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Late Onset Disorders

MedGen UID:
87698
•Concept ID:
C0376415
•
Finding
Synonyms: Disease, Late Onset; Diseases, Late Onset; Disorder, Late Onset; Disorder, Late-Onset; Disorder, Later Onset; Disorders, Late Onset; Disorders, Late-Onset; Disorders, Later Onset; Late Onset Disease; Late Onset Diseases; Late Onset Disorder; Late-Onset Disorder; Late-Onset Disorders; Later Onset Disorder; Later Onset Disorders; Onset Disease, Late; Onset Diseases, Late; Onset Disorder, Late; Onset Disorder, Later; Onset Disorders, Late; Onset Disorders, Later

Definition

Pathological conditions (Disorder, SYNDROME, or DISEASE) whose SIGNS AND SYMPTOMS manifest late in the life of an individual. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLate Onset Disorders

Professional guidelines

PubMed

Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.
Fischer CE, Namasivayam A, Crawford-Holland L, Hakobyan N, Schweizer TA, Munoz DG, Pollock BG
Psychiatr Clin North Am 2022 Dec;45(4):691-705. Epub 2022 Oct 14 doi: 10.1016/j.psc.2022.07.001. PMID: 36396273
Microarrays in prenatal diagnosis.
Oneda B, Rauch A
Best Pract Res Clin Obstet Gynaecol 2017 Jul;42:53-63. Epub 2017 Jan 23 doi: 10.1016/j.bpobgyn.2017.01.003. PMID: 28215395
Prenatal diagnosis.
Kabra M
Indian J Pediatr 2003 Jan;70(1):81-5. doi: 10.1007/BF02722749. PMID: 12619957

Recent clinical studies

Etiology

Late-onset Alzheimer Disease.
Rabinovici GD
Continuum (Minneap Minn) 2019 Feb;25(1):14-33. doi: 10.1212/CON.0000000000000700. PMID: 30707185Free PMC Article
Newborn screening in mucopolysaccharidoses.
Donati MA, Pasquini E, Spada M, Polo G, Burlina A
Ital J Pediatr 2018 Nov 16;44(Suppl 2):126. doi: 10.1186/s13052-018-0552-3. PMID: 30442156Free PMC Article
Diagnosis and surveillance of late-onset fetal growth restriction.
Figueras F, Caradeux J, Crispi F, Eixarch E, Peguero A, Gratacos E
Am J Obstet Gynecol 2018 Feb;218(2S):S790-S802.e1. doi: 10.1016/j.ajog.2017.12.003. PMID: 29422212
Microarrays in prenatal diagnosis.
Oneda B, Rauch A
Best Pract Res Clin Obstet Gynaecol 2017 Jul;42:53-63. Epub 2017 Jan 23 doi: 10.1016/j.bpobgyn.2017.01.003. PMID: 28215395
Prenatal diagnosis.
Kabra M
Indian J Pediatr 2003 Jan;70(1):81-5. doi: 10.1007/BF02722749. PMID: 12619957

Diagnosis

Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.
Fischer CE, Namasivayam A, Crawford-Holland L, Hakobyan N, Schweizer TA, Munoz DG, Pollock BG
Psychiatr Clin North Am 2022 Dec;45(4):691-705. Epub 2022 Oct 14 doi: 10.1016/j.psc.2022.07.001. PMID: 36396273
Late-onset Alzheimer Disease.
Rabinovici GD
Continuum (Minneap Minn) 2019 Feb;25(1):14-33. doi: 10.1212/CON.0000000000000700. PMID: 30707185Free PMC Article
Diagnosis and surveillance of late-onset fetal growth restriction.
Figueras F, Caradeux J, Crispi F, Eixarch E, Peguero A, Gratacos E
Am J Obstet Gynecol 2018 Feb;218(2S):S790-S802.e1. doi: 10.1016/j.ajog.2017.12.003. PMID: 29422212
Anemia at older age: etiologies, clinical implications, and management.
Stauder R, Valent P, Theurl I
Blood 2018 Feb 1;131(5):505-514. Epub 2017 Nov 15 doi: 10.1182/blood-2017-07-746446. PMID: 29141943
Frailty and the management of hematologic malignancies.
Abel GA, Klepin HD
Blood 2018 Feb 1;131(5):515-524. Epub 2017 Nov 15 doi: 10.1182/blood-2017-09-746420. PMID: 29141942

Therapy

Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.
Fischer CE, Namasivayam A, Crawford-Holland L, Hakobyan N, Schweizer TA, Munoz DG, Pollock BG
Psychiatr Clin North Am 2022 Dec;45(4):691-705. Epub 2022 Oct 14 doi: 10.1016/j.psc.2022.07.001. PMID: 36396273
Late-onset hypogonadism a challenging task for the andrology field.
Corona G, Krausz C
Andrology 2020 Nov;8(6):1504-1505. doi: 10.1111/andr.12917. PMID: 33460316
Risk of stroke after new-onset seizures.
Larsson D, Farahmand B, Åsberg S, Zelano J
Seizure 2020 Dec;83:76-82. Epub 2020 Oct 5 doi: 10.1016/j.seizure.2020.09.033. PMID: 33120325
Nonlesional late-onset epilepsy: Semiology, EEG, cerebrospinal fluid, and seizure outcome characteristics.
Süße M, Hamann L, Flöel A, von Podewils F
Epilepsy Behav 2019 Feb;91:75-80. Epub 2018 Jun 22 doi: 10.1016/j.yebeh.2018.05.043. PMID: 29941211
A systematic review and meta-analysis of psychotherapy for late-life depression.
Huang AX, Delucchi K, Dunn LB, Nelson JC
Am J Geriatr Psychiatry 2015 Mar;23(3):261-73. Epub 2014 Apr 23 doi: 10.1016/j.jagp.2014.04.003. PMID: 24856580

Prognosis

Sleep disorders and late-onset epilepsy of unknown origin: Understanding new trajectories to brain amyloidopathy.
Liguori C, Spanetta M, Romoli M, Placidi F, Nardi Cesarini E, Mercuri NB, Costa C
Mech Ageing Dev 2021 Mar;194:111434. Epub 2021 Jan 11 doi: 10.1016/j.mad.2021.111434. PMID: 33444630
Presentation and outcomes of early and late onset neonatal sepsis in a Nigerian Hospital.
Ogundare E, Akintayo A, Aladekomo T, Adeyemi L, Ogunlesi T, Oyelami O
Afr Health Sci 2019 Sep;19(3):2390-2399. doi: 10.4314/ahs.v19i3.12. PMID: 32127809Free PMC Article
Newborn screening in mucopolysaccharidoses.
Donati MA, Pasquini E, Spada M, Polo G, Burlina A
Ital J Pediatr 2018 Nov 16;44(Suppl 2):126. doi: 10.1186/s13052-018-0552-3. PMID: 30442156Free PMC Article
Microarrays in prenatal diagnosis.
Oneda B, Rauch A
Best Pract Res Clin Obstet Gynaecol 2017 Jul;42:53-63. Epub 2017 Jan 23 doi: 10.1016/j.bpobgyn.2017.01.003. PMID: 28215395
The attenuated/late onset lysosomal storage disorders: Therapeutic goals and indications for enzyme replacement treatment in Gaucher and Fabry disease.
Hollak CE, Weinreb NJ
Best Pract Res Clin Endocrinol Metab 2015 Mar;29(2):205-18. Epub 2014 Aug 27 doi: 10.1016/j.beem.2014.08.006. PMID: 25987174

Clinical prediction guides

Not Just an Intrapartum Problem: Late-Onset Group B Streptococcus Disease.
Lucas LH, Earp MT, Bauserman M
Neonatal Netw 2023 Mar 1;42(2):81-87. doi: 10.1891/NN.2022-0027. PMID: 36868807
Artificial intelligence and leukocyte epigenomics: Evaluation and prediction of late-onset Alzheimer's disease.
Bahado-Singh RO, Vishweswaraiah S, Aydas B, Yilmaz A, Metpally RP, Carey DJ, Crist RC, Berrettini WH, Wilson GD, Imam K, Maddens M, Bisgin H, Graham SF, Radhakrishna U
PLoS One 2021;16(3):e0248375. Epub 2021 Mar 31 doi: 10.1371/journal.pone.0248375. PMID: 33788842Free PMC Article
Clinical and Laboratory Differences Between Early-Onset and Late-Onset Adult Atopic Dermatitis.
Ha DL, Park GH, Kim HS, Ko HC, Kim MB, Lim KM, Kim BS
J Cutan Med Surg 2020 Jul/Aug;24(4):360-366. Epub 2020 Apr 22 doi: 10.1177/1203475420921385. PMID: 32316754
Presentation and outcomes of early and late onset neonatal sepsis in a Nigerian Hospital.
Ogundare E, Akintayo A, Aladekomo T, Adeyemi L, Ogunlesi T, Oyelami O
Afr Health Sci 2019 Sep;19(3):2390-2399. doi: 10.4314/ahs.v19i3.12. PMID: 32127809Free PMC Article
Newborn screening in mucopolysaccharidoses.
Donati MA, Pasquini E, Spada M, Polo G, Burlina A
Ital J Pediatr 2018 Nov 16;44(Suppl 2):126. doi: 10.1186/s13052-018-0552-3. PMID: 30442156Free PMC Article

Recent systematic reviews

Antidepressants for anxiety disorders in late-life: A systematic review.
Balasubramaniam M, Joshi P, Alag P, Gupta S, Maher S, Tampi D, Gupta A, Young J, Tampi RR
Ann Clin Psychiatry 2019 Nov;31(4):277-291. PMID: 31369663
Routine screening for colonization by Gram-negative bacteria in neonates at intensive care units for the prediction of sepsis: systematic review and meta-analysis.
Seidel J, Haller S, Eckmanns T, Harder T
J Hosp Infect 2018 Aug;99(4):367-380. Epub 2018 Mar 22 doi: 10.1016/j.jhin.2018.03.017. PMID: 29577993
Predictors of treatment outcome in depression in later life: A systematic review and meta-analysis.
Tunvirachaisakul C, Gould RL, Coulson MC, Ward EV, Reynolds G, Gathercole RL, Grocott H, Supasitthumrong T, Tunvirachaisakul A, Kimona K, Howard RJ
J Affect Disord 2018 Feb;227:164-182. Epub 2017 Oct 10 doi: 10.1016/j.jad.2017.10.008. PMID: 29100149
A systematic review and meta-analysis of cutaneous manifestations in late- versus early-onset systemic lupus erythematosus.
Medlin JL, Hansen KE, Fitz SR, Bartels CM
Semin Arthritis Rheum 2016 Jun;45(6):691-7. Epub 2016 Jan 21 doi: 10.1016/j.semarthrit.2016.01.004. PMID: 26972993Free PMC Article
A systematic review and meta-analysis of psychotherapy for late-life depression.
Huang AX, Delucchi K, Dunn LB, Nelson JC
Am J Geriatr Psychiatry 2015 Mar;23(3):261-73. Epub 2014 Apr 23 doi: 10.1016/j.jagp.2014.04.003. PMID: 24856580

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