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Leiomyosarcoma of Deep Soft Tissue

MedGen UID:
882471
•Concept ID:
C4054654
•
Neoplastic Process
Synonym: Leiomyosarcoma of the Deep Soft Tissue

Definition

A rare leiomyosarcoma that arises from the deep soft tissue in the retroperitoneum or abdominal cavity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeiomyosarcoma of Deep Soft Tissue

Professional guidelines

PubMed

Treatment outcome of superficial leiomyosarcoma.
Wellings EP, Tibbo ME, Rose PS, Folpe AL, Houdek MT
J Surg Oncol 2021 Jan;123(1):127-132. Epub 2020 Oct 15 doi: 10.1002/jso.26262. PMID: 33063336
Soft tissue sarcomas in skin: presentations and management.
Patt JC, Haines N
Semin Oncol 2016 Jun;43(3):413-8. Epub 2016 Feb 23 doi: 10.1053/j.seminoncol.2016.02.026. PMID: 27178697
Soft tissue sarcoma - A review of presentation, management and outcomes in 110 patients.
Bains R, Magdum A, Bhat W, Roy A, Platt A, Stanley P
Surgeon 2016 Jun;14(3):129-35. Epub 2014 Sep 30 doi: 10.1016/j.surge.2014.06.002. PMID: 25261278

Recent clinical studies

Etiology

Cutaneous leiomyosarcoma: a retrospective review of 45 cases.
Khan S, Asher R, Perkins W, Matin RN
Clin Exp Dermatol 2023 Dec 19;49(1):2-8. doi: 10.1093/ced/llad276. PMID: 37595134
Deep learning for diagnosis and survival prediction in soft tissue sarcoma.
Foersch S, Eckstein M, Wagner DC, Gach F, Woerl AC, Geiger J, Glasner C, Schelbert S, Schulz S, Porubsky S, Kreft A, Hartmann A, Agaimy A, Roth W
Ann Oncol 2021 Sep;32(9):1178-1187. Epub 2021 Jun 15 doi: 10.1016/j.annonc.2021.06.007. PMID: 34139273
Treatment outcome of superficial leiomyosarcoma.
Wellings EP, Tibbo ME, Rose PS, Folpe AL, Houdek MT
J Surg Oncol 2021 Jan;123(1):127-132. Epub 2020 Oct 15 doi: 10.1002/jso.26262. PMID: 33063336
Leiomyosarcoma of the somatic soft tissues.
Radkowski CA, Dodd LG, Johnson JL, Harrelson JM, Brigman BE
J Surg Orthop Adv 2012 Summer;21(2):96-101. doi: 10.3113/jsoa.2012.0096. PMID: 22995359
Smooth muscle tumors of soft tissue.
Weiss SW
Adv Anat Pathol 2002 Nov;9(6):351-9. doi: 10.1097/00125480-200211000-00004. PMID: 12409644

Diagnosis

S1-guideline cutaneous and subcutaneous leiomyosarcoma.
Helbig D, Dippel E, Erdmann M, Frisman A, Kage P, Leiter U, Mentzel T, Seidel C, Weishaupt C, Ziemer M, Ugurel S
J Dtsch Dermatol Ges 2023 May;21(5):555-563. Epub 2023 Mar 31 doi: 10.1111/ddg.14989. PMID: 36999582
Review of primary superficial soft tissue mesenchymal tumors of malignant or intermediate biological potential.
Oettel DJ, Bernard SA
Skeletal Radiol 2023 Mar;52(3):435-445. Epub 2022 Jul 22 doi: 10.1007/s00256-022-04127-0. PMID: 35867123
Deep learning for diagnosis and survival prediction in soft tissue sarcoma.
Foersch S, Eckstein M, Wagner DC, Gach F, Woerl AC, Geiger J, Glasner C, Schelbert S, Schulz S, Porubsky S, Kreft A, Hartmann A, Agaimy A, Roth W
Ann Oncol 2021 Sep;32(9):1178-1187. Epub 2021 Jun 15 doi: 10.1016/j.annonc.2021.06.007. PMID: 34139273
Myofibroblastic malignancies.
Fisher C
Adv Anat Pathol 2004 Jul;11(4):190-201. doi: 10.1097/01.pap.0000131773.16130.aa. PMID: 15220822
Myofibrosarcoma.
Fisher C
Virchows Arch 2004 Sep;445(3):215-23. Epub 2004 Jun 2 doi: 10.1007/s00428-004-1038-9. PMID: 15173943

Therapy

Non-surgical Treatments for Lung Metastases in Patients with Soft Tissue Sarcoma: Stereotactic Body Radiation Therapy (SBRT) and Radiofrequency Ablation (RFA).
Tetta C, Carpenzano M, Algargoush ATJ, Algargoosh M, Londero F, Maessen JG, Gelsomino S
Curr Med Imaging 2021;17(2):261-275. doi: 10.2174/1573405616999200819165709. PMID: 32819261
Machine learning analysis of gene expression data reveals novel diagnostic and prognostic biomarkers and identifies therapeutic targets for soft tissue sarcomas.
van IJzendoorn DGP, Szuhai K, Briaire-de Bruijn IH, Kostine M, Kuijjer ML, Bovée JVMG
PLoS Comput Biol 2019 Feb;15(2):e1006826. Epub 2019 Feb 20 doi: 10.1371/journal.pcbi.1006826. PMID: 30785874Free PMC Article
Soft-tissue sarcomas in the inguinal region may present as deep vein thrombosis.
Emori M, Naka N, Hamada K, Tomita Y, Takami H, Araki N
Ann Vasc Surg 2010 Oct;24(7):951.e7-951.e11. Epub 2010 May 14 doi: 10.1016/j.avsg.2010.03.001. PMID: 20471794
Do radiation-associated soft tissue sarcomas have the same prognosis as sporadic soft tissue sarcomas?
Gladdy RA, Qin LX, Moraco N, Edgar MA, Antonescu CR, Alektiar KM, Brennan MF, Singer S
J Clin Oncol 2010 Apr 20;28(12):2064-9. Epub 2010 Mar 22 doi: 10.1200/JCO.2009.25.1728. PMID: 20308666Free PMC Article
Brachytherapy tubes and free tissue transfer after soft tissue sarcoma resection.
Aflatoon K, Manoso MW, Deune EG, Frassica DA, Frassica FJ
Clin Orthop Relat Res 2003 Oct;(415):248-53. doi: 10.1097/01.blo.0000093886.12372.74. PMID: 14612653

Prognosis

Cutaneous leiomyosarcoma: a retrospective review of 45 cases.
Khan S, Asher R, Perkins W, Matin RN
Clin Exp Dermatol 2023 Dec 19;49(1):2-8. doi: 10.1093/ced/llad276. PMID: 37595134
Deep learning for diagnosis and survival prediction in soft tissue sarcoma.
Foersch S, Eckstein M, Wagner DC, Gach F, Woerl AC, Geiger J, Glasner C, Schelbert S, Schulz S, Porubsky S, Kreft A, Hartmann A, Agaimy A, Roth W
Ann Oncol 2021 Sep;32(9):1178-1187. Epub 2021 Jun 15 doi: 10.1016/j.annonc.2021.06.007. PMID: 34139273
Treatment outcome of superficial leiomyosarcoma.
Wellings EP, Tibbo ME, Rose PS, Folpe AL, Houdek MT
J Surg Oncol 2021 Jan;123(1):127-132. Epub 2020 Oct 15 doi: 10.1002/jso.26262. PMID: 33063336
Sarcomas of the skin in the elderly.
Mentzel T
Clin Dermatol 2011 Jan-Feb;29(1):80-90. doi: 10.1016/j.clindermatol.2010.07.011. PMID: 21146736
Smooth muscle tumors of soft tissue.
Weiss SW
Adv Anat Pathol 2002 Nov;9(6):351-9. doi: 10.1097/00125480-200211000-00004. PMID: 12409644

Clinical prediction guides

Deep learning for diagnosis and survival prediction in soft tissue sarcoma.
Foersch S, Eckstein M, Wagner DC, Gach F, Woerl AC, Geiger J, Glasner C, Schelbert S, Schulz S, Porubsky S, Kreft A, Hartmann A, Agaimy A, Roth W
Ann Oncol 2021 Sep;32(9):1178-1187. Epub 2021 Jun 15 doi: 10.1016/j.annonc.2021.06.007. PMID: 34139273
Cutaneous Leiomyosarcoma: The Clinical Experience of Taipei Veterans General Hospital Revisited.
Liao WC, Wang YC, Ma H
Ann Plast Surg 2017 Mar;78(3 Suppl 2):S47-S51. doi: 10.1097/SAP.0000000000001005. PMID: 28177971
Predictors of survival and recurrence in primary leiomyosarcoma.
Gladdy RA, Qin LX, Moraco N, Agaram NP, Brennan MF, Singer S
Ann Surg Oncol 2013 Jun;20(6):1851-7. Epub 2013 Jan 25 doi: 10.1245/s10434-013-2876-y. PMID: 23354568Free PMC Article
Leiomyosarcoma of the somatic soft tissues.
Radkowski CA, Dodd LG, Johnson JL, Harrelson JM, Brigman BE
J Surg Orthop Adv 2012 Summer;21(2):96-101. doi: 10.3113/jsoa.2012.0096. PMID: 22995359
Smooth muscle tumors of soft tissue.
Weiss SW
Adv Anat Pathol 2002 Nov;9(6):351-9. doi: 10.1097/00125480-200211000-00004. PMID: 12409644

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