654Free PMC Article
Soft Tissue Special Issue: Cutaneous Pleomorphic Spindle Cell Tumors.
Brenn T
Head Neck Pathol 2020 Mar;14(1):109-120. Epub 2020 Jan 16 doi: 10.1007/s12105-019-01084-4. PMID: 31950467Free PMC Article
Cutaneous cryosurgery.
Zimmerman EE, Crawford P
Am Fam Physician 2012 Dec 15;86(12):1118-24. PMID: 23316984

Recent systematic reviews

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review.
Seifi G, Kalantari Y, Etesami I
J Dtsch Dermatol Ges 2022 Dec;20(12):1569-1579. Epub 2022 Dec 4 doi: 10.1111/ddg.14888. PMID: 36464809
Clinicopathologic Features of Facial Dermatofibromas, a Cohort Study, and a Systematic Review of Literature.
Alsawas M, Dundar B, Prokop L, Murad MH, Swick B
Am J Dermatopathol 2022 Nov 1;44(11):822-827. Epub 2022 Apr 27 doi: 10.1097/DAD.0000000000002211. PMID: 35503883
Generalized multinucleate cell angiohistiocytoma: case report and literature review.
Wang M, Abdul-Fattah B, Wang C, Zhao Y, Qu X, Al-Muriesh M, Wang X, Zhu L, Qian Y, Huang C, Chen S
J Cutan Pathol 2017 Feb;44(2):125-134. Epub 2016 Nov 28 doi: 10.1111/cup.12853. PMID: 27813137
Surgery for Dupuytren's contracture of the fingers.
Rodrigues JN, Becker GW, Ball C, Zhang W, Giele H, Hobby J, Pratt AL, Davis T
Cochrane Database Syst Rev 2015 Dec 9;2015(12):CD010143. doi: 10.1002/14651858.CD010143.pub2. PMID: 26648251Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...