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Microgliosis

MedGen UID:
881706
Concept ID:
C3686874
Pathologic Function

Definition

An accumulation of microglial cells in nervous tissue as a result of injury. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicrogliosis

Professional guidelines

PubMed

Sivasaravanaparan M, Olesen LØ, Severino M, von Linstow CU, Lambertsen KL, Gramsbergen JB, Hasselstrøm J, Metaxas A, Wiborg O, Finsen B
J Alzheimers Dis 2022;87(2):685-699. doi: 10.3233/JAD-220019. PMID: 35342093
Appleton CT
Osteoarthritis Cartilage 2017 May;25(5):613-615. Epub 2017 Feb 20 doi: 10.1016/j.joca.2017.02.798. PMID: 28223124
Reitz C, Mayeux R
Biochem Pharmacol 2014 Apr 15;88(4):640-51. Epub 2014 Jan 4 doi: 10.1016/j.bcp.2013.12.024. PMID: 24398425Free PMC Article

Recent clinical studies

Etiology

Gannon OJ, Robison LS, Salinero AE, Abi-Ghanem C, Mansour FM, Kelly RD, Tyagi A, Brawley RR, Ogg JD, Zuloaga KL
J Neuroinflammation 2022 May 14;19(1):110. doi: 10.1186/s12974-022-02466-2. PMID: 35568928Free PMC Article
Huang J, U KP, Yang F, Ji Z, Lin J, Weng Z, Tsang LL, Merson TD, Ruan YC, Wan C, Li G, Jiang X
Theranostics 2022;12(1):143-166. Epub 2022 Jan 1 doi: 10.7150/thno.57234. PMID: 34987639Free PMC Article
de Araújo FM, Cuenca-Bermejo L, Fernández-Villalba E, Costa SL, Silva VDA, Herrero MT
Cell Mol Neurobiol 2022 Jul;42(5):1283-1300. Epub 2021 Jan 2 doi: 10.1007/s10571-020-01027-6. PMID: 33387119
Qiu S, Palavicini JP, Wang J, Gonzalez NS, He S, Dustin E, Zou C, Ding L, Bhattacharjee A, Van Skike CE, Galvan V, Dupree JL, Han X
Mol Neurodegener 2021 Sep 15;16(1):64. doi: 10.1186/s13024-021-00488-7. PMID: 34526055Free PMC Article
Wang P, Velagapudi R, Kong C, Rodriguiz RM, Wetsel WC, Yang T, Berger M, Gelbard HA, Colton CA, Terrando N
Alzheimers Dement 2020 May;16(5):734-749. Epub 2020 Apr 14 doi: 10.1002/alz.12064. PMID: 32291962Free PMC Article

Diagnosis

Murray HC, Osterman C, Bell P, Vinnell L, Curtis MA
Acta Neuropathol Commun 2022 Aug 6;10(1):108. doi: 10.1186/s40478-022-01413-9. PMID: 35933388Free PMC Article
Logan T, Simon MJ, Rana A, Cherf GM, Srivastava A, Davis SS, Low RLY, Chiu CL, Fang M, Huang F, Bhalla A, Llapashtica C, Prorok R, Pizzo ME, Calvert MEK, Sun EW, Hsiao-Nakamoto J, Rajendra Y, Lexa KW, Srivastava DB, van Lengerich B, Wang J, Robles-Colmenares Y, Kim DJ, Duque J, Lenser M, Earr TK, Nguyen H, Chau R, Tsogtbaatar B, Ravi R, Skuja LL, Solanoy H, Rosen HJ, Boeve BF, Boxer AL, Heuer HW, Dennis MS, Kariolis MS, Monroe KM, Przybyla L, Sanchez PE, Meisner R, Diaz D, Henne KR, Watts RJ, Henry AG, Gunasekaran K, Astarita G, Suh JH, Lewcock JW, DeVos SL, Di Paolo G
Cell 2021 Sep 2;184(18):4651-4668.e25. Epub 2021 Aug 26 doi: 10.1016/j.cell.2021.08.002. PMID: 34450028Free PMC Article
Wang P, Velagapudi R, Kong C, Rodriguiz RM, Wetsel WC, Yang T, Berger M, Gelbard HA, Colton CA, Terrando N
Alzheimers Dement 2020 May;16(5):734-749. Epub 2020 Apr 14 doi: 10.1002/alz.12064. PMID: 32291962Free PMC Article
Molnar MJ, Kovacs GG
Handb Clin Neurol 2017;145:147-155. doi: 10.1016/B978-0-12-802395-2.00010-9. PMID: 28987165
Dalmau J, Tüzün E, Wu HY, Masjuan J, Rossi JE, Voloschin A, Baehring JM, Shimazaki H, Koide R, King D, Mason W, Sansing LH, Dichter MA, Rosenfeld MR, Lynch DR
Ann Neurol 2007 Jan;61(1):25-36. doi: 10.1002/ana.21050. PMID: 17262855Free PMC Article

Therapy

Logan T, Simon MJ, Rana A, Cherf GM, Srivastava A, Davis SS, Low RLY, Chiu CL, Fang M, Huang F, Bhalla A, Llapashtica C, Prorok R, Pizzo ME, Calvert MEK, Sun EW, Hsiao-Nakamoto J, Rajendra Y, Lexa KW, Srivastava DB, van Lengerich B, Wang J, Robles-Colmenares Y, Kim DJ, Duque J, Lenser M, Earr TK, Nguyen H, Chau R, Tsogtbaatar B, Ravi R, Skuja LL, Solanoy H, Rosen HJ, Boeve BF, Boxer AL, Heuer HW, Dennis MS, Kariolis MS, Monroe KM, Przybyla L, Sanchez PE, Meisner R, Diaz D, Henne KR, Watts RJ, Henry AG, Gunasekaran K, Astarita G, Suh JH, Lewcock JW, DeVos SL, Di Paolo G
Cell 2021 Sep 2;184(18):4651-4668.e25. Epub 2021 Aug 26 doi: 10.1016/j.cell.2021.08.002. PMID: 34450028Free PMC Article
Jayanthi S, Daiwile AP, Cadet JL
Exp Neurol 2021 Oct;344:113795. Epub 2021 Jun 26 doi: 10.1016/j.expneurol.2021.113795. PMID: 34186102Free PMC Article
Da Mesquita S, Papadopoulos Z, Dykstra T, Brase L, Farias FG, Wall M, Jiang H, Kodira CD, de Lima KA, Herz J, Louveau A, Goldman DH, Salvador AF, Onengut-Gumuscu S, Farber E, Dabhi N, Kennedy T, Milam MG, Baker W, Smirnov I, Rich SS; Dominantly Inherited Alzheimer Network, Benitez BA, Karch CM, Perrin RJ, Farlow M, Chhatwal JP, Holtzman DM, Cruchaga C, Harari O, Kipnis J
Nature 2021 May;593(7858):255-260. Epub 2021 Apr 28 doi: 10.1038/s41586-021-03489-0. PMID: 33911285Free PMC Article
Roy ER, Wang B, Wan YW, Chiu G, Cole A, Yin Z, Propson NE, Xu Y, Jankowsky JL, Liu Z, Lee VM, Trojanowski JQ, Ginsberg SD, Butovsky O, Zheng H, Cao W
J Clin Invest 2020 Apr 1;130(4):1912-1930. doi: 10.1172/JCI133737. PMID: 31917687Free PMC Article
Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VM
Neuron 2007 Feb 1;53(3):337-51. doi: 10.1016/j.neuron.2007.01.010. PMID: 17270732

Prognosis

Rizzo FR, Guadalupi L, Sanna K, Vanni V, Fresegna D, De Vito F, Musella A, Caioli S, Balletta S, Bullitta S, Bruno A, Dolcetti E, Stampanoni Bassi M, Buttari F, Gilio L, Mandolesi G, Centonze D, Gentile A
Brain Behav Immun 2021 Nov;98:13-27. Epub 2021 Aug 12 doi: 10.1016/j.bbi.2021.08.212. PMID: 34391817
Wang P, Velagapudi R, Kong C, Rodriguiz RM, Wetsel WC, Yang T, Berger M, Gelbard HA, Colton CA, Terrando N
Alzheimers Dement 2020 May;16(5):734-749. Epub 2020 Apr 14 doi: 10.1002/alz.12064. PMID: 32291962Free PMC Article
Domercq M, Matute C
Curr Opin Pharmacol 2019 Aug;47:119-125. Epub 2019 Apr 20 doi: 10.1016/j.coph.2019.03.010. PMID: 31015145
Atwood CS, Bowen RL
J Alzheimers Dis 2015;47(1):33-47. doi: 10.3233/JAD-143210. PMID: 26402752Free PMC Article
Reitz C, Brayne C, Mayeux R
Nat Rev Neurol 2011 Mar;7(3):137-52. Epub 2011 Feb 8 doi: 10.1038/nrneurol.2011.2. PMID: 21304480Free PMC Article

Clinical prediction guides

Koronyo Y, Rentsendorj A, Mirzaei N, Regis GC, Sheyn J, Shi H, Barron E, Cook-Wiens G, Rodriguez AR, Medeiros R, Paulo JA, Gupta VB, Kramerov AA, Ljubimov AV, Van Eyk JE, Graham SL, Gupta VK, Ringman JM, Hinton DR, Miller CA, Black KL, Cattaneo A, Meli G, Mirzaei M, Fuchs DT, Koronyo-Hamaoui M
Acta Neuropathol 2023 Apr;145(4):409-438. Epub 2023 Feb 11 doi: 10.1007/s00401-023-02548-2. PMID: 36773106Free PMC Article
Seehusen F, Clark JJ, Sharma P, Bentley EG, Kirby A, Subramaniam K, Wunderlin-Giuliani S, Hughes GL, Patterson EI, Michael BD, Owen A, Hiscox JA, Stewart JP, Kipar A
Viruses 2022 May 11;14(5) doi: 10.3390/v14051020. PMID: 35632761Free PMC Article
Rizzo FR, Guadalupi L, Sanna K, Vanni V, Fresegna D, De Vito F, Musella A, Caioli S, Balletta S, Bullitta S, Bruno A, Dolcetti E, Stampanoni Bassi M, Buttari F, Gilio L, Mandolesi G, Centonze D, Gentile A
Brain Behav Immun 2021 Nov;98:13-27. Epub 2021 Aug 12 doi: 10.1016/j.bbi.2021.08.212. PMID: 34391817
Crapser JD, Spangenberg EE, Barahona RA, Arreola MA, Hohsfield LA, Green KN
EBioMedicine 2020 Aug;58:102919. Epub 2020 Jul 31 doi: 10.1016/j.ebiom.2020.102919. PMID: 32745992Free PMC Article
Roy ER, Wang B, Wan YW, Chiu G, Cole A, Yin Z, Propson NE, Xu Y, Jankowsky JL, Liu Z, Lee VM, Trojanowski JQ, Ginsberg SD, Butovsky O, Zheng H, Cao W
J Clin Invest 2020 Apr 1;130(4):1912-1930. doi: 10.1172/JCI133737. PMID: 31917687Free PMC Article

Recent systematic reviews

Murray HC, Osterman C, Bell P, Vinnell L, Curtis MA
Acta Neuropathol Commun 2022 Aug 6;10(1):108. doi: 10.1186/s40478-022-01413-9. PMID: 35933388Free PMC Article
Maiese A, Manetti AC, Bosetti C, Del Duca F, La Russa R, Frati P, Di Paolo M, Turillazzi E, Fineschi V
Brain Pathol 2021 Nov;31(6):e13013. Epub 2021 Aug 13 doi: 10.1111/bpa.13013. PMID: 34390282Free PMC Article
Cosentino G, Todisco M, Hota N, Della Porta G, Morbini P, Tassorelli C, Pisani A
Eur J Neurol 2021 Nov;28(11):3856-3865. Epub 2021 Aug 17 doi: 10.1111/ene.15045. PMID: 34339563Free PMC Article

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