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Fungemia

MedGen UID:
88323
•Concept ID:
C0085082
•
Disease or Syndrome
SNOMED CT: Fungemia (434532004)

Definition

A laboratory test result indicating the presence of fungi or yeasts in the blood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFungemia

Professional guidelines

PubMed

Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection.
Fleiss N, Coggins SA, Lewis AN, Zeigler A, Cooksey KE, Walker LA, Husain AN, de Jong BS, Wallman-Stokes A, Alrifai MW, Visser DH, Good M, Sullivan B, Polin RA, Martin CR, Wynn JL
JAMA Netw Open 2021 Feb 1;4(2):e2036518. doi: 10.1001/jamanetworkopen.2020.36518. PMID: 33538825Free PMC Article
Saccharomyces boulardii CNCM I-745: A Non-bacterial Microorganism Used as Probiotic Agent in Supporting Treatment of Selected Diseases.
Kaźmierczak-Siedlecka K, Ruszkowski J, Fic M, Folwarski M, Makarewicz W
Curr Microbiol 2020 Sep;77(9):1987-1996. Epub 2020 May 29 doi: 10.1007/s00284-020-02053-9. PMID: 32472262Free PMC Article
Updates in the epidemiology and management of candidemia and Clostridioides difficile coinfection.
Falcone M, Tiseo G, Venditti M, Menichetti F
Expert Rev Anti Infect Ther 2019 May;17(5):375-382. Epub 2019 May 3 doi: 10.1080/14787210.2019.1608183. PMID: 30982376

Recent clinical studies

Etiology

Candida haemulonii complex, an emerging threat from tropical regions?
Françoise U, Desnos-Ollivier M, Le Govic Y, Sitbon K, Valentino R, Peugny S, Chouaki T, Mazars E, Paugam A, Nicolas M, Desbois-Nogard N, Lortholary O; French Mycoses Study Group
PLoS Negl Trop Dis 2023 Jul;17(7):e0011453. Epub 2023 Jul 31 doi: 10.1371/journal.pntd.0011453. PMID: 37523406Free PMC Article
A systematic review of the safety of probiotics.
Didari T, Solki S, Mozaffari S, Nikfar S, Abdollahi M
Expert Opin Drug Saf 2014 Feb;13(2):227-39. Epub 2014 Jan 3 doi: 10.1517/14740338.2014.872627. PMID: 24405164
The clinical and prognostic importance of positive blood cultures in adults.
Pien BC, Sundaram P, Raoof N, Costa SF, Mirrett S, Woods CW, Reller LB, Weinstein MP
Am J Med 2010 Sep;123(9):819-28. doi: 10.1016/j.amjmed.2010.03.021. PMID: 20800151
The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults.
Weinstein MP, Towns ML, Quartey SM, Mirrett S, Reimer LG, Parmigiani G, Reller LB
Clin Infect Dis 1997 Apr;24(4):584-602. doi: 10.1093/clind/24.4.584. PMID: 9145732
Pediatric blood cultures.
Paisley JW, Lauer BA
Clin Lab Med 1994 Mar;14(1):17-30. PMID: 8181229

Diagnosis

Malassezia spp. Yeasts of Emerging Concern in Fungemia.
Rhimi W, Theelen B, Boekhout T, Otranto D, Cafarchia C
Front Cell Infect Microbiol 2020;10:370. Epub 2020 Jul 28 doi: 10.3389/fcimb.2020.00370. PMID: 32850475Free PMC Article
Diagnosis and Management of Sepsis and Blood Stream Infections.
Chambliss AB, Butler-Wu SM, Dien Bard J
J Appl Lab Med 2019 Jan;3(4):525-526. doi: 10.1373/jalm.2018.028472. PMID: 31639719
Microbiological diagnosis of bacteraemia and fungaemia: Blood cultures and molecular methods.
Guna Serrano MR, Larrosa Escartín N, Marín Arriaza M, Rodríguez Díaz JC
Enferm Infecc Microbiol Clin (Engl Ed) 2019 May;37(5):335-340. Epub 2018 Apr 22 doi: 10.1016/j.eimc.2018.03.005. PMID: 29691073
Nonculture techniques for the detection of bacteremia and fungemia.
Valencia-Shelton F, Loeffelholz M
Future Microbiol 2014;9(4):543-59. doi: 10.2217/fmb.14.8. PMID: 24810352
The clinical and prognostic importance of positive blood cultures in adults.
Pien BC, Sundaram P, Raoof N, Costa SF, Mirrett S, Woods CW, Reller LB, Weinstein MP
Am J Med 2010 Sep;123(9):819-28. doi: 10.1016/j.amjmed.2010.03.021. PMID: 20800151

Therapy

Candida haemulonii complex, an emerging threat from tropical regions?
Françoise U, Desnos-Ollivier M, Le Govic Y, Sitbon K, Valentino R, Peugny S, Chouaki T, Mazars E, Paugam A, Nicolas M, Desbois-Nogard N, Lortholary O; French Mycoses Study Group
PLoS Negl Trop Dis 2023 Jul;17(7):e0011453. Epub 2023 Jul 31 doi: 10.1371/journal.pntd.0011453. PMID: 37523406Free PMC Article
Malassezia spp. Yeasts of Emerging Concern in Fungemia.
Rhimi W, Theelen B, Boekhout T, Otranto D, Cafarchia C
Front Cell Infect Microbiol 2020;10:370. Epub 2020 Jul 28 doi: 10.3389/fcimb.2020.00370. PMID: 32850475Free PMC Article
Risk and safety of probiotics.
Doron S, Snydman DR
Clin Infect Dis 2015 May 15;60 Suppl 2(Suppl 2):S129-34. doi: 10.1093/cid/civ085. PMID: 25922398Free PMC Article
A systematic review of the safety of probiotics.
Didari T, Solki S, Mozaffari S, Nikfar S, Abdollahi M
Expert Opin Drug Saf 2014 Feb;13(2):227-39. Epub 2014 Jan 3 doi: 10.1517/14740338.2014.872627. PMID: 24405164
Pulmonary fungal infections.
Silveira F, Paterson DL
Curr Opin Pulm Med 2005 May;11(3):242-6. doi: 10.1097/01.mcp.0000159832.20648.70. PMID: 15818187

Prognosis

The Effect of Molecular Rapid Diagnostic Testing on Clinical Outcomes in Bloodstream Infections: A Systematic Review and Meta-analysis.
Timbrook TT, Morton JB, McConeghy KW, Caffrey AR, Mylonakis E, LaPlante KL
Clin Infect Dis 2017 Jan 1;64(1):15-23. Epub 2016 Sep 26 doi: 10.1093/cid/ciw649. PMID: 27678085
Anidulafungin for the treatment of invasive candidiasis.
Mayr A, Aigner M, Lass-Flörl C
Clin Microbiol Infect 2011 Mar;17 Suppl 1:1-12. doi: 10.1111/j.1469-0691.2010.03448.x. PMID: 21251147
The clinical and prognostic importance of positive blood cultures in adults.
Pien BC, Sundaram P, Raoof N, Costa SF, Mirrett S, Woods CW, Reller LB, Weinstein MP
Am J Med 2010 Sep;123(9):819-28. doi: 10.1016/j.amjmed.2010.03.021. PMID: 20800151
Pulmonary fungal infections.
Silveira F, Paterson DL
Curr Opin Pulm Med 2005 May;11(3):242-6. doi: 10.1097/01.mcp.0000159832.20648.70. PMID: 15818187
Intravenous catheter-related infections.
Salzman MB, Rubin LG
Adv Pediatr Infect Dis 1995;10:337-68. PMID: 7718211

Clinical prediction guides

Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection.
Fleiss N, Coggins SA, Lewis AN, Zeigler A, Cooksey KE, Walker LA, Husain AN, de Jong BS, Wallman-Stokes A, Alrifai MW, Visser DH, Good M, Sullivan B, Polin RA, Martin CR, Wynn JL
JAMA Netw Open 2021 Feb 1;4(2):e2036518. doi: 10.1001/jamanetworkopen.2020.36518. PMID: 33538825Free PMC Article
The Effect of Molecular Rapid Diagnostic Testing on Clinical Outcomes in Bloodstream Infections: A Systematic Review and Meta-analysis.
Timbrook TT, Morton JB, McConeghy KW, Caffrey AR, Mylonakis E, LaPlante KL
Clin Infect Dis 2017 Jan 1;64(1):15-23. Epub 2016 Sep 26 doi: 10.1093/cid/ciw649. PMID: 27678085
A systematic review of the safety of probiotics.
Didari T, Solki S, Mozaffari S, Nikfar S, Abdollahi M
Expert Opin Drug Saf 2014 Feb;13(2):227-39. Epub 2014 Jan 3 doi: 10.1517/14740338.2014.872627. PMID: 24405164
Detection of bloodstream infections in adults: how many blood cultures are needed?
Lee A, Mirrett S, Reller LB, Weinstein MP
J Clin Microbiol 2007 Nov;45(11):3546-8. Epub 2007 Sep 19 doi: 10.1128/JCM.01555-07. PMID: 17881544Free PMC Article
Human fusariosis.
Dignani MC, Anaissie E
Clin Microbiol Infect 2004 Mar;10 Suppl 1:67-75. doi: 10.1111/j.1470-9465.2004.00845.x. PMID: 14748803

Recent systematic reviews

Cirrhosis and fungal infections-a cocktail for catastrophe: A systematic review and meta-analysis with machine learning.
Verma N, Singh S, Roy A, Valsan A, Garg P, Pradhan P, Chakrabarti A, Singh M
Mycoses 2022 Sep;65(9):844-858. Epub 2022 Jun 30 doi: 10.1111/myc.13482. PMID: 35713607
Neutropenic diets to prevent cancer infections: updated systematic review and meta-analysis.
Sonbol MB, Jain T, Firwana B, Hilal T, Deleon T, Murad A, Murad MH, Khera N
BMJ Support Palliat Care 2019 Dec;9(4):425-433. Epub 2019 Apr 4 doi: 10.1136/bmjspcare-2018-001742. PMID: 30948447
Candida auris: A systematic review and meta-analysis of current updates on an emerging multidrug-resistant pathogen.
Osei Sekyere J
Microbiologyopen 2018 Aug;7(4):e00578. Epub 2018 Jan 18 doi: 10.1002/mbo3.578. PMID: 29345117Free PMC Article
The Effect of Molecular Rapid Diagnostic Testing on Clinical Outcomes in Bloodstream Infections: A Systematic Review and Meta-analysis.
Timbrook TT, Morton JB, McConeghy KW, Caffrey AR, Mylonakis E, LaPlante KL
Clin Infect Dis 2017 Jan 1;64(1):15-23. Epub 2016 Sep 26 doi: 10.1093/cid/ciw649. PMID: 27678085
A systematic review of the safety of probiotics.
Didari T, Solki S, Mozaffari S, Nikfar S, Abdollahi M
Expert Opin Drug Saf 2014 Feb;13(2):227-39. Epub 2014 Jan 3 doi: 10.1517/14740338.2014.872627. PMID: 24405164

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