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Granuloma annulare

MedGen UID:
88319
•Concept ID:
C0085074
•
Disease or Syndrome
Synonym: Granuloma Annulare
SNOMED CT: Granuloma annulare (65508009); GA - granuloma annulare (65508009); Necrobiotic papulosis (65508009)
 
Monarch Initiative: MONDO:0006554

Definition

A localized or generalized inflammatory skin disorder characterized by the formation of papules and ring-shaped plaques in the skin. Morphologically these lesions are granulomatous inflammatory processes with central necrosis surrounded by palisading histiocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGranuloma annulare

Professional guidelines

PubMed

Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options.
Joshi TP, Duvic M
Am J Clin Dermatol 2022 Jan;23(1):37-50. Epub 2021 Sep 8 doi: 10.1007/s40257-021-00636-1. PMID: 34495491Free PMC Article
Nickel Allergy: Epidemiology, Pathomechanism, Clinical Patterns, Treatment and Prevention Programs.
Tramontana M, Bianchi L, Hansel K, Agostinelli D, Stingeni L
Endocr Metab Immune Disord Drug Targets 2020;20(7):992-1002. doi: 10.2174/1871530320666200128141900. PMID: 31994473
Annular Lesions: Diagnosis and Treatment.
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021

Recent clinical studies

Etiology

Scleromyxedema.
Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
Cutaneous Granulomatosis: a Comprehensive Review.
Terziroli Beretta-Piccoli B, Mainetti C, Peeters MA, Laffitte E
Clin Rev Allergy Immunol 2018 Feb;54(1):131-146. doi: 10.1007/s12016-017-8666-8. PMID: 29352388
Granulomatous & histiocytic dermatitides.
Wick MR
Semin Diagn Pathol 2017 May;34(3):301-311. Epub 2016 Dec 14 doi: 10.1053/j.semdp.2016.12.003. PMID: 28094163
Granulomatous Drug Eruptions.
Dodiuk-Gad RP, Shear NH
Dermatol Clin 2015 Jul;33(3):525-39. doi: 10.1016/j.det.2015.03.015. PMID: 26143430
Treatment of generalized granuloma annulare - a systematic review.
Lukács J, Schliemann S, Elsner P
J Eur Acad Dermatol Venereol 2015 Aug;29(8):1467-80. Epub 2015 Feb 4 doi: 10.1111/jdv.12976. PMID: 25651003

Diagnosis

Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options.
Joshi TP, Duvic M
Am J Clin Dermatol 2022 Jan;23(1):37-50. Epub 2021 Sep 8 doi: 10.1007/s40257-021-00636-1. PMID: 34495491Free PMC Article
Cutaneous Manifestations of Diabetes Mellitus and Prediabetes.
Sanches MM, Roda Â, Pimenta R, Filipe PL, Freitas JP
Acta Med Port 2019 Jun 28;32(6):459-465. doi: 10.20344/amp.10738. PMID: 31292028
Annular Lesions: Diagnosis and Treatment.
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021
Cutaneous Granulomatosis: a Comprehensive Review.
Terziroli Beretta-Piccoli B, Mainetti C, Peeters MA, Laffitte E
Clin Rev Allergy Immunol 2018 Feb;54(1):131-146. doi: 10.1007/s12016-017-8666-8. PMID: 29352388
Cutaneous Manifestations of Diabetes Mellitus: A Review.
Lima AL, Illing T, Schliemann S, Elsner P
Am J Clin Dermatol 2017 Aug;18(4):541-553. doi: 10.1007/s40257-017-0275-z. PMID: 28374407

Therapy

Pentoxifylline in dermatology.
Balazic E, Axler E, Konisky H, Khanna U, Kobets K
J Cosmet Dermatol 2023 Feb;22(2):410-417. Epub 2022 Oct 31 doi: 10.1111/jocd.15445. PMID: 36208009
Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options.
Joshi TP, Duvic M
Am J Clin Dermatol 2022 Jan;23(1):37-50. Epub 2021 Sep 8 doi: 10.1007/s40257-021-00636-1. PMID: 34495491Free PMC Article
Janus kinase inhibitors in dermatology: Part II. A comprehensive review.
Chapman S, Gold LS, Lim HW
J Am Acad Dermatol 2022 Feb;86(2):414-422. Epub 2021 Jul 3 doi: 10.1016/j.jaad.2021.06.873. PMID: 34228996
Cutaneous Manifestations of Diabetes Mellitus: A Review.
Lima AL, Illing T, Schliemann S, Elsner P
Am J Clin Dermatol 2017 Aug;18(4):541-553. doi: 10.1007/s40257-017-0275-z. PMID: 28374407
Treatment of generalized granuloma annulare - a systematic review.
Lukács J, Schliemann S, Elsner P
J Eur Acad Dermatol Venereol 2015 Aug;29(8):1467-80. Epub 2015 Feb 4 doi: 10.1111/jdv.12976. PMID: 25651003

Prognosis

Scleromyxedema.
Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
Cutaneous Manifestations of Diabetes Mellitus and Prediabetes.
Sanches MM, Roda Â, Pimenta R, Filipe PL, Freitas JP
Acta Med Port 2019 Jun 28;32(6):459-465. doi: 10.20344/amp.10738. PMID: 31292028
Granuloma Annulare: A Focused Review of Therapeutic Options.
Wang J, Khachemoune A
Am J Clin Dermatol 2018 Jun;19(3):333-344. doi: 10.1007/s40257-017-0334-5. PMID: 29230666
Treatment of generalized granuloma annulare - a systematic review.
Lukács J, Schliemann S, Elsner P
J Eur Acad Dermatol Venereol 2015 Aug;29(8):1467-80. Epub 2015 Feb 4 doi: 10.1111/jdv.12976. PMID: 25651003
Rheumatoid nodule.
García-Patos V
Semin Cutan Med Surg 2007 Jun;26(2):100-7. doi: 10.1016/j.sder.2007.02.007. PMID: 17544962

Clinical prediction guides

Clinical Manifestations and Management of Pediatric Granuloma Annulare: A Systematic Review.
Albert M, Maruani A, Leducq S
J Pediatr 2023 Jun;257:113392. Epub 2023 Mar 21 doi: 10.1016/j.jpeds.2023.03.006. PMID: 36948386
Granuloma annulare subtypes: sonographic features and clinicopathological correlation.
Rodríguez-Garijo N, Tomás-Velázquez A, Estenaga A, Antoñanzas J, Segurado-Rodríguez MA, García-Tobar L, Idoate MA, García-Martínez FJ
J Ultrasound 2022 Jun;25(2):289-295. Epub 2021 Jan 16 doi: 10.1007/s40477-020-00532-0. PMID: 33453055Free PMC Article
Incidence and Prevalence of Granuloma Annulare in the United States.
Barbieri JS, Rodriguez O, Rosenbach M, Margolis D
JAMA Dermatol 2021 Jul 1;157(7):824-830. doi: 10.1001/jamadermatol.2021.1847. PMID: 34106215Free PMC Article
Granuloma annulare - is it a paraneoplastic condition for malignant lymphoma?
Müller CSL, Vogt T
J Dtsch Dermatol Ges 2021 Jun;19(6):803-812. Epub 2021 May 5 doi: 10.1111/ddg.14401. PMID: 33949780
Granuloma annulare.
Goucha S, Khaled A, Kharfi M, Fazaa B, Zermani R, Ben Jilani S, Kamoun MR
G Ital Dermatol Venereol 2008 Dec;143(6):359-63. PMID: 19169208

Recent systematic reviews

Clinical Manifestations and Management of Pediatric Granuloma Annulare: A Systematic Review.
Albert M, Maruani A, Leducq S
J Pediatr 2023 Jun;257:113392. Epub 2023 Mar 21 doi: 10.1016/j.jpeds.2023.03.006. PMID: 36948386
Light- and laser-based treatments for granuloma annulare: A systematic review.
Mukovozov IM, Kashetsky N, Richer V
Photodermatol Photoimmunol Photomed 2022 Jul;38(4):301-310. Epub 2021 Dec 15 doi: 10.1111/phpp.12756. PMID: 34875119
Oral isotretinoin for the treatment of dermatologic conditions other than acne: a systematic review and discussion of future directions.
Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA
Arch Dermatol Res 2021 Aug;313(6):391-430. Epub 2020 Nov 5 doi: 10.1007/s00403-020-02152-4. PMID: 33151346
Granulomatous Cutaneous Drug Eruptions: A Systematic Review.
Shah N, Shah M, Drucker AM, Shear NH, Ziv M, Dodiuk-Gad RP
Am J Clin Dermatol 2021 Jan;22(1):39-53. doi: 10.1007/s40257-020-00566-4. PMID: 33108647
Treatment of generalized granuloma annulare - a systematic review.
Lukács J, Schliemann S, Elsner P
J Eur Acad Dermatol Venereol 2015 Aug;29(8):1467-80. Epub 2015 Feb 4 doi: 10.1111/jdv.12976. PMID: 25651003

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