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ERG Deregulation

MedGen UID:: 883390
•Concept ID:: C4053784
•: Cell or Molecular Dysfunction

Definition

A molecular genetic abnormality indicating deregulation of the ERG oncogene. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVERG Deregulation

Molecular Abnormality
- Molecular Sequence Variation
  - Molecular Genetic Variation
    - Gene Abnormality
      - Oncogene Deregulation
        ERG Deregulation

Professional guidelines

PubMed

Targeting the PI3K/AKT pathway for the treatment of prostate cancer.

Sarker D, Reid AH, Yap TA, de Bono JS
Clin Cancer Res 2009 Aug 1;15(15):4799-805. Epub 2009 Jul 28 doi: 10.1158/1078-0432.CCR-08-0125. PMID: 19638457

Recent clinical studies

Diagnosis

ERG deregulation induces IGF-1R expression in prostate cancer cells and affects sensitivity to anti-IGF-1R agents.

Mancarella C, Casanova-Salas I, Calatrava A, Ventura S, Garofalo C, Rubio-Briones J, Magistroni V, Manara MC, López-Guerrero JA, Scotlandi K
Oncotarget 2015 Jun 30;6(18):16611-22. doi: 10.18632/oncotarget.3425. PMID: 25906745 Free PMC Article

Therapy

ERG deregulation induces PIM1 over-expression and aneuploidy in prostate epithelial cells.

Magistroni V, Mologni L, Sanselicio S, Reid JF, Redaelli S, Piazza R, Viltadi M, Bovo G, Strada G, Grasso M, Gariboldi M, Gambacorti-Passerini C
PLoS One 2011;6(11):e28162. Epub 2011 Nov 30 doi: 10.1371/journal.pone.0028162. PMID: 22140532 Free PMC Article

Clinical prediction guides

Changes in cortical cytoskeletal and extracellular matrix gene expression in prostate cancer are related to oncogenic ERG deregulation.

Schulz WA, Ingenwerth M, Djuidje CE, Hader C, Rahnenführer J, Engers R
BMC Cancer 2010 Sep 22;10:505. doi: 10.1186/1471-2407-10-505. PMID: 20860828 Free PMC Article

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Related information

PMC Articles
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