U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Granular cell tumor

MedGen UID:
88345
Concept ID:
C0085167
Neoplastic Process
Synonyms: Abrikosoff's granulous cell tumor; Abrikosoff's tumor; Abrikosov's tumor; Giant granulocellular Abrikosov's tumor; Malignant variant of Abrikosov's tumor
SNOMED CT: Granular cell tumor (404035005); Abrikossoff's tumor (404035005); Granular cell myoblastoma (404035005); Granular cell tumor (12169001); Granular cell myoblastoma (12169001)
 
Monarch Initiative: MONDO:0006235

Definition

An unusual benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. It was originally thought to be a tumor originating from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells. It affects females more often than males and it usually presents as a solitary mass. A minority of patients have multiple tumors. It can arise from many anatomic sites including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast. [from NCI]

Professional guidelines

PubMed

Russell DH, Montgomery EA, Susnik B
Adv Anat Pathol 2022 Sep 1;29(5):309-323. Epub 2022 Jul 12 doi: 10.1097/PAP.0000000000000353. PMID: 35838633
Corso G, Di Nubila B, Ciccia A, De Camilli E, Vicini E, Trentin C, Lissidini G, Cairns L, Veronesi P, Galimberti V
Breast J 2018 Sep;24(5):778-782. Epub 2018 Jun 13 doi: 10.1111/tbj.13036. PMID: 29900629
Chen WS, Zheng XL, Jin L, Pan XJ, Ye MF
Ann Thorac Surg 2014 Jan;97(1):296-302. Epub 2013 Oct 17 doi: 10.1016/j.athoracsur.2013.08.042. PMID: 24140217

Recent clinical studies

Etiology

Shen Z, Yao L, Jiang H, Li M, Tang Y
Hua Xi Kou Qiang Yi Xue Za Zhi 2023 Aug 1;41(4):414-420. doi: 10.7518/hxkq.2023.2023035. PMID: 37474473Free PMC Article
Zheng C, Su J, Liang X, Wu J, Gu W, Zhao X
Hua Xi Kou Qiang Yi Xue Za Zhi 2022 Dec 1;40(6):710-715. doi: 10.7518/hxkq.2022.06.013. PMID: 36416325Free PMC Article
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Reddi D, Chandler C, Cardona D, Schild M, Westerhoff M, McMullen E, Tomizawa Y, Clinton L, Swanson PE
Diagn Pathol 2021 Jun 8;16(1):49. doi: 10.1186/s13000-021-01113-3. PMID: 34103065Free PMC Article
Ha C, Regan J, Cetindag IB, Ali A, Mellinger JD
Surg Clin North Am 2015 Jun;95(3):491-514. Epub 2015 Mar 21 doi: 10.1016/j.suc.2015.02.005. PMID: 25965126

Diagnosis

Shen Z, Yao L, Jiang H, Li M, Tang Y
Hua Xi Kou Qiang Yi Xue Za Zhi 2023 Aug 1;41(4):414-420. doi: 10.7518/hxkq.2023.2023035. PMID: 37474473Free PMC Article
Malik F, Bernieh A, Saad AG
Am J Clin Pathol 2023 Jul 5;160(1):106-112. doi: 10.1093/ajcp/aqad025. PMID: 37026754
Zheng C, Su J, Liang X, Wu J, Gu W, Zhao X
Hua Xi Kou Qiang Yi Xue Za Zhi 2022 Dec 1;40(6):710-715. doi: 10.7518/hxkq.2022.06.013. PMID: 36416325Free PMC Article
Bashir A, Suchi M, Martinez AM, Lerner D
J Pediatr Gastroenterol Nutr 2021 Dec 1;73(6):e126. doi: 10.1097/MPG.0000000000003274. PMID: 34347679
Noonan V, Lerman MA, Woo SB, Kabani S
J Mass Dent Soc 2014 Spring;63(1):45. PMID: 24941552

Therapy

Evmorfopoulos K, Tzortzis V, Vlachostergios PJ
Cancer Treat Res Commun 2023;35:100695. Epub 2023 Mar 17 doi: 10.1016/j.ctarc.2023.100695. PMID: 36940531
Kumar S, Chandrasekhara V, Kochman ML, Ahmad N, Attalla S, Ho IK, Jaffe DL, Lee PJ, Panganamamula KV, Saumoy M, Fortuna D, Ginsberg GG
Dis Esophagus 2020 Aug 3;33(8) doi: 10.1093/dote/doaa027. PMID: 32448896Free PMC Article
Sun Y, Reuter VE, Magi-Galluzzi C, Sankin A, Epstein JI
Urology 2018 Nov;121:203.e1-203.e5. Epub 2018 Aug 29 doi: 10.1016/j.urology.2018.08.018. PMID: 30170086Free PMC Article
Riffle ME, Polydorides AD, Niakan J, Chehade M
Am J Surg Pathol 2017 May;41(5):616-621. doi: 10.1097/PAS.0000000000000832. PMID: 28296675
Gupta N, Sanchety N, Verma PS, Verma G
Indian J Pathol Microbiol 2015 Apr-Jun;58(2):238-40. doi: 10.4103/0377-4929.155330. PMID: 25885145

Prognosis

Shen Z, Yao L, Jiang H, Li M, Tang Y
Hua Xi Kou Qiang Yi Xue Za Zhi 2023 Aug 1;41(4):414-420. doi: 10.7518/hxkq.2023.2023035. PMID: 37474473Free PMC Article
Zheng C, Su J, Liang X, Wu J, Gu W, Zhao X
Hua Xi Kou Qiang Yi Xue Za Zhi 2022 Dec 1;40(6):710-715. doi: 10.7518/hxkq.2022.06.013. PMID: 36416325Free PMC Article
Amphlett A
Clin Exp Dermatol 2022 Nov;47(11):1916-1922. Epub 2022 Sep 6 doi: 10.1111/ced.15309. PMID: 35727729
Moten AS, Zhao H, Wu H, Farma JM
J Surg Oncol 2018 Nov;118(6):891-897. Epub 2018 Sep 9 doi: 10.1002/jso.25227. PMID: 30196562
Charu V, Cimino-Mathews A
Semin Diagn Pathol 2017 Sep;34(5):420-426. Epub 2017 May 27 doi: 10.1053/j.semdp.2017.05.011. PMID: 28647116

Clinical prediction guides

Shen Z, Yao L, Jiang H, Li M, Tang Y
Hua Xi Kou Qiang Yi Xue Za Zhi 2023 Aug 1;41(4):414-420. doi: 10.7518/hxkq.2023.2023035. PMID: 37474473Free PMC Article
Corso G, Di Nubila B, Ciccia A, De Camilli E, Vicini E, Trentin C, Lissidini G, Cairns L, Veronesi P, Galimberti V
Breast J 2018 Sep;24(5):778-782. Epub 2018 Jun 13 doi: 10.1111/tbj.13036. PMID: 29900629
Charu V, Cimino-Mathews A
Semin Diagn Pathol 2017 Sep;34(5):420-426. Epub 2017 May 27 doi: 10.1053/j.semdp.2017.05.011. PMID: 28647116
Machado I, Cruz J, Lavernia J, Llombart-Bosch A
Virchows Arch 2016 May;468(5):527-38. Epub 2015 Dec 5 doi: 10.1007/s00428-015-1877-6. PMID: 26637199
Conrad R, Perez MC
Arch Pathol Lab Med 2014 Jan;138(1):128-31. doi: 10.5858/arpa.2012-0306-RS. PMID: 24377822

Recent systematic reviews

Luke AS, Mairson TM, Husain IA, Kaplan SE
Laryngoscope 2024 Apr;134(4):1523-1530. Epub 2023 Oct 2 doi: 10.1002/lary.31071. PMID: 37782552
Tree K, Kotecha K, Mehta S, Fuchs TL, Toon CW, Gill AJ, Samra JS, Mittal A
Langenbecks Arch Surg 2023 Jan 25;408(1):64. doi: 10.1007/s00423-023-02761-3. PMID: 36694023Free PMC Article
Mobarki M, Dumollard JM, Dal Col P, Camy F, Peoc'h M, Karpathiou G
Pathol Res Pract 2020 Apr;216(4):152865. Epub 2020 Feb 12 doi: 10.1016/j.prp.2020.152865. PMID: 32089415
Lafuente Ibáñez de Mendoza I, López Ortega K, Trierveiler M, Oliveira Alves MG, Dias Almeida J, Gándara Vila P, Aguirre Urízar JM, Pérez Sayans M
Oral Dis 2020 Apr;26(3):573-589. Epub 2020 Jan 28 doi: 10.1111/odi.13273. PMID: 31898368
Sarode SC, Sarode GS, Vaidya K
J Oral Pathol Med 2014 Mar;43(3):167-76. Epub 2013 May 13 doi: 10.1111/jop.12085. PMID: 23668324

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...