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Optic perineuritis

MedGen UID:
881493
Concept ID:
C4076165
Disease or Syndrome
Synonyms: Idiopathic OPN; Idiopathic optic perineuritis; OPN; optic perineuritis
SNOMED CT: Optic perineuritis (713417000)
 
Monarch Initiative: MONDO:0044690
Orphanet: ORPHA499107

Definition

A rare ophthalmic disorder characterized by idiopathic orbital inflammation in which the specific target tissue is the optic nerve sheath. Patients typically present with ocular pain, pain on eye movement, visual symptoms with loss of vision progressing over several weeks, dyschromatopsia, and variable visual field defects. Orbital signs and symptoms may be present and include ptosis, ophthalmoplegia, and exophthalmos. Optic disc edema is observed in most cases. The condition is usually unilateral. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOptic perineuritis

Professional guidelines

PubMed

Maleki A, Ramezani K, Colombo A, Foster CS
Can J Ophthalmol 2022 Jun;57(3):e100-e103. Epub 2021 Nov 3 doi: 10.1016/j.jcjo.2021.09.012. PMID: 34742701
Takeuchi M, Kanda T, Kaburaki T, Tanaka R, Namba K, Kamoi K, Maruyama K, Shibuya E, Mizuki N
Medicine (Baltimore) 2019 Mar;98(9):e14668. doi: 10.1097/MD.0000000000014668. PMID: 30817592Free PMC Article

Recent clinical studies

Therapy

Jeyakumar N, Lerch M, Dale RC, Ramanathan S
Eye (Lond) 2024 Aug;38(12):2289-2301. Epub 2024 May 23 doi: 10.1038/s41433-024-03108-y. PMID: 38783085Free PMC Article
Bhatti MT, Gilbert AL, Watson G, Waheed M, Spencer D
Surv Ophthalmol 2023 Jul-Aug;68(4):821-829. Epub 2022 Sep 21 doi: 10.1016/j.survophthal.2022.09.003. PMID: 36150481Free PMC Article
Saitakis G, Chwalisz BK
Curr Opin Ophthalmol 2022 Nov 1;33(6):519-524. Epub 2022 Aug 26 doi: 10.1097/ICU.0000000000000900. PMID: 36066374
Abel A, McClelland C, Lee MS
Surv Ophthalmol 2019 Nov-Dec;64(6):770-779. Epub 2019 Jun 20 doi: 10.1016/j.survophthal.2019.06.001. PMID: 31229520
Takazawa T, Ikeda K, Nagaoka T, Hirayama T, Yamamoto T, Yanagihashi M, Tochikubo T, Iwasaki Y
Orbit 2014 Feb;33(1):13-6. Epub 2013 Oct 21 doi: 10.3109/01676830.2013.841716. PMID: 24144064

Prognosis

Jeyakumar N, Lerch M, Dale RC, Ramanathan S
Eye (Lond) 2024 Aug;38(12):2289-2301. Epub 2024 May 23 doi: 10.1038/s41433-024-03108-y. PMID: 38783085Free PMC Article
Greco G, Colombo E, Gastaldi M, Ahmad L, Tavazzi E, Bergamaschi R, Rigoni E
Int J Mol Sci 2023 Nov 5;24(21) doi: 10.3390/ijms242115986. PMID: 37958968Free PMC Article
Saitakis G, Chwalisz BK
Curr Opin Ophthalmol 2022 Nov 1;33(6):519-524. Epub 2022 Aug 26 doi: 10.1097/ICU.0000000000000900. PMID: 36066374
Finsterer J, Scorza FA, Scorza CA, Fiorini AC
J Neuroophthalmol 2021 Jun 1;41(2):166-169. doi: 10.1097/WNO.0000000000001273. PMID: 33999887
Abel A, McClelland C, Lee MS
Surv Ophthalmol 2019 Nov-Dec;64(6):770-779. Epub 2019 Jun 20 doi: 10.1016/j.survophthal.2019.06.001. PMID: 31229520

Clinical prediction guides

Jeyakumar N, Lerch M, Dale RC, Ramanathan S
Eye (Lond) 2024 Aug;38(12):2289-2301. Epub 2024 May 23 doi: 10.1038/s41433-024-03108-y. PMID: 38783085Free PMC Article
Grosso S, Cornacchione S, Romano D, Bertrando S, Franceschini R, Balestri P
Brain Dev 2014 Nov;36(10):932-5. Epub 2014 Feb 7 doi: 10.1016/j.braindev.2013.12.011. PMID: 24512681
Fay AM, Kane SA, Kazim M, Millar WS, Odel JG
J Neuroophthalmol 1997 Dec;17(4):247-9. PMID: 9427176

Recent systematic reviews

Vosoughi AR, Ling J, Tam KT, Blackwood J, Micieli JA
Br J Ophthalmol 2021 Nov;105(11):1591-1598. Epub 2020 Sep 30 doi: 10.1136/bjophthalmol-2020-317267. PMID: 32998905

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